GREMLIN Database
CYSC1 - Probable adenylyl-sulfate kinase
UniProt: O34577 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 197 (178)
Sequences: 2691 (1663)
Seq/√Len: 124.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_E150_R4.2641.00
136_I139_Q3.9851.00
88_G116_V2.8551.00
131_K173_V2.6771.00
28_I120_V2.6221.00
109_F162_S2.6211.00
179_H187_Q2.6201.00
22_N56_Q2.5471.00
155_P161_D2.3461.00
58_I96_Q2.3101.00
156_F161_D2.3001.00
179_H184_C2.2421.00
133_D177_G2.2031.00
114_Q118_E2.2001.00
28_I95_V2.1791.00
131_K175_D2.1711.00
49_E186_N2.1131.00
174_L184_C2.0791.00
110_R168_E2.0581.00
76_S79_D2.0491.00
31_L102_I2.0181.00
87_I105_F2.0121.00
180_D183_A1.9961.00
69_L90_V1.9901.00
65_I87_I1.9791.00
55_Y100_I1.9651.00
46_A188_L1.9601.00
126_N191_F1.9551.00
45_A181_R1.9091.00
175_D178_Q1.8811.00
148_K153_E1.8711.00
29_L128_V1.8341.00
131_K166_E1.8091.00
53_Q193_K1.7861.00
117_R171_E1.7341.00
181_R185_K1.7131.00
19_Q26_S1.6781.00
132_C137_C1.6721.00
133_D136_I1.6681.00
77_D162_S1.6591.00
129_Y173_V1.6381.00
77_D109_F1.6261.00
49_E53_Q1.5731.00
147_K151_N1.5171.00
110_R114_Q1.5061.00
94_F99_T1.4511.00
74_G79_D1.4451.00
45_A185_K1.4181.00
95_V120_V1.4161.00
186_N190_E1.3831.00
49_E185_K1.3811.00
46_A185_K1.3651.00
24_H55_Y1.3581.00
49_E52_E1.3371.00
21_K51_F1.3221.00
81_K112_D1.2981.00
176_S184_C1.2931.00
82_E85_R1.2881.00
172_L191_F1.2871.00
42_I130_I1.2851.00
42_I185_K1.2471.00
174_L188_L1.2461.00
115_Q118_E1.1730.99
42_I174_L1.1590.99
76_S156_F1.1510.99
134_L138_E1.1380.99
44_N59_V1.1330.99
21_K56_Q1.1050.99
30_W107_S1.1030.99
45_A48_R1.1000.99
129_Y166_E1.0900.99
26_S95_V1.0880.99
150_R160_I1.0730.99
132_C176_S1.0570.98
68_G89_E1.0490.98
132_C136_I1.0490.98
116_V125_F1.0450.98
17_E20_Q1.0400.98
35_S106_I1.0320.98
81_K111_E1.0290.98
92_K119_L1.0190.98
28_I91_A1.0180.98
48_R52_E1.0120.98
88_G119_L1.0120.98
46_A189_I1.0090.98
136_I177_G1.0080.98
45_A49_E1.0040.98
65_I105_F0.9980.98
47_A102_I0.9930.98
110_R166_E0.9930.98
84_I105_F0.9610.97
27_S100_I0.9550.97
121_E124_E0.9510.97
114_Q168_E0.9380.97
157_F161_D0.9340.96
47_A59_V0.9290.96
190_E194_Q0.9260.96
27_S192_V0.9230.96
84_I116_V0.9210.96
127_E170_P0.9180.96
126_N172_L0.9110.96
170_P173_V0.9100.96
34_L137_C0.9040.96
32_T164_Y0.8960.96
58_I97_Q0.8910.95
46_A102_I0.8810.95
64_N67_H0.8760.95
49_E189_I0.8740.95
19_Q25_K0.8740.95
36_G142_P0.8630.95
107_S125_F0.8630.95
135_D139_Q0.8610.94
17_E48_R0.8600.94
181_R184_C0.8550.94
94_F97_Q0.8540.94
132_C177_G0.8490.94
187_Q190_E0.8410.94
120_V124_E0.8400.94
156_F162_S0.8390.94
120_V123_G0.8340.93
19_Q22_N0.8330.93
24_H56_Q0.8320.93
49_E182_E0.8290.93
53_Q189_I0.8250.93
25_K124_E0.8220.93
138_E160_I0.8170.93
36_G145_L0.8160.93
45_A182_E0.8120.93
29_L46_A0.8070.92
179_H183_A0.8050.92
190_E193_K0.8050.92
187_Q191_F0.8040.92
134_L160_I0.8030.92
17_E51_F0.8030.92
47_A51_F0.8020.92
126_N171_E0.7960.92
18_Y47_A0.7900.91
134_L150_R0.7820.91
73_L79_D0.7800.91
