GREMLIN Database
ACOB - Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit beta
UniProt: O34591 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 342 (302)
Sequences: 13903 (7983)
Seq/√Len: 459.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
239_R333_L4.5601.00
20_R60_E3.7041.00
235_Q329_V3.2911.00
324_T327_K2.9071.00
217_V332_T2.8391.00
208_A258_A2.8281.00
80_A92_A2.7461.00
212_R233_A2.4901.00
230_L245_V2.3841.00
16_K60_E2.3621.00
212_R234_A2.2971.00
235_Q325_P2.1871.00
215_N242_E2.1701.00
233_A245_V2.1541.00
159_V170_L2.1331.00
16_K61_F2.1091.00
231_E325_P2.1031.00
325_P329_V2.0771.00
302_K334_E2.0611.00
256_E288_L2.0261.00
217_V243_A1.9881.00
218_T266_T1.9831.00
319_D324_T1.9751.00
83_A88_L1.9021.00
228_T325_P1.8761.00
89_R123_Q1.8741.00
237_S242_E1.8511.00
260_F288_L1.8401.00
302_K331_V1.8091.00
235_Q238_E1.8071.00
291_D303_R1.7881.00
20_R61_F1.7721.00
216_D267_N1.7651.00
77_M111_G1.7541.00
212_R237_S1.7491.00
244_E265_K1.7471.00
81_M111_G1.7221.00
216_D242_E1.7201.00
244_E262_S1.7191.00
229_A272_I1.7181.00
148_G275_A1.6751.00
221_A229_A1.6471.00
235_Q326_D1.6461.00
244_E266_T1.6421.00
283_T287_A1.6371.00
121_K155_G1.6361.00
157_K177_D1.6291.00
329_V333_L1.6231.00
210_I244_E1.6131.00
256_E292_K1.5971.00
330_S334_E1.5951.00
277_P305_T1.5941.00
219_L229_A1.5891.00
5_I13_E1.5801.00
260_F292_K1.5681.00
151_T284_D1.5671.00
17_L168_K1.5591.00
156_L182_F1.5521.00
213_E244_E1.5491.00
231_E234_A1.5451.00
26_L83_A1.5371.00
18_A172_L1.5351.00
111_G126_I1.5321.00
91_I175_I1.5311.00
316_V319_D1.5301.00
125_P174_A1.5301.00
157_K179_D1.5201.00
228_T231_E1.5141.00
286_A301_I1.5041.00
77_M126_I1.4831.00
261_T266_T1.4821.00
174_A181_V1.4501.00
151_T287_A1.4421.00
221_A226_V1.4401.00
227_N231_E1.4341.00
220_F248_P1.4181.00
331_V334_E1.4111.00
208_A248_P1.4071.00
77_M92_A1.4061.00
232_A329_V1.3761.00
234_A238_E1.3721.00
270_I335_L1.3631.00
228_T328_I1.3581.00
22_D89_R1.3541.00
327_K331_V1.3531.00
14_A168_K1.3471.00
150_F182_F1.3461.00
246_L258_A1.3441.00
319_D326_D1.3311.00
209_D247_D1.3131.00
123_Q179_D1.3061.00
219_L332_T1.3061.00
14_A172_L1.3031.00
255_D288_L1.2961.00
172_L176_E1.2931.00
235_Q239_R1.2751.00
157_K250_S1.2751.00
89_R125_P1.2741.00
204_P207_K1.2741.00
18_A176_E1.2721.00
15_M91_I1.2661.00
173_A205_L1.2521.00
234_A237_S1.2501.00
166_D247_D1.2481.00
77_M103_C1.2381.00
107_V156_L1.2341.00
18_A25_V1.2321.00
159_V250_S1.2291.00
248_P281_I1.2231.00
