GREMLIN Database
BRAB - Branched-chain amino acid transport system carrier protein BraB
UniProt: O34545 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 445 (427)
Sequences: 1608 (1192)
Seq/√Len: 57.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_T301_V5.2871.00
380_G424_G4.8871.00
381_T421_G4.3411.00
136_Y322_T4.1061.00
129_L329_L4.0981.00
228_A232_K3.8811.00
190_K194_E3.8731.00
377_C425_A3.8161.00
424_G428_G3.6771.00
135_T297_S3.6651.00
327_F331_I3.6211.00
39_H179_V3.4831.00
203_A207_F3.1211.00
59_G204_S2.9131.00
57_L238_A2.8581.00
167_K171_T2.8261.00
9_D218_K2.6561.00
264_E337_A2.6221.00
235_V239_L2.5621.00
305_G320_V2.4771.00
81_F378_L2.4211.00
41_V249_A2.4051.00
19_A149_V2.3861.00
356_V381_T2.3771.00
14_G236_I2.3681.00
301_V321_V2.3671.00
103_G128_T2.3581.00
156_I291_V2.3341.00
59_G358_I2.2951.00
85_F354_A2.2451.00
376_A380_G2.2261.00
98_A202_L2.2071.00
356_V421_G2.1981.00
128_T333_N2.1871.00
316_S319_I2.1771.00
125_L129_L2.1571.00
136_Y140_L2.1341.00
166_L170_F2.1251.00
138_L298_I2.1141.00
107_Y123_S2.0191.00
371_R375_I2.0121.00
222_Q225_A2.0001.00
52_G56_P1.9741.00
215_V226_L1.9611.00
301_V325_T1.9511.00
88_V350_I1.9431.00
138_L146_V1.9371.00
315_L319_I1.9281.00
134_V294_L1.9221.00
22_F27_M1.9071.00
135_T325_T1.8851.00
15_F154_T1.8631.00
77_A81_F1.8411.00
136_Y321_V1.8290.99
102_T297_S1.7680.99
103_G133_G1.7670.99
419_L423_V1.7550.99
334_F338_Q1.7490.99
162_L166_L1.7460.99
338_Q341_A1.7370.99
37_A44_A1.7350.99
45_I249_A1.7220.99
263_G267_K1.7010.99
103_G132_F1.6880.99
138_L294_L1.6760.99
130_I134_V1.6490.99
61_I231_I1.6450.99
421_G424_G1.6330.99
158_F244_I1.6310.99
165_V247_S1.6260.99
83_T87_V1.6170.99
376_A428_G1.5860.98
157_K288_A1.5820.98
201_A358_I1.5800.98
224_K228_A1.5700.98
250_Y254_T1.5640.98
380_G428_G1.5630.98
97_F346_I1.5620.98
160_I288_A1.5520.98
315_L320_V1.5410.98
172_P254_T1.5350.98
31_P248_L1.5290.98
139_A302_T1.5280.98
107_Y120_E1.5230.98
122_L126_I1.5210.98
294_L298_I1.5180.98
380_G383_L1.5130.98
136_Y325_T1.5110.98
13_I215_V1.5060.98
137_Y148_R1.5060.98
6_P9_D1.4990.98
59_G201_A1.4940.98
389_G393_A1.4910.98
304_C324_V1.4850.98
353_L382_G1.4820.98
104_T124_L1.4770.98
309_S316_S1.4700.98
91_L96_L1.4680.98
205_I354_A1.4560.97
379_I382_G1.4460.97
349_A386_I1.4330.97
330_I334_F1.4210.97
45_I246_V1.4170.97
31_P268_I1.4120.97
17_L60_I1.4100.97
344_V348_S1.4030.97
240_G244_I1.4000.97
353_L378_L1.3870.96
157_K295_T1.3810.96
103_G135_T1.3800.96
305_G321_V1.3770.96
284_V288_A1.3740.96
182_A190_K1.3690.96
93_I98_A1.3690.96
127_F290_T1.3660.96
168_A251_L1.3510.96
176_L253_A1.3480.96
388_D416_G1.3470.96
43_K46_G1.3430.96
46_G188_V1.3390.96
76_K364_D1.3350.96
97_F340_I1.3350.96
