GREMLIN Database
YLBO - Uncharacterized protein YlbO
UniProt: O34549 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (179)
Sequences: 344 (257)
Seq/√Len: 19.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_I65_I4.2931.00
142_E147_R4.1391.00
24_H29_G3.6401.00
135_Q140_Q3.4401.00
129_R132_L3.4201.00
105_S112_F3.0410.99
107_Q117_K2.8700.99
141_K145_D2.6930.98
13_E43_T2.6500.98
149_E154_R2.3440.96
64_G67_L2.2620.95
64_G71_Q2.2390.94
163_D173_R2.2290.94
12_D55_S2.2050.94
109_V112_F2.1240.92
104_L109_V1.9660.89
23_R64_G1.9600.89
4_T10_T1.9450.89
19_E23_R1.9190.88
119_T184_G1.8680.86
3_I55_S1.8620.86
67_L71_Q1.7640.83
56_Y172_D1.7100.81
20_V38_V1.7080.81
6_Q51_F1.7050.81
12_D43_T1.6910.80
147_R151_Q1.6590.79
137_Q141_K1.6440.78
62_Q66_E1.6210.77
51_F72_R1.5330.73
33_S36_E1.5300.73
16_L74_E1.5240.73
23_R67_L1.4980.71
143_L146_L1.4900.71
23_R26_R1.4690.70
20_V55_S1.4580.69
112_F116_F1.4500.69
29_G109_V1.4380.68
20_V77_K1.4310.68
6_Q72_R1.4210.67
136_I139_L1.3970.66
15_L23_R1.3930.66
43_T55_S1.3870.65
38_V51_F1.3870.65
11_Q25_I1.3860.65
106_I116_F1.3650.64
20_V43_T1.3360.62
19_E64_G1.3330.62
21_V73_K1.3310.62
108_D144_E1.3280.62
137_Q151_Q1.3250.62
3_I12_D1.2970.60
31_Q58_R1.2960.60
115_Q135_Q1.2810.59
26_R71_Q1.2800.59
170_I173_R1.2750.58
3_I43_T1.2670.58
20_V40_R1.2620.58
126_Q130_E1.2570.57
94_A97_S1.2550.57
40_R55_S1.2490.57
25_I172_D1.2360.56
123_Q126_Q1.2110.54
43_T59_K1.2090.54
85_N88_N1.2020.54
10_T46_A1.1810.53
16_L51_F1.1650.52
25_I76_R1.1610.51
150_N153_L1.1490.51
156_Q161_E1.1440.50
55_S77_K1.1240.49
40_R62_Q1.1230.49
6_Q55_S1.1040.48
15_L71_Q1.1020.48
74_E116_F1.0960.47
13_E62_Q1.0920.47
46_A77_K1.0880.47
170_I176_K1.0860.47
108_D148_S1.0800.46
138_S142_E1.0780.46
6_Q164_Y1.0740.46
13_E63_S1.0670.45
23_R27_E1.0540.45
171_M174_A1.0480.44
163_D171_M1.0470.44
154_R160_T1.0460.44
144_E147_R1.0410.44
35_F44_R1.0340.43
2_T129_R1.0320.43
100_G103_D1.0240.43
73_K153_L1.0220.43
36_E59_K1.0120.42
40_R77_K1.0050.41
3_I56_Y0.9890.41
44_R49_C0.9810.40
58_R68_A0.9800.40
51_F55_S0.9750.40
152_T156_Q0.9700.39
66_E149_E0.9610.39
10_T167_L0.9440.38
4_T169_D0.9440.38
18_A57_V0.9440.38
153_L178_V0.9380.37
83_S182_E0.9310.37
55_S59_K0.9250.37
31_Q68_A0.9240.37
12_D20_V0.9220.36
10_T84_V0.9140.36
128_E133_K0.9120.36
177_M180_S0.9060.36
163_D168_I0.9060.36
3_I40_R0.9000.35
118_E121_S0.8990.35
32_L37_E0.8990.35
170_I174_A0.8880.34
150_N183_D0.8840.34
177_M181_K0.8820.34
7_D47_A0.8700.33
164_Y171_M0.8640.33
11_Q76_R0.8600.33
78_Q136_I0.8580.33
177_M182_E0.8580.33
125_F167_L0.8450.32
33_S80_G0.8390.32
29_G33_S0.8380.32
15_L64_G0.8340.31
159_M162_E0.8260.31
95_S98_S0.8250.31
163_D170_I0.8250.31
30_T58_R0.8130.30
15_L26_R0.8120.30
152_T155_N0.8080.30
21_V132_L0.8050.30
65_I165_K0.7980.30
103_D107_Q0.7960.29
160_T171_M0.7940.29
130_E134_E0.7930.29
36_E46_A0.7920.29
35_F49_C0.7910.29
43_T70_K0.7910.29
44_R50_G0.7900.29
75_L79_I0.7760.28
