GREMLIN Database
YDJP - AB hydrolase superfamily protein YdjP
UniProt: O34592 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 271 (251)
Sequences: 63008 (50913)
Seq/√Len: 3213.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_T48_Q4.8331.00
89_V114_A4.4591.00
55_R75_D4.1911.00
39_Q257_N3.2411.00
77_R103_Y2.8631.00
216_E242_P2.7901.00
119_D218_K2.7711.00
211_L263_F2.6221.00
252_E255_A2.6151.00
239_V259_T2.5341.00
87_H113_Q2.5291.00
89_V113_Q2.5271.00
118_I256_F2.4401.00
97_A120_Q2.2741.00
241_F259_T2.2501.00
80_L88_V2.1571.00
230_R236_A2.1451.00
11_R61_D2.1401.00
103_Y107_F2.1261.00
81_N111_N2.1201.00
77_R107_F2.0601.00
90_L100_V2.0491.00
15_E33_G2.0471.00
77_R111_N1.9691.00
46_N261_L1.9401.00
216_E240_T1.9391.00
74_R106_Q1.9361.00
77_R81_N1.9221.00
13_Y59_E1.9001.00
89_V116_V1.8911.00
14_Y79_F1.8791.00
104_L115_A1.7811.00
27_H57_H1.7741.00
102_D106_Q1.7681.00
244_S252_E1.7371.00
100_V115_A1.7361.00
89_V264_L1.7071.00
22_P50_I1.6811.00
16_T50_I1.6811.00
42_V257_N1.6601.00
21_T89_V1.6581.00
223_T240_T1.6481.00
17_H51_R1.6441.00
47_Y89_V1.6351.00
52_L76_I1.6121.00
27_H54_L1.6091.00
70_S106_Q1.5971.00
211_L239_V1.5811.00
22_P85_L1.5571.00
107_F111_N1.5531.00
210_A233_I1.5441.00
13_Y33_G1.5411.00
76_I103_Y1.5381.00
116_V260_L1.5151.00
54_L99_V1.4971.00
258_S262_S1.4941.00
22_P48_Q1.4921.00
259_T262_S1.4911.00
21_T113_Q1.4691.00
228_H232_N1.4671.00
26_I100_V1.4481.00
45_A261_L1.4401.00
68_T71_Q1.4251.00
31_M35_F1.4241.00
26_I54_L1.4171.00
103_Y112_I1.4041.00
168_A171_E1.4001.00
202_T205_N1.3671.00
107_F110_D1.3591.00
117_I120_Q1.3401.00
25_F91_A1.3321.00
50_I79_F1.3321.00
73_A102_D1.3311.00
18_G48_Q1.2951.00
25_F49_C1.2921.00
26_I76_I1.2841.00
30_L57_H1.2601.00
53_D58_G1.2521.00
40_F51_R1.2461.00
13_Y53_D1.2371.00
81_N107_F1.2331.00
214_F226_G1.2301.00
42_V261_L1.2291.00
103_Y111_N1.2211.00
255_A259_T1.2131.00
93_W249_F1.2101.00
33_G53_D1.2071.00
227_E231_S1.2041.00
223_T227_E1.1961.00
85_L88_V1.1871.00
52_L79_F1.1861.00
10_T55_R1.1771.00
33_G59_E1.1751.00
102_D105_N1.1721.00
20_G48_Q1.1721.00
216_E243_K1.1721.00
79_F83_M1.1701.00
24_L80_L1.1631.00
30_L94_S1.1561.00
12_L60_S1.1471.00
101_W117_I1.1441.00
42_V45_A1.1401.00
116_V211_L1.1311.00
256_F260_L1.1271.00
91_A118_I1.1251.00
17_H40_F1.1231.00
80_L85_L1.1161.00
233_I236_A1.1101.00
12_L75_D1.1091.00
94_S246_H1.1081.00
80_L103_Y1.1001.00
241_F244_S1.0991.00
88_V112_I1.0841.00
244_S248_P1.0581.00
255_A258_S1.0541.00
213_C241_F1.0511.00
204_Q232_N1.0491.00
35_F249_F1.0471.00
21_T47_Y1.0371.00
105_N202_T1.0361.00
228_H231_S1.0331.00
42_V254_D1.0271.00
33_G51_R1.0081.00
23_I47_Y1.0061.00
77_R80_L1.0011.00
47_Y264_L0.9981.00
169_E173_E0.9961.00