172_P255_S1.3250.95
429_Y433_L1.3140.95
266_A336_L1.3120.95
124_L128_T1.3100.95
73_L361_S1.3090.95
367_F373_V1.2920.95
188_V192_F1.2740.94
381_T385_S1.2730.94
98_A308_F1.2720.94
20_L149_V1.2690.94
82_G164_I1.2680.94
167_K277_F1.2600.94
376_A424_G1.2540.94
20_L339_I1.2510.94
133_G137_Y1.2440.94
301_V324_V1.2430.94
376_A431_L1.2410.93
92_S97_F1.2400.93
360_L373_V1.2360.93
20_L98_A1.2330.93
113_P116_T1.2330.93
419_L426_V1.2320.93
262_V268_I1.2280.93
197_K339_I1.2160.93
410_L413_L1.2110.93
124_L333_N1.2040.92
49_L242_T1.2030.92
126_I130_I1.2010.92
364_D374_Y1.2010.92
49_L53_V1.2010.92
422_I435_I1.2000.92
372_E376_A1.1990.92
375_I379_I1.1990.92
159_T163_I1.1900.92
320_V324_V1.1890.92
81_F353_L1.1860.92
19_A295_T1.1810.92
268_I272_S1.1660.91
99_I328_S1.1560.91
364_D369_E1.1530.91
356_V378_L1.1460.90
128_T332_A1.1440.90
54_G95_P1.1440.90
312_I320_V1.1430.90
70_A86_T1.1420.90
75_D82_G1.1280.90
80_V84_I1.1280.90
32_E36_A1.1220.89
47_G188_V1.1130.89
15_F19_A1.1100.89
376_A427_I1.1080.89
125_L329_L1.1010.89
329_L332_A1.0930.88
370_R432_T1.0910.88
120_E123_S1.0860.88
349_A389_G1.0770.87
106_S290_T1.0740.87
237_A241_L1.0740.87
96_L342_F1.0670.87
291_V295_T1.0650.87
51_T56_P1.0650.87
40_N43_K1.0580.86
63_I208_G1.0580.86
189_F415_I1.0520.86
380_G384_F1.0520.86
322_T326_L1.0460.86
41_V253_A1.0440.86
154_T157_K1.0340.85
53_V242_T1.0340.85
55_L355_I1.0280.85
63_I212_V1.0280.85
349_A353_L1.0280.85
109_I208_G1.0250.85
58_L359_V1.0210.84
20_L105_V1.0200.84
16_M20_L1.0150.84
49_L161_I1.0150.84
383_L427_I1.0120.84
31_P269_L1.0090.84
98_A207_F1.0080.84
388_D391_K0.9960.83
20_L207_F0.9940.83
431_L434_F0.9870.82
91_L308_F0.9820.82
50_L188_V0.9750.82
391_K401_D0.9730.82
213_N216_K0.9730.82
107_Y127_F0.9730.82
20_L340_I0.9710.81
141_N148_R0.9690.81
164_I288_A0.9690.81
376_A425_A0.9690.81
207_F211_V0.9670.81
12_I19_A0.9550.80
202_L350_I0.9540.80
106_S127_F0.9510.80
384_F408_L0.9510.80
125_L333_N0.9500.80
22_F158_F0.9500.80
384_F404_L0.9490.80
274_H282_N0.9490.80
69_D310_K0.9480.80
19_A157_K0.9460.80
305_G342_F0.9460.80
86_T307_Y0.9460.80
85_F89_L0.9440.79
380_G421_G0.9430.79
17_L22_F0.9400.79
309_S315_L0.9390.79
265_G336_L0.9370.79
430_V434_F0.9350.79
10_T232_K0.9350.79
21_F60_I0.9330.79
385_S389_G0.9320.79
121_R125_L0.9310.79
27_M288_A0.9300.78
102_T106_S0.9300.78
226_L230_C0.9290.78
92_S350_I0.9280.78
197_K385_S0.9270.78
388_D392_A0.9200.78
157_K292_A0.9180.78
79_P192_F0.9180.78
58_L362_F0.9170.77
147_D218_K0.9170.77
300_L343_S0.9160.77
170_F173_M0.9150.77
62_A361_S0.9110.77
356_V377_C0.9100.77
241_L295_T0.9100.77
115_L123_S0.9060.77
160_I287_A0.8980.76
62_A66_T0.8980.76
176_L254_T0.8980.76
10_T240_G0.8970.76
8_K12_I0.8890.75
