GREMLIN Database
ACCC2 - Biotin carboxylase 2
UniProt: O34544 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 444 (395)
Sequences: 18452 (10912)
Seq/√Len: 549.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_S174_E3.9901.00
68_K72_K3.3051.00
145_C178_K3.2801.00
173_N176_A3.2791.00
257_Q261_K3.2231.00
140_D143_A3.1761.00
4_K27_K3.0421.00
62_N65_R2.9311.00
93_E111_A2.9071.00
132_P201_K2.7321.00
279_D283_N2.6861.00
394_T397_E2.6701.00
253_M257_Q2.6091.00
153_Y174_E2.6061.00
93_E97_Q2.5701.00
314_R319_H2.4511.00
172_E176_A2.3991.00
87_E114_G2.3881.00
71_K98_E2.3331.00
125_A265_A2.3041.00
392_G397_E2.2761.00
254_K283_N2.2551.00
227_R231_V2.2411.00
249_D253_M2.2211.00
242_A303_I2.1821.00
260_V264_K2.1751.00
34_E50_L2.1691.00
123_M262_A2.1621.00
254_K258_T2.1381.00
20_T23_R2.1081.00
136_E150_Q2.1011.00
94_R98_E2.0421.00
7_I18_I2.0161.00
147_T150_Q2.0071.00
118_E121_K2.0031.00
121_K125_A2.0021.00
217_Q269_T1.9921.00
353_T377_V1.9821.00
172_E204_E1.9801.00
248_D251_L1.9691.00
204_E280_Q1.9411.00
393_Q397_E1.9201.00
258_T284_F1.9171.00
170_R202_V1.9011.00
67_I98_E1.8931.00
310_E314_R1.8711.00
63_I94_R1.8531.00
174_E178_K1.8501.00
311_Q322_T1.8341.00
337_V402_L1.8191.00
147_T151_I1.8101.00
23_R310_E1.7961.00
5_V103_I1.7841.00
189_A195_G1.7711.00
141_I182_E1.7501.00
106_S109_I1.7161.00
178_K182_E1.7151.00
141_I178_K1.7081.00
21_C28_T1.7021.00
261_K264_K1.6961.00
185_K195_G1.6881.00
67_I71_K1.6551.00
258_T261_K1.6541.00
78_I100_I1.6541.00
254_K257_Q1.6491.00
145_C174_E1.6491.00
368_E371_V1.6471.00
121_K124_E1.6411.00
65_R68_K1.6391.00
251_L254_K1.6241.00
214_L311_Q1.6141.00
49_Y69_T1.6011.00
146_R150_Q1.5931.00
349_P352_G1.5831.00
141_I145_C1.5801.00
22_S46_T1.5751.00
20_T310_E1.5751.00
15_M44_A1.5621.00
179_K183_G1.5611.00
111_A118_E1.5561.00
47_E73_A1.5271.00
69_T73_A1.5211.00
96_K107_P1.5171.00
122_A126_A1.5011.00
94_R97_Q1.4841.00
139_G143_A1.4731.00
95_C100_I1.4701.00
112_K122_A1.4561.00
146_R149_S1.4551.00
64_E94_R1.4531.00
253_M256_G1.4531.00
214_L271_A1.4351.00
96_K106_S1.4191.00
251_L278_V1.4181.00
117_I121_K1.4161.00
215_A221_T1.4151.00
211_V255_I1.4041.00
145_C149_S1.4041.00
141_I181_Y1.4001.00
117_I137_S1.3961.00
302_E391_K1.3821.00
5_V21_C1.3781.00
203_I287_L1.3751.00
160_S196_S1.3701.00
396_T400_E1.3661.00
302_E389_I1.3651.00
155_V199_I1.3601.00
49_Y73_A1.3431.00
101_V317_A1.3341.00
27_K47_E1.3291.00
404_T408_D1.3261.00
122_A265_A1.3251.00
112_K118_E1.3231.00
214_L315_I1.3221.00
63_I67_I1.3161.00
