GREMLIN Database
MHQE - Putative ring-cleaving dioxygenase MhqE
UniProt: O34543 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (300)
Sequences: 1303 (865)
Seq/√Len: 49.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_S146_E4.3351.00
59_M82_F4.0521.00
84_V89_L4.0281.00
278_E281_T3.7731.00
93_K105_E3.6891.00
17_Q21_R3.6191.00
50_N54_D3.5331.00
219_R266_D3.5311.00
165_I186_L3.4601.00
21_R25_E3.3071.00
250_S264_A3.2571.00
154_V216_V3.0971.00
223_K249_T2.9241.00
9_V154_V2.8591.00
176_K179_E2.8181.00
275_T278_E2.7301.00
271_M276_F2.6571.00
91_F142_I2.5241.00
220_T263_I2.5041.00
87_G128_E2.4931.00
96_L103_L2.4571.00
91_F95_R2.4451.00
4_E221_K2.2731.00
70_G212_T2.2531.00
185_R197_D2.2381.00
12_F67_S2.2281.00
94_E98_K2.2241.00
49_G58_I2.1921.00
47_Y58_I2.1911.00
176_K186_L2.1821.00
175_T187_A2.1131.00
18_E120_E2.0731.00
107_T112_K2.0561.00
177_V187_A1.9851.00
26_V99_S1.9430.99
292_H295_Q1.9120.99
226_A242_I1.8990.99
161_P200_L1.8760.99
86_S130_A1.8100.99
29_L82_F1.8040.99
290_E293_R1.7920.99
108_L125_A1.7860.99
67_S210_Y1.7860.99
254_R260_L1.7820.99
166_Q170_E1.7620.99
174_Y188_S1.7420.99
285_L293_R1.7150.99
38_F47_Y1.6830.98
143_T146_E1.6770.98
102_S117_D1.6660.98
82_F151_M1.6430.98
176_K184_V1.6180.98
165_I198_V1.6090.98
72_V117_D1.6020.98
23_Y124_L1.5890.98
223_K226_A1.5860.98
78_G157_Y1.5680.97
40_D43_T1.5480.97
19_N48_F1.5360.97
47_Y247_Y1.5350.97
84_V126_I1.5160.97
74_K159_Y1.5110.97
15_D65_Q1.5070.97
104_E115_I1.4890.96
222_K225_Q1.4890.96
86_S128_E1.4880.96
12_F40_D1.4760.96
183_I199_H1.4750.96
224_E227_K1.4600.96
35_T247_Y1.4500.96
229_L233_A1.4430.96
14_R210_Y1.4370.96
289_L292_H1.4330.96
11_A122_L1.4190.95
30_R137_W1.3740.94
51_Q276_F1.3730.94
221_K225_Q1.3640.94
36_V289_L1.3480.94
165_I176_K1.3380.94
26_V119_T1.3370.93
179_E184_V1.3370.93
20_L31_L1.3330.93
13_A16_P1.3300.93
111_E197_D1.3300.93
9_V80_V1.3180.93
43_T64_F1.3120.93
174_Y218_F1.3090.93
253_F263_I1.3040.93
90_S94_E1.2960.92
246_E287_E1.2950.92
167_L172_F1.2950.92
35_T38_F1.2910.92
180_E197_D1.2810.92
247_Y284_K1.2750.92
19_N61_F1.2730.92
104_E117_D1.2700.92
156_L164_T1.2560.91
239_S251_V1.2500.91
31_L46_F1.2480.91
93_K97_E1.2420.91
77_A259_I1.2390.91
97_E103_L1.2350.90
231_I235_N1.2280.90
111_E185_R1.2210.90
52_N276_F1.2120.90
273_D279_L1.2070.89
83_S129_D1.2050.89
32_V49_G1.1970.89
111_E195_V1.1930.89
93_K114_L1.1890.89
