GREMLIN Database
YTLP - UPF0097 protein YtlP
UniProt: O34570 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 183 (172)
Sequences: 2299 (1784)
Seq/√Len: 136.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_D95_H3.5051.00
48_I112_K3.4721.00
162_S176_E3.4371.00
160_R179_K3.3441.00
75_F158_A3.2201.00
167_H175_E3.0551.00
13_P164_F2.9831.00
35_Q134_A2.8671.00
22_I96_L2.8651.00
10_I65_L2.8371.00
165_Q175_E2.7261.00
61_L115_V2.7021.00
83_D97_E2.5711.00
165_Q177_I2.4071.00
12_V158_A2.2911.00
11_G164_F2.2781.00
10_I50_L2.2661.00
6_P52_A2.2151.00
8_Y53_A2.1681.00
168_L172_P2.1521.00
80_G99_K2.1341.00
26_A43_Y2.0821.00
76_S155_S2.0481.00
6_P165_Q2.0401.00
65_L111_T2.0251.00
76_S157_M1.9611.00
10_I111_T1.8971.00
161_F180_F1.8741.00
79_F96_L1.8421.00
78_K155_S1.8171.00
66_A178_F1.7831.00
164_F176_E1.7791.00
48_I122_V1.7691.00
50_L115_V1.7561.00
15_P156_M1.7531.00
54_D57_Q1.7431.00
108_R112_K1.7261.00
176_E179_K1.6391.00
72_I110_H1.5821.00
62_E178_F1.5551.00
20_N40_P1.5231.00
8_Y163_L1.5081.00
68_I161_F1.4711.00
42_D172_P1.4561.00
85_F95_H1.4561.00
15_P18_I1.4491.00
162_S179_K1.4411.00
42_D174_Y1.3941.00
38_V172_P1.3501.00
169_N173_K1.3361.00
96_L133_L1.3181.00
58_I62_E1.3081.00
35_Q136_K1.3041.00
112_K122_V1.2951.00
47_L161_F1.2661.00
14_I164_F1.2311.00
14_I19_A1.2191.00
111_T115_V1.2031.00
39_H42_D1.2001.00
38_V135_R1.1891.00
79_F131_M1.1560.99
37_W134_A1.1470.99
21_P154_V1.1250.99
144_P147_V1.1180.99
168_L174_Y1.1100.99
16_E19_A1.1070.99
91_P136_K1.0930.99
57_Q60_K1.0870.99
8_Y50_L1.0780.99
19_A40_P1.0740.99
135_R168_L1.0700.99
7_H135_R1.0570.99
39_H171_S1.0540.99
116_L122_V1.0390.99
7_H166_I1.0220.98
13_P162_S1.0200.98
65_L163_L1.0170.98
163_L180_F1.0140.98
114_A118_A0.9950.98
62_E180_F0.9840.98
115_V118_A0.9840.98
50_L111_T0.9820.98
53_A57_Q0.9630.98
65_L161_F0.9630.98
7_H49_F0.9560.98
12_V75_F0.9490.98
120_F123_E0.9490.98
86_G91_P0.9470.98
72_I182_L0.9440.97
14_I156_M0.9360.97
6_P55_E0.9340.97
86_G92_R0.9330.97
50_L53_A0.9230.97
85_F97_E0.9230.97
108_R129_P0.9180.97
135_R166_I0.9050.97
94_L134_A0.9010.97
68_I71_E0.8790.96
18_I156_M0.8740.96
47_L107_L0.8690.96
42_D166_I0.8660.96
50_L120_F0.8650.96
48_I108_R0.8580.96
142_G146_H0.8570.96
38_V43_Y0.8460.95
79_F98_P0.8440.95
48_I111_T0.8430.95
36_K137_W0.8200.94
45_I98_P0.8190.94
92_R136_K0.8120.94
12_V47_L0.8070.94
60_K117_Q0.8030.94
75_F101_N0.7980.93
53_A58_I0.7950.93
100_K105_D0.7840.93
78_K99_K0.7760.93
106_R110_H0.7760.93
48_I115_V0.7550.91
68_I110_H0.7520.91
8_Y51_G0.7520.91
54_D58_I0.7440.91
169_N172_P0.7350.90
10_I163_L0.7350.90
77_I156_M0.7310.90
178_F181_Q0.7220.90
12_V161_F0.7210.90
131_M134_A0.7160.89
57_Q120_F0.7160.89
22_I79_F0.7150.89
22_I133_L0.7130.89
13_P19_A0.7060.89
49_F135_R0.7030.88
36_K135_R0.7030.88
7_H52_A0.7000.88
66_A180_F0.6980.88
47_L108_R0.6980.88
135_R172_P0.6930.88
