GREMLIN Database
YECA - Uncharacterized amino acid permease YecA
UniProt: O34560 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 424 (399)
Sequences: 24441 (15762)
Seq/√Len: 789.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_I325_A4.2391.00
306_F319_R4.2071.00
50_S230_A3.0511.00
309_K319_R2.9391.00
358_I382_F2.9081.00
216_K220_L2.8401.00
10_T212_H2.8021.00
311_S314_K2.7451.00
211_F217_D2.6451.00
213_R216_K2.5701.00
401_V405_A2.5431.00
311_S318_I2.4971.00
90_G297_L2.4761.00
74_T300_E2.4731.00
406_G410_M2.4671.00
298_A308_G2.4491.00
128_G329_G2.4431.00
167_S239_V2.4411.00
306_F309_K2.4141.00
15_T224_L2.3221.00
397_L401_V2.2941.00
165_A169_P2.2721.00
11_W224_L2.2721.00
62_R368_L2.2601.00
78_Q86_G2.2161.00
209_E299_R2.1601.00
407_Y411_K2.1591.00
210_E292_R2.1301.00
361_M381_A2.1031.00
295_Y299_R2.0811.00
11_W217_D2.0731.00
322_T326_A2.0571.00
257_M260_S2.0391.00
136_L140_R2.0381.00
132_A329_G2.0231.00
408_F412_T2.0201.00
379_L383_V2.0021.00
14_G211_F1.9971.00
135_I321_L1.9731.00
139_M318_I1.9721.00
394_W397_L1.9511.00
143_Q147_N1.9451.00
128_G332_L1.9321.00
11_W15_T1.9251.00
154_C158_F1.9151.00
220_L224_L1.9051.00
81_F366_K1.8941.00
10_T13_Q1.8731.00
94_L324_M1.8571.00
266_S270_V1.8531.00
127_A332_L1.8481.00
78_Q83_K1.8341.00
51_F55_F1.8311.00
397_L400_A1.8131.00
248_E261_K1.7991.00
406_G409_Y1.7891.00
307_F323_A1.7851.00
59_T361_M1.7811.00
301_G305_V1.7801.00
81_F362_A1.7681.00
245_S248_E1.7611.00
132_A325_A1.7561.00
257_M261_K1.7281.00
34_T42_S1.7241.00
77_V89_L1.6731.00
13_Q150_T1.6601.00
131_L328_F1.6511.00
376_W380_G1.6341.00
383_V387_V1.6331.00
213_R217_D1.6301.00
45_V190_V1.6061.00
122_Q125_L1.6051.00
366_K369_G1.5901.00
396_L399_P1.5861.00
223_F227_S1.5811.00
89_L359_C1.5731.00
101_V328_F1.5711.00
18_T225_A1.5561.00
15_T228_C1.5531.00
139_M322_T1.5491.00
105_A283_I1.5401.00
400_A404_A1.5371.00
138_H284_H1.5371.00
158_F162_T1.5281.00
394_W399_P1.5211.00
362_A382_F1.5141.00
314_K318_I1.5131.00
227_S231_G1.5111.00
112_V126_I1.5031.00
140_R314_K1.4931.00
171_V174_A1.4901.00
121_W125_L1.4851.00
6_Q315_R1.4741.00
295_Y310_L1.4711.00
52_L384_A1.4691.00
394_W398_Y1.4691.00
41_A187_A1.4651.00
374_G378_A1.4571.00
395_A399_P1.4391.00
135_I322_T1.4341.00
294_V320_V1.4271.00
159_L274_L1.4231.00
319_R323_A1.4151.00
82_Q85_A1.4151.00
9_I13_Q1.4151.00
305_V308_G1.4121.00
362_A366_K1.4121.00
290_F324_M1.4001.00
57_V226_A1.3991.00
207_L288_A1.3981.00
396_L402_L1.3951.00
311_S316_T1.3891.00
396_L401_V1.3881.00
105_A131_L1.3761.00
387_V391_F1.3731.00