89_L202_L0.8860.75
80_V298_I0.8850.75
171_T276_L0.8810.75
169_I250_Y0.8800.75
57_L266_A0.8770.74
95_P347_L0.8760.74
234_G268_I0.8720.74
42_W46_G0.8720.74
99_I297_S0.8670.73
402_V406_A0.8660.73
61_I227_A0.8630.73
109_I289_I0.8600.73
81_F85_F0.8590.73
146_V214_A0.8590.73
89_L350_I0.8590.73
263_G337_A0.8570.73
157_K241_L0.8560.72
236_I355_I0.8540.72
12_I16_M0.8530.72
164_I273_S0.8520.72
77_A378_L0.8510.72
224_K423_V0.8510.72
134_V290_T0.8490.72
111_A114_F0.8470.72
153_L296_T0.8430.71
93_I203_A0.8380.71
154_T295_T0.8380.71
389_G392_A0.8360.71
63_I73_L0.8320.70
68_K72_G0.8310.70
55_L110_G0.8290.70
46_G50_L0.8260.70
71_K310_K0.8260.70
97_F343_S0.8240.70
16_M265_G0.8230.69
102_T328_S0.8220.69
76_K361_S0.8220.69
416_G426_V0.8210.69
44_A194_E0.8200.69
145_V244_I0.8190.69
35_Q255_S0.8140.69
144_K147_D0.8130.69
75_D79_P0.8120.68
67_G73_L0.8100.68
95_P300_L0.8080.68
9_D14_G0.8070.68
146_V295_T0.8060.68
18_F22_F0.8060.68
127_F289_I0.8040.68
326_L330_I0.7980.67
237_A291_V0.7980.67
264_E267_K0.7970.67
102_T324_V0.7970.67
372_E375_I0.7960.67
20_L60_I0.7950.67
10_T236_I0.7940.67
22_F240_G0.7930.67
406_A422_I0.7920.66
122_L166_L0.7920.66
159_T426_V0.7900.66
90_Y206_V0.7880.66
157_K307_Y0.7860.66
21_F204_S0.7850.66
169_I247_S0.7840.66
206_V241_L0.7770.65
141_N318_K0.7770.65
407_N423_V0.7760.65
52_G205_I0.7760.65
144_K148_R0.7740.65
224_K383_L0.7730.65
183_Y336_L0.7730.65
131_F288_A0.7710.64
96_L331_I0.7690.64
116_T353_L0.7670.64
273_S277_F0.7670.64
146_V157_K0.7660.64
289_I343_S0.7650.64
398_G401_D0.7630.64
226_L233_A0.7590.63
95_P99_I0.7580.63
343_S349_A0.7520.62
20_L97_F0.7500.62
387_L404_L0.7480.62
276_L374_Y0.7470.62
87_V311_L0.7450.62
185_G189_F0.7430.62
388_D411_Y0.7410.61
334_F339_I0.7400.61
348_S392_A0.7400.61
176_L250_Y0.7390.61
109_I270_S0.7350.61
123_S126_I0.7340.61
65_L210_V0.7330.60
19_A238_A0.7330.60
93_I305_G0.7320.60
126_I359_V0.7320.60
96_L346_I0.7310.60
288_A339_I0.7310.60
250_Y253_A0.7310.60
307_Y311_L0.7290.60
104_T247_S0.7270.60
326_L426_V0.7240.60
146_V149_V0.7240.60
184_K187_P0.7230.59
255_S272_S0.7230.59
90_Y187_P0.7220.59
70_A89_L0.7210.59
149_V350_I0.7200.59
220_V225_A0.7200.59
19_A241_L0.7200.59
411_Y416_G0.7190.59
74_A357_I0.7170.59
239_L242_T0.7170.59
102_T247_S0.7160.59
316_S323_I0.7160.59
105_V331_I0.7150.59
304_C308_F0.7130.58
16_M19_A0.7110.58
188_V194_E0.7110.58
156_I159_T0.7100.58
95_P343_S0.7100.58
177_G256_T0.7100.58
87_V308_F0.7100.58
49_L55_L0.7100.58
295_T307_Y0.7090.58
157_K291_V0.7070.58
127_F165_V0.7070.58
19_A197_K0.7070.58
206_V303_S0.7050.57
31_P210_V0.7050.57
98_A300_L0.7040.57
106_S282_N0.7040.57
315_L323_I0.7010.57
108_E264_E0.7010.57
209_V304_C0.6980.57
139_A203_A0.6960.57
