GREMLIN Database
YJNA - UPF0721 transmembrane protein YjnA
UniProt: O34578 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 254 (237)
Sequences: 9621 (6532)
Seq/√Len: 424.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_A229_L3.6711.00
81_S150_V3.5991.00
88_I154_F3.1171.00
67_N181_Q2.8891.00
6_I218_G2.7291.00
61_W68_F2.5111.00
236_R240_F2.4931.00
51_I216_L2.4851.00
148_I170_A2.4321.00
237_P240_F2.4101.00
75_A192_L2.3991.00
55_F220_I2.3521.00
8_M30_L2.3451.00
116_I120_V2.3421.00
71_V188_A2.2041.00
178_K181_Q2.2031.00
77_G146_I2.1951.00
46_L197_A2.1711.00
228_H232_R2.1111.00
55_F224_L2.0311.00
115_A250_G2.0141.00
83_S200_L1.9451.00
40_I43_G1.9371.00
44_T212_A1.9321.00
108_G250_G1.9221.00
67_N70_L1.8511.00
70_L177_M1.7921.00
234_S237_P1.7901.00
47_V212_A1.7881.00
115_A247_L1.7831.00
59_S227_S1.7731.00
112_T250_G1.7331.00
60_H65_T1.6981.00
10_L221_P1.6791.00
10_L222_G1.6711.00
69_K72_K1.6671.00
208_D211_L1.6531.00
12_V26_L1.6501.00
109_Y113_L1.6491.00
152_F166_L1.6461.00
87_G91_L1.6311.00
9_G215_L1.6201.00
119_I243_A1.6151.00
31_L215_L1.6091.00
79_I196_A1.5901.00
115_A243_A1.5731.00
150_V154_F1.5721.00
72_K76_I1.5321.00
63_Q231_P1.5281.00
93_P101_E1.5221.00
240_F244_S1.5181.00
247_L251_L1.5101.00
14_A225_I1.5041.00
69_K73_Y1.4711.00
213_A217_L1.4441.00
84_L150_V1.4421.00
60_H230_S1.4381.00
72_K75_A1.4361.00
57_V188_A1.4321.00
54_L191_F1.4291.00
202_A209_Y1.4131.00
71_V185_T1.3981.00
7_L11_F1.3681.00
50_S195_T1.3651.00
143_A147_L1.3601.00
224_L228_H1.3451.00
210_M214_N1.3431.00
36_I211_L1.3401.00
167_F189_H1.3381.00
102_I106_A1.3301.00
32_I38_P1.3291.00
81_S85_A1.3241.00
168_A182_I1.3191.00
58_A62_R1.3151.00
200_L204_F1.3141.00
82_A197_A1.3141.00
56_G187_I1.3121.00
199_I203_S1.2991.00
217_L221_P1.2911.00
123_F126_R1.2741.00
6_I214_N1.2671.00
110_V159_T1.2651.00
37_N40_I1.2591.00
68_F72_K1.2471.00
65_T231_P1.2421.00
65_T184_G1.2301.00
86_I200_L1.2271.00
40_I208_D1.2261.00
145_T175_F1.2241.00
78_S193_L1.2211.00
83_S87_G1.2191.00
244_S248_V1.2151.00
222_G225_I1.1931.00
206_S210_M1.1811.00
57_V61_W1.1721.00
56_G223_V1.1581.00
108_G112_T1.1541.00
120_V123_F1.1531.00
222_G226_G1.1341.00
92_F158_L1.1321.00
218_G222_G1.1251.00
9_G218_G1.1241.00
172_I182_I1.1231.00
86_I197_A1.1121.00
68_F71_V1.1091.00
190_A193_L1.1051.00
54_L58_A1.1011.00
123_F127_K1.0991.00
19_T241_I1.0931.00
77_G149_G1.0881.00
141_K144_L1.0741.00
42_V201_N1.0661.00
118_I242_M1.0561.00
237_P241_I1.0521.00
61_W66_I1.0501.00
60_H227_S1.0451.00
163_S167_F1.0431.00
52_T219_S1.0421.00
102_I105_H1.0421.00