51_F380_G1.3661.00
168_L239_V1.3631.00
77_V359_C1.3621.00
49_M194_I1.3521.00
108_G130_M1.3461.00
128_G132_A1.3451.00
309_K318_I1.3441.00
305_V309_K1.3331.00
108_G276_L1.3311.00
409_Y412_T1.3301.00
375_W379_L1.3261.00
131_L325_A1.3171.00
57_V222_L1.3161.00
81_F85_A1.3131.00
70_A209_E1.3111.00
55_F380_G1.3041.00
67_A79_L1.2911.00
13_Q146_A1.2901.00
213_R220_L1.2891.00
260_S268_V1.2881.00
269_Y273_C1.2831.00
164_I235_M1.2831.00
157_V161_V1.2781.00
172_T175_E1.2731.00
56_L361_M1.2531.00
231_G235_M1.2521.00
291_S321_L1.2511.00
11_W220_L1.2411.00
217_D220_L1.2371.00
75_A79_L1.2371.00
373_I377_M1.2321.00
214_P219_P1.2271.00
80_A363_A1.2271.00
395_A398_Y1.2261.00
376_W379_L1.2181.00
58_G223_F1.2091.00
163_S167_S1.2081.00
9_I14_G1.1981.00
43_L238_F1.1961.00
12_I16_A1.1951.00
171_V242_G1.1931.00
394_W403_A1.1921.00
386_A390_S1.1911.00
124_T128_G1.1881.00
396_L403_A1.1881.00
22_V229_V1.1791.00
62_R65_K1.1761.00
167_S243_T1.1761.00
399_P403_A1.1711.00
134_S283_I1.1711.00
395_A402_L1.1671.00
59_T378_A1.1631.00
371_R374_G1.1611.00
41_A180_L1.1591.00
397_L403_A1.1511.00
260_S265_E1.1511.00
94_L294_V1.1501.00
253_A257_M1.1491.00
9_I146_A1.1411.00
104_I282_T1.1411.00
319_R322_T1.1321.00
29_I107_T1.1221.00
87_A91_W1.1191.00
69_S75_A1.1181.00
81_F84_K1.1171.00
370_R373_I1.1171.00
60_L73_I1.1111.00
358_I386_A1.1111.00
212_H217_D1.1081.00
8_S212_H1.1071.00
394_W400_A1.1051.00
408_F411_K1.1021.00
394_W402_L1.0931.00
137_L148_I1.0911.00
365_L379_L1.0891.00
394_W401_V1.0881.00
398_Y401_V1.0841.00
294_V303_I1.0731.00
399_P402_L1.0721.00
77_V85_A1.0631.00
389_Y392_S1.0621.00
64_V76_Y1.0601.00
299_R308_G1.0601.00
14_G221_S1.0571.00
112_V116_T1.0561.00
407_Y410_M1.0551.00
326_A330_L1.0531.00
19_I228_C1.0531.00
35_A42_S1.0531.00
109_A126_I1.0501.00
263_A267_G1.0491.00
401_V404_A1.0431.00
18_T204_I1.0401.00
162_T166_V1.0401.00
129_C133_I1.0341.00
47_V234_I1.0311.00
148_I152_V1.0311.00
17_L207_L1.0271.00
19_I229_V1.0271.00
125_L129_C1.0261.00
370_R375_W1.0171.00
135_I139_M1.0121.00
395_A400_A1.0111.00
69_S79_L1.0041.00
371_R375_W1.0041.00
132_A136_L1.0031.00
264_G267_G0.9971.00
147_N151_L0.9921.00
396_L400_A0.9911.00
402_L405_A0.9891.00
149_S284_H0.9891.00
361_M382_F0.9861.00
397_L402_L0.9811.00
369_G375_W0.9781.00
309_K312_A0.9761.00
310_L315_R0.9741.00
161_V165_A0.9691.00
245_S261_K0.9671.00
407_Y412_T0.9661.00
364_A378_A0.9631.00
358_I362_A0.9571.00
199_V353_F0.9571.00
133_I280_F0.9551.00
74_T296_A0.9481.00
142_I288_A0.9461.00
382_F386_A0.9441.00
400_A403_A0.9361.00