220_T225_Q1.1760.88
161_P184_V1.1670.88
230_P234_E1.1650.88
14_R120_E1.1640.88
81_Y127_M1.1610.87
15_D18_E1.1580.87
180_E185_R1.1500.87
33_K274_E1.1450.87
82_F148_I1.1390.86
91_F143_T1.1350.86
38_F246_E1.1280.86
13_A63_P1.1260.86
292_H296_I1.1220.86
83_S152_K1.1060.85
229_L243_L1.1060.85
96_L126_I1.0940.84
295_Q299_I1.0890.84
50_N53_G1.0870.84
156_L259_I1.0870.84
23_Y61_F1.0790.83
77_A213_V1.0770.83
12_F64_F1.0720.83
247_Y270_F1.0700.83
107_T110_G1.0690.83
10_T64_F1.0510.82
208_G212_T1.0450.81
196_I218_F1.0420.81
11_A59_M1.0410.81
230_P233_A1.0350.81
90_S93_K1.0330.80
228_W263_I1.0310.80
115_I125_A1.0300.80
168_L261_F1.0280.80
16_P46_F1.0270.80
38_F284_K1.0250.80
27_L148_I1.0210.80
81_Y155_L1.0180.79
40_D64_F1.0140.79
16_P43_T1.0090.79
80_V213_V1.0060.79
10_T43_T1.0040.79
9_V151_M0.9820.77
81_Y152_K0.9800.77
38_F58_I0.9790.77
128_E193_G0.9740.76
291_K296_I0.9660.76
271_M279_L0.9650.76
76_Q206_G0.9620.76
229_L242_I0.9590.75
285_L290_E0.9560.75
96_L99_S0.9550.75
79_R125_A0.9550.75
33_K247_Y0.9530.75
94_E97_E0.9490.75
36_V285_L0.9440.74
140_D147_A0.9390.74
18_E21_R0.9350.73
293_R297_T0.9340.73
53_G57_T0.9300.73
34_K44_Y0.9240.73
113_G125_A0.9190.72
164_T255_E0.9090.71
6_L77_A0.8950.70
290_E296_I0.8950.70
71_T207_V0.8940.70
50_N55_P0.8770.69
50_N276_F0.8760.68
269_G280_G0.8760.68
43_T63_P0.8750.68
12_F208_G0.8750.68
243_L251_V0.8740.68
38_F243_L0.8650.67
139_P142_I0.8630.67
37_N62_F0.8580.67
226_A229_L0.8560.67
227_K230_P0.8530.66
246_E284_K0.8530.66
91_F146_E0.8490.66
185_R195_V0.8470.66
112_K128_E0.8450.66
47_Y284_K0.8450.66
35_T58_I0.8430.65
12_F43_T0.8410.65
194_G228_W0.8380.65
39_D44_Y0.8340.65
83_S134_K0.8290.64
241_E246_E0.8270.64
217_A264_A0.8270.64
14_R57_T0.8190.63
79_R117_D0.8190.63
162_Q166_Q0.8190.63
91_F139_P0.8170.63
91_F140_D0.8160.63
91_F141_G0.8130.63
117_D123_P0.8080.62
13_A46_F0.8030.62
274_E279_L0.8020.62
16_P34_K0.8010.61
229_L240_S0.7950.61
46_F127_M0.7930.61
217_A250_S0.7880.60
244_D288_W0.7870.60
117_D121_D0.7850.60
165_I169_T0.7840.60
159_Y203_E0.7830.60
63_P301_P0.7820.60
109_F180_E0.7780.59
288_W291_K0.7760.59
19_N255_E0.7710.58
52_N271_M0.7700.58
295_Q298_D0.7700.58
33_K273_D0.7650.58
21_R183_I0.7640.58
15_D301_P0.7620.58
138_T144_T0.7600.57
95_R99_S0.7560.57
229_L239_S0.7560.57
30_R281_T0.7520.57
39_D213_V0.7520.57
248_F252_Y0.7470.56
39_D62_F0.7440.56
105_E114_L0.7410.55
