GREMLIN Database
YOAA - Uncharacterized N-acetyltransferase YoaA
UniProt: O34569 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 177 (165)
Sequences: 20301 (15577)
Seq/√Len: 1212.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_S145_K2.6271.00
130_A143_L2.6001.00
13_R69_E2.5871.00
70_R73_T2.4291.00
13_R19_D2.2931.00
31_E100_P2.2701.00
6_E71_R2.1761.00
92_A125_L2.1631.00
132_V140_N2.1591.00
151_E171_S2.1551.00
150_K153_V2.1051.00
150_K168_N2.0981.00
9_R110_E2.0901.00
82_F119_G2.0561.00
7_T114_K1.9971.00
140_N144_L1.8971.00
132_V143_L1.8901.00
94_I112_I1.8841.00
141_R144_L1.8711.00
117_S121_S1.8071.00
116_V148_F1.8041.00
15_I67_G1.7981.00
67_G76_L1.7921.00
7_T110_E1.7491.00
29_N100_P1.7271.00
11_I71_R1.6771.00
20_A48_I1.6421.00
153_V168_N1.6331.00
22_A76_L1.6331.00
99_I102_H1.6311.00
116_V128_I1.6291.00
126_S156_Q1.6291.00
21_E44_I1.6201.00
112_I146_M1.6001.00
80_I111_V1.5841.00
98_I108_A1.5711.00
140_N168_N1.5341.00
44_I48_I1.5231.00
159_Y164_P1.5051.00
69_E74_K1.5051.00
50_M54_F1.4871.00
114_K117_S1.4631.00
134_T166_D1.4591.00
43_S46_Q1.4531.00
140_N150_K1.4301.00
137_E140_N1.3951.00
68_I98_I1.3831.00
126_S164_P1.3451.00
70_R77_I1.3421.00
6_E11_I1.3371.00
17_D52_Q1.3241.00
144_L150_K1.3121.00
80_I115_V1.2841.00
68_I111_V1.2711.00
118_Y122_A1.2671.00
109_S142_L1.2561.00
157_Y167_T1.2461.00
134_T153_V1.2371.00
135_D165_Y1.2371.00
11_I69_E1.2351.00
77_I102_H1.2311.00
140_N170_Y1.2221.00
154_L169_V1.1891.00
22_A75_E1.1891.00
70_R107_F1.1871.00
24_F44_I1.1851.00
96_Y143_L1.1771.00
119_G128_I1.1561.00
75_E101_E1.1531.00
108_A142_L1.1451.00
127_R171_S1.1441.00
75_E102_H1.1121.00
118_Y123_L1.1111.00
20_A51_I1.0991.00
79_T97_E1.0881.00
7_T10_L1.0821.00
86_A89_H1.0811.00
48_I52_Q1.0771.00
96_Y139_S1.0661.00
66_W115_V1.0641.00
32_V103_W1.0511.00
119_G123_L1.0481.00
26_C99_I1.0421.00
26_C97_E1.0381.00
109_S113_S1.0341.00
100_P103_W1.0261.00
103_W138_A1.0231.00
20_A44_I1.0161.00
155_R171_S1.0051.00
91_R129_G1.0041.00
156_Q166_D1.0031.00
93_E131_V1.0001.00
31_E34_R0.9971.00
153_V166_D0.9931.00
127_R151_E0.9831.00
130_A148_F0.9831.00
17_D48_I0.9751.00
132_V170_Y0.9681.00
22_A25_A0.9681.00
70_R75_E0.9631.00
10_L107_F0.9611.00
150_K170_Y0.9601.00
42_E46_Q0.9591.00
142_L146_M0.9591.00
56_A60_E0.9521.00
15_I79_T0.9411.00
109_S146_M0.9401.00
66_W118_Y0.9391.00
69_E76_L0.9371.00
155_R166_D0.9261.00
17_D55_A0.9211.00
31_E103_W0.9201.00
91_R127_R0.9181.00
133_F165_Y0.9101.00
137_E141_R0.9051.00
104_R138_A0.8971.00
143_L148_F0.8941.00
119_G125_L0.8911.00
82_F115_V0.8861.00
116_V146_M0.8771.00
113_S117_S0.8691.00
70_R105_N0.8681.00
49_S53_T0.8671.00
134_T168_N0.8671.00
22_A99_I0.8561.00
11_I74_K0.8541.00
25_A99_I0.8521.00
98_I107_F0.8511.00
113_S146_M0.8471.00
20_A24_F0.8291.00
