GREMLIN Database
RPE - Ribulose-phosphate 3-epimerase
UniProt: O34557 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (211)
Sequences: 4314 (2604)
Seq/√Len: 179.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_A18_N3.2871.00
162_A170_L3.2851.00
183_A194_L2.7391.00
171_L192_N2.5211.00
178_V186_V2.3411.00
24_E60_L2.2421.00
159_K163_D2.2351.00
64_V83_A2.2181.00
39_H69_E2.1941.00
86_L108_V2.1731.00
121_Q124_E2.1151.00
203_Q209_A2.0601.00
133_V158_V2.0561.00
76_P102_L2.0491.00
147_F152_L2.0431.00
149_H185_L2.0221.00
87_S113_V2.0051.00
70_E73_R1.9881.00
97_H129_D1.9211.00
205_D208_K1.8981.00
33_I51_V1.8801.00
111_G132_L1.8461.00
124_E157_E1.7991.00
79_A108_V1.7731.00
22_D206_R1.7601.00
184_P188_E1.7491.00
135_L151_V1.7371.00
72_D93_C1.7271.00
117_H139_N1.7101.00
160_R164_E1.7031.00
90_A122_V1.6921.00
61_P85_I1.6911.00
153_P156_K1.6901.00
76_P106_Q1.6861.00
76_P80_K1.6571.00
88_V96_L1.6481.00
207_K211_S1.6361.00
3_K171_L1.6281.00
187_I194_L1.6251.00
87_S132_L1.6171.00
137_T151_V1.6161.00
165_K168_K1.5961.00
102_L105_E1.5841.00
91_E118_T1.5721.00
159_K162_A1.5441.00
104_K110_A1.5381.00
120_V158_V1.5211.00
179_N182_T1.5041.00
124_E161_M1.5001.00
17_G21_K1.4851.00
72_D99_T1.4671.00
33_I62_L1.4561.00
115_N139_N1.4241.00
29_D214_R1.4241.00
21_K25_K1.4131.00
30_C193_L1.4091.00
135_L158_V1.4031.00
52_E80_K1.3981.00
182_T186_V1.3921.00
69_E94_P1.3831.00
23_V31_I1.3751.00
171_L193_L1.3351.00
95_H98_R1.3351.00
51_V62_L1.3331.00
14_A17_G1.3221.00
24_E59_D1.3161.00
180_K199_A1.3081.00
162_A168_K1.3021.00
104_K131_D1.3021.00
152_L185_L1.3021.00
55_R62_L1.3001.00
55_R84_D1.2991.00
19_E206_R1.2911.00
208_K212_E1.2891.00
101_Q105_E1.2851.00
39_H70_E1.2841.00
5_A193_L1.2751.00
19_E22_D1.2471.00
85_I109_K1.2451.00
14_A57_V1.2421.00
96_L112_V1.2301.00
112_V130_L1.2231.00
5_A30_C1.2181.00
162_A192_N1.2011.00
20_I54_V1.1981.00
120_V125_H1.1951.00
101_Q129_D1.1921.00
3_K30_C1.1711.00
96_L126_V1.1681.00
121_Q157_E1.1651.00
3_K193_L1.1601.00
173_E195_V1.1501.00
79_A106_Q1.1391.00
8_I31_I1.1351.00
21_K24_E1.1301.00
36_M41_V1.1271.00
100_I130_L1.1241.00
110_A131_D1.1131.00
9_L143_G1.1101.00
75_I106_Q1.0951.00
103_I110_A1.0861.00
40_F91_E1.0851.00
85_I132_L1.0801.00
88_V99_T1.0671.00
102_L106_Q1.0631.00
185_L188_E1.0631.00
30_C85_I1.0601.00
3_K29_D1.0591.00
180_K212_E1.0521.00
161_M165_K1.0501.00
63_D87_S1.0471.00
30_C171_L1.0361.00
99_T102_L1.0351.00
31_I60_L1.0120.99
96_L117_H1.0120.99
12_D15_A1.0040.99
90_A96_L0.9970.99
80_K106_Q0.9940.99
100_I129_D0.9890.99
25_K207_K0.9870.99
100_I104_K0.9850.99
112_V126_V0.9830.99
8_I33_I0.9820.99
46_I50_I0.9790.99
72_D102_L0.9770.99
125_H157_E0.9730.99
130_L133_V0.9680.99
24_E58_T0.9490.99
48_P77_A0.9450.99
77_A80_K0.9300.99
58_T62_L0.9280.99
162_A172_I0.9250.99
49_L52_E0.9210.99
100_I126_V0.9190.99
196_A200_V0.9180.99
137_T147_F0.9110.99
109_K171_L0.9090.99
33_I46_I0.9060.99
156_K160_R0.9050.99
14_A53_A0.9030.99
156_K188_E0.9030.99
49_L53_A0.9010.99
127_F168_K0.9010.99
100_I110_A0.9000.99
157_E161_M0.8990.99
18_N22_D0.8970.99
209_A212_E0.8970.99
173_E193_L0.8930.99
208_K211_S0.8920.99
55_R58_T0.8910.99
87_S111_G0.8850.98
160_R163_D0.8830.98
174_V191_A0.8810.98
4_V210_I0.8700.98
206_R209_A0.8700.98
152_L189_A0.8670.98
95_H139_N0.8660.98
155_I174_V0.8630.98
97_H150_S0.8610.98
29_D61_P0.8600.98
10_S45_T0.8580.98
20_I31_I0.8580.98
186_V194_L0.8580.98
40_F118_T0.8570.98
196_A199_A0.8570.98
191_A194_L0.8400.98
