GREMLIN Database
FLAW - Probable flavodoxin-2
UniProt: O34589 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 151 (141)
Sequences: 4602 (3078)
Seq/√Len: 259.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_E117_I3.8131.00
90_G103_V3.6111.00
104_D123_K3.2981.00
85_T116_D2.7611.00
11_M67_D2.7081.00
111_K117_I2.6861.00
101_G105_T2.3921.00
109_K112_E2.3831.00
109_K113_R2.3271.00
86_C107_E2.1381.00
23_E35_R2.1171.00
89_F124_I2.0301.00
86_C111_K1.9011.00
65_L102_A1.8981.00
4_I26_L1.8781.00
41_I50_Y1.8191.00
26_L144_A1.8071.00
88_V103_V1.7301.00
6_L23_E1.7241.00
52_H85_T1.7061.00
9_A69_F1.6661.00
7_V38_A1.6611.00
77_E109_K1.6611.00
86_C117_I1.6501.00
15_T56_G1.6201.00
16_E20_D1.6081.00
23_E33_V1.5601.00
38_A72_L1.5571.00
107_E121_S1.5341.00
107_E111_K1.4831.00
55_M110_I1.4741.00
7_V41_I1.4561.00
119_L142_Q1.4431.00
86_C115_G1.4391.00
3_K32_E1.4301.00
57_T106_L1.4161.00
55_M106_L1.4001.00
61_G64_D1.3841.00
10_T68_E1.3611.00
73_V106_L1.3411.00
73_V105_T1.3321.00
18_M91_S1.3191.00
23_E27_Q1.3131.00
18_M136_L1.3101.00
9_A57_T1.2821.00
20_D35_R1.2731.00
110_I115_G1.2681.00
54_I87_A1.2431.00
72_L106_L1.2411.00
56_G89_F1.2371.00
54_I143_F1.2361.00
53_V84_K1.2301.00
104_D121_S1.2201.00
5_L36_F1.1901.00
135_E139_F1.1691.00
34_D50_Y1.1621.00
9_A68_E1.1011.00
15_T91_S1.0951.00
87_A119_L1.0901.00
38_A69_F1.0891.00
22_I56_G1.0881.00
37_E40_D1.0781.00
25_G140_G1.0671.00
117_I120_P1.0631.00
89_F136_L1.0491.00
101_G104_D1.0381.00
141_R145_K1.0381.00
90_G100_C1.0261.00
73_V109_K1.0261.00
142_Q145_K1.0041.00
62_D98_F1.0011.00
57_T102_A0.9961.00
108_A112_E0.9911.00
100_C123_K0.9761.00
119_L143_F0.9751.00
25_G137_I0.9751.00
58_Y66_P0.9711.00
37_E68_E0.9691.00
89_F122_V0.9671.00
100_C103_V0.9621.00
87_A143_F0.9621.00
42_D45_Q0.9531.00
26_L33_V0.9531.00
25_G141_R0.9381.00
4_I31_A0.9071.00
65_L69_F0.9061.00
6_L33_V0.8811.00
59_T100_C0.8811.00
9_A66_P0.8791.00
7_V53_V0.8781.00
75_D79_I0.8771.00
83_G116_D0.8761.00
17_A21_L0.8731.00
73_V102_A0.8721.00
57_T69_F0.8691.00
22_I140_G0.8691.00
5_L50_Y0.8490.99
138_N141_R0.8470.99
65_L73_V0.8370.99
42_D46_L0.8270.99
41_I75_D0.8260.99
25_G29_A0.8240.99
10_T15_T0.8240.99
124_I131_E0.8200.99
36_F40_D0.8150.99
87_A118_V0.8140.99
8_Y16_E0.8130.99
67_D70_L0.8120.99
124_I136_L0.8070.99
81_F115_G0.7930.99
124_I128_P0.7870.99
65_L105_T0.7860.99
86_C110_I0.7760.99