5_R44_R0.7750.28
165_K177_M0.7690.28
118_E127_L0.7610.28
171_M176_K0.7610.28
115_Q142_E0.7530.27
39_G51_F0.7490.27
34_A38_V0.7490.27
163_D174_A0.7450.27
13_E25_I0.7440.27
32_L58_R0.7430.27
5_R45_T0.7420.27
103_D138_S0.7420.27
143_L147_R0.7360.26
145_D148_S0.7350.26
96_A127_L0.7290.26
151_Q155_N0.7240.26
7_D45_T0.7200.26
106_I114_E0.7200.26
125_F129_R0.7180.25
46_A139_L0.7170.25
62_Q65_I0.7150.25
130_E185_R0.7110.25
58_R69_K0.7070.25
18_A47_A0.7000.25
33_S76_R0.6990.25
76_R116_F0.6990.25
2_T36_E0.6970.24
168_I173_R0.6850.24
151_Q158_E0.6830.24
85_N107_Q0.6820.24
31_Q69_K0.6680.23
32_L65_I0.6630.23
8_A32_L0.6630.23
104_L120_P0.6620.23
114_E132_L0.6620.23
36_E174_A0.6590.23
100_G141_K0.6570.23
141_K148_S0.6560.23
22_L26_R0.6510.22
128_E160_T0.6460.22
33_S41_A0.6440.22
150_N180_S0.6430.22
36_E71_Q0.6430.22
15_L38_V0.6400.22
76_R85_N0.6390.22
36_E39_G0.6370.22
38_V64_G0.6310.22
33_S181_K0.6310.22
15_L19_E0.6290.21
145_D149_E0.6280.21
42_L139_L0.6270.21
26_R72_R0.6270.21
124_E127_L0.6250.21
123_Q133_K0.6240.21
95_S141_K0.6230.21
32_L50_G0.6220.21
23_R36_E0.6210.21
75_L81_V0.6170.21
35_F50_G0.6150.21
134_E151_Q0.6140.21
33_S86_M0.6120.21
5_R35_F0.6110.21
94_A99_E0.6080.21
115_Q120_P0.6070.20
124_E155_N0.6030.20
40_R43_T0.6020.20
31_Q37_E0.6010.20
6_Q32_L0.6000.20
6_Q38_V0.5990.20
55_S164_Y0.5910.20
129_R133_K0.5900.20
82_H158_E0.5900.20
26_R61_Y0.5890.20
56_Y76_R0.5880.20
29_G150_N0.5830.20
108_D112_F0.5820.19
29_G175_R0.5810.19
123_Q151_Q0.5780.19
94_A116_F0.5760.19
119_T122_A0.5740.19
73_K132_L0.5700.19
12_D64_G0.5700.19
137_Q140_Q0.5690.19
150_N154_R0.5680.19
41_A145_D0.5670.19
84_V88_N0.5660.19
55_S63_S0.5660.19
24_H37_E0.5660.19
19_E67_L0.5640.19
176_K182_E0.5630.19
83_S86_M0.5590.19
18_A31_Q0.5570.19
88_N101_K0.5570.19
38_V46_A0.5500.18
128_E132_L0.5490.18
102_R115_Q0.5470.18
82_H85_N0.5470.18
117_K142_E0.5440.18
63_S74_E0.5430.18
144_E148_S0.5400.18
87_P94_A0.5370.18
84_V156_Q0.5330.18
127_L147_R0.5320.18
106_I117_K0.5300.17
10_T150_N0.5290.17
57_V73_K0.5290.17
25_I168_I0.5280.17
10_T184_G0.5270.17
5_R49_C0.5270.17
114_E142_E0.5230.17
5_R32_L0.5220.17
161_E166_A0.5220.17
157_L185_R0.5210.17
42_L73_K0.5200.17
144_E149_E0.5180.17
18_A58_R0.5180.17
4_T12_D0.5160.17
150_N160_T0.5150.17
32_L35_F0.5130.17
41_A139_L0.5130.17
134_E145_D0.5100.17
131_K135_Q0.5090.17
13_E70_K0.5050.17
130_E149_E0.5030.17
5_R42_L0.5020.16
106_I134_E0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ltpA 1 0.3212 98.1 0.875 Contact Map
1gv2A 1 0.2642 97.8 0.882 Contact Map
1guuA 1 0.2539 97.7 0.886 Contact Map
2dinA 1 0.3264 97.7 0.886 Contact Map
1h8aC 1 0.2694 97.7 0.886 Contact Map
1gvdA 1 0.2642 97.6 0.887 Contact Map
2d9aA 1 0.2953 97.6 0.887 Contact Map
2k9nA 1 0.3057 97.5 0.891 Contact Map
2m2eA 1 0.3627 97.5 0.891 Contact Map
2dimA 1 0.342 97.4 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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