375_W378_A0.9351.00
188_G387_V0.9341.00
139_M316_T0.9331.00
385_C388_I0.9311.00
371_R378_A0.9241.00
208_A218_V0.9241.00
108_G279_T0.9241.00
358_I385_C0.9231.00
373_I376_W0.9211.00
164_I239_V0.9191.00
112_V276_L0.9171.00
91_W303_I0.9171.00
157_V232_L0.9151.00
390_S393_G0.9141.00
103_I196_F0.9061.00
23_L26_G0.9051.00
238_F242_G0.9041.00
202_E206_P0.9041.00
371_R377_M0.9021.00
152_V281_A0.9001.00
8_S143_Q0.8981.00
126_I129_C0.8971.00
164_I168_L0.8971.00
224_L228_C0.8961.00
381_A384_A0.8911.00
230_A234_I0.8801.00
364_A368_L0.8791.00
243_T258_L0.8791.00
171_V175_E0.8761.00
109_A127_A0.8761.00
16_A150_T0.8751.00
189_S193_M0.8691.00
398_Y402_L0.8681.00
287_I325_A0.8671.00
43_L241_V0.8661.00
307_F319_R0.8641.00
134_S284_H0.8621.00
147_N150_T0.8591.00
71_G74_T0.8581.00
85_A359_C0.8561.00
50_S198_F0.8541.00
348_G352_A0.8541.00
203_M289_G0.8501.00
398_Y403_A0.8491.00
78_Q300_E0.8471.00
381_A385_C0.8431.00
71_G75_A0.8431.00
113_S123_I0.8411.00
156_I278_I0.8381.00
365_L375_W0.8341.00
55_F377_M0.8341.00
13_Q147_N0.8291.00
163_S259_I0.8241.00
325_A329_G0.8231.00
103_I346_L0.8221.00
387_V390_S0.8221.00
388_I392_S0.8181.00
54_F58_G0.8161.00
175_E178_P0.8141.00
406_G412_T0.8101.00
12_I150_T0.8071.00
318_I322_T0.7991.00
44_F187_A0.7941.00
124_T332_L0.7931.00
265_E269_Y0.7921.00
395_A401_V0.7861.00
303_I307_F0.7831.00
363_A367_L0.7821.00
385_C389_Y0.7821.00
365_L369_G0.7771.00
54_F223_F0.7731.00
136_L139_M0.7721.00
140_R144_L0.7681.00
168_L235_M0.7671.00
131_L332_L0.7631.00
312_A318_I0.7631.00
406_G411_K0.7631.00
180_L187_A0.7591.00
254_S259_I0.7571.00
176_F242_G0.7551.00
55_F59_T0.7521.00
47_V51_F0.7511.00
63_L364_A0.7501.00
138_H321_L0.7451.00
11_W221_S0.7441.00
139_M311_S0.7431.00
109_A123_I0.7431.00
134_S287_I0.7421.00
172_T176_F0.7381.00
166_V170_H0.7361.00
98_P327_V0.7321.00
12_I147_N0.7281.00
77_V363_A0.7261.00
24_G28_L0.7261.00
219_P222_L0.7251.00
372_D376_W0.7241.00
388_I391_F0.7231.00
15_T221_S0.7221.00
180_L184_W0.7211.00
373_I378_A0.7181.00
378_A385_C0.7181.00
27_I236_L0.7151.00
84_K88_I0.7131.00
74_T78_Q0.7121.00
213_R219_P0.7111.00
108_G280_F0.7101.00
44_F48_F0.7101.00
199_V357_Y0.7091.00
81_F363_A0.7071.00
63_L76_Y0.7061.00
326_A329_G0.7061.00
8_S142_I0.7061.00
62_R66_I0.7051.00
139_M314_K0.7051.00
100_G349_P0.7031.00
292_R295_Y0.7001.00
164_I236_L0.6991.00
182_H185_S0.6981.00
298_A307_F0.6971.00
173_I176_F0.6941.00
146_A150_T0.6941.00
399_P405_A0.6931.00
291_S320_V0.6931.00
106_L345_L0.6911.00
341_D344_T0.6901.00
259_I264_G0.6881.00
70_A295_Y0.6881.00
