GREMLIN Database
YJIC - Uncharacterized UDP-glucosyltransferase YjiC
UniProt: O34539 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 392 (375)
Sequences: 13101 (10327)
Seq/√Len: 533.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
310_V351_V4.2781.00
360_R363_N4.0191.00
325_V331_G3.7871.00
294_G311_V3.5561.00
247_D345_Q3.4631.00
311_V322_A3.1391.00
8_M24_V3.0251.00
365_Q369_K2.9351.00
5_H33_R2.9181.00
350_A354_D2.8461.00
243_K341_V2.8421.00
43_A47_Q2.8131.00
345_Q349_Q2.7711.00
292_S309_L2.7231.00
211_E215_I2.5851.00
332_V350_A2.5441.00
358_L362_K2.4581.00
30_K382_E2.4531.00
349_Q353_S2.3971.00
185_S367_D2.3791.00
105_Y123_V2.2791.00
290_F298_S2.2431.00
26_K29_E2.1901.00
362_K365_Q2.1201.00
299_T325_V2.0411.00
240_M341_V2.0341.00
302_A309_L2.0321.00
183_P368_V2.0151.00
310_V347_A1.9981.00
142_D145_K1.9591.00
145_K149_E1.9561.00
366_K370_E1.9501.00
326_D333_Y1.9431.00
285_E305_A1.9201.00
5_H35_T1.8751.00
78_L82_K1.8641.00
330_L364_M1.8621.00
306_G361_V1.8021.00
246_R267_D1.7971.00
332_V351_V1.7891.00
116_A123_V1.7691.00
247_D341_V1.7641.00
253_I283_V1.7311.00
275_R278_V1.7241.00
33_R52_E1.7171.00
359_S363_N1.7021.00
239_K243_K1.6941.00
303_M330_L1.6911.00
26_K30_K1.6791.00
217_K251_Q1.6791.00
289_L348_V1.6771.00
124_I177_L1.6551.00
332_V347_A1.6481.00
323_N327_E1.6471.00
245_F252_V1.6441.00
208_K212_S1.6231.00
303_M361_V1.6191.00
325_V330_L1.5991.00
290_F302_A1.5971.00
92_E118_K1.5941.00
351_V357_L1.5821.00
6_I102_L1.5721.00
225_I245_F1.5681.00
90_Q93_E1.5591.00
145_K148_R1.5561.00
15_G19_P1.5431.00
24_V51_G1.5231.00
7_S37_A1.5181.00
157_Y161_E1.5081.00
146_K149_E1.5021.00
224_L280_Q1.4981.00
155_K159_E1.4861.00
363_N367_D1.4811.00
30_K378_A1.4791.00
332_V357_L1.4761.00
152_A155_K1.4621.00
158_L163_L1.4561.00
182_M187_Q1.4561.00
8_M104_I1.4431.00
329_G360_R1.4321.00
235_P239_K1.4291.00
90_Q94_L1.4241.00
324_R327_E1.4141.00
354_D357_L1.4111.00
86_S89_P1.4101.00
40_E55_I1.4051.00
32_H382_E1.4031.00
223_M291_I1.3991.00
43_A53_A1.3991.00
346_E350_A1.3981.00
117_E174_P1.3941.00
105_Y112_G1.3891.00
269_P272_F1.3701.00
244_A344_L1.3671.00
248_S349_Q1.3671.00
89_P93_E1.3671.00
366_K369_K1.3661.00
362_K366_K1.3591.00
219_D287_A1.3491.00
103_I121_V1.3431.00
311_V325_V1.3321.00
79_S82_K1.3241.00
379_A383_A1.3241.00
341_V345_Q1.3211.00
350_A357_L1.3181.00
218_D251_Q1.3171.00
372_G375_E1.3111.00