138_N142_Q0.7760.99
88_V107_E0.7740.99
50_Y53_V0.7710.99
18_M56_G0.7710.99
39_M68_E0.7710.99
57_T66_P0.7690.99
5_L34_D0.7680.99
3_K51_D0.7670.99
12_S62_D0.7650.99
64_D105_T0.7620.99
103_V121_S0.7520.99
25_G144_A0.7510.99
108_A111_K0.7490.99
4_I52_H0.7490.99
22_I54_I0.7440.99
4_I54_I0.7440.99
73_V77_E0.7420.99
3_K34_D0.7320.98
27_Q33_V0.7280.98
57_T103_V0.7230.98
117_I121_S0.7190.98
120_P142_Q0.7110.98
9_A38_A0.7110.98
8_Y35_R0.7090.98
127_N132_E0.7060.98
7_V36_F0.7020.98
98_F101_G0.6990.98
77_E105_T0.6970.98
31_A52_H0.6960.98
21_L137_I0.6930.98
119_L122_V0.6930.98
119_L146_K0.6900.98
124_I132_E0.6900.98
11_M15_T0.6860.98
29_A144_A0.6800.98
136_L139_F0.6790.97
24_K27_Q0.6780.97
17_A20_D0.6680.97
5_L51_D0.6600.97
62_D97_E0.6600.97
92_G96_Y0.6570.97
36_F41_I0.6510.97
137_I141_R0.6450.97
128_P132_E0.6440.97
44_A48_T0.6440.97
59_T103_V0.6420.96
122_V131_E0.6380.96
92_G100_C0.6380.96
16_E68_E0.6370.96
74_E78_E0.6210.96
80_D113_R0.6180.96
126_N131_E0.6060.95
63_G66_P0.6040.95
91_S126_N0.6020.95
44_A75_D0.5930.95
24_K29_A0.5920.95
142_Q146_K0.5900.94
46_L49_D0.5840.94
55_M66_P0.5790.94
7_V55_M0.5780.94
92_G99_F0.5770.94
45_Q80_D0.5770.94
79_I113_R0.5760.94
61_G91_S0.5700.93
9_A102_A0.5640.93
45_Q79_I0.5640.93
14_N17_A0.5600.93
93_D127_N0.5590.93
85_T118_V0.5590.93
110_I117_I0.5550.92
32_E111_K0.5500.92
33_V36_F0.5480.92
3_K50_Y0.5470.92
99_F121_S0.5470.92
22_I90_G0.5450.92
94_T125_E0.5440.92
105_T108_A0.5430.92
94_T127_N0.5430.92
84_K110_I0.5430.92
54_I118_V0.5430.92
15_T58_Y0.5380.91
60_W126_N0.5380.91
6_L26_L0.5340.91
76_M113_R0.5330.91
6_L35_R0.5270.90
24_K28_E0.5260.90
103_V123_K0.5260.90
41_I72_L0.5180.90
14_N58_Y0.5170.90
100_C104_D0.5160.89
77_E108_A0.5140.89
29_A141_R0.5100.89
94_T100_C0.5090.89
14_N18_M0.5050.88
127_N130_G0.5050.88
93_D96_Y0.5040.88
39_M71_D0.5030.88
19_A35_R0.5020.88
65_L106_L0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tllA 2 0.9735 100 0.149 Contact Map
2bpoA 1 0.9868 100 0.199 Contact Map
3qe2A 1 0.9801 100 0.205 Contact Map
3hr4A 2 0.9735 100 0.272 Contact Map
1bvyF 1 0.9669 100 0.341 Contact Map
4h2dA 1 0.9868 100 0.35 Contact Map
1ykgA 1 0.947 100 0.375 Contact Map
4oxxA 1 0.9801 100 0.379 Contact Map
2m6rA 1 0.9603 100 0.383 Contact Map
2hnaA 1 0.9603 100 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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