GREMLIN Database
YKUU - Thioredoxin-like protein YkuU
UniProt: O34564 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 180 (146)
Sequences: 9528 (5328)
Seq/√Len: 441.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_E26_K2.9371.00
38_W135_P2.9341.00
47_D84_H2.7241.00
37_K72_E2.7191.00
69_L161_Q2.7051.00
10_A116_Y2.4131.00
14_E28_S2.3991.00
63_Y67_E2.2831.00
17_A25_G2.2571.00
134_N140_Q2.1701.00
120_I127_L2.1221.00
60_S101_K2.1141.00
16_E26_K2.0781.00
9_Q138_E2.0551.00
18_V88_I2.0171.00
62_R65_E1.9221.00
5_M8_K1.8691.00
78_T110_H1.8471.00
12_R30_E1.7811.00
63_Y101_K1.7381.00
111_E115_E1.7151.00
78_T113_S1.7011.00
62_R153_V1.6611.00
28_S31_E1.6511.00
15_M112_V1.6461.00
48_F98_G1.6161.00
141_Y159_V1.6091.00
15_M105_A1.5161.00
71_A160_L1.5061.00
27_V32_N1.4891.00
134_N138_E1.4871.00
67_E72_E1.4811.00
12_R28_S1.4611.00
17_A103_P1.4481.00
48_F86_A1.4461.00
56_I100_L1.4421.00
110_H114_R1.4031.00
113_S126_A1.3741.00
16_E81_I1.3731.00
60_S102_Y1.3641.00
78_T126_A1.3591.00
65_E68_D1.3391.00
85_L89_N1.3171.00
64_D68_D1.2951.00
39_T74_I1.2931.00
54_T150_G1.2911.00
18_V23_E1.2481.00
143_T159_V1.2071.00
40_V132_I1.2031.00
75_G104_L1.1741.00
17_A27_V1.1701.00
62_R154_D1.1701.00
32_N39_T1.1631.00
114_R119_L1.1601.00
57_T61_D1.1571.00
110_H119_L1.1481.00
17_A23_E1.1441.00
154_D158_R1.1441.00
38_W71_A1.1361.00
64_D67_E1.1281.00
23_E85_L1.1281.00
133_I139_L1.1241.00
90_T98_G1.1231.00
155_E158_R1.1211.00
43_F76_V1.1161.00
82_H86_A1.0881.00
42_F56_I1.0871.00
48_F90_T1.0841.00
39_T72_E1.0841.00
17_A105_A1.0841.00
4_R139_L1.0701.00
32_N74_I1.0621.00
118_V131_F1.0601.00
65_E157_L1.0401.00
118_V129_G1.0371.00
6_V141_Y1.0261.00
112_V116_Y1.0231.00
38_W140_Q1.0091.00
85_L88_I1.0051.00
159_V162_A1.0011.00
42_F102_Y0.9951.00
57_T60_S0.9921.00
72_E103_P0.9741.00
29_L39_T0.9741.00
40_V130_L0.9671.00
80_T83_T0.9601.00
140_Q146_H0.9511.00
58_A62_R0.9491.00
132_I143_T0.9451.00
132_I159_V0.9421.00
131_F139_L0.9401.00
39_T137_G0.9311.00
55_E59_M0.9241.00
110_H113_S0.9211.00
81_I106_A0.9081.00
86_A89_N0.9061.00
65_E161_Q0.9041.00
151_R154_D0.9001.00
66_F157_L0.8971.00
40_V71_A0.8971.00
13_F116_Y0.8881.00
10_A139_L0.8761.00
6_V142_Q0.8761.00
76_V112_V0.8751.00
48_F83_T0.8741.00
36_D135_P0.8671.00
10_A133_I0.8661.00
158_R161_Q0.8591.00
157_L161_Q0.8571.00
59_M73_V0.8481.00
111_E114_R0.8451.00
70_D135_P0.8411.00
122_E125_V0.8381.00
148_N151_R0.8381.00
59_M156_T0.8381.00
27_V74_I0.8371.00
12_R29_L0.8361.00