359_S362_K1.3111.00
335_P338_E1.3101.00
93_E96_K1.3081.00
35_T54_L1.2981.00
158_L161_E1.2951.00
329_G356_E1.2881.00
82_K85_L1.2861.00
244_A345_Q1.2841.00
356_E359_S1.2841.00
363_N366_K1.2821.00
215_I286_K1.2791.00
340_T343_S1.2761.00
28_C51_G1.2761.00
30_K379_A1.2761.00
220_R249_S1.2681.00
240_M243_K1.2611.00
244_A348_V1.2591.00
246_R271_N1.2591.00
20_T36_Y1.2561.00
16_H106_D1.2431.00
92_E96_K1.2411.00
6_I32_H1.2381.00
268_I274_I1.2351.00
224_L255_S1.2331.00
304_N369_K1.2221.00
80_L84_S1.2121.00
91_L95_Y1.2031.00
153_E156_A1.2011.00
334_L347_A1.2001.00
42_F45_A1.1971.00
142_D146_K1.1951.00
96_K119_L1.1891.00
244_A341_V1.1871.00
6_I27_L1.1841.00
8_M20_T1.1791.00
243_K246_R1.1731.00
45_A48_Q1.1691.00
14_Y18_N1.1641.00
87_I90_Q1.1631.00
163_L166_V1.1621.00
81_L85_L1.1581.00
220_R251_Q1.1501.00
222_L289_L1.1481.00
290_F307_V1.1471.00
198_C380_E1.1451.00
376_R379_A1.1431.00
213_L251_Q1.1431.00
79_S83_E1.1421.00
213_L273_T1.1381.00
77_P84_S1.1351.00
343_S347_A1.1311.00
44_P47_Q1.1251.00
376_R380_E1.1241.00
89_P92_E1.1231.00
310_V332_V1.1201.00
323_N326_D1.1201.00
371_A376_R1.1181.00
13_A230_A1.1111.00
242_I254_M1.1091.00
280_Q301_E1.1081.00
306_G365_Q1.1071.00
81_L84_S1.1011.00
374_A378_A1.1011.00
221_P288_D1.0971.00
355_Q359_S1.0961.00
62_I66_Q1.0931.00
309_L325_V1.0921.00
156_A160_Q1.0911.00
103_I116_A1.0911.00
250_W349_Q1.0901.00
264_S268_I1.0891.00
380_E383_A1.0881.00
242_I272_F1.0831.00
375_E379_A1.0801.00
318_Q321_T1.0791.00
26_K374_A1.0771.00
148_R151_E1.0711.00
224_L283_V1.0681.00
7_S100_P1.0651.00
299_T309_L1.0641.00
87_I92_E1.0571.00
144_L149_E1.0561.00
231_F314_Q1.0561.00
154_F157_Y1.0561.00
10_N20_T1.0551.00
330_L361_V1.0421.00
35_T98_D1.0411.00
367_D370_E1.0411.00
154_F158_L1.0401.00
145_K151_E1.0361.00
224_L287_A1.0281.00
142_D149_E1.0231.00
222_L251_Q1.0191.00
309_L331_G1.0181.00
117_E176_A1.0171.00
281_L305_A1.0171.00
113_K123_V1.0161.00
92_E95_Y1.0151.00
356_E360_R1.0121.00
44_P48_Q1.0071.00
102_L124_I1.0051.00
143_M147_I1.0041.00
147_I150_A1.0031.00
40_E43_A1.0011.00
26_K378_A0.9961.00
89_P118_K0.9961.00
23_L203_S0.9951.00
28_C34_V0.9891.00
294_G322_A0.9861.00
280_Q284_L0.9861.00
143_M146_K0.9841.00
303_M364_M0.9821.00
284_L290_F0.9811.00
272_F275_R0.9761.00
299_T321_T0.9701.00
153_E157_Y0.9681.00
88_L92_E0.9681.00
291_I344_L0.9661.00
146_K150_A0.9651.00
86_S90_Q0.9611.00
