GREMLIN Database
URHG2 - Unsaturated rhamnogalacturonyl hydrolase YteR
UniProt: O34559 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (323)
Sequences: 1866 (1371)
Seq/√Len: 76.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
212_A279_G5.0131.00
290_G296_L4.3921.00
284_M307_A4.1321.00
255_D258_T3.8611.00
251_C303_T3.7571.00
247_I287_I3.6601.00
60_K64_E3.4691.00
109_V113_K3.1541.00
260_L280_S3.0741.00
292_N363_E2.9871.00
243_L290_G2.9751.00
253_Y265_V2.8161.00
291_I304_L2.7701.00
339_D343_S2.7271.00
219_V286_A2.7171.00
258_T275_L2.6711.00
64_E68_A2.5581.00
219_V247_I2.4961.00
236_R240_K2.4411.00
188_Y210_F2.4111.00
314_H328_D2.3951.00
129_G140_M2.3411.00
91_Q94_L2.2791.00
101_E158_L2.2671.00
308_Y361_M2.1581.00
124_R167_Q2.0891.00
181_D184_T2.0561.00
254_Q307_A2.0341.00
54_W63_F2.0261.00
255_D275_L2.0051.00
173_S238_V1.9001.00
212_A265_V1.8981.00
288_A304_L1.8721.00
240_K295_Y1.8681.00
255_D262_Y1.8551.00
301_E305_L1.8481.00
181_D210_F1.8481.00
117_S120_G1.8481.00
169_V235_N1.8431.00
250_I283_Y1.8381.00
267_K272_D1.8351.00
219_V246_M1.8351.00
260_L310_G1.7981.00
185_G249_S1.7831.00
49_G358_I1.7731.00
227_E293_K1.7711.00
309_Q313_Q1.7521.00
251_C299_A1.7511.00
248_K299_A1.7471.00
298_R301_E1.7421.00
281_C311_L1.7421.00
259_G306_K1.7361.00
231_K236_R1.7271.00
156_A165_F1.7141.00
244_Q297_D1.6971.00
176_R245_D1.6891.00
261_W307_A1.6781.00
248_K300_Y1.6751.00
55_E102_Q1.6601.00
220_M282_L1.6461.00
288_A364_L1.6421.00
176_R242_T1.6251.00
230_P233_H1.6071.00
127_E177_K1.5981.00
100_Y109_V1.5850.99
67_K105_D1.5440.99
67_K71_D1.5180.99
330_C333_T1.5110.99
162_T166_D1.5060.99
240_K244_Q1.5040.99
180_K185_G1.5010.99
244_Q248_K1.5000.99
169_V229_L1.4940.99
329_I353_G1.4930.99
64_E67_K1.4770.99
222_L239_W1.4660.99
166_D233_H1.4610.99
129_G174_L1.4550.99
25_M28_Y1.4510.99
141_W147_M1.4500.99
280_S307_A1.4310.99
325_L349_N1.4290.99
52_R55_E1.4280.99
219_V250_I1.4240.99
363_E366_P1.4220.99
152_A167_Q1.4140.99
180_K245_D1.4130.99
338_Y342_V1.4060.99
223_A243_L1.3970.99
176_R187_F1.3930.99
277_S328_D1.3840.99
98_P154_K1.3780.99
251_C287_I1.3340.98
145_L172_E1.3130.98
71_D108_Y1.3100.98
54_W57_T1.3070.98
45_V282_L1.2900.98
291_I302_T1.2810.98
127_E178_H1.2790.98
215_I246_M1.2770.98
249_S252_R1.2740.98
153_L228_E1.2680.97
51_L66_A1.2640.97
229_L233_H1.2570.97
118_L122_L1.2550.97
220_M285_Y1.2360.97
157_N228_E1.2360.97
247_I296_L1.2320.97
254_Q310_G1.2290.97
87_L148_G1.2280.97
277_S315_K1.2270.97
181_D188_Y1.2220.97
167_Q170_L1.2160.97
110_K114_R1.2130.97
302_T305_L1.2080.97
25_M29_T1.1990.96
247_I251_C1.1960.96
87_L122_L1.1940.96
