GREMLIN Database
YFLK - Uncharacterized protein YflK
UniProt: O34542 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 221 (207)
Sequences: 1659 (1184)
Seq/√Len: 82.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_V116_Q4.5841.00
114_V167_L3.1441.00
38_A159_S2.8361.00
102_V108_F2.8261.00
114_V154_E2.8181.00
66_V150_F2.7801.00
43_R155_E2.7081.00
62_K149_Y2.6991.00
109_R165_E2.6671.00
78_F139_K2.6181.00
98_T101_N2.4631.00
110_L164_L2.3991.00
109_R154_E2.3941.00
16_P50_G2.1211.00
207_R211_M2.0461.00
186_D189_N2.0431.00
103_C175_S1.9721.00
41_L46_F1.9651.00
113_A158_V1.9451.00
159_S162_A1.9171.00
128_A137_V1.9151.00
166_L169_R1.8551.00
116_Q153_L1.8021.00
41_L113_A1.8021.00
15_K50_G1.7851.00
66_V94_V1.7721.00
190_L194_E1.7591.00
109_R167_L1.7571.00
116_Q151_R1.7501.00
40_M47_E1.7481.00
41_L158_V1.7261.00
67_Y75_W1.7151.00
100_E177_Q1.6851.00
70_E96_G1.6851.00
107_V153_L1.6831.00
8_V92_L1.6771.00
12_N93_T1.6731.00
64_V115_V1.6701.00
117_V150_F1.6511.00
178_F195_R1.6451.00
110_L115_V1.6161.00
92_L158_V1.6011.00
13_L35_A1.5621.00
29_G50_G1.5581.00
181_R186_D1.5571.00
211_M215_D1.5220.99
118_S151_R1.5170.99
114_V153_L1.5170.99
131_F136_M1.5160.99
61_D151_R1.5110.99
44_E54_L1.5030.99
26_I125_V1.4640.99
70_E94_V1.4540.99
31_M130_K1.4340.99
71_H143_T1.4110.99
112_E162_A1.3970.99
61_D204_E1.3960.99
38_A157_R1.3910.99
53_D56_N1.3900.99
68_P71_H1.3680.99
17_Q31_M1.3590.99
28_T31_M1.3470.99
112_E157_R1.3310.99
64_V158_V1.3280.99
41_L115_V1.3260.99
18_T27_E1.3230.99
106_D169_R1.3100.98
52_A126_K1.3100.98
79_L83_L1.3040.98
76_E82_P1.3030.98
92_L110_L1.2760.98
103_C173_G1.2740.98
109_R114_V1.2720.98
62_K122_Q1.2660.98
65_C140_V1.2630.98
46_F64_V1.2580.98
68_P99_E1.2240.98
40_M157_R1.2190.97
16_P29_G1.2160.97
104_I179_A1.2030.97
103_C169_R1.1920.97
17_Q33_R1.1850.97
43_R60_P1.1830.97
110_L158_V1.1740.97
16_P27_E1.1730.97
30_I89_G1.1570.96
74_F78_F1.1560.96
107_V114_V1.1340.96
103_C106_D1.1120.96
103_C171_E1.1120.96
71_H99_E1.0990.95
119_Q203_S1.0930.95
135_E139_K1.0900.95
133_V139_K1.0900.95
113_A155_E1.0870.95
40_M112_E1.0830.95
182_I196_I1.0760.95
127_L140_V1.0700.95
128_A135_E1.0680.95
40_M155_E1.0650.94
138_L142_Q1.0540.94
7_S95_A1.0530.94
189_N192_A1.0450.94
42_Y47_E1.0440.94
37_S160_P1.0300.93
69_A73_P1.0290.93
9_L95_A1.0280.93
16_P52_A1.0260.93
104_I176_V1.0210.93
108_F150_F1.0130.93
37_S159_S1.0060.93
112_E154_E1.0020.92
116_Q201_A0.9840.92
12_N86_A0.9800.92
115_V150_F0.9790.92
174_I199_E0.9790.92
51_Q54_L0.9630.91
68_P98_T0.9620.91
104_I120_P0.9530.90
94_V164_L0.9510.90
103_C172_K0.9490.90
86_A149_Y0.9470.90
62_K119_Q0.9420.90
102_V150_F0.9390.90
87_A131_F0.9290.89
42_Y155_E0.9270.89
39_V46_F0.9240.89
97_L108_F0.9240.89
193_I210_F0.9190.89
63_A152_V0.9180.89
29_G52_A0.9110.88
72_Y93_T0.9040.88
45_N63_A0.9010.88
11_L39_V0.8980.88
204_E211_M0.8940.87
108_F166_L0.8800.86
122_Q141_Q0.8760.86
174_I178_F0.8740.86
20_E23_G0.8540.85
179_A196_I0.8530.85
16_P51_Q0.8520.85
11_L46_F0.8480.84
111_D162_A0.8450.84
70_E98_T0.8340.83
44_E51_Q0.8310.83
108_F164_L0.8270.83
70_E95_A0.8260.83
8_V110_L0.8230.83
74_F145_Y0.8210.82
125_V129_K0.8190.82
144_G180_N0.8110.82
8_V113_A0.8050.81
41_L64_V0.7990.81
67_Y71_H0.7980.81
102_V148_F0.7940.80
66_V92_L0.7910.80
18_T25_K0.7850.80
204_E208_A0.7840.79
141_Q180_N0.7820.79
9_L85_N0.7790.79
74_F77_E0.7710.78
193_I197_L0.7670.78