56_L385_C0.6881.00
15_T18_T0.6871.00
124_T127_A0.6861.00
174_A177_K0.6861.00
224_L227_S0.6831.00
312_A315_R0.6821.00
139_M321_L0.6811.00
109_A112_V0.6801.00
134_S280_F0.6791.00
379_L382_F0.6791.00
374_G377_M0.6791.00
128_G333_A0.6791.00
22_V225_A0.6771.00
307_F320_V0.6771.00
80_A366_K0.6761.00
395_A405_A0.6751.00
254_S258_L0.6731.00
44_F47_V0.6721.00
53_S201_W0.6721.00
23_L28_L0.6711.00
306_F323_A0.6711.00
59_T371_R0.6701.00
144_L147_N0.6691.00
236_L240_T0.6671.00
132_A135_I0.6661.00
42_S237_S0.6651.00
209_E295_Y0.6641.00
403_A406_G0.6631.00
33_V343_T0.6621.00
20_G153_I0.6601.00
34_T38_A0.6581.00
384_A388_I0.6581.00
93_M97_V0.6571.00
112_V130_M0.6541.00
74_T90_G0.6531.00
186_A189_S0.6531.00
287_I291_S0.6511.00
138_H288_A0.6511.00
368_L375_W0.6511.00
23_L156_I0.6501.00
55_F381_A0.6491.00
253_A256_A0.6491.00
61_A65_K0.6411.00
183_G186_A0.6411.00
31_P237_S0.6401.00
43_L234_I0.6381.00
99_I348_G0.6381.00
228_C232_L0.6371.00
375_W392_S0.6361.00
48_F191_S0.6341.00
294_V323_A0.6331.00
235_M239_V0.6331.00
64_V218_V0.6321.00
155_V274_L0.6311.00
63_L80_A0.6301.00
60_L360_T0.6271.00
383_V386_A0.6271.00
100_G103_I0.6261.00
171_V176_F0.6251.00
114_Y272_V0.6231.00
43_L47_V0.6221.00
46_W197_S0.6201.00
378_A382_F0.6181.00
365_L378_A0.6181.00
273_C277_F0.6181.00
80_A367_L0.6171.00
8_S12_I0.6171.00
64_V205_T0.6161.00
385_C392_S0.6151.00
40_P241_V0.6151.00
354_I385_C0.6151.00
21_A203_M0.6151.00
57_V201_W0.6121.00
123_I127_A0.6081.00
113_S117_E0.6071.00
115_I272_V0.6061.00
205_T222_L0.6061.00
73_I202_E0.6061.00
97_V286_N0.6051.00
104_I283_I0.6051.00
96_S353_F0.6051.00
144_L148_I0.6051.00
131_L329_G0.6041.00
102_P345_L0.6021.00
206_P289_G0.6011.00
37_T189_S0.6001.00
377_M391_F0.6001.00
66_I367_L0.6001.00
266_S269_Y0.5991.00
184_W187_A0.5971.00
188_G391_F0.5961.00
18_T22_V0.5961.00
135_I287_I0.5931.00
311_S315_R0.5931.00
378_A393_G0.5931.00
92_I355_A0.5931.00
259_I267_G0.5921.00
92_I356_S0.5911.00
102_P331_V0.5871.00
98_P324_M0.5871.00
290_F294_V0.5871.00
278_I281_A0.5861.00
57_V61_A0.5861.00
292_R310_L0.5861.00
158_F161_V0.5861.00
228_C231_G0.5851.00
317_P320_V0.5831.00
21_A286_N0.5831.00
374_G379_L0.5821.00
130_M283_I0.5821.00
141_G144_L0.5821.00
146_A284_H0.5811.00
397_L405_A0.5811.00
343_T346_L0.5811.00
378_A392_S0.5801.00
236_L255_L0.5791.00
218_V222_L0.5791.00
21_A285_A0.5781.00
150_T154_C0.5781.00
74_T86_G0.5781.00
384_A387_V0.5771.00
104_I107_T0.5761.00
142_I207_L0.5761.00
155_V159_L0.5751.00
82_Q86_G0.5751.00
105_A109_A0.5751.00
370_R374_G0.5731.00