28_I80_A1.2191.00
218_T262_S1.2091.00
210_I213_E1.2071.00
19_M57_L1.2051.00
9_D13_E1.2021.00
254_L259_I1.2001.00
257_D261_T1.1971.00
246_L262_S1.1821.00
18_A175_I1.1821.00
273_D282_A1.1811.00
24_N88_L1.1811.00
166_D249_R1.1811.00
162_S226_V1.1781.00
286_A290_A1.1781.00
107_V128_V1.1771.00
27_L54_T1.1741.00
261_T265_K1.1731.00
56_G59_Q1.1721.00
123_Q178_N1.1641.00
270_I332_T1.1611.00
28_I69_T1.1551.00
211_K226_V1.1541.00
260_F293_G1.1541.00
162_S247_D1.1411.00
220_F269_L1.1221.00
13_E168_K1.1211.00
219_L243_A1.1161.00
26_L88_L1.0971.00
159_V181_V1.0881.00
208_A246_L1.0861.00
263_L289_V1.0781.00
302_K335_L1.0781.00
243_A332_T1.0741.00
312_P320_Q1.0731.00
327_K330_S1.0721.00
260_F264_E1.0711.00
210_I246_L1.0711.00
104_F149_L1.0701.00
290_A301_I1.0681.00
22_D25_V1.0631.00
128_V182_F1.0591.00
17_L172_L1.0581.00
18_A21_K1.0571.00
207_K257_D1.0551.00
10_A164_P1.0531.00
13_E17_L1.0521.00
210_I258_A1.0501.00
214_G242_E1.0481.00
148_G152_S1.0461.00
129_R185_E1.0391.00
14_A17_L1.0381.00
286_A303_R1.0361.00
225_Q228_T1.0291.00
281_I285_I1.0251.00
294_F299_A1.0231.00
147_Y222_V1.0221.00
269_L289_V1.0181.00
256_E260_F1.0161.00
212_R242_E1.0151.00
84_A90_P1.0131.00
288_L292_K1.0111.00
21_K172_L1.0111.00
98_D146_L1.0031.00
272_I328_I1.0031.00
22_D175_I0.9961.00
287_A303_R0.9931.00
17_L21_K0.9821.00
74_A106_Q0.9811.00
252_S308_H0.9781.00
270_I304_I0.9761.00
157_K181_V0.9681.00
19_M25_V0.9621.00
239_R329_V0.9591.00
80_A124_V0.9591.00
97_N184_F0.9491.00
229_A273_D0.9461.00
147_Y184_F0.9391.00
13_E56_G0.9361.00
89_R178_N0.9351.00
306_A321_Y0.9291.00
27_L32_V0.9291.00
218_T246_L0.9281.00
16_K20_R0.9241.00
162_S209_D0.9241.00
278_R308_H0.9241.00
222_V251_L0.9211.00
322_L327_K0.9201.00
232_A328_I0.9201.00
262_S265_K0.9161.00
268_R335_L0.9121.00
96_F99_F0.9101.00
218_T244_E0.9071.00
326_D330_S0.9061.00
17_L20_R0.9051.00
76_Y92_A0.8961.00
56_G60_E0.8961.00
111_G124_V0.8931.00
159_V205_L0.8921.00
148_G279_C0.8881.00
282_A305_T0.8861.00
236_L332_T0.8841.00
271_I282_A0.8841.00
69_T79_A0.8841.00
9_D12_N0.8831.00
112_A153_I0.8781.00
147_Y275_A0.8781.00
55_K59_Q0.8701.00
24_N89_R0.8691.00
157_K253_P0.8641.00
33_A66_V0.8591.00
268_R300_P0.8581.00
309_T320_Q0.8561.00
107_V150_F0.8551.00
121_K179_D0.8521.00
164_P192_M0.8411.00
241_I333_L0.8401.00
332_T335_L0.8401.00
229_A245_V0.8401.00
294_F334_E0.8391.00
100_I150_F0.8361.00
261_T264_E0.8351.00
171_L183_F0.8351.00
258_A262_S0.8341.00
113_K140_A0.8191.00