191_T194_E0.7620.77
116_Q168_S0.7610.77
103_C174_I0.7570.77
116_Q179_A0.7570.77
62_K118_S0.7500.76
128_A136_M0.7490.76
194_E214_K0.7480.76
86_A130_K0.7430.76
102_V117_V0.7400.75
194_E198_S0.7350.75
188_K193_I0.7290.74
71_H100_E0.7280.74
8_V162_A0.7270.74
146_T180_N0.7260.74
75_W145_Y0.7210.73
14_G29_G0.7190.73
190_L214_K0.7190.73
88_F140_V0.7180.73
65_C180_N0.7130.73
103_C170_G0.7120.73
66_V148_F0.7070.72
177_Q181_R0.7060.72
179_A206_W0.7030.72
66_V115_V0.7020.71
65_C127_L0.7010.71
205_S209_S0.7010.71
19_L28_T0.6990.71
178_F192_A0.6980.71
75_W88_F0.6950.71
208_A211_M0.6910.70
67_Y88_F0.6900.70
13_L37_S0.6880.70
46_F110_L0.6840.70
107_V168_S0.6800.69
186_D214_K0.6780.69
133_V136_M0.6770.69
19_L26_I0.6750.69
80_S83_L0.6740.68
51_Q62_K0.6700.68
44_E60_P0.6660.67
170_G201_A0.6630.67
106_D166_L0.6630.67
173_G178_F0.6600.67
127_L141_Q0.6590.67
51_Q137_V0.6590.67
179_A210_F0.6550.66
199_E210_F0.6550.66
29_G32_K0.6530.66
46_F158_V0.6520.66
28_T74_F0.6520.66
81_R133_V0.6510.66
104_I203_S0.6470.65
65_C131_F0.6470.65
119_Q206_W0.6420.65
61_D150_F0.6400.64
9_L12_N0.6390.64
10_S93_T0.6370.64
50_G54_L0.6370.64
192_A195_R0.6370.64
26_I129_K0.6310.63
122_Q184_Y0.6240.62
53_D125_V0.6230.62
61_D203_S0.6230.62
108_F115_V0.6180.62
51_Q126_K0.6150.61
195_R198_S0.6120.61
94_V150_F0.6110.61
151_R196_I0.6110.61
71_H98_T0.6040.60
120_P203_S0.6020.60
135_E142_Q0.5990.59
137_V141_Q0.5950.59
172_K198_S0.5940.59
196_I210_F0.5940.59
27_E200_A0.5900.58
182_I192_A0.5900.58
7_S163_N0.5890.58
69_A72_Y0.5880.58
99_E106_D0.5880.58
181_R189_N0.5860.58
10_S86_A0.5860.58
138_L141_Q0.5840.57
69_A93_T0.5830.57
56_N62_K0.5820.57
171_E201_A0.5790.57
75_W139_K0.5770.57
86_A92_L0.5770.57
19_L24_K0.5760.56
32_K51_Q0.5760.56
102_V106_D0.5740.56
23_G27_E0.5730.56
65_C148_F0.5710.56
104_I175_S0.5710.56
39_V48_G0.5700.56
71_H75_W0.5690.55
168_S171_E0.5690.55
67_Y72_Y0.5680.55
197_L200_A0.5680.55
30_I65_C0.5650.55
187_A213_K0.5630.55
181_R192_A0.5610.54
127_L136_M0.5590.54
120_P125_V0.5580.54
75_W78_F0.5580.54
120_P179_A0.5570.54
148_F174_I0.5520.53
125_V174_I0.5480.53
28_T94_V0.5480.53
120_P184_Y0.5460.52
35_A39_V0.5460.52
99_E102_V0.5450.52
99_E148_F0.5440.52
128_A131_F0.5430.52
9_L93_T0.5410.52
193_I214_K0.5390.52
88_F210_F0.5390.52
43_R142_Q0.5390.52
83_L146_T0.5380.51
69_A85_N0.5370.51
175_S180_N0.5340.51
97_L101_N0.5330.51
57_H123_P0.5310.50
49_D58_G0.5300.50
66_V117_V0.5290.50
113_A157_R0.5290.50
175_S178_F0.5280.50
126_K131_F0.5280.50
140_V180_N0.5260.50
39_V63_A0.5260.50
67_Y143_T0.5250.50
74_F143_T0.5240.50
122_Q127_L0.5230.49
51_Q119_Q0.5210.49
97_L102_V0.5180.49
54_L92_L0.5170.49
38_A160_P0.5160.49
94_V97_L0.5130.48
9_L69_A0.5120.48
44_E155_E0.5110.48
130_K136_M0.5100.48
37_S161_G0.5090.48
141_Q184_Y0.5080.47
36_K160_P0.5080.47
68_P94_V0.5080.47
11_L37_S0.5060.47
29_G213_K0.5050.47
24_K55_V0.5010.47
81_R142_Q0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o65A 1 0.9186 100 0.308 Contact Map
1oruA 2 0.7149 100 0.568 Contact Map
1y8oB 1 0.4253 65.1 0.952 Contact Map
3crkC 1 0.3756 52.6 0.955 Contact Map
1zy8K 1 0.0724 31.6 0.961 Contact Map
1pmrA 1 0.3529 19.7 0.964 Contact Map
2dncA 1 0.4299 14.7 0.966 Contact Map
2dneA 1 0.4751 14.3 0.967 Contact Map
1z6hA 1 0.3167 14.3 0.967 Contact Map
2mkxA 1 0.2308 13.3 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0081 seconds.