GREMLIN Database
YLBC - Uncharacterized membrane protein YlbC
UniProt: O34586 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 346 (292)
Sequences: 386 (331)
Seq/√Len: 19.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
278_S281_D4.7261.00
259_H282_R4.4791.00
185_S309_E4.4641.00
315_E319_K4.4231.00
260_S339_T4.2221.00
273_S277_G4.0261.00
174_L183_L3.9181.00
249_D328_H3.8701.00
294_G326_Y3.7521.00
68_V107_V3.6351.00
77_R232_D3.0440.99
227_E257_F2.9790.99
99_Q232_D2.9050.99
164_T194_F2.8010.99
72_L98_I2.6800.98
263_M339_T2.3970.96
260_S263_M2.3850.96
262_D273_S2.3760.96
214_V222_I2.3710.96
261_E265_E2.2620.95
268_Y274_K2.2200.94
233_L243_L2.1710.93
172_V188_A2.1230.93
53_P56_G2.0880.92
259_H263_M2.0670.92
231_L248_W2.0620.91
231_L329_L2.0520.91
292_Q323_N1.9820.90
234_T329_L1.9590.89
230_I297_I1.9490.89
34_D37_P1.9480.89
248_W329_L1.9440.89
271_H295_E1.8700.87
258_G286_G1.8700.87
262_D266_N1.8570.86
260_S332_G1.8100.85
50_I53_P1.8010.85
75_P90_Y1.7980.84
263_M271_H1.7940.84
77_R90_Y1.7850.84
283_L293_A1.7650.83
255_V286_G1.7620.83
184_S309_E1.7140.81
100_I110_L1.6810.80
78_I86_D1.6780.80
68_V100_I1.6680.80
230_I311_W1.6400.78
252_T255_V1.6400.78
79_D232_D1.6080.77
262_D281_D1.6030.77
229_Q232_D1.5980.76
65_A88_W1.5590.75
274_K277_G1.5350.73
99_Q229_Q1.5200.73
279_L312_L1.5160.73
235_N296_N1.5100.72
219_W335_R1.4960.71
271_H316_G1.4900.71
263_M282_R1.4630.70
79_D89_V1.4450.69
314_S317_H1.4450.69
282_R341_N1.4360.68
190_D193_T1.4350.68
263_M332_G1.4270.68
69_T74_E1.4240.68
296_N317_H1.4150.67
235_N317_H1.3870.66
166_K169_K1.3860.65
36_E44_A1.3690.64
260_S269_F1.3610.64
237_I308_V1.3450.63
101_G109_T1.3390.63
269_F332_G1.3230.62
89_V326_Y1.3220.62
95_D104_N1.2950.60
230_I340_Q1.2890.60
179_F315_E1.2830.59
297_I340_Q1.2680.58
263_M269_F1.2610.58
304_G308_V1.2490.57
290_F300_N1.2470.57
234_T308_V1.2330.56
101_G240_K1.2260.56
259_H341_N1.2250.56
269_F295_E1.2220.55
174_L338_Y1.2110.55
283_L343_I1.2090.55
109_T198_R1.2010.54
257_F287_H1.1970.54
36_E43_E1.1880.53
263_M273_S1.1820.53
73_G77_R1.1800.53
47_G51_H1.1750.53
117_I155_S1.1650.52
111_F309_E1.1620.52
142_N149_S1.1590.51
34_D38_Q1.1550.51
316_G320_A1.1540.51
140_F309_E1.1530.51
282_R339_T1.1490.51
101_G108_V1.1470.51
52_M58_L1.1450.51
117_I342_F1.1390.50
112_A305_P1.1350.50
308_V336_K1.1350.50
238_R296_N1.1270.49
123_K250_Q1.1250.49
301_Y306_A1.1170.49
187_R194_F1.1110.48
39_V44_A1.1050.48
259_H339_T1.1020.48
187_R303_D1.0950.47
96_Q169_K1.0940.47
230_I331_V1.0920.47
73_G90_Y1.0840.47
259_H295_E1.0820.47
113_S233_L1.0810.47
311_W340_Q1.0760.46
89_V99_Q1.0650.46
55_S64_H1.0640.45
36_E46_S1.0580.45
259_H269_F1.0530.45
115_N172_V1.0520.45
81_S101_G1.0490.44
35_S38_Q1.0470.44
271_H317_H1.0420.44
56_G59_S1.0350.44
175_Y333_V1.0330.43
259_H307_A1.0330.43
122_F183_L1.0310.43
292_Q325_D1.0290.43
248_W253_A1.0180.43
229_Q333_V1.0150.42
272_V280_K1.0030.42
194_F303_D0.9960.41
235_N238_R0.9940.41
39_V45_Q0.9930.41
49_R287_H0.9920.41
238_R317_H0.9890.41
263_M298_A0.9880.41
280_K293_A0.9840.40
82_A303_D0.9840.40
298_A332_G0.9820.40
124_I290_F0.9740.40
152_F164_T0.9710.40
194_F301_Y0.9710.40