210_E310_L0.5731.00
31_P35_A0.5721.00
396_L405_A0.5711.00
107_T111_Y0.5711.00
239_V242_G0.5691.00
405_A408_F0.5681.00
216_K219_P0.5681.00
306_F310_L0.5671.00
210_E317_P0.5661.00
115_I273_C0.5661.00
395_A403_A0.5651.00
34_T190_V0.5651.00
166_V264_G0.5641.00
111_Y275_A0.5641.00
380_G383_V0.5641.00
19_I153_I0.5641.00
199_V202_E0.5641.00
371_R376_W0.5631.00
37_T40_P0.5611.00
14_G207_L0.5611.00
100_G104_I0.5601.00
270_V274_L0.5601.00
181_P185_S0.5591.00
352_A356_S0.5591.00
73_I206_P0.5591.00
7_R212_H0.5581.00
33_V37_T0.5581.00
169_P172_T0.5571.00
372_D375_W0.5531.00
244_H248_E0.5521.00
211_F221_S0.5511.00
368_L374_G0.5511.00
58_G377_M0.5511.00
394_W405_A0.5511.00
12_I15_T0.5511.00
153_I156_I0.5501.00
176_F241_V0.5501.00
365_L382_F0.5491.00
77_V86_G0.5471.00
244_H258_L0.5471.00
184_W188_G0.5471.00
49_M198_F0.5461.00
49_M195_F0.5451.00
91_W406_G0.5451.00
33_V36_D0.5451.00
323_A327_V0.5441.00
202_E357_Y0.5421.00
104_I279_T0.5411.00
211_F218_V0.5411.00
399_P404_A0.5411.00
204_I218_V0.5411.00
23_L232_L0.5401.00
403_A410_M0.5391.00
248_E251_E0.5381.00
195_F350_S0.5371.00
30_L346_L0.5371.00
23_L30_L0.5351.00
67_A80_A0.5351.00
166_V263_A0.5331.00
382_F385_C0.5321.00
330_L333_A0.5311.00
400_A405_A0.5311.00
110_H123_I0.5301.00
133_I137_L0.5301.00
396_L404_A0.5291.00
214_P217_D0.5251.00
389_Y397_L0.5251.00
292_R317_P0.5241.00
145_S288_A0.5221.00
388_I393_G0.5211.00
372_D378_A0.5211.00
214_P218_V0.5201.00
40_P43_L0.5191.00
283_I286_N0.5191.00
159_L270_V0.5181.00
10_T143_Q0.5181.00
45_V48_F0.5171.00
381_A392_S0.5161.00
38_A45_V0.5151.00
318_I321_L0.5151.00
351_A389_Y0.5141.00
34_T194_I0.5141.00
370_R377_M0.5131.00
259_I263_A0.5121.00
335_H341_D0.5121.00
89_L356_S0.5101.00
199_V349_P0.5091.00
31_P240_T0.5091.00
382_F392_S0.5091.00
155_V277_F0.5081.00
178_P181_P0.5081.00
151_L154_C0.5071.00
61_A222_L0.5071.00
99_I349_P0.5061.00
329_G332_L0.5061.00
129_C132_A0.5061.00
24_G233_Y0.5051.00
56_L202_E0.5041.00
322_T325_A0.5041.00
151_L155_V0.5031.00
149_S281_A0.5021.00
27_I31_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9646 100 0.25 Contact Map
3giaA 1 0.9764 100 0.289 Contact Map
4djkA 2 0.9316 100 0.346 Contact Map
3dh4A 3 0.9481 99 0.845 Contact Map
2xq2A 2 0.9505 98.9 0.849 Contact Map
2jlnA 1 0.9292 98.6 0.864 Contact Map
4wgvA 2 0.8373 97.8 0.889 Contact Map
2a65A 2 0.9387 96.5 0.91 Contact Map
4xp4A 1 0.9505 95.1 0.919 Contact Map
4us3A 1 0.9033 92.9 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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