378_A382_E0.9571.00
177_L198_C0.9571.00
8_M27_L0.9551.00
144_L148_R0.9521.00
78_L84_S0.9521.00
24_V34_V0.9501.00
224_L278_V0.9461.00
42_F46_V0.9451.00
76_A84_S0.9451.00
25_E29_E0.9441.00
146_K151_E0.9401.00
326_D332_V0.9401.00
223_M250_W0.9401.00
84_S88_L0.9391.00
115_F119_L0.9381.00
63_D66_Q0.9361.00
88_L94_L0.9351.00
238_Y256_V0.9351.00
84_S87_I0.9281.00
263_E267_D0.9241.00
79_S84_S0.9211.00
291_I312_I0.9201.00
78_L81_L0.9141.00
124_I384_F0.9121.00
26_K375_E0.9071.00
214_L222_L0.9051.00
343_S346_E0.9001.00
77_P81_L0.8991.00
157_Y160_Q0.8941.00
54_L94_L0.8941.00
171_L174_P0.8861.00
247_D342_S0.8841.00
212_S215_I0.8801.00
162_K165_A0.8781.00
250_W352_S0.8761.00
263_E266_E0.8721.00
364_M367_D0.8701.00
80_L83_E0.8691.00
208_K211_E0.8691.00
324_R328_L0.8681.00
322_A333_Y0.8671.00
43_A46_V0.8621.00
162_K166_V0.8621.00
253_I273_T0.8581.00
210_K213_L0.8541.00
77_P80_L0.8541.00
35_T52_E0.8481.00
9_I112_G0.8461.00
76_A80_L0.8411.00
307_V358_L0.8361.00
21_L25_E0.8311.00
153_E158_L0.8301.00
373_G378_A0.8291.00
330_L360_R0.8281.00
156_A159_E0.8281.00
291_I310_V0.8281.00
279_P282_E0.8261.00
357_L360_R0.8211.00
225_I291_I0.8191.00
76_A83_E0.8171.00
68_R71_M0.8171.00
212_S216_D0.8171.00
137_Q142_D0.8071.00
373_G377_A0.8021.00
241_C245_F0.8021.00
209_E212_S0.8011.00
210_K214_L0.7981.00
153_E161_E0.7971.00
251_Q273_T0.7971.00
282_E285_E0.7961.00
89_P95_Y0.7951.00
250_W353_S0.7931.00
90_Q95_Y0.7931.00
357_L361_V0.7891.00
113_K117_E0.7881.00
75_D79_S0.7871.00
292_S299_T0.7841.00
167_S170_Q0.7831.00
84_S111_A0.7781.00
142_D148_R0.7781.00
225_I252_V0.7761.00
64_P68_R0.7751.00
144_L150_A0.7671.00
76_A79_S0.7651.00
37_A91_L0.7571.00
137_Q148_R0.7571.00
281_L301_E0.7561.00
143_M148_R0.7501.00
339_V344_L0.7491.00
91_L94_L0.7481.00
85_L88_L0.7471.00
69_E72_E0.7461.00
78_L83_E0.7461.00
244_A248_S0.7441.00
53_A56_Y0.7401.00
80_L85_L0.7391.00
361_V365_Q0.7391.00
183_P371_A0.7381.00
38_T53_A0.7381.00
82_K86_S0.7381.00
62_I65_K0.7341.00
264_S267_D0.7331.00
381_I385_M0.7321.00
153_E160_Q0.7321.00
15_G297_N0.7301.00
71_M74_N0.7251.00
142_D147_I0.7241.00
179_I200_V0.7231.00
105_Y113_K0.7211.00
248_S345_Q0.7191.00
117_E158_L0.7161.00
67_I73_K0.7161.00
240_M244_A0.7151.00
83_E87_I0.7151.00
211_E214_L0.7141.00
292_S302_A0.7141.00
89_P94_L0.7141.00
229_T277_S0.7121.00
280_Q290_F0.7121.00
292_S298_S0.7121.00
312_I339_V0.7111.00
