GREMLIN Database
YOAT - Uncharacterized protein YoaT
UniProt: O34535 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (248)
Sequences: 402 (209)
Seq/√Len: 13.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_L98_S4.4971.00
23_V52_M4.2871.00
174_W185_R4.0991.00
27_S48_I4.0741.00
191_S195_I3.7140.99
155_S158_I3.2240.98
57_V67_L3.1550.98
147_L151_T3.1510.98
138_V241_L2.8940.96
17_S124_R2.8430.96
65_D68_K2.7310.95
197_F201_I2.7090.94
55_W59_S2.6720.94
6_Q13_E2.4930.91
6_Q184_Y2.4890.91
163_S230_S2.3280.88
216_N222_S2.2420.86
82_L101_F2.2400.86
64_R68_K2.1760.84
54_L58_R2.1730.84
178_E183_R2.1550.84
67_L96_G2.0710.81
42_Y93_P2.0060.79
60_G64_R1.9910.78
199_I237_I1.9370.76
31_T94_E1.9360.76
40_P97_Y1.9250.76
118_L191_S1.9000.75
132_W138_V1.8340.72
175_V192_F1.8300.72
166_V237_I1.7990.71
7_I11_G1.7480.68
120_Q124_R1.7190.67
175_V240_F1.7050.66
77_G112_A1.6610.64
80_L120_Q1.6420.63
175_V195_I1.6330.63
56_M112_A1.6320.63
136_F158_I1.6100.62
167_I189_A1.6080.62
76_I242_I1.6070.61
39_L47_I1.5810.60
56_M201_I1.5530.59
123_R207_T1.5460.58
63_T155_S1.5300.58
132_W240_F1.5210.57
45_L115_A1.4750.55
14_Q117_Y1.4730.55
215_P221_W1.4620.54
75_L190_L1.4600.54
29_A209_F1.4500.53
121_A195_I1.4460.53
76_I145_I1.4340.53
195_I236_V1.3970.51
196_G229_V1.3900.50
186_M194_L1.3820.50
42_Y94_E1.3670.49
193_I233_L1.3610.49
49_C124_R1.3550.48
60_G140_P1.3540.48
137_A169_V1.3490.48
67_L71_T1.3350.47
53_Q133_P1.3320.47
193_I229_V1.3290.47
122_W244_A1.3250.47
46_L50_V1.3230.47
132_W241_L1.3090.46
97_Y168_I1.3020.46
120_Q236_V1.2990.45
118_L127_V1.2980.45
122_W127_V1.2950.45
138_V192_F1.2700.44
39_L44_W1.2670.44
14_Q26_A1.2660.44
133_P170_F1.2600.43
69_V119_C1.2570.43
114_V240_F1.2510.43
27_S45_L1.2490.43
25_F120_Q1.2410.42
63_T118_L1.2400.42
98_S220_T1.2180.41
83_F150_F1.2040.41
50_V237_I1.2010.40
126_K162_L1.1990.40
24_I113_S1.1890.40
233_L240_F1.1850.40
13_E17_S1.1810.39
177_Y220_T1.1580.38
47_I51_L1.1510.38
118_L177_Y1.1470.38
118_L175_V1.1460.38
166_V173_T1.1390.37
56_M59_S1.1340.37
227_G231_S1.1190.36
196_G236_V1.1160.36
50_V107_S1.1070.36
199_I239_S1.1030.35
117_Y121_A1.0980.35
40_P223_L1.0960.35
40_P50_V1.0910.35
215_P242_I1.0870.35
77_G102_G1.0700.34
192_F211_A1.0660.34
177_Y184_Y1.0620.34
63_T164_G1.0610.33
8_V11_G1.0590.33
175_V191_S1.0550.33
23_V95_E1.0540.33
64_R170_F1.0540.33
137_A168_I1.0520.33
51_L55_W1.0410.33
156_I161_W1.0380.32
87_M250_K1.0360.32
11_G186_M1.0340.32
127_V175_V1.0340.32
145_I238_V1.0260.32
200_W207_T1.0230.32
112_A192_F1.0220.32
54_L147_L1.0220.32
137_A201_I1.0120.31
58_R226_L1.0020.31
11_G194_L0.9980.31
127_V195_I0.9960.30
168_I216_N0.9910.30
179_V209_F0.9870.30
