GREMLIN Database
HIS5 - Imidazole glycerol phosphate synthase subunit HisH
UniProt: O34565 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (197)
Sequences: 3889 (2552)
Seq/√Len: 181.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_G29_S3.2551.00
87_E99_G3.1061.00
57_G62_D3.0131.00
88_E104_K2.8161.00
165_A173_A2.7961.00
27_F34_E2.7091.00
134_S176_G2.5731.00
199_T203_K2.5291.00
106_V154_D2.4351.00
31_K34_E2.3301.00
19_L42_I2.2261.00
108_L171_V2.0651.00
3_G38_A2.0611.00
36_K67_D1.9831.00
166_D170_R1.9651.00
87_E102_K1.9641.00
86_F153_I1.9381.00
68_M73_R1.9351.00
164_S170_R1.9151.00
49_F97_G1.9051.00
137_L174_V1.8901.00
128_L145_A1.8061.00
54_D58_Y1.8031.00
17_K20_E1.7871.00
147_F173_A1.7831.00
41_F68_M1.7751.00
16_S20_E1.7621.00
52_A80_L1.7071.00
86_F175_V1.7041.00
88_E94_T1.6701.00
90_E106_V1.6391.00
68_M71_E1.6281.00
55_N58_Y1.6131.00
139_K200_Q1.6081.00
162_L176_G1.6061.00
30_E59_T1.6001.00
163_A174_V1.5971.00
69_V100_L1.5911.00
196_S199_T1.5811.00
145_A193_V1.5601.00
152_Y169_V1.5481.00
105_A153_I1.5471.00
2_I202_T1.5281.00
136_L181_F1.5181.00
24_V202_T1.5101.00
161_L172_P1.5091.00
66_H100_L1.5011.00
118_L168_G1.4831.00
4_V16_S1.4781.00
174_V183_A1.4621.00
160_A177_K1.4361.00
19_L24_V1.4141.00
145_A197_I1.3921.00
90_E104_K1.3871.00
108_L152_Y1.3841.00
16_S28_V1.3811.00
155_G161_L1.3791.00
12_L28_V1.3781.00
33_E37_E1.3681.00
16_S26_Y1.3641.00
85_L180_V1.3641.00
62_D66_H1.3521.00
106_V152_Y1.3491.00
4_V19_L1.2991.00
87_E103_G1.2981.00
102_K160_A1.2781.00
128_L163_A1.2781.00
3_G35_L1.2711.00
21_R195_M1.2601.00
122_H171_V1.2551.00
56_L62_D1.2521.00
78_I198_L1.2511.00
29_S34_E1.2391.00
50_G95_A1.2351.00
88_E96_S1.2241.00
101_L160_A1.2121.00
67_D71_E1.2081.00
183_A197_I1.2071.00
196_S200_Q1.2061.00
138_T203_K1.2031.00
20_E25_P1.1961.00
82_M182_G1.1931.00
135_P176_G1.1921.00
35_L64_L1.1701.00
131_H164_S1.1481.00
55_N59_T1.1361.00
109_K169_V1.1341.00
3_G41_F1.1131.00
64_L68_M1.1031.00
129_S170_R1.0961.00
85_L100_L1.0951.00
33_E36_K1.0741.00
139_K196_S1.0731.00
86_F105_A1.0701.00
90_E94_T1.0601.00
29_S38_A1.0601.00
20_E26_Y1.0461.00
140_T143_G1.0431.00
7_Y10_G1.0421.00
157_E160_A1.0331.00
23_G26_Y1.0291.00
50_G93_G1.0180.99
35_L38_A1.0160.99
123_M148_V1.0040.99
13_Y17_K1.0030.99
36_K68_M1.0020.99
32_P36_K0.9870.99
166_D169_V0.9870.99
87_E104_K0.9850.99
140_T200_Q0.9750.99
82_M153_I0.9700.99
152_Y172_P0.9700.99
128_L173_A0.9700.99
50_G92_N0.9680.99
86_F101_L0.9630.99
19_L26_Y0.9630.99
127_R144_Y0.9620.99
86_F103_G0.9530.99
134_S181_F0.9490.99
69_V75_L0.9420.99
43_L75_L0.9370.99
136_L200_Q0.9330.99
46_V80_L0.9230.99
102_K156_M0.9160.99
162_L174_V0.9160.99
104_K154_D0.9160.99
130_F142_Q0.9150.99
165_A171_V0.9090.99
90_E107_R0.9010.99
176_G181_F0.8950.99
76_L183_A0.8900.99
4_V26_Y0.8870.99
32_P64_L0.8850.99
75_L100_L0.8810.98
35_L68_M0.8800.98
129_S166_D0.8740.98
5_I65_I0.8720.98
147_F165_A0.8700.98
134_S162_L0.8690.98
65_I100_L0.8670.98
63_Q66_H0.8670.98
53_M62_D0.8640.98
127_R143_G0.8610.98
19_L202_T0.8600.98
29_S61_L0.8540.98
63_Q67_D0.8430.98
48_S92_N0.8250.98
8_G55_N0.8240.98
8_G59_T0.8230.98
19_L198_L0.8180.98
67_D70_S0.8130.97
34_E37_E0.8130.97
107_R110_A0.8090.97
49_F84_L0.8070.97
92_N95_A0.8030.97