70_R102_H0.8181.00
19_D69_E0.8161.00
102_H105_N0.8121.00
10_L111_V0.8111.00
90_R164_P0.8091.00
17_D20_A0.8091.00
75_E99_I0.8031.00
68_I80_I0.8021.00
96_Y108_A0.8001.00
13_R67_G0.7971.00
24_F47_A0.7911.00
110_E114_K0.7881.00
154_L157_Y0.7831.00
41_M47_A0.7781.00
27_F97_E0.7641.00
91_R157_Y0.7581.00
7_T12_L0.7501.00
21_E25_A0.7441.00
139_S143_L0.7411.00
93_E129_G0.7251.00
45_E48_I0.7231.00
33_T36_Y0.7221.00
65_R81_G0.7201.00
52_Q56_A0.7201.00
49_S52_Q0.7201.00
25_A75_E0.7191.00
35_Y135_D0.7181.00
35_Y133_F0.7171.00
54_F65_R0.7151.00
159_Y163_T0.7131.00
133_F160_Q0.7131.00
151_E155_R0.7081.00
137_E144_L0.7021.00
90_R159_Y0.6961.00
156_Q164_P0.6881.00
24_F28_S0.6871.00
96_Y112_I0.6851.00
26_C76_L0.6821.00
47_A51_I0.6821.00
14_Q58_Y0.6801.00
68_I107_F0.6761.00
9_R106_G0.6761.00
25_A101_E0.6731.00
46_Q49_S0.6721.00
53_T56_A0.6711.00
131_V167_T0.6701.00
45_E49_S0.6661.00
112_I142_L0.6661.00
131_V154_L0.6651.00
104_R109_S0.6631.00
29_N99_I0.6571.00
8_D110_E0.6501.00
68_I78_G0.6461.00
104_R141_R0.6451.00
33_T38_L0.6431.00
77_I107_F0.6431.00
98_I103_W0.6411.00
14_Q55_A0.6381.00
144_L170_Y0.6381.00
141_R145_K0.6341.00
29_N103_W0.6301.00
138_A141_R0.6251.00
135_D163_T0.6171.00
96_Y142_L0.6161.00
109_S138_A0.6151.00
132_V139_S0.6141.00
16_T19_D0.6131.00
132_V168_N0.6091.00
82_F92_A0.6071.00
83_H93_E0.6071.00
13_R16_T0.6071.00
76_L79_T0.6051.00
30_D34_R0.6041.00
116_V120_F0.6001.00
32_V97_E0.5991.00
92_A119_G0.5921.00
36_Y97_E0.5901.00
42_E47_A0.5901.00
152_G171_S0.5881.00
129_G154_L0.5841.00
129_G157_Y0.5751.00
131_V169_V0.5741.00
158_M167_T0.5731.00
160_Q163_T0.5731.00
98_I102_H0.5721.00
90_R126_S0.5721.00
107_F110_E0.5721.00
80_I112_I0.5671.00
68_I108_A0.5621.00
84_A92_A0.5581.00
130_A139_S0.5551.00
63_G81_G0.5531.00
55_A58_Y0.5491.00
134_T140_N0.5471.00
104_R142_L0.5451.00
29_N33_T0.5431.00
10_L110_E0.5431.00
81_G95_G0.5401.00
160_Q165_Y0.5381.00
108_A112_I0.5281.00
51_I55_A0.5231.00
58_Y64_I0.5181.00
22_A26_C0.5171.00
12_L114_K0.5161.00
94_I128_I0.5161.00
130_A170_Y0.5151.00
149_Q155_R0.5141.00
51_I54_F0.5121.00
23_I79_T0.5101.00
112_I116_V0.5101.00
21_E24_F0.5091.00
85_L92_A0.5041.00
19_D22_A0.5041.00
22_A69_E0.5041.00
131_V157_Y0.5031.00
27_F79_T0.5021.00
128_I148_F0.5011.00
127_R157_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fckA 2 0.9661 100 0.297 Contact Map
3r9fA 1 0.9718 100 0.298 Contact Map
2vzyA 3 0.8927 100 0.309 Contact Map
3pzjA 2 0.9774 100 0.311 Contact Map
1yreA 2 0.9435 100 0.311 Contact Map
1nslA 3 0.9887 100 0.313 Contact Map
1s7kA 2 0.887 100 0.322 Contact Map
3fbuA 2 0.9435 100 0.328 Contact Map
3igrA 2 0.9944 100 0.336 Contact Map
2z10A 2 0.9661 100 0.336 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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