222_K267_E0.7410.55
68_G71_T0.7390.55
120_E210_Y0.7380.55
44_Y214_H0.7350.55
108_L197_D0.7350.55
70_G206_G0.7340.55
288_W296_I0.7300.54
294_Q298_D0.7300.54
72_V76_Q0.7290.54
23_Y59_M0.7260.54
5_G28_G0.7260.54
3_T188_S0.7260.54
36_V293_R0.7240.54
242_I249_T0.7220.54
180_E183_I0.7200.53
36_V288_W0.7130.53
20_L220_T0.7090.52
171_S231_I0.7070.52
96_L101_L0.7040.52
92_W217_A0.7000.51
179_E182_Q0.6990.51
32_V279_L0.6950.51
4_E220_T0.6950.51
246_E288_W0.6940.51
98_K103_L0.6890.50
172_F231_I0.6840.50
104_E114_L0.6830.50
80_V122_L0.6800.49
109_F178_A0.6730.49
38_F241_E0.6720.48
72_V212_T0.6720.48
35_T284_K0.6720.48
155_L199_H0.6710.48
255_E258_G0.6710.48
158_S161_P0.6700.48
25_E99_S0.6690.48
283_L297_T0.6680.48
250_S267_E0.6660.48
32_V280_G0.6630.48
167_L253_F0.6600.47
289_L296_I0.6600.47
273_D280_G0.6590.47
59_M80_V0.6590.47
17_Q26_V0.6580.47
61_F268_P0.6580.47
177_V195_V0.6570.47
166_Q235_N0.6560.47
72_V123_P0.6540.47
105_E112_K0.6530.46
247_Y280_G0.6530.46
75_G159_Y0.6520.46
23_Y118_D0.6480.46
176_K198_V0.6470.46
240_S260_L0.6440.46
88_S95_R0.6410.45
54_D106_K0.6400.45
250_S272_T0.6390.45
69_Q210_Y0.6390.45
253_F261_F0.6380.45
232_I253_F0.6380.45
70_G147_A0.6370.45
64_F210_Y0.6350.45
206_G212_T0.6350.45
256_K259_I0.6350.45
68_G210_Y0.6340.45
50_N56_G0.6320.44
94_E144_T0.6320.44
138_T143_T0.6310.44
38_F247_Y0.6300.44
154_V196_I0.6290.44
172_F226_A0.6280.44
167_L256_K0.6270.44
71_T114_L0.6260.44
76_Q122_L0.6260.44
96_L124_L0.6250.44
37_N293_R0.6240.44
229_L251_V0.6220.43
154_V174_Y0.6220.43
246_E296_I0.6220.43
76_Q212_T0.6210.43
133_G149_T0.6200.43
236_H239_S0.6200.43
55_P219_R0.6190.43
13_A120_E0.6190.43
31_L172_F0.6180.43
144_T149_T0.6150.43
132_S149_T0.6140.43
182_Q201_H0.6080.42
30_R279_L0.6080.42
48_F212_T0.6080.42
6_L151_M0.6070.42
43_T210_Y0.6030.41
171_S198_V0.6020.41
10_T206_G0.6020.41
247_Y274_E0.6000.41
249_T263_I0.5980.41
17_Q25_E0.5980.41
57_T194_G0.5970.41
19_N120_E0.5970.41
45_H60_T0.5940.41
20_L24_T0.5920.40
121_D260_L0.5910.40
82_F259_I0.5900.40
207_V296_I0.5870.40
167_L198_V0.5870.40
158_S191_A0.5860.40
75_G240_S0.5860.40
84_V154_V0.5820.39
164_T257_G0.5820.39
64_F208_G0.5810.39
170_E198_V0.5800.39
17_Q301_P0.5800.39
42_G230_P0.5790.39
99_S142_I0.5780.39
275_T281_T0.5780.39
95_R103_L0.5760.39
123_P219_R0.5740.39
158_S163_A0.5720.38
288_W292_H0.5720.38
6_L116_F0.5710.38
189_S275_T0.5700.38
