GREMLIN Database
GLNH - ABC transporter glutamine-binding protein GlnH
UniProt: O34563 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 273 (229)
Sequences: 20762 (14212)
Seq/√Len: 939.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_G110_I3.6861.00
161_L199_G3.5451.00
47_K92_Q3.3491.00
83_D252_K2.8171.00
169_S183_E2.3821.00
184_F193_A2.3451.00
63_N66_S2.2311.00
104_M110_I2.2211.00
186_N189_E2.2191.00
131_D251_K2.2151.00
47_K90_K2.1261.00
119_I124_K2.1251.00
63_N70_E2.1231.00
119_I232_G2.1201.00
49_V92_Q2.1141.00
169_S173_R2.0341.00
121_E124_K2.0021.00
79_Q82_K1.9971.00
260_D264_K1.9921.00
49_V94_K1.9901.00
258_R261_E1.9881.00
106_Q126_E1.9741.00
159_K182_L1.9431.00
251_K255_S1.9421.00
235_V243_A1.9101.00
128_D243_A1.9091.00
127_V234_A1.8831.00
81_A91_A1.8611.00
243_A247_N1.8391.00
190_A202_L1.8341.00
83_D249_S1.8061.00
131_D247_N1.8011.00
150_S153_N1.7871.00
204_T209_L1.7831.00
235_V246_I1.7541.00
50_F77_A1.7121.00
240_S244_K1.7031.00
114_V233_I1.6631.00
193_A198_Q1.6601.00
159_K180_S1.6571.00
141_L209_L1.6501.00
149_K153_N1.6231.00
79_Q258_R1.6051.00
79_Q83_D1.5451.00
79_Q253_M1.5441.00
143_K197_G1.5261.00
143_K146_S1.5141.00
164_K185_E1.4961.00
104_M109_D1.4861.00
236_K239_Q1.4761.00
63_N68_E1.4731.00
130_S247_N1.4651.00
171_N175_K1.4481.00
40_A44_D1.4481.00
170_Q174_E1.4361.00
244_K248_A1.4141.00
144_K218_N1.4061.00
83_D256_D1.3811.00
135_E230_P1.3771.00
84_I89_K1.3471.00
102_I127_V1.3281.00
61_L70_E1.3241.00
145_G220_Q1.3201.00
245_E248_A1.3181.00
78_K93_F1.3011.00
101_R113_I1.3011.00
75_D265_K1.2991.00
193_A199_G1.2891.00
128_D238_G1.2831.00
195_K218_N1.2801.00
159_K200_D1.2621.00
80_I249_S1.2581.00
206_N210_Y1.2541.00
74_I78_K1.2521.00
158_S200_D1.2501.00
77_A114_V1.2451.00
139_S206_N1.2351.00
96_V104_M1.2311.00
54_T95_E1.2291.00
62_K95_E1.2261.00
185_E189_E1.2181.00
84_I249_S1.2151.00
50_F112_A1.2121.00
173_R183_E1.2111.00
117_M234_A1.2061.00
138_Q168_S1.2031.00
108_G236_K1.1901.00
194_L219_Y1.1741.00
161_L184_F1.1691.00
140_L201_A1.1661.00
144_K220_Q1.1561.00
41_A45_N1.1431.00
128_D240_S1.1431.00
103_P106_Q1.1391.00
252_K256_D1.1381.00
142_V201_A1.1321.00
73_D133_Y1.1251.00
249_S252_K1.1171.00
192_T195_K1.1141.00
113_I117_M1.1091.00
245_E249_S1.1081.00
254_K259_Y1.1071.00
122_E125_K1.1071.00
240_S243_A1.0901.00
162_A169_S1.0901.00
72_F262_I1.0881.00
40_A43_K1.0841.00
160_V201_A1.0811.00
46_D89_K1.0681.00
192_T196_S1.0641.00
68_E78_K1.0641.00
176_A179_A1.0481.00
97_T100_T1.0421.00
194_L202_L1.0381.00
77_A93_F1.0371.00