77_M128_V0.8171.00
248_P251_L0.8121.00
236_L329_V0.8111.00
151_T251_L0.8101.00
134_A318_E0.8091.00
100_I130_T0.8091.00
28_I67_L0.8091.00
79_A83_A0.8061.00
203_I206_G0.8031.00
26_L67_L0.8011.00
75_G79_A0.7971.00
5_I10_A0.7951.00
173_A204_P0.7941.00
316_V320_Q0.7931.00
156_L180_P0.7931.00
9_D189_S0.7911.00
167_A185_E0.7901.00
259_I288_L0.7901.00
255_D287_A0.7881.00
140_A143_S0.7881.00
270_I273_D0.7841.00
216_D241_I0.7811.00
212_R230_L0.7781.00
282_A303_R0.7771.00
217_V270_I0.7761.00
254_L288_L0.7761.00
228_T318_E0.7711.00
228_T324_T0.7691.00
160_V222_V0.7651.00
220_F246_L0.7631.00
30_E52_G0.7621.00
231_E235_Q0.7611.00
221_A225_Q0.7611.00
186_D190_Y0.7611.00
97_N150_F0.7591.00
191_N227_N0.7591.00
111_G180_P0.7561.00
237_S243_A0.7531.00
270_I302_K0.7511.00
331_V335_L0.7501.00
11_I93_E0.7491.00
14_A171_L0.7491.00
213_E265_K0.7491.00
14_A18_A0.7471.00
157_K205_L0.7451.00
84_A124_V0.7451.00
233_A237_S0.7441.00
196_V199_D0.7421.00
271_I274_E0.7411.00
146_L184_F0.7411.00
157_K252_S0.7371.00
172_L200_Y0.7341.00
57_L66_V0.7331.00
319_D327_K0.7331.00
27_L91_I0.7301.00
61_F65_R0.7291.00
58_V66_V0.7281.00
165_Y197_P0.7261.00
125_P181_V0.7251.00
169_G172_L0.7191.00
112_A310_P0.7161.00
149_L153_I0.7151.00
107_V126_I0.7141.00
330_S333_L0.7121.00
51_L54_T0.7061.00
151_T279_C0.7051.00
12_N16_K0.7041.00
28_I79_A0.7001.00
251_L255_D0.6971.00
80_A93_E0.6911.00
262_S266_T0.6901.00
232_A272_I0.6881.00
33_A58_V0.6831.00
277_P303_R0.6821.00
15_M54_T0.6821.00
30_E76_Y0.6821.00
112_A156_L0.6811.00
259_I289_V0.6781.00
28_I76_Y0.6781.00
10_A14_A0.6741.00
317_L321_Y0.6731.00
153_I156_L0.6731.00
100_I128_V0.6731.00
78_G106_Q0.6721.00
163_N211_K0.6721.00
98_D144_Q0.6701.00
84_A122_A0.6661.00
211_K230_L0.6651.00
277_P291_D0.6631.00
313_F318_E0.6621.00
23_E65_R0.6621.00
5_I9_D0.6581.00
173_A202_T0.6581.00
222_V248_P0.6581.00
260_F294_F0.6551.00
169_G202_T0.6541.00
170_L249_R0.6531.00
241_I336_L0.6521.00
57_L62_G0.6511.00
92_A126_I0.6511.00
173_A176_E0.6481.00
232_A332_T0.6471.00
85_S122_A0.6471.00
284_D287_A0.6461.00
8_S53_V0.6431.00
147_Y158_T0.6401.00
210_I261_T0.6381.00
290_A293_G0.6360.99
58_V61_F0.6350.99
176_E200_Y0.6310.99
307_P321_Y0.6300.99
304_I331_V0.6300.99
97_N146_L0.6300.99
207_K255_D0.6290.99
269_L301_I0.6280.99
25_V91_I0.6250.99
25_V175_I0.6230.99
159_V173_A0.6230.99
108_I153_I0.6220.99
159_V174_A0.6200.99
216_D243_A0.6200.99
295_D299_A0.6180.99
218_T265_K0.6170.99