79_F156_M0.6930.88
21_P24_Q0.6910.87
64_S111_T0.6900.87
93_V135_R0.6900.87
59_K62_E0.6850.87
34_F140_E0.6850.87
60_K64_S0.6840.87
61_L65_L0.6780.86
137_W171_S0.6780.86
14_I131_M0.6760.86
105_D129_P0.6750.86
64_S115_V0.6720.86
62_E66_A0.6720.86
77_I98_P0.6700.86
159_E181_Q0.6620.85
108_R126_P0.6580.85
10_I180_F0.6540.84
36_K39_H0.6530.84
167_H173_K0.6510.84
75_F104_L0.6460.84
102_K105_D0.6450.84
114_A117_Q0.6440.84
10_I161_F0.6420.83
65_L180_F0.6420.83
75_F107_L0.6400.83
36_K172_P0.6390.83
80_G150_E0.6390.83
52_A168_L0.6350.83
86_G93_V0.6350.83
48_I120_F0.6340.83
13_P176_E0.6340.83
9_F174_Y0.6330.82
105_D109_E0.6320.82
35_Q137_W0.6300.82
143_F147_V0.6270.82
160_R182_L0.6250.82
108_R127_Y0.6240.82
10_I48_I0.6220.81
45_I131_M0.6200.81
12_V104_L0.6200.81
18_I154_V0.6200.81
8_Y177_I0.6190.81
6_P58_I0.6140.81
77_I104_L0.6130.80
137_W173_K0.6110.80
25_A28_N0.6100.80
68_I72_I0.5990.79
23_Y43_Y0.5940.78
80_G153_E0.5920.78
141_D144_P0.5910.78
110_H114_A0.5840.77
158_A161_F0.5830.77
79_F153_E0.5820.77
140_E143_F0.5790.77
80_G102_K0.5780.76
140_E145_A0.5780.76
137_W166_I0.5760.76
64_S114_A0.5710.76
47_L104_L0.5710.76
53_A61_L0.5670.75
166_I171_S0.5660.75
61_L64_S0.5640.75
73_D103_T0.5640.75
140_E147_V0.5640.75
60_K63_G0.5620.74
55_E59_K0.5600.74
22_I131_M0.5600.74
58_I177_I0.5590.74
67_E114_A0.5590.74
18_I79_F0.5590.74
56_T60_K0.5580.74
34_F166_I0.5530.73
62_E65_L0.5520.73
80_G152_G0.5520.73
141_D146_H0.5510.73
16_E40_P0.5480.73
56_T116_L0.5470.72
136_K172_P0.5470.72
56_T73_D0.5470.72
113_Q116_L0.5460.72
67_E117_Q0.5460.72
84_V144_P0.5450.72
24_Q117_Q0.5420.72
10_I115_V0.5410.72
102_K106_R0.5400.72
12_V156_M0.5390.71
20_N24_Q0.5380.71
23_Y26_A0.5380.71
83_D140_E0.5380.71
7_H171_S0.5380.71
115_V121_Q0.5370.71
22_I43_Y0.5350.71
82_I94_L0.5350.71
21_P151_S0.5350.71
21_P153_E0.5350.71
10_I61_L0.5320.70
63_G181_Q0.5290.70
47_L111_T0.5290.70
50_L61_L0.5290.70
160_R181_Q0.5270.70
65_L68_I0.5240.69
39_H173_K0.5240.69
161_F182_L0.5230.69
38_V42_D0.5220.69
37_W94_L0.5220.69
38_V132_T0.5220.69
81_K98_P0.5160.68
52_A126_P0.5140.68
111_T118_A0.5120.67
44_H132_T0.5110.67
13_P179_K0.5090.67
54_D60_K0.5080.67
98_P104_L0.5070.67
33_T134_A0.5060.67
140_E144_P0.5050.66
64_S68_I0.5040.66
64_S118_A0.5020.66
61_L118_A0.5010.66
25_A152_G0.5010.66
135_R167_H0.5000.66
122_V125_R0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iuhA 1 0.9454 100 0.239 Contact Map
1vgjA 1 0.9672 100 0.249 Contact Map
4qakA 1 0.9344 100 0.25 Contact Map
3j4qA 1 0.9617 100 0.285 Contact Map
2vfkA 1 0.9617 100 0.328 Contact Map
4h7wA 1 0.9454 100 0.369 Contact Map
2d4gA 2 0.9071 100 0.375 Contact Map
1jh6A 5 0.9344 100 0.379 Contact Map
2fsqA 1 0.9071 97.1 0.844 Contact Map
3oq2A 3 0.5301 32 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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