233_L246_L0.9650.39
37_P40_S0.9610.39
39_V324_S0.9570.39
289_D342_F0.9570.39
85_Y194_F0.9540.39
84_D186_I0.9500.38
273_S282_R0.9420.38
295_E332_G0.9370.38
239_V245_K0.9370.38
272_V278_S0.9340.37
223_Q326_Y0.9330.37
65_A69_T0.9260.37
166_K191_A0.9240.37
45_Q48_K0.9190.37
64_H106_K0.9100.36
38_Q43_E0.9090.36
259_H318_R0.9070.36
79_D99_Q0.9060.36
87_W99_Q0.9060.36
237_I312_L0.9040.36
62_G77_R0.9040.36
42_E67_E0.9010.35
175_Y187_R0.8920.35
282_R307_A0.8910.35
283_L294_G0.8650.33
62_G73_G0.8640.33
40_S43_E0.8630.33
107_V138_A0.8630.33
46_S247_E0.8630.33
254_E324_S0.8610.33
246_L321_L0.8580.33
35_S42_E0.8580.33
45_Q67_E0.8580.33
61_M232_D0.8560.33
263_M314_S0.8510.33
235_N314_S0.8460.32
81_S102_V0.8390.32
51_H54_T0.8390.32
296_N314_S0.8390.32
279_L283_L0.8390.32
240_K309_E0.8370.32
217_E337_Y0.8330.32
85_Y101_G0.8330.32
94_K239_V0.8300.31
175_Y306_A0.8300.31
38_Q67_E0.8280.31
51_H55_S0.8200.31
162_R301_Y0.8190.31
68_V92_Q0.8160.31
83_Y87_W0.8130.31
259_H271_H0.8130.31
269_F316_G0.8120.30
132_F172_V0.8070.30
129_G167_V0.8050.30
73_G97_Y0.8030.30
226_S262_D0.8010.30
61_M86_D0.8010.30
260_S282_R0.7960.30
249_D252_T0.7890.29
79_D304_G0.7890.29
86_D270_S0.7880.29
285_E337_Y0.7870.29
238_R295_E0.7870.29
126_E333_V0.7820.29
34_D39_V0.7810.29
41_N46_S0.7790.29
91_N231_L0.7790.29
79_D91_N0.7780.29
43_E267_N0.7780.29
109_T306_A0.7750.28
37_P41_N0.7740.28
271_H339_T0.7720.28
35_S46_S0.7720.28
182_K266_N0.7700.28
188_A320_A0.7680.28
110_L117_I0.7660.28
273_S276_Y0.7660.28
297_I329_L0.7660.28
255_V274_K0.7650.28
79_D229_Q0.7610.28
319_K325_D0.7600.28
103_L196_K0.7580.28
45_Q220_K0.7580.28
234_T312_L0.7570.28
173_Q306_A0.7520.27
291_Q344_K0.7510.27
36_E64_H0.7490.27
101_G303_D0.7470.27
173_Q308_V0.7460.27
38_Q41_N0.7440.27
72_L231_L0.7420.27
295_E316_G0.7420.27
223_Q309_E0.7380.27
127_S326_Y0.7350.26
230_I342_F0.7350.26
73_G107_V0.7350.26
77_R177_D0.7340.26
298_A307_A0.7320.26
88_W229_Q0.7310.26
173_Q303_D0.7300.26
35_S41_N0.7290.26
85_Y303_D0.7280.26
67_E250_Q0.7260.26
127_S130_E0.7240.26
68_V102_V0.7200.26
70_K191_A0.7200.26
87_W329_L0.7190.26
102_V107_V0.7170.26
101_G340_Q0.7170.26
43_E46_S0.7170.26
74_E130_E0.7120.25
44_A59_S0.7120.25
35_S40_S0.7120.25
221_K302_V0.7110.25
74_E251_P0.7110.25
259_H273_S0.7100.25
168_G247_E0.7070.25
178_K252_T0.7070.25
37_P43_E0.7020.25
66_D254_E0.7000.25
290_F313_N0.6970.25
232_D331_V0.6960.25
241_H304_G0.6960.25
81_S85_Y0.6960.25
162_R175_Y0.6950.25
303_D306_A0.6950.25
163_P176_M0.6910.24
90_Y232_D0.6870.24
234_T248_W0.6860.24
97_Y311_W0.6830.24
75_P81_S0.6810.24
283_L315_E0.6790.24
142_N249_D0.6760.24
268_Y278_S0.6750.24
109_T163_P0.6740.24
297_I341_N0.6730.24
162_R173_Q0.6730.24
75_P79_D0.6720.23
227_E290_F0.6710.23
177_D338_Y0.6710.23
35_S47_G0.6670.23
87_W232_D0.6660.23
66_D244_A0.6650.23
133_K265_E0.6650.23
308_V311_W0.6640.23
332_G339_T0.6600.23
289_D327_T0.6590.23
89_V102_V0.6580.23
37_P323_N0.6580.23
271_H297_I0.6570.23
177_D318_R0.6570.23
239_V242_G0.6570.23
66_D102_V0.6520.23
275_K343_I0.6510.23
54_T106_K0.6500.22
221_K244_A0.6500.22
293_A307_A0.6490.22
281_D300_N0.6490.22
39_V42_E0.6480.22
64_H251_P0.6480.22