172_I179_A1.0401.00
94_A101_E1.0371.00
143_A146_I1.0371.00
101_E105_H1.0341.00
74_L189_H1.0251.00
59_S63_Q1.0201.00
57_V68_F1.0171.00
84_L87_G1.0061.00
77_G81_S1.0061.00
57_V191_F1.0001.00
180_S230_S0.9921.00
81_S154_F0.9821.00
27_L215_L0.9811.00
45_D49_N0.9781.00
168_A186_D0.9711.00
78_S189_H0.9711.00
35_G41_A0.9631.00
147_L151_V0.9631.00
74_L171_M0.9621.00
163_S169_I0.9591.00
179_A183_V0.9571.00
59_S224_L0.9541.00
55_F223_V0.9531.00
4_S7_L0.9491.00
89_L201_N0.9481.00
6_I217_L0.9481.00
87_G90_H0.9411.00
6_I10_L0.9401.00
113_L117_S0.9391.00
76_I80_P0.9381.00
149_G167_F0.9311.00
213_A216_L0.9291.00
230_S238_L0.9241.00
161_I165_S0.9221.00
105_H109_Y0.9151.00
60_H184_G0.9111.00
59_S228_H0.9101.00
12_V27_L0.9001.00
248_V251_L0.8931.00
86_I196_A0.8921.00
5_I214_N0.8881.00
112_T247_L0.8861.00
228_H231_P0.8851.00
5_I211_L0.8721.00
43_G207_V0.8711.00
242_M246_I0.8541.00
168_A183_V0.8521.00
116_I247_L0.8481.00
85_A154_F0.8461.00
28_T45_D0.8441.00
82_A86_I0.8401.00
10_L218_G0.8391.00
88_I91_L0.8391.00
50_S198_G0.8331.00
80_P84_L0.8291.00
112_T116_I0.8291.00
214_N218_G0.8281.00
221_P224_L0.8271.00
47_V198_G0.8261.00
121_R124_L0.8261.00
61_W64_K0.8251.00
66_I185_T0.8211.00
44_T207_V0.8211.00
84_L154_F0.8181.00
40_I44_T0.8161.00
144_L147_L0.8161.00
101_E104_K0.8131.00
24_A157_G0.8011.00
156_V193_L0.7991.00
17_G56_G0.7971.00
63_Q228_H0.7861.00
43_G198_G0.7791.00
10_L225_I0.7701.00
9_G27_L0.7701.00
233_F237_P0.7681.00
59_S62_R0.7601.00
84_L88_I0.7601.00
77_G80_P0.7591.00
167_F171_M0.7591.00
223_V227_S0.7581.00
51_I220_I0.7581.00
188_A192_L0.7561.00
32_I41_A0.7501.00
53_K190_A0.7491.00
106_A159_T0.7481.00
36_I40_I0.7461.00
152_F163_S0.7431.00
18_L226_G0.7421.00
55_F59_S0.7411.00
16_V24_A0.7381.00
73_Y142_R0.7361.00
149_G153_G0.7361.00
201_N206_S0.7361.00
94_A104_K0.7341.00
90_H204_F0.7281.00
105_H108_G0.7211.00
73_Y76_I0.7201.00
125_D128_L0.7191.00
39_S43_G0.7181.00
5_I215_L0.7181.00
87_G204_F0.7171.00
86_I201_N0.7141.00
58_A61_W0.7141.00
121_R239_Q0.7131.00
27_L31_L0.7111.00
4_S8_M0.7091.00
156_V163_S0.7051.00
210_M213_A0.7021.00
10_L14_A0.7011.00
18_L233_F0.6981.00
71_V189_H0.6961.00
17_G227_S0.6961.00
127_K130_P0.6941.00
78_S167_F0.6941.00
114_V165_S0.6841.00
139_E143_A0.6841.00
176_N182_I0.6821.00
15_L26_L0.6811.00
18_L238_L0.6761.00
74_L149_G0.6751.00
234_S238_L0.6751.00
225_I228_H0.6741.00
53_K191_F0.6651.00
12_V30_L0.6640.99
36_I208_D0.6640.99
87_G200_L0.6620.99
144_L170_A0.6620.99
198_G212_A0.6590.99
115_A246_I0.6580.99
93_P102_I0.6580.99
160_S163_S0.6560.99
14_A222_G0.6540.99