165_Y169_G0.6160.99
256_E291_D0.6160.99
294_F331_V0.6160.99
195_E198_E0.6090.99
91_I171_L0.6080.99
103_C107_V0.6080.99
206_G209_D0.6070.99
213_E261_T0.6070.99
174_A183_F0.6060.99
121_K178_N0.6010.99
172_L202_T0.6000.99
307_P327_K0.5980.99
309_T321_Y0.5940.99
114_F122_A0.5920.99
197_P201_Y0.5920.99
83_A90_P0.5890.99
67_L79_A0.5890.99
169_G173_A0.5880.99
280_S283_T0.5870.99
273_D280_S0.5860.99
271_I285_I0.5860.99
177_D181_V0.5840.99
218_T268_R0.5830.99
151_T158_T0.5810.99
270_I274_E0.5790.99
263_L269_L0.5790.99
225_Q272_I0.5770.99
101_G104_F0.5760.99
282_A287_A0.5740.99
236_L243_A0.5740.99
304_I323_P0.5740.99
96_F138_A0.5720.99
6_S9_D0.5710.99
224_K228_T0.5690.99
226_V245_V0.5690.99
52_G55_K0.5680.99
323_P327_K0.5670.99
148_G276_N0.5660.99
105_D109_N0.5660.99
11_I171_L0.5650.99
19_M66_V0.5650.99
221_A248_P0.5640.99
9_D56_G0.5630.99
206_G250_S0.5620.99
157_K206_G0.5560.99
218_T269_L0.5560.99
165_Y201_Y0.5550.99
289_V301_I0.5550.99
85_S114_F0.5550.99
72_S75_G0.5520.99
158_T182_F0.5520.99
232_A325_P0.5520.99
250_S253_P0.5480.98
162_S166_D0.5480.98
89_R175_I0.5470.98
104_F152_S0.5460.98
210_I262_S0.5460.98
165_Y192_M0.5440.98
169_G200_Y0.5440.98
284_D303_R0.5430.98
101_G146_L0.5430.98
267_N270_I0.5430.98
278_R303_R0.5420.98
208_A255_D0.5400.98
314_S317_L0.5360.98
291_D302_K0.5360.98
186_D224_K0.5350.98
201_Y209_D0.5340.98
311_V321_Y0.5330.98
77_M94_L0.5330.98
127_T174_A0.5330.98
213_E242_E0.5320.98
151_T281_I0.5320.98
271_I301_I0.5280.98
191_N231_E0.5280.98
269_L273_D0.5270.98
177_D205_L0.5230.98
272_I304_I0.5220.98
289_V295_D0.5220.98
160_V224_K0.5220.98
283_T303_R0.5210.98
268_R292_K0.5210.98
125_P183_F0.5210.98
214_G237_S0.5200.98
160_V223_G0.5200.98
134_A317_L0.5180.98
168_K172_L0.5140.98
22_D176_E0.5130.98
9_D53_V0.5120.98
16_K66_V0.5120.98
125_P171_L0.5070.98
294_F300_P0.5060.97
233_A243_A0.5050.97
57_L61_F0.5030.97
179_D256_E0.5030.97
251_L281_I0.5020.97
25_V89_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w85B 2 0.9327 100 0.267 Contact Map
2ozlB 2 0.9444 100 0.272 Contact Map
1umdB 2 0.9327 100 0.277 Contact Map
1ik6A 3 0.8099 100 0.284 Contact Map
1qs0B 2 0.9298 100 0.29 Contact Map
2o1xA 2 0.8947 100 0.298 Contact Map
2bfdB 2 0.9386 100 0.302 Contact Map
4kxvA 2 0.8889 100 0.306 Contact Map
2o1sA 2 0.8772 100 0.312 Contact Map
1gpuA 2 0.883 100 0.35 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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