68_K71_K1.3141.00
70_A100_I1.3121.00
142_E146_R1.3101.00
93_E108_D1.3051.00
19_R23_R1.2941.00
122_A125_A1.2931.00
124_E132_P1.2901.00
148_A153_Y1.2901.00
143_A146_R1.2891.00
305_G329_Q1.2891.00
137_S196_S1.2841.00
201_K285_Y1.2731.00
119_A123_M1.2581.00
249_D252_R1.2581.00
108_D112_K1.2441.00
113_M289_M1.2401.00
95_C102_F1.2381.00
106_S269_T1.2341.00
252_R256_G1.2251.00
148_A155_V1.2211.00
52_G61_L1.2191.00
209_I278_V1.2161.00
353_T376_T1.2151.00
142_E145_C1.2151.00
397_E401_K1.2141.00
43_K372_A1.2141.00
34_E37_K1.2141.00
153_Y173_N1.2101.00
293_L308_L1.2081.00
115_S160_S1.2041.00
372_A375_S1.2021.00
354_I371_V1.2011.00
340_Y383_P1.1941.00
392_G401_K1.1931.00
78_I95_C1.1901.00
4_K29_V1.1891.00
132_P151_I1.1891.00
213_L263_A1.1871.00
403_E407_R1.1851.00
32_Y37_K1.1791.00
179_K182_E1.1791.00
126_A265_A1.1641.00
121_K133_G1.1591.00
120_R200_E1.1581.00
123_M286_F1.1511.00
345_K348_F1.1471.00
141_I185_K1.1451.00
124_E130_V1.1441.00
175_E179_K1.1421.00
120_R130_V1.1401.00
4_K47_E1.1381.00
256_G260_V1.1351.00
156_M170_R1.1331.00
70_A78_I1.1221.00
263_A266_I1.1181.00
390_V402_L1.1141.00
248_D282_Q1.1091.00
205_H280_Q1.1071.00
364_G367_H1.1031.00
136_E147_T1.1031.00
250_E254_K1.1021.00
138_L147_T1.0961.00
399_I403_E1.0931.00
169_Q184_N1.0911.00
263_A267_G1.0891.00
335_I398_A1.0861.00
247_V251_L1.0841.00
149_S178_K1.0821.00
306_L311_Q1.0821.00
213_L274_I1.0741.00
388_M409_Y1.0731.00
5_V26_I1.0731.00
388_M405_A1.0701.00
24_L314_R1.0671.00
129_P258_T1.0671.00
96_K269_T1.0651.00
404_T407_R1.0651.00
400_E404_T1.0621.00
17_I79_H1.0571.00
139_G196_S1.0561.00
280_Q283_N1.0391.00
108_D111_A1.0381.00
218_H320_T1.0371.00
117_I160_S1.0351.00
29_V33_S1.0291.00
401_K404_T1.0291.00
30_A41_H1.0251.00
220_H223_H1.0241.00
45_A48_A1.0231.00
67_I94_R1.0211.00
262_A267_G1.0201.00
6_L31_V1.0101.00
92_A102_F1.0091.00
392_G398_A1.0001.00
157_L197_M0.9981.00
305_G331_N0.9981.00
4_K76_D0.9971.00
176_A179_K0.9951.00
144_A177_L0.9931.00
101_V217_Q0.9921.00
6_L70_A0.9921.00
218_H267_G0.9901.00
250_E253_M0.9891.00
335_I399_I0.9841.00
211_V256_G0.9811.00
18_I44_A0.9771.00
138_L144_A0.9771.00
124_E133_G0.9771.00
26_I317_A0.9761.00
373_K376_T0.9761.00
336_E387_K0.9741.00
373_K377_V0.9741.00
182_E186_K0.9731.00
359_L409_Y0.9691.00
18_I45_A0.9661.00
21_C313_L0.9641.00
91_F95_C0.9621.00
169_Q180_A0.9601.00
204_E279_D0.9591.00
374_D377_V0.9571.00
151_I155_V0.9571.00
30_A34_E0.9561.00
259_A276_F0.9531.00
222_V323_F0.9531.00
66_I95_C0.9511.00
69_T75_A0.9481.00