134_V137_Y0.6950.56
59_G240_G0.6950.56
126_I426_V0.6950.56
110_G113_P0.6940.56
6_P46_G0.6930.56
126_I133_G0.6920.56
398_G402_V0.6910.56
70_A206_V0.6910.56
14_G240_G0.6900.56
326_L329_L0.6900.56
26_N29_Y0.6900.56
108_E112_V0.6900.56
105_V124_L0.6880.56
377_C428_G0.6880.56
201_A348_S0.6870.56
241_L307_Y0.6840.55
360_L374_Y0.6840.55
348_S389_G0.6840.55
64_A199_M0.6790.55
181_E185_G0.6760.54
207_F300_L0.6760.54
229_A339_I0.6740.54
111_A244_I0.6720.54
142_P306_Q0.6710.54
25_G29_Y0.6700.54
266_A411_Y0.6700.54
183_Y187_P0.6670.53
97_F339_I0.6670.53
372_E431_L0.6660.53
173_M254_T0.6660.53
61_I234_G0.6630.53
64_A234_G0.6590.52
90_Y299_G0.6590.52
410_L415_I0.6580.52
175_G423_V0.6550.52
356_V359_V0.6550.52
135_T294_L0.6540.52
41_V45_I0.6540.52
80_V83_T0.6500.51
89_L238_A0.6450.51
99_I103_G0.6440.51
19_A285_L0.6430.51
263_G268_I0.6400.50
154_T158_F0.6400.50
108_E211_V0.6400.50
52_G208_G0.6370.50
323_I386_I0.6340.50
370_R433_L0.6340.50
21_F233_A0.6330.50
400_L408_L0.6310.49
21_F26_N0.6300.49
102_T132_F0.6300.49
12_I145_V0.6290.49
131_F374_Y0.6280.49
33_L104_T0.6270.49
372_E422_I0.6250.49
365_K368_K0.6240.49
165_V216_K0.6240.49
103_G240_G0.6240.49
20_L203_A0.6230.49
33_L249_A0.6210.48
72_G75_D0.6200.48
27_M327_F0.6200.48
58_L358_I0.6190.48
224_K287_A0.6170.48
126_I423_V0.6170.48
183_Y265_G0.6160.48
69_D72_G0.6160.48
139_A321_V0.6150.48
323_I376_A0.6150.48
396_S399_S0.6130.47
181_E419_L0.6120.47
77_A272_S0.6110.47
107_Y158_F0.6100.47
312_I349_A0.6100.47
360_L377_C0.6100.47
194_E197_K0.6100.47
230_C236_I0.6090.47
422_I425_A0.6090.47
94_G98_A0.6090.47
382_G386_I0.6070.47
22_F272_S0.6060.47
52_G273_S0.6060.47
400_L404_L0.6050.47
245_Y293_C0.6050.47
282_N286_G0.6030.46
220_V247_S0.6030.46
98_A102_T0.6010.46
10_T229_A0.6000.46
372_E423_V0.6000.46
88_V346_I0.5990.46
251_L262_V0.5990.46
90_Y303_S0.5970.46
107_Y125_L0.5960.46
289_I310_K0.5950.45
23_G26_N0.5950.45
271_A274_H0.5950.45
262_V272_S0.5930.45
366_I426_V0.5920.45
133_G274_H0.5920.45
67_G254_T0.5920.45
309_S320_V0.5890.45
92_S328_S0.5890.45
6_P11_I0.5890.45
94_G300_L0.5880.45
96_L327_F0.5880.45
85_F206_V0.5870.45
88_V145_V0.5870.45
76_K374_Y0.5860.44
173_M275_Y0.5850.44
408_L416_G0.5840.44
396_S426_V0.5840.44
94_G207_F0.5830.44
172_P219_G0.5810.44
237_A411_Y0.5810.44
164_I340_I0.5790.44
66_T153_L0.5780.44
37_A287_A0.5780.44
220_V229_A0.5770.43
132_F237_A0.5760.43
133_G136_Y0.5760.43
267_K271_A0.5750.43
98_A203_A0.5750.43
206_V354_A0.5740.43
114_F145_V0.5730.43
52_G238_A0.5730.43
22_F165_V0.5720.43
288_A291_V0.5720.43
131_F135_T0.5720.43
256_T259_I0.5710.43
263_G298_I0.5700.43
84_I326_L0.5690.43
59_G203_A0.5680.43
194_E265_G0.5670.42
142_P302_T0.5670.42
426_V430_V0.5650.42