169_V239_W1.1870.96
230_P236_R1.1820.96
332_G335_A1.1720.96
170_L173_S1.1690.96
262_Y275_L1.1550.96
241_N245_D1.1370.95
209_E264_I1.1330.95
93_G115_L1.1330.95
263_Q333_T1.1320.95
157_N165_F1.1270.95
238_V241_N1.1220.95
151_F155_Y1.1190.95
263_Q330_C1.1190.95
305_L309_Q1.1120.95
63_F67_K1.1050.94
215_I265_V1.0930.94
172_E239_W1.0930.94
170_L174_L1.0880.94
292_N366_P1.0860.94
87_L130_F1.0860.94
184_T249_S1.0840.94
70_A95_I1.0820.94
226_I236_R1.0770.94
116_R152_A1.0750.93
142_L214_S1.0670.93
71_D107_R1.0580.93
216_G356_A1.0550.93
254_Q259_G1.0550.93
331_V345_E1.0480.93
267_K338_Y1.0470.93
227_E289_K1.0420.92
106_E109_V1.0300.92
138_Y194_A1.0280.92
173_S242_T1.0250.92
254_Q303_T1.0250.92
175_M179_T1.0240.92
97_F158_L1.0220.92
272_D342_V1.0090.91
247_I290_G1.0050.91
180_K184_T1.0030.91
243_L247_I1.0010.91
185_G245_D0.9980.91
156_A168_V0.9970.91
254_Q280_S0.9960.91
49_G355_G0.9890.90
262_Y273_N0.9860.90
52_R359_L0.9820.90
45_V355_G0.9800.90
187_F242_T0.9760.90
287_I303_T0.9750.90
308_Y364_L0.9560.89
247_I300_Y0.9550.89
67_K99_L0.9540.89
237_H241_N0.9510.88
56_A362_T0.9510.88
185_G252_R0.9460.88
142_L218_Y0.9440.88
249_S253_Y0.9420.88
152_A156_A0.9420.88
26_N29_T0.9410.88
103_T108_Y0.9390.88
260_L275_L0.9380.88
154_K228_E0.9360.88
232_K236_R0.9300.87
260_L314_H0.9290.87
254_Q306_K0.9270.87
106_E110_K0.9260.87
169_V233_H0.9240.87
97_F112_A0.9220.87
304_L364_L0.9220.87
289_K293_K0.9180.87
243_L286_A0.9140.86
93_G151_F0.9110.86
332_G352_H0.9050.86
284_M304_L0.9030.86
319_S325_L0.8740.84
265_V283_Y0.8730.84
132_H139_Q0.8720.84
187_F218_Y0.8720.84
296_L300_Y0.8710.84
241_N244_Q0.8680.83
260_L315_K0.8680.83
112_A119_Y0.8660.83
119_Y167_Q0.8590.83
169_V173_S0.8590.83
220_M224_D0.8570.83
173_S235_N0.8560.83
41_Y352_H0.8510.82
271_S274_W0.8510.82
116_R164_L0.8510.82
112_A151_F0.8450.82
235_N238_V0.8380.81
90_I115_L0.8380.81
100_Y106_E0.8360.81
195_K204_T0.8350.81
281_C357_F0.8350.81
216_G282_L0.8340.81
132_H141_W0.8320.81
315_K328_D0.8300.81
188_Y208_P0.8300.81
113_K117_S0.8250.80
261_W287_I0.8230.80
311_L315_K0.8220.80
94_L154_K0.8220.80
226_I240_K0.8200.80
166_D235_N0.8190.80
88_D175_M0.8160.79
60_K63_F0.8160.79
48_C52_R0.8150.79
277_S311_L0.8150.79
176_R238_V0.8070.79
331_V334_S0.8050.79
100_Y103_T0.8030.78
182_A237_H0.8000.78
132_H147_M0.7990.78
248_K251_C0.7960.78
285_Y359_L0.7940.78
209_E267_K0.7910.77
109_V159_K0.7890.77
172_E222_L0.7870.77
105_D108_Y0.7840.77
180_K187_F0.7820.77
319_S327_K0.7760.76
55_E98_P0.7760.76
213_R278_S0.7740.76
210_F266_D0.7730.76
42_H351_L0.7700.75
248_K252_R0.7680.75
156_A164_L0.7680.75
231_K293_K0.7660.75