93_E107_P0.9471.00
64_E68_K0.9451.00
227_R230_S0.9441.00
274_I289_M0.9411.00
332_G391_K0.9381.00
156_M202_V0.9371.00
301_E389_I0.9361.00
124_E136_E0.9311.00
255_I258_T0.9311.00
143_A147_T0.9291.00
24_L307_D0.9221.00
223_H256_G0.9201.00
32_Y35_A0.9181.00
5_V313_L0.9151.00
324_S327_D0.9141.00
262_A266_I0.9111.00
96_K108_D0.9111.00
24_L310_E0.9101.00
29_V34_E0.9101.00
332_G393_Q0.9091.00
311_Q314_R0.9031.00
46_T49_Y0.9011.00
313_L317_A0.9001.00
63_I91_F0.9001.00
405_A408_D0.9001.00
153_Y177_L0.8941.00
175_E178_K0.8931.00
32_Y48_A0.8851.00
31_V51_I0.8821.00
215_A263_A0.8811.00
264_K267_G0.8791.00
262_A265_A0.8771.00
169_Q183_G0.8731.00
246_F278_V0.8701.00
21_C79_H0.8671.00
48_A51_I0.8621.00
305_G330_R0.8621.00
356_A360_P0.8601.00
161_A194_D0.8571.00
7_I21_C0.8561.00
30_A45_A0.8521.00
314_R317_A0.8521.00
254_K284_F0.8511.00
278_V284_F0.8501.00
138_L143_A0.8481.00
337_V344_P0.8461.00
338_R341_A0.8461.00
390_V405_A0.8421.00
128_V286_F0.8401.00
367_H386_A0.8391.00
117_I196_S0.8311.00
79_H312_Q0.8291.00
144_A181_Y0.8271.00
113_M266_I0.8231.00
84_L89_S0.8211.00
148_A181_Y0.8181.00
8_A91_F0.8131.00
30_A35_A0.8091.00
90_R94_R0.8071.00
203_I285_Y0.8051.00
148_A177_L0.8011.00
18_I28_T0.7981.00
37_K40_P0.7961.00
340_Y344_P0.7941.00
157_L180_A0.7931.00
115_S196_S0.7911.00
109_I269_T0.7911.00
21_C26_I0.7891.00
365_V390_V0.7871.00
257_Q260_V0.7831.00
145_C182_E0.7811.00
26_I29_V0.7811.00
156_M168_M0.7801.00
157_L171_V0.7801.00
216_D220_H0.7801.00
92_A95_C0.7801.00
83_G86_S0.7801.00
47_E50_L0.7791.00
27_K46_T0.7761.00
157_L181_Y0.7751.00
129_P283_N0.7751.00
95_C98_E0.7741.00
241_E395_R0.7741.00
327_D330_R0.7721.00
220_H264_K0.7711.00
28_T32_Y0.7701.00
144_A199_I0.7681.00
148_A152_G0.7671.00
155_V171_V0.7591.00
263_A272_G0.7591.00
337_V342_E0.7561.00
226_E252_R0.7561.00
103_I313_L0.7501.00
397_E400_E0.7461.00
256_G261_K0.7451.00
255_I284_F0.7441.00
355_T410_R0.7421.00
247_V252_R0.7411.00
209_I244_S0.7401.00
4_K73_A0.7401.00
181_Y185_K0.7391.00
352_G412_E0.7381.00
239_I337_V0.7381.00
211_V259_A0.7381.00
356_A410_R0.7361.00
132_P150_Q0.7361.00
121_K137_S0.7361.00
207_R246_F0.7351.00
39_A42_T0.7351.00
240_E299_V0.7321.00
355_T412_E0.7321.00
90_R111_A0.7321.00
242_A299_V0.7321.00
22_S28_T0.7301.00
29_V32_Y0.7281.00
171_V180_A0.7271.00
115_S161_A0.7261.00
30_A33_S0.7251.00
356_A373_K0.7251.00
33_S37_K0.7241.00
93_E96_K0.7231.00
298_P301_E0.7221.00
213_L272_G0.7211.00
106_S267_G0.7211.00
356_A412_E0.7201.00
212_Q271_A0.7191.00