254_D258_S0.9961.00
14_Y83_M0.9941.00
227_E240_T0.9921.00
115_A210_A0.9921.00
70_S102_D0.9771.00
46_N265_D0.9681.00
141_K145_H0.9641.00
93_W247_C0.9641.00
244_S251_E0.9631.00
73_A99_V0.9611.00
26_I90_L0.9591.00
24_L76_I0.9501.00
214_F223_T0.9501.00
237_T259_T0.9471.00
28_G94_S0.9471.00
50_I83_M0.9401.00
88_V111_N0.9381.00
214_F238_L0.9361.00
230_R238_L0.9351.00
173_E177_A0.9341.00
213_C259_T0.9271.00
227_E238_L0.9181.00
91_A260_L0.9131.00
47_Y265_D0.9031.00
241_F255_A0.9021.00
77_R106_Q0.9011.00
24_L88_V0.9011.00
26_I52_L0.8991.00
108_G111_N0.8941.00
118_I249_F0.8941.00
214_F240_T0.8941.00
21_T87_H0.8881.00
245_S251_E0.8881.00
211_L237_T0.8881.00
173_E176_L0.8881.00
151_P154_F0.8821.00
38_K41_S0.8811.00
176_L180_L0.8811.00
22_P47_Y0.8801.00
23_I49_C0.8791.00
114_A209_P0.8781.00
37_H51_R0.8671.00
92_G97_A0.8611.00
192_F195_T0.8581.00
261_L265_D0.8581.00
102_D202_T0.8541.00
92_G100_V0.8531.00
104_L112_I0.8521.00
78_E82_A0.8521.00
239_V262_S0.8461.00
78_E81_N0.8421.00
54_L95_M0.8421.00
241_F252_E0.8321.00
187_S190_I0.8281.00
212_L236_A0.8231.00
90_L103_Y0.8191.00
227_E230_R0.8171.00
183_P187_S0.8161.00
73_A106_Q0.8161.00
143_A147_I0.8151.00
23_I91_A0.8141.00
217_D243_K0.8131.00
239_V255_A0.8081.00
174_W178_E0.8021.00
22_P88_V0.7931.00
140_L147_I0.7931.00
21_T114_A0.7911.00
84_E87_H0.7901.00
116_V264_L0.7891.00
53_D59_E0.7891.00
27_H52_L0.7871.00
184_A188_S0.7801.00
140_L143_A0.7771.00
33_G52_L0.7711.00
226_G238_L0.7701.00
185_A189_T0.7691.00
10_T61_D0.7671.00
141_K144_M0.7661.00
114_A263_F0.7651.00
178_E181_K0.7631.00
224_A227_E0.7621.00
243_K252_E0.7591.00
74_R77_R0.7571.00
71_Q74_R0.7521.00
140_L144_M0.7391.00
174_W177_A0.7371.00
215_G248_P0.7351.00
213_C256_F0.7351.00
29_V95_M0.7331.00
137_F141_K0.7311.00
207_N234_P0.7281.00
66_G71_Q0.7271.00
118_I248_P0.7271.00
30_L95_M0.7261.00
50_I85_L0.7261.00
175_M179_I0.7211.00
34_Q37_H0.7211.00
12_L55_R0.7171.00
25_F36_F0.7171.00
114_A264_L0.7041.00
90_L112_I0.7031.00
73_A103_Y0.7031.00
74_R78_E0.7021.00
184_A187_S0.6991.00
119_D214_F0.6961.00
119_D248_P0.6951.00
40_F49_C0.6931.00
48_Q85_L0.6901.00
183_P186_I0.6901.00
72_Y95_M0.6891.00
185_A188_S0.6851.00
172_T175_M0.6851.00
86_D111_N0.6831.00
54_L57_H0.6811.00
54_L72_Y0.6761.00
188_S192_F0.6761.00
112_I208_V0.6741.00
199_Y202_T0.6721.00
47_Y261_L0.6681.00
19_S48_Q0.6681.00
41_S44_S0.6651.00
24_L90_L0.6641.00
257_N261_L0.6611.00
91_A116_V0.6611.00
150_D154_F0.6561.00
116_V263_F0.6531.00
171_E174_W0.6521.00
39_Q42_V0.6501.00
93_W119_D0.6481.00
156_E159_I0.6481.00
54_L76_I0.6441.00
55_R72_Y0.6441.00
153_P157_S0.6441.00
159_I163_F0.6411.00
36_F39_Q0.6411.00
92_G96_G0.6401.00
93_W118_I0.6401.00
172_T176_L0.6381.00