184_F190_A1.0361.00
72_F267_I1.0341.00
249_S253_M1.0231.00
139_S221_L1.0211.00
142_V222_T1.0161.00
96_V110_I1.0121.00
248_A252_K1.0061.00
76_I253_M1.0041.00
45_N49_V1.0031.00
78_K82_K1.0021.00
163_V166_S1.0001.00
170_Q173_R0.9981.00
39_L42_I0.9971.00
128_D237_K0.9961.00
72_F263_Y0.9951.00
62_K67_G0.9911.00
258_R262_I0.9901.00
194_L199_G0.9831.00
112_A246_I0.9831.00
50_F91_A0.9731.00
75_D78_K0.9711.00
161_L190_A0.9631.00
102_I117_M0.9581.00
75_D266_W0.9531.00
103_P107_N0.9521.00
77_A91_A0.9511.00
76_I259_Y0.9501.00
142_V146_S0.9481.00
89_K245_E0.9471.00
37_D241_A0.9461.00
253_M258_R0.9451.00
164_K183_E0.9451.00
211_G215_E0.9441.00
112_A235_V0.9351.00
259_Y263_Y0.9201.00
241_A245_E0.9191.00
189_E192_T0.9191.00
120_T123_R0.9161.00
69_I74_I0.9151.00
195_K216_N0.9141.00
131_D254_K0.9101.00
42_I45_N0.8991.00
261_E264_K0.8991.00
80_I246_I0.8911.00
130_S246_I0.8901.00
72_F259_Y0.8881.00
121_E125_K0.8851.00
70_E75_D0.8821.00
106_Q127_V0.8801.00
112_A233_I0.8781.00
83_D258_R0.8711.00
54_T69_I0.8681.00
136_A207_A0.8671.00
247_N251_K0.8641.00
156_K178_E0.8621.00
247_N250_L0.8591.00
59_F134_F0.8521.00
57_R61_L0.8441.00
98_S101_R0.8391.00
38_T41_A0.8381.00
171_N174_E0.8381.00
37_D40_A0.8231.00
42_I46_D0.8211.00
188_A192_T0.8191.00
100_T104_M0.8151.00
123_R129_F0.8151.00
77_A233_I0.8121.00
62_K69_I0.8111.00
39_L43_K0.8101.00
263_Y267_I0.8091.00
129_F234_A0.8091.00
48_I112_A0.8041.00
124_K237_K0.8041.00
137_G206_N0.7991.00
252_K255_S0.7971.00
79_Q249_S0.7881.00
182_L193_A0.7841.00
37_D41_A0.7821.00
261_E265_K0.7771.00
52_V74_I0.7721.00
48_I89_K0.7711.00
49_V111_D0.7691.00
48_I81_A0.7681.00
113_I234_A0.7551.00
142_V220_Q0.7541.00
77_A112_A0.7541.00
43_K46_D0.7521.00
80_I84_I0.7521.00
83_D253_M0.7511.00
84_I245_E0.7471.00
140_L203_T0.7451.00
241_A244_K0.7411.00
260_D263_Y0.7401.00
253_M256_D0.7371.00
118_T229_E0.7361.00
154_L201_A0.7351.00
52_V93_F0.7311.00
130_S235_V0.7291.00
141_L219_Y0.7141.00
187_Y204_T0.7121.00
152_E156_K0.7111.00
191_F195_K0.7091.00
161_L193_A0.7081.00
80_I114_V0.7031.00
61_L266_W0.7021.00
253_M257_G0.6991.00
248_A251_K0.6971.00
42_I89_K0.6971.00
233_I246_I0.6931.00
105_L113_I0.6931.00
119_I132_V0.6911.00
105_L110_I0.6871.00
136_A206_N0.6871.00
210_Y214_D0.6851.00
36_K41_A0.6851.00
239_Q242_L0.6831.00
47_K89_K0.6831.00
94_K109_D0.6821.00
76_I250_L0.6781.00
147_K220_Q0.6781.00
102_I106_Q0.6761.00
184_F199_G0.6731.00
253_M259_Y0.6701.00
148_I153_N0.6701.00
130_S233_I0.6681.00
139_S223_G0.6651.00
244_K247_N0.6611.00