19_Q124_E0.7790.91
157_F160_I0.7730.91
117_R125_F0.7600.90
95_V124_E0.7570.90
68_G82_E0.7560.90
89_E92_K0.7530.89
116_V119_L0.7520.89
132_C173_V0.7510.89
44_N47_A0.7480.89
109_F112_D0.7420.89
27_S126_N0.7390.89
62_G143_K0.7390.89
42_I184_C0.7350.88
129_Y175_D0.7160.87
109_F163_P0.7130.87
180_D184_C0.7060.86
81_K115_Q0.7020.86
22_N26_S0.6960.85
35_S145_L0.6950.85
91_A103_T0.6880.85
110_R165_E0.6860.85
82_E89_E0.6830.84
35_S134_L0.6820.84
128_V172_L0.6710.83
118_E122_A0.6700.83
71_R119_L0.6660.83
183_A186_N0.6610.82
47_A57_V0.6540.82
77_D111_E0.6520.81
158_T162_S0.6520.81
18_Y58_I0.6520.81
73_L86_R0.6520.81
58_I94_F0.6500.81
32_T107_S0.6460.81
22_N51_F0.6450.81
185_K188_L0.6440.81
64_N89_E0.6420.80
111_E115_Q0.6410.80
68_G72_D0.6390.80
21_K57_V0.6370.80
33_G38_G0.6370.80
149_A161_D0.6330.80
44_N101_V0.6320.79
77_D81_K0.6280.79
103_T116_V0.6250.79
59_V104_A0.6210.78
166_E175_D0.6200.78
20_Q23_K0.6200.78
138_E149_A0.6180.78
63_D143_K0.6180.78
17_E21_K0.6120.77
46_A192_V0.6120.77
110_R127_E0.6100.77
73_L83_N0.6100.77
17_E52_E0.6090.77
31_L43_A0.6080.77
103_T106_I0.6060.77
127_E169_A0.6050.76
91_A95_V0.5990.76
88_G120_V0.5970.76
184_C187_Q0.5950.75
154_I157_F0.5930.75
172_L187_Q0.5900.75
106_I158_T0.5890.75
172_L188_L0.5860.74
126_N192_V0.5800.73
107_S127_E0.5800.73
117_R127_E0.5800.73
77_D156_F0.5800.73
65_I69_L0.5800.73
51_F57_V0.5790.73
41_T181_R0.5790.73
84_I109_F0.5750.73
108_P158_T0.5730.73
27_S101_V0.5700.72
141_D144_G0.5690.72
28_I104_A0.5670.72
78_E81_K0.5640.71
125_F164_Y0.5640.71
107_S164_Y0.5620.71
71_R115_Q0.5580.71
72_D86_R0.5580.71
106_I162_S0.5570.70
30_W127_E0.5570.70
120_V125_F0.5560.70
85_R112_D0.5550.70
44_N48_R0.5530.70
83_N87_I0.5520.70
41_T63_D0.5500.69
44_N57_V0.5470.69
28_I103_T0.5470.69
83_N86_R0.5450.69
27_S95_V0.5420.68
110_R164_Y0.5410.68
31_L130_I0.5410.68
64_N93_L0.5390.68
145_L157_F0.5390.68
142_P147_K0.5390.68
32_T125_F0.5390.68
23_K55_Y0.5360.68
191_F194_Q0.5350.67
171_E191_F0.5330.67
116_V120_V0.5320.67
186_N193_K0.5300.67
26_S124_E0.5290.66
31_L188_L0.5250.66
75_F106_I0.5230.66
43_A104_A0.5210.65
137_C150_R0.5200.65
95_V121_E0.5200.65
115_Q119_L0.5130.64
23_K193_K0.5120.64
20_Q53_Q0.5110.64
19_Q24_H0.5100.64
31_L42_I0.5090.64
18_Y22_N0.5090.64
83_N108_P0.5080.63
26_S99_T0.5070.63
43_A72_D0.5070.63
153_E161_D0.5040.63
85_R89_E0.5040.63
125_F171_E0.5040.63
88_G109_F0.5010.62
60_L101_V0.5010.62
29_L102_I0.5000.62
58_I95_V0.5000.62
48_R111_E0.5000.62
189_I193_K0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1x6vB 2 0.9239 100 0.443 Contact Map
1m8pA 5 1 100 0.509 Contact Map
2gksA 2 1 100 0.519 Contact Map
1m7gA 4 0.9898 100 0.541 Contact Map
3cr8A 4 0.868 100 0.543 Contact Map
4rfvA 2 0.7157 100 0.573 Contact Map
2yvuA 2 0.8985 100 0.601 Contact Map
2pezA 2 0.8832 100 0.603 Contact Map
4bzpA 2 0.868 100 0.609 Contact Map
3uieA 2 0.9797 99.9 0.656 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.014 seconds.