215_A264_K0.7181.00
4_K74_K0.7181.00
48_A52_G0.7171.00
51_I69_T0.7171.00
203_I279_D0.7161.00
261_K265_A0.7121.00
359_L362_Q0.7091.00
277_I287_L0.7091.00
312_Q316_A0.7081.00
70_A95_C0.7071.00
101_V269_T0.7061.00
220_H224_L0.7061.00
207_R278_V0.7061.00
237_K240_E0.7041.00
357_F409_Y0.7031.00
188_A195_G0.7021.00
6_L75_A0.6991.00
282_Q285_Y0.6991.00
120_R131_V0.6971.00
92_A96_K0.6931.00
215_A269_T0.6911.00
183_G186_K0.6901.00
396_T399_I0.6901.00
331_N391_K0.6891.00
390_V398_A0.6891.00
370_A375_S0.6821.00
15_M41_H0.6791.00
90_R93_E0.6781.00
321_L324_S0.6781.00
337_V340_Y0.6771.00
201_K283_N0.6761.00
371_V375_S0.6741.00
141_I177_L0.6731.00
357_F361_D0.6731.00
151_I201_K0.6731.00
279_D282_Q0.6721.00
117_I198_Y0.6721.00
192_F195_G0.6701.00
20_T24_L0.6641.00
335_I344_P0.6631.00
219_G223_H0.6621.00
28_T33_S0.6591.00
354_I357_F0.6571.00
213_L259_A0.6561.00
67_I97_Q0.6561.00
259_A274_I0.6551.00
38_D42_T0.6531.00
259_A263_A0.6521.00
24_L313_L0.6511.00
226_E229_C0.6501.00
372_A379_P0.6471.00
358_S410_R0.6471.00
181_Y197_M0.6461.00
341_A344_P0.6441.00
67_I100_I0.6441.00
359_L408_D0.6431.00
115_S118_E0.6431.00
347_F350_S0.6421.00
298_P336_E0.6421.00
268_Y272_G0.6411.00
323_F328_I0.6411.00
336_E344_P0.6401.00
46_T50_L0.6401.00
109_I267_G0.6391.00
206_A280_Q0.6361.00
339_I344_P0.6351.00
84_L87_E0.6331.00
171_V176_A0.6321.00
225_F228_D0.6301.00
258_T276_F0.6301.00
336_E341_A0.6241.00
25_G310_E0.6211.00
148_A199_I0.6201.00
33_S36_D0.6201.00
339_I342_E0.6191.00
305_G328_I0.6181.00
160_S198_Y0.6171.00
363_K401_K0.6171.00
255_I259_A0.6171.00
40_P48_A0.6141.00
333_H395_R0.6131.00
171_V177_L0.6131.00
96_K102_F0.6121.00
336_E340_Y0.6121.00
380_F411_V0.6121.00
215_A219_G0.6091.00
319_H323_F0.6081.00
363_K366_R0.6071.00
279_D285_Y0.6071.00
5_V309_V0.6061.00
365_V405_A0.6051.00
357_F378_T0.6051.00
31_V66_I0.6021.00
221_T260_V0.6021.00
218_H318_G0.6001.00
20_T307_D0.5981.00
34_E38_D0.5971.00
348_F351_P0.5961.00
311_Q323_F0.5951.00
148_A151_I0.5941.00
386_A409_Y0.5941.00
28_T35_A0.5941.00
329_Q332_G0.5921.00
268_Y291_T0.5911.00
136_E143_A0.5911.00
360_P405_A0.5901.00
303_I334_A0.5901.00
28_T47_E0.5881.00
225_F229_C0.5871.00
364_G368_E0.5851.00
288_E292_R0.5851.00
350_S354_I0.5841.00
32_Y36_D0.5831.00
47_E51_I0.5831.00
262_A289_M0.5820.99
157_L177_L0.5810.99
131_V203_I0.5790.99
31_V34_E0.5790.99
144_A147_T0.5780.99
185_K189_A0.5770.99
299_V302_E0.5770.99
227_R233_R0.5760.99
40_P44_A0.5760.99
360_P364_G0.5750.99
214_L224_L0.5750.99