189_E193_A0.6591.00
128_D239_Q0.6581.00
52_V115_A0.6571.00
172_I181_V0.6571.00
53_K60_G0.6571.00
54_T60_G0.6551.00
100_T103_P0.6551.00
135_E228_D0.6521.00
56_T116_T0.6501.00
173_R181_V0.6481.00
129_F232_G0.6461.00
78_K91_A0.6451.00
109_D198_Q0.6441.00
159_K199_G0.6421.00
182_L199_G0.6411.00
79_Q262_I0.6391.00
53_K98_S0.6341.00
52_V69_I0.6341.00
50_F93_F0.6321.00
143_K218_N0.6321.00
191_F219_Y0.6291.00
132_V135_E0.6251.00
211_G214_D0.6241.00
162_A183_E0.6241.00
108_G238_G0.6221.00
106_Q236_K0.6221.00
51_G101_R0.6201.00
105_L236_K0.6181.00
137_G228_D0.6181.00
56_T98_S0.6171.00
210_Y221_L0.6131.00
251_K254_K0.6121.00
51_G113_I0.6111.00
70_E266_W0.6101.00
98_S117_M0.6091.00
209_L213_A0.6091.00
105_L127_V0.6081.00
131_D250_L0.6071.00
81_A86_G0.6051.00
219_Y222_T0.6041.00
167_T229_E0.6021.00
53_K163_V0.6001.00
257_G261_E0.5991.00
96_V101_R0.5971.00
60_G115_A0.5971.00
94_K110_I0.5971.00
118_T123_R0.5961.00
119_I129_F0.5951.00
138_Q203_T0.5941.00
77_A81_A0.5931.00
141_L213_A0.5931.00
141_L191_F0.5911.00
117_M127_V0.5901.00
172_I176_A0.5901.00
172_I203_T0.5891.00
137_G225_P0.5881.00
81_A84_I0.5751.00
130_S250_L0.5741.00
43_K245_E0.5741.00
139_S209_L0.5731.00
73_D116_T0.5721.00
204_T208_I0.5691.00
147_K158_S0.5631.00
38_T236_K0.5621.00
195_K219_Y0.5621.00
136_A231_Y0.5611.00
53_K115_A0.5591.00
74_I93_F0.5571.00
213_A216_N0.5511.00
80_I233_I0.5501.00
137_G227_T0.5461.00
41_A44_D0.5451.00
213_A217_K0.5451.00
118_T167_T0.5441.00
75_D262_I0.5421.00
45_N111_D0.5421.00
253_M262_I0.5411.00
254_K257_G0.5401.00
36_K40_A0.5391.00
54_T62_K0.5391.00
57_R215_E0.5381.00
257_G260_D0.5351.00
193_A196_S0.5351.00
164_K169_S0.5341.00
38_T42_I0.5341.00
213_A219_Y0.5331.00
145_G197_G0.5311.00
134_F231_Y0.5301.00
205_D231_Y0.5291.00
163_V187_Y0.5251.00
101_R117_M0.5251.00
162_A172_I0.5241.00
160_V179_A0.5231.00
124_K128_D0.5201.00
140_L154_L0.5161.00
82_K258_R0.5111.00
83_D245_E0.5111.00
77_A80_I0.5101.00
39_L89_K0.5051.00
235_V239_Q0.5041.00
48_I84_I0.5041.00
84_I242_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xt8A 1 0.8681 100 0.24 Contact Map
2ylnA 1 0.8571 100 0.244 Contact Map
2yjpA 1 0.8571 100 0.245 Contact Map
1pb7A 1 0.9194 100 0.261 Contact Map
4ohnA 1 0.8608 100 0.267 Contact Map
3kbrA 4 0.8242 100 0.269 Contact Map
4ymxA 1 0.7985 100 0.271 Contact Map
4powA 1 0.8205 100 0.272 Contact Map
2vhaA 2 0.8755 100 0.276 Contact Map
3hv1A 2 0.8791 100 0.283 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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