3_T220_T0.5680.38
51_Q147_A0.5680.38
213_V251_V0.5670.38
84_V93_K0.5670.38
160_D166_Q0.5670.38
293_R296_I0.5660.38
233_A236_H0.5650.38
239_S243_L0.5640.38
246_E272_T0.5630.38
21_R26_V0.5630.38
187_A195_V0.5620.37
84_V114_L0.5620.37
114_L298_D0.5620.37
253_F260_L0.5610.37
269_G273_D0.5600.37
100_G130_A0.5570.37
6_L174_Y0.5550.37
81_Y153_G0.5550.37
63_P257_G0.5540.37
276_F279_L0.5530.37
108_L113_G0.5530.37
58_I270_F0.5520.36
164_T216_V0.5510.36
85_P148_I0.5500.36
6_L216_V0.5500.36
167_L232_I0.5490.36
104_E181_D0.5490.36
218_F261_F0.5490.36
168_L198_V0.5490.36
62_F296_I0.5460.36
70_G125_A0.5450.36
49_G267_E0.5440.36
58_I246_E0.5440.36
88_S103_L0.5440.36
47_Y63_P0.5420.36
220_T250_S0.5420.36
124_L156_L0.5410.35
11_A213_V0.5390.35
36_V43_T0.5390.35
11_A193_G0.5380.35
252_Y262_E0.5380.35
164_T197_D0.5370.35
28_G50_N0.5370.35
162_Q200_L0.5370.35
36_V290_E0.5350.35
61_F118_D0.5330.35
157_Y201_H0.5320.35
183_I197_D0.5320.35
23_Y255_E0.5290.34
102_S145_N0.5290.34
247_Y273_D0.5270.34
99_S103_L0.5240.34
55_P266_D0.5240.34
66_G212_T0.5240.34
161_P198_V0.5240.34
97_E204_K0.5230.34
177_V186_L0.5220.34
98_K224_E0.5210.34
217_A252_Y0.5210.34
3_T228_W0.5210.34
48_F79_R0.5190.33
233_A298_D0.5190.33
43_T120_E0.5180.33
160_D200_L0.5180.33
130_A142_I0.5180.33
136_E149_T0.5180.33
49_G57_T0.5180.33
92_W250_S0.5170.33
34_K297_T0.5170.33
153_G157_Y0.5150.33
16_P65_Q0.5150.33
84_V232_I0.5140.33
214_H240_S0.5130.33
101_L136_E0.5110.33
63_P206_G0.5110.33
100_G188_S0.5100.33
10_T63_P0.5100.33
276_F281_T0.5090.33
191_A194_G0.5090.33
40_D207_V0.5090.33
274_E280_G0.5090.33
118_D255_E0.5090.33
79_R115_I0.5080.32
150_G214_H0.5080.32
68_G207_V0.5080.32
32_V58_I0.5070.32
233_A239_S0.5070.32
9_V122_L0.5070.32
52_N135_S0.5060.32
223_K267_E0.5050.32
82_F113_G0.5040.32
87_G145_N0.5040.32
61_F251_V0.5030.32
13_A50_N0.5010.32
95_R141_G0.5000.32
165_I170_E0.5000.32
83_S241_E0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oajA 2 0.9967 100 0.439 Contact Map
4huzA 2 0.9901 100 0.568 Contact Map
1zswA 1 1 100 0.593 Contact Map
3e0rA 1 0.7525 100 0.736 Contact Map
3vb0A 1 0.8548 100 0.756 Contact Map
4ro6A 1 0.8482 100 0.756 Contact Map
2zyqA 2 0.8779 100 0.758 Contact Map
2ehzA 5 0.8878 100 0.759 Contact Map
3zi1A 1 0.8383 100 0.76 Contact Map
3hpyA 4 0.8548 100 0.763 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0338 seconds.