2_I40_A0.8020.97
22_V202_T0.8010.97
60_K63_Q0.8010.97
118_L167_Y0.7970.97
56_L61_L0.7960.97
122_H149_H0.7960.97
87_E101_L0.7940.97
66_H70_S0.7910.97
128_L197_I0.7890.97
72_G178_R0.7890.97
53_M57_G0.7880.97
40_A201_F0.7850.97
131_H170_R0.7840.97
96_S99_G0.7840.97
41_F64_L0.7790.97
111_E168_G0.7780.97
32_P35_L0.7750.97
13_Y16_S0.7700.96
75_L85_L0.7700.96
5_I43_L0.7490.96
52_A84_L0.7480.96
163_A173_A0.7440.96
108_L120_V0.7400.96
129_S143_G0.7400.96
57_G96_S0.7380.96
46_V82_M0.7370.95
53_M95_A0.7360.95
129_S142_Q0.7350.95
32_P60_K0.7340.95
2_I24_V0.7320.95
3_G27_F0.7310.95
35_L61_L0.7290.95
101_L175_V0.7270.95
41_F65_I0.7260.95
18_A22_V0.7210.95
129_S164_S0.7210.95
122_H126_N0.7110.95
100_L180_V0.7090.94
155_G172_P0.7060.94
3_G34_E0.7020.94
154_D169_V0.6970.94
123_M144_Y0.6950.94
6_D30_E0.6930.94
9_M13_Y0.6870.93
138_T196_S0.6830.93
122_H165_A0.6830.93
56_L65_I0.6720.93
72_G179_N0.6680.93
7_Y52_A0.6660.92
50_G54_D0.6660.92
19_L22_V0.6590.92
49_F95_A0.6580.92
141_E193_V0.6570.92
50_G94_T0.6490.91
80_L84_L0.6480.91
75_L180_V0.6480.91
130_F163_A0.6430.91
4_V28_V0.6420.91
133_E138_T0.6400.91
29_S64_L0.6400.91
175_V182_G0.6390.91
102_K157_E0.6360.91
40_A74_L0.6350.91
48_S95_A0.6350.91
9_M12_L0.6310.90
32_P63_Q0.6300.90
15_V18_A0.6300.90
103_G153_I0.6240.90
5_I41_F0.6230.90
26_Y42_I0.6180.89
22_V195_M0.6170.89
5_I35_L0.6160.89
101_L180_V0.6160.89
102_K177_K0.6090.89
15_V78_I0.6090.89
40_A191_S0.6050.88
110_A118_L0.6030.88
162_L181_F0.6010.88
144_Y193_V0.6000.88
17_K195_M0.5960.88
22_V198_L0.5930.87
69_V72_G0.5910.87
13_Y171_V0.5890.87
29_S35_L0.5870.87
140_T145_A0.5860.87
132_N159_N0.5830.86
135_P138_T0.5820.86
132_N162_L0.5680.85
128_L171_V0.5650.85
54_D57_G0.5650.85
89_S108_L0.5640.85
9_M52_A0.5630.84
126_N167_Y0.5610.84
26_Y80_L0.5590.84
48_S51_D0.5570.84
65_I68_M0.5460.83
56_L59_T0.5440.82
76_L201_F0.5400.82
90_E109_K0.5390.82
87_E156_M0.5390.82
136_L197_I0.5360.81
40_A181_F0.5350.81
53_M90_E0.5330.81
52_A55_N0.5320.81
104_K156_M0.5310.81
15_V80_L0.5310.81
154_D158_E0.5310.81
121_P150_S0.5300.81
162_L182_G0.5290.81
88_E95_A0.5260.80
107_R151_Y0.5260.80
181_F201_F0.5240.80
145_A183_A0.5230.80
123_M147_F0.5220.80
57_G95_A0.5210.80
49_F89_S0.5210.80
89_S92_N0.5190.79
53_M84_L0.5180.79
9_M80_L0.5160.79
15_V42_I0.5140.79
41_F73_R0.5140.79
8_G105_A0.5140.79
9_M51_D0.5130.79
14_S17_K0.5130.79
43_L84_L0.5120.78
48_S93_G0.5120.78
169_V172_P0.5120.78
17_K191_S0.5100.78
145_A185_F0.5090.78
40_A202_T0.5080.78
156_M160_A0.5080.78
111_E117_K0.5070.78
99_G102_K0.5070.78
48_S148_V0.5070.78
12_L119_K0.5060.78
156_M159_N0.5060.78
65_I98_L0.5030.77
42_I78_I0.5020.77
59_T80_L0.5010.77
49_F86_F0.5000.77
161_L164_S0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jvnA 1 0.9623 100 0.442 Contact Map
4gudA 1 0.9292 100 0.497 Contact Map
1ka9H 1 0.9104 100 0.519 Contact Map
1gpwB 1 0.9104 100 0.53 Contact Map
3uowA 2 0.9151 100 0.547 Contact Map
2v4uA 1 0.9481 100 0.569 Contact Map
2ywdA 1 0.8774 100 0.585 Contact Map
2w7tA 1 0.9434 100 0.591 Contact Map
3d54D 1 0.8821 100 0.592 Contact Map
2issD 1 0.8396 100 0.593 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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