183_A187_I0.8390.98
88_V100_I0.8370.98
93_C99_T0.8370.98
16_L50_I0.8370.98
68_I74_Y0.8350.98
90_A120_V0.8310.98
90_A123_I0.8270.98
79_A86_L0.8260.98
120_V135_L0.8220.98
11_A16_L0.8220.98
66_L78_F0.8210.98
43_N142_F0.8160.97
120_V161_M0.8110.97
73_R77_A0.8090.97
44_I78_F0.8060.97
128_D165_K0.8060.97
156_K189_A0.8030.97
158_V172_I0.8000.97
116_P138_V0.7960.97
35_V51_V0.7890.97
54_V62_L0.7810.97
18_N21_K0.7790.97
35_V78_F0.7760.96
128_D150_S0.7700.96
97_H101_Q0.7670.96
158_V162_A0.7620.96
120_V157_E0.7610.96
52_E56_P0.7580.96
159_K170_L0.7490.96
125_H128_D0.7470.96
88_V93_C0.7390.95
155_I172_I0.7350.95
39_H73_R0.7340.95
143_G177_G0.7290.95
153_P157_E0.7290.95
123_I133_V0.7220.95
199_A209_A0.7210.95
9_L177_G0.7210.95
15_A19_E0.7180.95
118_T122_V0.7080.94
180_K209_A0.7070.94
53_A56_P0.7000.94
24_E27_G0.7000.94
132_L193_L0.6970.94
96_L99_T0.6970.94
161_M164_E0.6960.94
155_I191_A0.6940.94
6_P28_A0.6920.93
151_V154_K0.6910.93
152_L186_V0.6890.93
10_S198_S0.6840.93
45_T48_P0.6810.93
11_A19_E0.6770.93
143_G197_G0.6760.93
20_I24_E0.6670.92
200_V210_I0.6600.92
27_G211_S0.6580.92
77_A81_A0.6560.92
103_I108_V0.6490.91
174_V178_V0.6430.91
130_L170_L0.6430.91
30_C132_L0.6420.91
66_L86_L0.6420.91
90_A114_L0.6420.91
183_A213_I0.6400.91
200_V206_R0.6390.90
112_V123_I0.6360.90
95_H117_H0.6300.90
23_V28_A0.6300.90
67_M89_H0.6270.90
148_I151_V0.6260.90
203_Q206_R0.6220.89
149_H153_P0.6220.89
146_K181_E0.6190.89
26_G206_R0.6170.89
179_N199_A0.6170.89
75_I99_T0.6120.89
12_D19_E0.6090.88
101_Q104_K0.6080.88
116_P140_P0.6040.88
182_T213_I0.6020.88
180_K213_I0.6010.88
88_V112_V0.5990.87
162_A165_K0.5900.87
165_K170_L0.5900.87
124_E165_K0.5880.86
123_I126_V0.5860.86
114_L135_L0.5850.86
21_K57_V0.5830.86
23_V206_R0.5790.86
52_E77_A0.5770.85
138_V145_Q0.5730.85
68_I78_F0.5720.85
157_E160_R0.5720.85
45_T51_V0.5700.85
48_P81_A0.5690.85
75_I79_A0.5680.85
199_A212_E0.5680.85
153_P165_K0.5610.84
10_S23_V0.5560.83
95_H126_V0.5540.83
61_P84_D0.5510.83
127_F170_L0.5460.82
84_D108_V0.5450.82
199_A213_I0.5450.82
57_V61_P0.5410.82
127_F162_A0.5410.82
120_V154_K0.5400.82
44_I47_G0.5400.82
137_T174_V0.5380.81
20_I60_L0.5370.81
31_I58_T0.5350.81
5_A173_E0.5310.80
10_S19_E0.5300.80
17_G57_V0.5300.80
97_H139_N0.5290.80
75_I102_L0.5290.80
95_H115_N0.5280.80
23_V201_Y0.5270.80
76_P105_E0.5240.80
129_D150_S0.5230.79
75_I103_I0.5210.79
133_V170_L0.5210.79
127_F133_V0.5210.79
104_K129_D0.5200.79
43_N145_Q0.5190.79
44_I68_I0.5190.79
22_D207_K0.5170.79
166_G170_L0.5170.79
143_G196_A0.5170.79
4_V213_I0.5170.79
45_T49_L0.5160.79
138_V143_G0.5140.78
101_Q139_N0.5120.78
46_I49_L0.5100.78
71_P88_V0.5100.78
98_R102_L0.5100.78
178_V194_L0.5090.78
38_G74_Y0.5070.77
142_F145_Q0.5070.77
33_I64_V0.5070.77
84_D109_K0.5070.77
10_S177_G0.5060.77
10_S143_G0.5060.77
70_E94_P0.5050.77
33_I54_V0.5040.77
161_M168_K0.5030.77
120_V124_E0.5010.77
152_L182_T0.5000.76
146_K179_N0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cu2A 2 0.977 100 0.333 Contact Map
3ctlA 4 0.9862 100 0.431 Contact Map
3inpA 6 0.977 100 0.447 Contact Map
4df0A 2 0.8802 100 0.447 Contact Map
4muzA 2 0.9401 100 0.458 Contact Map
1rpxA 4 0.9954 100 0.458 Contact Map
1tqjA 4 0.977 100 0.462 Contact Map
2yyuA 2 0.9355 100 0.466 Contact Map
3w07A 2 0.9355 100 0.466 Contact Map
1dbtA 2 0.9447 100 0.468 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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