119_D215_G0.6361.00
23_I43_L0.6351.00
74_R107_F0.6311.00
23_I264_L0.6301.00
186_I189_T0.6291.00
104_L208_V0.6281.00
88_V113_Q0.6281.00
23_I89_V0.6271.00
39_Q256_F0.6261.00
216_E223_T0.6251.00
137_F144_M0.6221.00
150_D153_P0.6221.00
237_T262_S0.6201.00
15_E37_H0.6191.00
154_F158_F0.6161.00
101_W120_Q0.6161.00
152_L155_Y0.6151.00
138_D141_K0.6101.00
189_T193_N0.6101.00
212_L238_L0.6091.00
36_F40_F0.6091.00
25_F51_R0.6081.00
97_A117_I0.6071.00
117_I212_L0.6041.00
157_S160_Q0.6041.00
212_L233_I0.6031.00
258_S261_L0.6001.00
138_D142_T0.5991.00
144_M147_I0.5981.00
170_T174_W0.5971.00
192_F196_A0.5971.00
69_I102_D0.5941.00
253_P257_N0.5921.00
212_L230_R0.5891.00
154_F157_S0.5881.00
88_V103_Y0.5881.00
157_S161_N0.5861.00
206_I233_I0.5851.00
164_A167_P0.5841.00
70_S74_R0.5841.00
139_G143_A0.5831.00
198_D202_T0.5801.00
98_F121_S0.5801.00
155_Y158_F0.5791.00
17_H41_S0.5791.00
32_S57_H0.5771.00
213_C239_V0.5761.00
94_S247_C0.5751.00
177_A180_L0.5741.00
37_H41_S0.5701.00
242_P255_A0.5701.00
76_I99_V0.5681.00
225_A228_H0.5681.00
46_N49_C0.5671.00
101_W122_A0.5671.00
142_T146_A0.5661.00
201_G204_Q0.5651.00
159_I162_M0.5621.00
137_F140_L0.5611.00
144_M148_Q0.5601.00
15_E34_Q0.5591.00
145_H149_T0.5591.00
260_L264_L0.5581.00
87_H111_N0.5561.00
169_E172_T0.5551.00
79_F82_A0.5541.00
191_L194_Q0.5501.00
104_L206_I0.5491.00
183_P189_T0.5481.00
80_L111_N0.5481.00
177_A181_K0.5481.00
142_T145_H0.5481.00
158_F162_M0.5461.00
72_Y99_V0.5451.00
186_I190_I0.5441.00
152_L156_E0.5431.00
156_E160_Q0.5431.00
212_L226_G0.5411.00
116_V213_C0.5401.00
26_I99_V0.5391.00
158_F163_F0.5391.00
155_Y162_M0.5351.00
35_F93_W0.5341.00
120_Q229_L0.5341.00
95_M99_V0.5321.00
53_D60_S0.5321.00
153_P156_E0.5311.00
16_T83_M0.5301.00
249_F256_F0.5271.00
73_A77_R0.5251.00
105_N205_N0.5251.00
31_M247_C0.5211.00
106_Q202_T0.5211.00
25_F43_L0.5201.00
175_M178_E0.5201.00
154_F159_I0.5181.00
200_R232_N0.5161.00
63_V67_H0.5151.00
193_N196_A0.5141.00
107_F112_I0.5121.00
13_Y60_S0.5121.00
31_M93_W0.5121.00
217_D244_S0.5111.00
248_P256_F0.5081.00
44_S49_C0.5081.00
71_Q75_D0.5061.00
123_S228_H0.5031.00
214_F221_F0.5031.00
145_H148_Q0.5021.00
17_H44_S0.5011.00
39_Q249_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ehyA 1 0.9336 100 0.154 Contact Map
3om8A 4 0.9446 100 0.158 Contact Map
4inzA 1 0.9779 100 0.16 Contact Map
2xuaA 2 0.9446 100 0.164 Contact Map
1zoiA 3 0.9779 100 0.169 Contact Map
2pujA 4 0.9631 100 0.177 Contact Map
1iupA 2 0.9594 100 0.178 Contact Map
3oosA 1 0.9668 100 0.181 Contact Map
3fobA 3 0.9779 100 0.183 Contact Map
1a8qA 3 0.9742 100 0.184 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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