54_T57_T0.8341.00
41_L116_Y0.8271.00
65_E69_L0.8201.00
39_T133_I0.8151.00
58_A61_D0.8131.00
60_S63_Y0.8111.00
16_E108_T0.7971.00
158_R162_A0.7951.00
74_I105_A0.7931.00
113_S119_L0.7921.00
13_F112_V0.7881.00
80_T108_T0.7801.00
44_Y47_D0.7781.00
57_T98_G0.7761.00
10_A29_L0.7721.00
35_N137_G0.7631.00
141_Y155_E0.7591.00
143_T156_T0.7541.00
18_V85_L0.7281.00
18_V81_I0.7271.00
6_V139_L0.7231.00
64_D101_K0.7201.00
10_A112_V0.7171.00
151_R155_E0.7111.00
127_L145_F0.7061.00
18_V103_P0.7061.00
46_M125_V0.7051.00
142_Q145_F0.7031.00
41_L133_I0.7001.00
56_I75_G0.6991.00
132_I141_Y0.6861.00
69_L160_L0.6861.00
130_L156_T0.6821.00
32_N72_E0.6781.00
40_V156_T0.6751.00
38_W160_L0.6691.00
42_F75_G0.6641.00
46_M79_D0.6631.00
23_E88_I0.6631.00
69_L157_L0.6611.00
140_Q163_L0.6571.00
44_Y75_G0.6561.00
62_R66_F0.6551.00
127_L146_H0.6460.99
45_P49_T0.6350.99
41_L76_V0.6330.99
139_L142_Q0.6310.99
63_Y73_V0.6300.99
30_E35_N0.6300.99
47_D83_T0.6230.99
29_L32_N0.6170.99
59_M153_V0.6150.99
9_Q35_N0.6140.99
42_F55_E0.6130.99
38_W70_D0.6120.99
37_K70_D0.6050.99
120_I123_E0.5970.99
49_T128_R0.5950.99
58_A153_V0.5910.99
11_P115_E0.5880.99
82_H85_L0.5860.99
43_F116_Y0.5850.99
56_I102_Y0.5820.99
143_T155_E0.5780.99
129_G145_F0.5760.99
51_V149_I0.5760.99
129_G142_Q0.5710.99
58_A154_D0.5680.99
81_I85_L0.5660.99
37_K67_E0.5650.99
46_M80_T0.5650.99
12_R35_N0.5630.99
24_F81_I0.5630.99
73_V102_Y0.5620.99
74_I103_P0.5570.98
50_F53_P0.5550.98
78_T119_L0.5550.98
43_F118_V0.5510.98
5_M142_Q0.5400.98
133_I137_G0.5400.98
112_V115_E0.5360.98
54_T149_I0.5350.98
149_I162_A0.5300.98
127_L147_N0.5290.98
63_Y72_E0.5260.98
125_V147_N0.5190.98
40_V160_L0.5180.98
123_E127_L0.5180.98
8_K142_Q0.5130.97
44_Y87_W0.5120.97
24_F85_L0.5100.97
121_E124_G0.5090.97
120_I125_V0.5060.97
130_L152_D0.5050.97
66_F73_V0.5040.97
10_A39_T0.5030.97
105_A112_V0.5030.97
71_A156_T0.5030.97
66_F71_A0.5020.97
35_N136_E0.5010.97
149_I163_L0.5000.97
42_F84_H0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v2gA 2 0.9556 100 0.301 Contact Map
1prxA 2 0.9667 100 0.303 Contact Map
3a2vA 5 0.9667 100 0.308 Contact Map
1xccA 2 0.9667 100 0.311 Contact Map
3w6gA 6 0.9444 100 0.313 Contact Map
3tjjA 3 0.9056 100 0.395 Contact Map
2c0dA 2 0.95 100 0.416 Contact Map
3zl5A 3 0.8833 100 0.416 Contact Map
4rqxA 3 0.9 100 0.418 Contact Map
2pn8A 4 0.9667 100 0.422 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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