227_L312_I0.7091.00
152_A156_A0.7081.00
240_M344_L0.7021.00
218_D221_P0.7001.00
147_I151_E0.6971.00
6_I34_V0.6971.00
207_R282_E0.6961.00
303_M368_V0.6951.00
70_M74_N0.6931.00
54_L60_L0.6921.00
379_A382_E0.6911.00
52_E55_I0.6911.00
292_S311_V0.6901.00
368_V371_A0.6901.00
240_M339_V0.6891.00
55_I58_T0.6881.00
131_A187_Q0.6871.00
280_Q297_N0.6871.00
68_R72_E0.6841.00
293_H298_S0.6831.00
308_P358_L0.6801.00
293_H297_N0.6771.00
223_M348_V0.6741.00
22_A26_K0.6731.00
202_P205_G0.6721.00
342_S346_E0.6721.00
155_K165_A0.6721.00
188_I324_R0.6701.00
12_P16_H0.6691.00
177_L380_E0.6671.00
229_T318_Q0.6661.00
249_S349_Q0.6651.00
226_S298_S0.6651.00
153_E159_E0.6601.00
322_A331_G0.6601.00
56_Y60_L0.6591.00
277_S280_Q0.6591.00
278_V283_V0.6591.00
297_N301_E0.6581.00
79_S85_L0.6581.00
108_V316_Y0.6561.00
246_R270_A0.6551.00
186_F202_P0.6551.00
83_E88_L0.6551.00
75_D84_S0.6541.00
177_L181_F0.6541.00
198_C376_R0.6541.00
248_S252_V0.6541.00
317_E321_T0.6511.00
255_S280_Q0.6511.00
22_A25_E0.6481.00
13_A16_H0.6481.00
374_A379_A0.6481.00
76_A81_L0.6481.00
75_D78_L0.6471.00
112_G116_A0.6471.00
155_K158_L0.6441.00
355_Q358_L0.6441.00
209_E273_T0.6431.00
56_Y59_S0.6431.00
89_P96_K0.6431.00
32_H101_D0.6431.00
200_V203_S0.6401.00
67_I70_M0.6391.00
226_S290_F0.6371.00
137_Q146_K0.6361.00
6_I381_I0.6351.00
265_L268_I0.6331.00
186_F328_L0.6331.00
185_S370_E0.6331.00
87_I91_L0.6321.00
325_V329_G0.6301.00
220_R250_W0.6291.00
92_E119_L0.6281.00
169_E172_A0.6261.00
23_L377_A0.6261.00
78_L85_L0.6241.00
242_I268_I0.6241.00
19_P297_N0.6241.00
87_I94_L0.6231.00
374_A377_A0.6231.00
69_E73_K0.6221.00
170_Q173_V0.6211.00
34_V51_G0.6201.00
187_Q190_H0.6191.00
328_L364_M0.6181.00
102_L385_M0.6171.00
219_D222_L0.6171.00
128_S131_A0.6171.00
310_V334_L0.6171.00
125_K178_N0.6161.00
253_I278_V0.6161.00
382_E385_M0.6161.00
154_F161_E0.6141.00
66_Q69_E0.6141.00
237_F241_C0.6141.00
119_L122_P0.6131.00
270_A273_T0.6131.00
323_N333_Y0.6091.00
144_L147_I0.6081.00
364_M368_V0.6081.00
126_L203_S0.6081.00
178_N181_F0.6061.00
96_K118_K0.6061.00
180_V183_P0.6051.00
319_E322_A0.6051.00
207_R211_E0.6051.00
228_G295_G0.6041.00
69_E74_N0.6031.00
159_E165_A0.6021.00
231_F316_Y0.6001.00
241_C244_A0.6001.00
137_Q143_M0.5991.00
223_M352_S0.5991.00
158_L162_K0.5951.00
224_L228_G0.5880.99
127_C134_E0.5870.99
143_M149_E0.5870.99
20_T126_L0.5870.99
312_I334_L0.5870.99