16_M90_Y0.5650.42
33_L194_E0.5650.42
186_T329_L0.5640.42
28_I266_A0.5630.42
379_I383_L0.5630.42
89_L321_V0.5620.42
53_V192_F0.5610.42
148_R152_I0.5610.42
109_I249_A0.5600.42
327_F330_I0.5600.42
53_V241_L0.5600.42
209_V336_L0.5600.42
403_F406_A0.5590.42
127_F393_A0.5580.41
70_A208_G0.5580.41
215_V230_C0.5570.41
223_S310_K0.5560.41
8_K75_D0.5560.41
93_I110_G0.5560.41
48_F64_A0.5550.41
239_L243_F0.5550.41
153_L230_C0.5530.41
140_L318_K0.5520.41
169_I228_A0.5510.41
421_G428_G0.5510.41
19_A51_T0.5500.41
376_A379_I0.5500.41
90_Y265_G0.5480.40
69_D208_G0.5470.40
15_F197_K0.5470.40
214_A309_S0.5460.40
22_F339_I0.5460.40
292_A298_I0.5450.40
286_G313_P0.5450.40
36_A103_G0.5440.40
356_V411_Y0.5430.40
67_G71_K0.5430.40
372_E390_I0.5400.40
322_T431_L0.5400.40
22_F33_L0.5400.40
103_G297_S0.5400.40
258_A288_A0.5390.39
361_S420_P0.5380.39
131_F297_S0.5370.39
189_F193_L0.5370.39
103_G106_S0.5370.39
90_Y209_V0.5360.39
8_K143_S0.5350.39
140_L322_T0.5350.39
14_G98_A0.5350.39
72_G349_A0.5350.39
197_K415_I0.5350.39
408_L421_G0.5340.39
169_I375_I0.5330.39
367_F425_A0.5330.39
212_V234_G0.5320.39
52_G289_I0.5310.39
221_T430_V0.5310.39
15_F161_I0.5310.39
171_T221_T0.5310.39
109_I282_N0.5300.38
262_V267_K0.5290.38
61_I64_A0.5280.38
401_D430_V0.5280.38
13_I17_L0.5280.38
156_I288_A0.5280.38
23_G30_P0.5270.38
326_L429_Y0.5250.38
174_G236_I0.5250.38
336_L340_I0.5240.38
418_V422_I0.5220.38
203_A244_I0.5220.38
36_A40_N0.5220.38
400_L407_N0.5210.38
130_I383_L0.5210.38
177_G326_L0.5210.38
157_K244_I0.5200.37
331_I425_A0.5190.37
79_P84_I0.5180.37
49_L246_V0.5180.37
407_N434_F0.5180.37
47_G56_P0.5170.37
54_G350_I0.5150.37
323_I359_V0.5120.37
102_T343_S0.5120.37
251_L413_L0.5120.37
251_L284_V0.5110.37
104_T161_I0.5110.37
258_A275_Y0.5110.37
402_V433_L0.5100.36
322_T378_L0.5090.36
423_V427_I0.5080.36
215_V289_I0.5080.36
397_L426_V0.5080.36
52_G65_L0.5080.36
363_I366_I0.5070.36
210_V277_F0.5060.36
50_L84_I0.5050.36
85_F90_Y0.5050.36
329_L334_F0.5050.36
85_F205_I0.5040.36
227_A385_S0.5040.36
237_A292_A0.5030.36
106_S289_I0.5030.36
19_A303_S0.5010.36
274_H279_S0.5010.36
134_V330_I0.5010.36
221_T423_V0.5010.36
84_I274_H0.5000.35
427_I431_L0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3giaA 1 0.9281 100 0.807 Contact Map
3l1lA 2 0.8742 99.3 0.905 Contact Map
3dh4A 3 0.8787 98.7 0.927 Contact Map
4djkA 2 0.8719 98.5 0.931 Contact Map
2xq2A 2 0.8921 98.4 0.932 Contact Map
2a65A 2 0.9438 97.7 0.944 Contact Map
2jlnA 1 0.8966 97.3 0.948 Contact Map
4us3A 1 0.8854 96.5 0.953 Contact Map
4wgvA 2 0.7865 96.1 0.955 Contact Map
4xp4A 1 0.9416 96.1 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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