191_S201_I0.9860.30
55_W161_W0.9730.29
21_P113_S0.9680.29
96_G99_K0.9650.29
129_L238_V0.9600.29
130_V174_W0.9560.29
7_I206_A0.9550.29
106_Y211_A0.9530.29
69_V206_A0.9480.28
96_G100_I0.9470.28
44_W94_E0.9460.28
9_H240_F0.9380.28
25_F132_W0.9310.28
24_I49_C0.9280.28
16_L21_P0.9250.27
131_K172_Q0.9200.27
169_V173_T0.9190.27
57_V169_V0.9140.27
4_I145_I0.9120.27
176_T185_R0.9080.27
73_F236_V0.8910.26
122_W247_K0.8900.26
201_I223_L0.8840.26
47_I185_R0.8830.26
44_W48_I0.8830.26
21_P78_L0.8790.26
33_I130_V0.8770.25
78_L119_C0.8750.25
60_G147_L0.8700.25
35_P56_M0.8650.25
17_S125_L0.8600.25
84_K153_H0.8580.25
85_V180_N0.8490.24
55_W72_L0.8480.24
142_A241_L0.8480.24
75_L82_L0.8460.24
26_A154_F0.8460.24
144_A220_T0.8440.24
147_L155_S0.8420.24
87_M113_S0.8420.24
50_V186_M0.8400.24
91_S96_G0.8370.24
151_T154_F0.8350.24
53_Q170_F0.8350.24
16_L129_L0.8330.24
97_Y231_S0.8220.23
153_H200_W0.8210.23
165_L185_R0.8180.23
158_I161_W0.8170.23
154_F172_Q0.8120.23
29_A63_T0.8120.23
61_L73_F0.8120.23
18_C221_W0.8100.23
158_I209_F0.8090.23
133_P172_Q0.8060.23
56_M61_L0.8040.23
158_I240_F0.8010.23
14_Q120_Q0.8000.22
25_F236_V0.7980.22
210_G225_H0.7980.22
50_V173_T0.7960.22
77_G107_S0.7920.22
15_A125_L0.7920.22
56_M199_I0.7910.22
18_C215_P0.7880.22
4_I171_W0.7850.22
79_A196_G0.7840.22
5_K180_N0.7780.22
42_Y175_V0.7750.22
29_A195_I0.7740.22
221_W242_I0.7730.21
25_F98_S0.7730.21
15_A30_I0.7720.21
53_Q57_V0.7720.21
106_Y206_A0.7710.21
119_C124_R0.7690.21
140_P144_A0.7650.21
29_A82_L0.7650.21
82_L102_G0.7620.21
93_P122_W0.7620.21
97_Y101_F0.7620.21
130_V231_S0.7590.21
106_Y115_A0.7550.21
46_L86_H0.7550.21
140_P155_S0.7540.21
77_G238_V0.7540.21
32_Q37_P0.7520.21
113_S250_K0.7510.21
14_Q186_M0.7490.21
127_V240_F0.7490.21
45_L220_T0.7480.21
179_V184_Y0.7460.21
45_L83_F0.7410.20
11_G179_V0.7410.20
40_P51_L0.7390.20
200_W223_L0.7380.20
26_A181_G0.7340.20
78_L229_V0.7320.20
17_S177_Y0.7320.20
22_A115_A0.7310.20
51_L75_L0.7270.20
210_G227_G0.7270.20
85_V99_K0.7240.20
126_K183_R0.7230.20
82_L141_L0.7170.20
49_C106_Y0.7160.20
123_R200_W0.7160.20
39_L51_L0.7160.20
49_C119_C0.7130.19
82_L223_L0.7090.19
96_G176_T0.7070.19
24_I27_S0.7070.19
23_V178_E0.7010.19
145_I162_L0.7000.19
172_Q246_L0.6970.19
75_L79_A0.6940.19
91_S167_I0.6930.19
24_I120_Q0.6930.19
169_V185_R0.6920.19
98_S120_Q0.6890.19
164_G169_V0.6860.19
121_A236_V0.6820.18
34_I60_G0.6820.18
48_I197_F0.6810.18
113_S202_A0.6790.18
34_I37_P0.6790.18
163_S233_L0.6780.18
26_A47_I0.6780.18
69_V170_F0.6750.18
63_T123_R0.6750.18
63_T100_I0.6730.18
58_R155_S0.6720.18
144_A169_V0.6710.18
13_E49_C0.6700.18
144_A193_I0.6680.18
101_F145_I0.6680.18
75_L177_Y0.6670.18