281_C327_K0.7660.75
125_T129_G0.7640.75
162_T232_K0.7600.74
69_Y73_L0.7550.74
250_I287_I0.7500.73
328_D346_R0.7480.73
163_E166_D0.7420.73
303_T306_K0.7410.73
149_G172_E0.7390.72
100_Y159_K0.7390.72
49_G362_T0.7390.72
326_V353_G0.7390.72
259_G307_A0.7370.72
263_Q352_H0.7350.72
104_K313_Q0.7320.72
157_N160_Q0.7320.72
116_R130_F0.7300.71
140_M174_L0.7300.71
85_D122_L0.7270.71
305_L364_L0.7260.71
41_Y263_Q0.7220.71
243_L296_L0.7220.71
140_M175_M0.7210.71
152_A172_E0.7210.71
166_D169_V0.7150.70
167_Q171_Q0.7130.70
278_S329_I0.7100.69
154_K158_L0.7080.69
100_Y104_K0.7040.69
116_R161_E0.7000.68
41_Y350_D0.6990.68
52_R366_P0.6990.68
110_K113_K0.6990.68
125_T193_E0.6990.68
43_Q351_L0.6940.68
90_I118_L0.6940.68
179_T214_S0.6910.67
103_T107_R0.6900.67
260_L277_S0.6900.67
335_A340_Y0.6880.67
172_E225_M0.6870.67
57_T62_Y0.6870.67
213_R352_H0.6860.67
209_E338_Y0.6860.67
156_A160_Q0.6860.67
290_G294_G0.6820.66
150_P225_M0.6820.66
179_T206_C0.6790.66
291_I296_L0.6790.66
254_Q261_W0.6790.66
328_D334_S0.6780.66
284_M311_L0.6770.66
120_G123_N0.6770.66
70_A99_L0.6750.65
152_A168_V0.6740.65
290_G300_Y0.6730.65
101_E154_K0.6730.65
267_K342_V0.6710.65
156_A162_T0.6700.65
188_Y206_C0.6690.65
277_S314_H0.6630.64
113_K155_Y0.6600.64
35_P281_C0.6590.64
100_Y105_D0.6590.64
51_L95_I0.6580.63
148_G165_F0.6570.63
242_T245_D0.6570.63
116_R120_G0.6550.63
291_I297_D0.6550.63
211_W217_W0.6550.63
124_R128_G0.6540.63
56_A365_E0.6530.63
336_G340_Y0.6530.63
262_Y272_D0.6520.63
353_G356_A0.6510.63
122_L130_F0.6510.63
46_F50_V0.6500.63
240_K243_L0.6500.63
146_Y224_D0.6490.62
53_L62_Y0.6480.62
225_M239_W0.6470.62
219_V243_L0.6460.62
26_N321_D0.6450.62
330_C341_Y0.6450.62
145_L239_W0.6430.62
86_E89_A0.6410.61
67_K108_Y0.6390.61
54_W102_Q0.6380.61
87_L144_G0.6370.61
297_D303_T0.6360.61
164_L168_V0.6350.61
261_W283_Y0.6300.60
153_L225_M0.6290.60
98_P101_E0.6290.60
284_M360_A0.6290.60
97_F154_K0.6270.60
298_R302_T0.6240.59
277_S326_V0.6240.59
361_M365_E0.6220.59
300_Y303_T0.6210.59
116_R155_Y0.6190.59
297_D300_Y0.6180.59
143_D217_W0.6180.59
161_E164_L0.6170.59
152_A164_L0.6160.58
77_N80_L0.6160.58
182_A241_N0.6150.58
262_Y271_S0.6130.58
97_F101_E0.6130.58
61_R113_K0.6090.58
266_D271_S0.6080.57
328_D331_V0.6070.57
93_G112_A0.6070.57
123_N141_W0.6060.57
238_V242_T0.6060.57
264_I338_Y0.5990.56
189_H289_K0.5990.56
76_D301_E0.5970.56
330_C335_A0.5970.56
145_L171_Q0.5950.56
146_Y155_Y0.5950.56
311_L357_F0.5940.56
358_I362_T0.5930.56
125_T132_H0.5920.55
67_K103_T0.5910.55
264_I335_A0.5900.55
119_Y123_N0.5880.55
48_C146_Y0.5880.55
63_F102_Q0.5850.55
62_Y188_Y0.5830.54
126_S196_K0.5810.54