28_T34_E0.5740.99
303_I330_R0.5730.99
68_K98_E0.5730.99
225_F303_I0.5720.99
356_A359_L0.5700.99
141_I144_A0.5690.99
225_F330_R0.5680.99
354_I359_L0.5660.99
152_G174_E0.5660.99
45_A49_Y0.5650.99
367_H409_Y0.5650.99
4_K28_T0.5650.99
149_S153_Y0.5620.99
49_Y52_G0.5600.99
172_E202_V0.5600.99
402_L406_L0.5590.99
46_T51_I0.5580.99
228_D231_V0.5580.99
346_T351_P0.5570.99
313_L316_A0.5560.99
395_R399_I0.5550.99
118_E122_A0.5540.99
244_S247_V0.5530.99
51_I65_R0.5520.99
89_S111_A0.5520.99
129_P285_Y0.5510.99
147_T199_I0.5510.99
357_F360_P0.5500.99
323_F327_D0.5500.99
155_V201_K0.5500.99
358_S373_K0.5500.99
358_S361_D0.5480.99
229_C232_Q0.5480.99
363_K367_H0.5470.99
366_R369_C0.5460.99
123_M289_M0.5460.99
209_I255_I0.5460.99
8_A66_I0.5440.99
29_V35_A0.5410.99
186_K190_D0.5410.99
361_D364_G0.5410.99
157_L199_I0.5400.99
170_R235_H0.5390.99
112_K291_T0.5380.99
308_L312_Q0.5360.99
209_I276_F0.5360.99
248_D278_V0.5360.99
258_T262_A0.5360.99
209_I247_V0.5350.99
31_V35_A0.5350.99
333_H344_P0.5350.99
251_L284_F0.5340.99
107_P111_A0.5320.99
122_A266_I0.5320.99
30_A36_D0.5320.99
66_I78_I0.5300.99
123_M128_V0.5290.99
29_V47_E0.5280.99
314_R322_T0.5280.99
78_I102_F0.5260.99
19_R367_H0.5260.99
386_A389_I0.5260.99
255_I261_K0.5260.99
216_D321_L0.5260.99
71_K100_I0.5250.99
69_T72_K0.5250.99
207_R244_S0.5240.99
331_N393_Q0.5240.99
369_C372_A0.5240.99
238_V340_Y0.5230.99
15_M40_P0.5210.99
76_D101_V0.5200.99
110_I291_T0.5200.99
65_R69_T0.5190.99
168_M235_H0.5190.99
131_V287_L0.5190.99
28_T31_V0.5180.99
91_F94_R0.5180.99
148_A174_E0.5180.99
400_E403_E0.5160.99
180_A183_G0.5160.99
269_T315_I0.5140.99
232_Q237_K0.5130.99
254_K261_K0.5120.99
212_Q273_T0.5110.99
64_E67_I0.5100.99
259_A262_A0.5100.99
116_K158_K0.5100.99
315_I321_L0.5100.99
142_E178_K0.5090.99
176_A180_A0.5080.99
407_R410_R0.5070.99
52_G60_Y0.5070.99
363_K370_A0.5050.99
373_K379_P0.5050.99
337_V341_A0.5040.99
12_E387_K0.5030.99
336_E342_E0.5030.99
96_K101_V0.5010.99
398_A402_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n6rA 1 0.8378 100 0.301 Contact Map
3u9tA 3 0.964 100 0.308 Contact Map
4rcnA 6 0.9077 100 0.311 Contact Map
3va7A 1 0.8333 100 0.312 Contact Map
2qf7A 4 0.8874 100 0.314 Contact Map
4qshA 4 0.8536 100 0.317 Contact Map
4mv4A 2 0.9797 100 0.326 Contact Map
3hblA 4 0.9932 100 0.329 Contact Map
1ulzA 2 0.9887 100 0.331 Contact Map
3ouzA 2 0.9865 100 0.332 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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