40_P227_G0.6650.18
219_D225_H0.6620.18
37_P99_K0.6590.18
120_Q129_L0.6560.18
5_K56_M0.6540.18
82_L154_F0.6510.17
134_S137_A0.6510.17
40_P58_R0.6490.17
190_L193_I0.6380.17
121_A225_H0.6360.17
69_V239_S0.6350.17
211_A236_V0.6350.17
168_I171_W0.6340.17
62_E110_M0.6330.17
192_F195_I0.6300.17
141_L206_A0.6300.17
47_I199_I0.6280.17
28_L98_S0.6250.17
106_Y238_V0.6250.17
79_A182_A0.6220.17
134_S158_I0.6220.17
22_A143_A0.6210.17
170_F179_V0.6200.17
163_S169_V0.6190.17
78_L82_L0.6180.16
131_K140_P0.6170.16
47_I167_I0.6150.16
8_V91_S0.6130.16
191_S197_F0.6130.16
21_P120_Q0.6100.16
44_W47_I0.6090.16
107_S225_H0.6080.16
14_Q121_A0.6070.16
125_L196_G0.6070.16
86_H113_S0.6060.16
29_A78_L0.6040.16
229_V240_F0.6020.16
137_A178_E0.6010.16
40_P125_L0.5990.16
9_H12_W0.5970.16
46_L213_K0.5960.16
83_F98_S0.5960.16
60_G142_A0.5950.16
53_Q189_A0.5920.16
48_I80_L0.5880.16
113_S241_L0.5880.16
84_K152_H0.5870.16
173_T192_F0.5860.16
38_F97_Y0.5850.16
60_G244_A0.5850.16
118_L240_F0.5850.16
231_S247_K0.5780.15
11_G18_C0.5760.15
95_E137_A0.5740.15
192_F236_V0.5730.15
54_L60_G0.5720.15
118_L237_I0.5720.15
60_G154_F0.5700.15
66_E110_M0.5700.15
30_I46_L0.5670.15
145_I237_I0.5660.15
40_P99_K0.5650.15
28_L112_A0.5640.15
134_S240_F0.5630.15
77_G192_F0.5590.15
49_C85_V0.5590.15
73_F199_I0.5590.15
4_I160_W0.5550.15
17_S49_C0.5550.15
93_P175_V0.5530.15
128_E165_L0.5510.15
237_I242_I0.5490.15
15_A18_C0.5450.14
122_W215_P0.5450.14
13_E16_L0.5430.14
27_S141_L0.5420.14
65_D132_W0.5420.14
33_I50_V0.5360.14
56_M130_V0.5350.14
152_H240_F0.5330.14
115_A119_C0.5290.14
209_F236_V0.5280.14
160_W230_S0.5280.14
190_L233_L0.5260.14
126_K178_E0.5260.14
42_Y96_G0.5260.14
68_K237_I0.5230.14
127_V191_S0.5210.14
93_P119_C0.5210.14
18_C122_W0.5200.14
152_H160_W0.5180.14
133_P189_A0.5180.14
46_L94_E0.5140.14
144_A168_I0.5140.14
171_W174_W0.5130.14
99_K210_G0.5130.14
241_L246_L0.5110.14
236_V247_K0.5100.14
102_G151_T0.5090.14
10_F18_C0.5090.14
135_F139_V0.5090.14
21_P25_F0.5080.14
87_M97_Y0.5080.14
19_L65_D0.5070.13
8_V64_R0.5060.13
151_T155_S0.5040.13
85_V107_S0.5020.13
107_S211_A0.5020.13
12_W208_F0.5020.13
73_F107_S0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kncA 1 0.197 11.7 0.978 Contact Map
2m7gA 1 0.2311 9.3 0.979 Contact Map
2m20A 2 0.1553 5 0.982 Contact Map
3tx3A 2 0.3333 2.9 0.984 Contact Map
4bw5A 2 0.6894 2.4 0.984 Contact Map
2rddB 1 0.125 2.2 0.985 Contact Map
1m56D 1 0.1515 2.1 0.985 Contact Map
2kluA 1 0.1818 1.9 0.985 Contact Map
4he8H 1 0.2083 1.7 0.986 Contact Map
1hznA 1 0.0947 1.6 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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