329_I332_G0.5810.54
224_D289_K0.5750.53
70_A92_A0.5740.53
247_I286_A0.5740.53
229_L360_A0.5730.53
309_Q320_E0.5700.53
299_A302_T0.5700.53
234_P237_H0.5700.53
337_F340_Y0.5690.53
40_H43_Q0.5680.52
61_R306_K0.5670.52
224_D279_G0.5670.52
34_P37_N0.5660.52
57_T365_E0.5660.52
131_W144_G0.5660.52
184_T210_F0.5640.52
155_Y159_K0.5630.52
326_V330_C0.5610.52
219_V283_Y0.5600.51
308_Y312_I0.5590.51
146_Y359_L0.5590.51
337_F358_I0.5590.51
326_V329_I0.5580.51
263_Q344_R0.5570.51
46_F69_Y0.5550.51
129_G132_H0.5540.51
237_H240_K0.5540.51
66_A98_P0.5540.51
113_K161_E0.5520.50
71_D74_I0.5520.50
226_I230_P0.5510.50
41_Y330_C0.5510.50
42_H352_H0.5500.50
250_I265_V0.5500.50
260_L311_L0.5500.50
88_D144_G0.5500.50
104_K108_Y0.5500.50
218_Y242_T0.5490.50
287_I291_I0.5490.50
153_L157_N0.5470.50
153_L168_V0.5460.50
220_M223_A0.5450.49
280_S311_L0.5430.49
176_R180_K0.5400.49
149_G168_V0.5390.49
276_E353_G0.5390.49
246_M286_A0.5370.48
310_G315_K0.5370.48
151_F171_Q0.5360.48
167_Q172_E0.5360.48
291_I301_E0.5360.48
124_R171_Q0.5340.48
66_A99_L0.5340.48
330_C350_D0.5330.48
309_Q364_L0.5320.48
170_L235_N0.5320.48
112_A155_Y0.5310.48
303_T307_A0.5310.48
329_I333_T0.5300.48
41_Y144_G0.5290.47
42_H95_I0.5290.47
61_R298_R0.5280.47
130_F152_A0.5280.47
154_K225_M0.5270.47
260_L313_Q0.5260.47
88_D143_D0.5260.47
192_D204_T0.5260.47
173_S237_H0.5250.47
218_Y222_L0.5250.47
350_D355_G0.5230.47
261_W303_T0.5230.47
42_H84_R0.5220.47
51_L98_P0.5220.47
298_R313_Q0.5210.46
240_K293_K0.5210.46
60_K241_N0.5200.46
177_K238_V0.5200.46
128_G140_M0.5200.46
195_K205_G0.5200.46
315_K361_M0.5190.46
327_K348_T0.5190.46
55_E298_R0.5190.46
185_G248_K0.5180.46
333_T344_R0.5170.46
226_I229_L0.5150.46
115_L118_L0.5150.46
99_L108_Y0.5150.46
88_D217_W0.5140.46
206_C210_F0.5130.45
149_G179_T0.5130.45
329_I334_S0.5110.45
160_Q164_L0.5090.45
226_I295_Y0.5090.45
267_K271_S0.5070.45
133_K136_Y0.5070.45
312_I320_E0.5050.44
326_V333_T0.5040.44
139_Q147_M0.5030.44
113_K159_K0.5030.44
205_G267_K0.5030.44
187_F215_I0.5030.44
137_P194_A0.5030.44
55_E227_E0.5010.44
139_Q192_D0.5010.44
332_G350_D0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nc5A 1 0.9732 100 0.274 Contact Map
4wu0A 1 0.9383 100 0.304 Contact Map
3k11A 3 0.9544 100 0.361 Contact Map
4ce7A 3 0.9088 100 0.378 Contact Map
4xuvA 2 0.8713 100 0.387 Contact Map
3pmmA 1 0.933 100 0.421 Contact Map
4q88A 1 0.8928 100 0.422 Contact Map
3wiwA 1 0.9088 100 0.565 Contact Map
2ahfA 1 0.9249 100 0.609 Contact Map
2zzrA 1 0.9303 100 0.61 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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