138_L141_K0.6530.99
66_I71_V0.6530.99
6_I9_G0.6520.99
48_Y219_S0.6500.99
88_I92_F0.6480.99
170_A174_L0.6460.99
69_K142_R0.6450.99
49_N53_K0.6410.99
65_T181_Q0.6390.99
229_L233_F0.6380.99
166_L169_I0.6360.99
27_L48_Y0.6330.99
9_G13_G0.6320.99
180_S235_P0.6280.99
24_A49_N0.6270.99
179_A242_M0.6260.99
220_I224_L0.6250.99
54_L57_V0.6230.99
163_S190_A0.6230.99
209_Y213_A0.6230.99
68_F188_A0.6210.99
46_L49_N0.6160.99
92_F102_I0.6160.99
137_P140_N0.6150.99
235_P239_Q0.6130.99
115_A119_I0.6120.99
42_V89_L0.6120.99
181_Q184_G0.6100.99
207_V212_A0.6100.99
67_N72_K0.6080.99
152_F167_F0.6070.99
212_A216_L0.6060.99
13_G23_G0.6050.99
16_V156_V0.6020.99
49_N163_S0.6020.99
187_I190_A0.6010.99
195_T199_I0.5960.99
236_R239_Q0.5930.99
44_T208_D0.5930.99
18_L229_L0.5910.99
229_L232_R0.5890.99
198_G202_A0.5880.99
38_P42_V0.5860.99
38_P103_I0.5840.99
39_S42_V0.5840.99
42_V46_L0.5800.99
16_V26_L0.5790.99
118_I243_A0.5790.99
177_M181_Q0.5780.99
46_L160_S0.5780.99
25_A111_L0.5770.99
170_A175_F0.5760.99
6_I221_P0.5730.99
83_S203_S0.5680.98
53_K160_S0.5660.98
49_N156_V0.5660.98
75_A78_S0.5660.98
42_V103_I0.5570.98
147_L150_V0.5560.98
16_V21_V0.5550.98
182_I186_D0.5550.98
240_F243_A0.5550.98
82_A196_A0.5550.98
47_V216_L0.5520.98
112_T251_L0.5510.98
19_T245_I0.5500.98
22_G50_S0.5490.98
164_G223_V0.5460.98
139_E142_R0.5450.98
14_A18_L0.5450.98
36_I44_T0.5420.98
90_H206_S0.5410.98
39_S103_I0.5380.98
145_T171_M0.5380.98
70_L74_L0.5350.98
20_G162_G0.5340.98
13_G219_S0.5320.98
27_L45_D0.5290.98
94_A158_L0.5280.98
197_A200_L0.5260.97
33_V252_K0.5260.97
221_P225_I0.5260.97
202_A207_V0.5250.97
19_T223_V0.5240.97
67_N185_T0.5240.97
16_V52_T0.5230.97
30_L34_L0.5220.97
160_S186_D0.5220.97
46_L156_V0.5210.97
36_I41_A0.5200.97
167_F190_A0.5180.97
74_L196_A0.5140.97
186_D190_A0.5110.97
16_V190_A0.5100.97
177_M182_I0.5090.97
53_K194_V0.5090.97
17_G223_V0.5080.97
38_P104_K0.5070.97
171_M189_H0.5050.97
248_V252_K0.5020.97
117_S121_R0.5010.97
57_V184_G0.5010.97
123_F240_F0.5000.97
164_G186_D0.5000.97
17_G183_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o7qA 1 0.874 84.3 0.901 Contact Map
2gfpA 2 0.8346 83.1 0.903 Contact Map
1pw4A 1 0.8425 79.2 0.907 Contact Map
4j05A 3 0.8465 74.3 0.911 Contact Map
3wdoA 1 0.8346 61.8 0.918 Contact Map
4m64A 1 0.878 60.5 0.918 Contact Map
2cfqA 1 0.8386 59.9 0.919 Contact Map
4pypA 1 0.8425 56.7 0.92 Contact Map
4xnjA 1 0.9331 40.1 0.928 Contact Map
4rp9A 2 0.4724 34.4 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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