66_D287_H0.6460.22
43_E48_K0.6460.22
46_S54_T0.6450.22
35_S285_E0.6440.22
316_G333_V0.6440.22
300_N320_A0.6430.22
253_A311_W0.6430.22
41_N49_R0.6410.22
113_S305_P0.6390.22
154_F334_D0.6380.22
214_V218_K0.6370.22
175_Y311_W0.6370.22
170_M240_K0.6370.22
37_P49_R0.6370.22
176_M188_A0.6360.22
53_P178_K0.6360.22
216_D219_W0.6330.22
215_S219_W0.6300.22
288_V293_A0.6290.22
227_E300_N0.6290.22
99_Q248_W0.6290.22
80_P225_T0.6270.21
112_A306_A0.6250.21
35_S44_A0.6240.21
318_R322_L0.6230.21
79_D185_S0.6230.21
237_I321_L0.6230.21
288_V341_N0.6210.21
259_H332_G0.6200.21
44_A49_R0.6190.21
177_D187_R0.6190.21
111_F178_K0.6150.21
176_M183_L0.6150.21
56_G118_N0.6150.21
246_L283_L0.6130.21
252_T343_I0.6120.21
281_D320_A0.6110.21
39_V104_N0.6110.21
183_L304_G0.6100.21
269_F339_T0.6080.21
40_S287_H0.6040.20
287_H324_S0.6030.20
262_D268_Y0.6030.20
54_T285_E0.6020.20
132_F153_E0.6000.20
167_V172_V0.5940.20
271_H282_R0.5940.20
50_I56_G0.5920.20
41_N45_Q0.5900.20
40_S45_Q0.5890.20
125_G324_S0.5870.20
70_K192_Q0.5860.20
259_H262_D0.5860.20
311_W336_K0.5860.20
169_K323_N0.5840.20
35_S45_Q0.5840.20
266_N274_K0.5830.20
263_M268_Y0.5830.20
230_I333_V0.5830.20
49_R54_T0.5830.20
279_L301_Y0.5810.20
54_T70_K0.5800.20
155_S241_H0.5800.20
297_I311_W0.5790.19
83_Y177_D0.5790.19
51_H106_K0.5780.19
176_M255_V0.5780.19
188_A193_T0.5770.19
96_Q254_E0.5770.19
213_A216_D0.5760.19
66_D294_G0.5760.19
262_D297_I0.5750.19
272_V285_E0.5750.19
227_E320_A0.5750.19
328_H343_I0.5740.19
72_L100_I0.5730.19
145_Y176_M0.5730.19
40_S44_A0.5700.19
221_K251_P0.5670.19
249_D343_I0.5660.19
143_V171_Y0.5660.19
277_G281_D0.5630.19
54_T287_H0.5620.19
131_V137_V0.5600.19
108_V299_Y0.5590.19
150_Y171_Y0.5590.19
127_S285_E0.5580.19
61_M299_Y0.5570.19
295_E340_Q0.5560.19
51_H59_S0.5560.19
173_Q273_S0.5560.19
282_R295_E0.5560.19
128_T137_V0.5550.19
338_Y343_I0.5530.18
312_L339_T0.5530.18
133_K185_S0.5510.18
187_R306_A0.5500.18
137_V176_M0.5490.18
271_H332_G0.5470.18
308_V312_L0.5460.18
98_I129_G0.5460.18
86_D126_E0.5450.18
294_G332_G0.5430.18
86_D232_D0.5420.18
74_E88_W0.5410.18
36_E45_Q0.5400.18
73_G88_W0.5370.18
192_Q292_Q0.5330.18
238_R314_S0.5320.18
248_W259_H0.5300.18
173_Q194_F0.5300.18
89_V97_Y0.5270.17
57_L60_F0.5260.17
49_R133_K0.5260.17
122_F250_Q0.5250.17
41_N44_A0.5240.17
260_S273_S0.5240.17
38_Q216_D0.5210.17
36_E41_N0.5200.17
154_F173_Q0.5190.17
314_S318_R0.5180.17
62_G90_Y0.5180.17
236_V239_V0.5170.17
260_S318_R0.5160.17
182_K290_F0.5140.17
302_V343_I0.5120.17
250_Q254_E0.5100.17
215_S343_I0.5090.17
273_S343_I0.5040.17
44_A47_G0.5030.17
137_V175_Y0.5020.17
173_Q187_R0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ifaA 1 0.8613 100 0.269 Contact Map
4h0aA 1 0.8699 100 0.294 Contact Map
4aiwA 1 0.3266 99.9 0.757 Contact Map
1cfeA 1 0.3006 99.8 0.78 Contact Map
3q2uA 1 0.3555 99.6 0.83 Contact Map
4p27A 1 0.3208 99.6 0.832 Contact Map
2ddbA 2 0.3237 99.5 0.843 Contact Map
1xtaA 2 0.3468 99.4 0.844 Contact Map
4tpvA 2 0.3237 99.1 0.87 Contact Map
1qnxA 1 0.4335 98.9 0.879 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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