346_E349_Q0.5870.99
178_N197_F0.5840.99
15_G21_L0.5830.99
313_P322_A0.5790.99
115_F118_K0.5780.99
339_V343_S0.5780.99
15_G18_N0.5770.99
127_C131_A0.5770.99
241_C344_L0.5760.99
35_T100_P0.5750.99
372_G376_R0.5740.99
313_P318_Q0.5730.99
132_Q135_S0.5730.99
224_L290_F0.5690.99
62_I68_R0.5690.99
68_R73_K0.5660.99
214_L289_L0.5660.99
83_E86_S0.5650.99
299_T318_Q0.5640.99
320_L324_R0.5630.99
143_M151_E0.5630.99
296_M300_M0.5600.99
143_M150_A0.5600.99
257_G260_I0.5590.99
226_S280_Q0.5590.99
114_L171_L0.5580.99
338_E343_S0.5580.99
373_G376_R0.5580.99
253_I287_A0.5580.99
85_L160_Q0.5560.99
51_G54_L0.5540.99
46_V49_A0.5540.99
159_E164_P0.5540.99
42_F48_Q0.5530.99
246_R249_S0.5530.99
159_E162_K0.5520.99
283_V290_F0.5520.99
22_A205_G0.5520.99
221_P250_W0.5460.99
335_P343_S0.5460.99
293_H318_Q0.5450.99
86_S92_E0.5440.99
82_K95_Y0.5440.99
88_L95_Y0.5440.99
128_S318_Q0.5440.99
17_V36_Y0.5430.99
152_A161_E0.5420.99
87_I95_Y0.5420.99
223_M289_L0.5400.99
64_P70_M0.5400.99
37_A56_Y0.5370.99
7_S95_Y0.5370.99
243_K345_Q0.5350.99
314_Q318_Q0.5340.99
46_V53_A0.5340.99
249_S270_A0.5340.99
221_P248_S0.5340.99
249_S271_N0.5330.99
38_T43_A0.5330.99
236_E239_K0.5330.99
32_H378_A0.5320.99
152_A157_Y0.5320.99
237_F240_M0.5310.99
104_I179_I0.5310.99
137_Q145_K0.5310.99
57_H60_L0.5290.99
112_G123_V0.5290.99
168_F171_L0.5270.99
156_A161_E0.5270.99
310_V348_V0.5250.99
313_P333_Y0.5240.99
88_L91_L0.5240.99
316_Y319_E0.5240.99
224_L289_L0.5210.99
98_D101_D0.5200.99
243_K247_D0.5190.99
67_I72_E0.5190.99
231_F315_M0.5170.99
40_E57_H0.5160.99
179_I384_F0.5160.99
75_D85_L0.5140.99
224_L253_I0.5130.99
65_K69_E0.5130.99
342_S345_Q0.5110.99
191_E194_D0.5100.99
245_F348_V0.5100.99
296_M321_T0.5090.99
298_S301_E0.5090.99
334_L338_E0.5080.98
142_D151_E0.5050.98
347_A350_A0.5040.98
77_P83_E0.5010.98
284_L302_A0.5010.98
167_S171_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iyaA 1 0.9821 100 0.327 Contact Map
2pq6A 1 0.9464 100 0.347 Contact Map
3rscA 1 0.9847 100 0.351 Contact Map
2iyfA 1 0.9796 100 0.353 Contact Map
3ia7A 2 0.9847 100 0.357 Contact Map
1rrvA 1 0.9541 100 0.359 Contact Map
2p6pA 2 0.9362 100 0.38 Contact Map
2vchA 1 0.9668 100 0.388 Contact Map
3otiA 2 0.9107 100 0.393 Contact Map
2c1xA 1 0.9745 100 0.394 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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