GREMLIN Database
RSGA - Putative ribosome biogenesis GTPase RsgA
UniProt: O34530 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 298 (280)
Sequences: 4016 (2773)
Seq/√Len: 165.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
278_Q282_D4.0271.00
49_V62_E3.7571.00
49_V64_K3.5461.00
51_Q61_M3.3291.00
5_K47_Y3.3221.00
80_Q167_T3.1641.00
110_Q143_D3.0411.00
269_Q273_D3.0311.00
17_L213_H2.8021.00
87_A115_I2.7321.00
253_K264_K2.6551.00
196_S199_L2.6071.00
3_E64_K2.5881.00
81_A104_V2.5761.00
105_E142_Y2.5321.00
190_L212_I2.3281.00
143_D161_H2.3231.00
248_K270_A2.2341.00
82_V112_I2.2331.00
82_V167_T2.1821.00
4_G16_V2.1791.00
112_I161_H2.1581.00
18_D50_Y2.1391.00
29_C33_G2.1151.00
80_Q165_K2.0871.00
116_T149_S2.0581.00
260_L285_V2.0541.00
79_D165_K1.9861.00
82_V114_C1.9721.00
82_V169_F1.9701.00
98_D283_H1.9631.00
29_C58_G1.9531.00
75_I220_A1.9401.00
67_T79_D1.9381.00
258_L261_K1.8951.00
15_Y28_Q1.8761.00
81_A168_V1.8341.00
8_K210_E1.8111.00
135_E138_R1.7961.00
149_S179_S1.7861.00
281_Y285_V1.7841.00
266_A270_A1.6991.00
16_V50_Y1.6811.00
248_K276_L1.6801.00
151_D154_S1.6721.00
78_V168_V1.6711.00
3_E49_V1.6461.00
159_I215_S1.6431.00
81_A109_I1.6371.00
6_I42_P1.6071.00
134_A138_R1.6071.00
3_E47_Y1.6051.00
260_L288_M1.5831.00
106_A237_E1.5671.00
27_I50_Y1.5631.00
266_A269_Q1.5451.00
268_K272_E1.5331.00
145_Y161_H1.4861.00
169_F219_V1.4841.00
18_D25_K1.4721.00
103_L228_L1.4611.00
135_E139_N1.4521.00
271_V281_Y1.4501.00
6_I16_V1.4431.00
89_Q200_G1.4261.00
14_Y60_L1.4191.00
244_D280_R1.4101.00
98_D137_Y1.4071.00
193_N203_K1.4061.00
154_S157_D1.4041.00
245_I249_S1.3961.00
182_N192_T1.3881.00
110_Q165_K1.3841.00
85_F97_L1.3681.00
190_L208_H1.3591.00
148_S179_S1.3521.00
213_H218_L1.3471.00
5_K166_T1.3431.00
251_S266_A1.3331.00
80_Q112_I1.3241.00
289_T293_D1.3121.00
70_L109_I1.3061.00
131_Q134_A1.3011.00
136_D277_K1.2941.00
97_L113_I1.2841.00
80_Q162_F1.2731.00
248_K266_A1.2691.00
152_Q183_A1.2581.00
42_P63_I1.2521.00
131_Q135_E1.2501.00
185_S188_L1.2491.00
179_S192_T1.2421.00
47_Y67_T1.2391.00
95_A283_H1.2361.00
245_I248_K1.2351.00
157_D160_P1.2321.00
16_V29_C1.2221.00
122_E125_D1.2221.00
8_K15_Y1.2181.00
7_I17_L1.2171.00
86_S89_Q1.2141.00
234_E237_E1.2111.00
30_R33_G1.1951.00
87_A118_M1.1851.00
258_L288_M1.1831.00
82_V158_I1.1791.00
104_V111_P1.1751.00
105_E243_P1.1751.00
156_A159_I1.1731.00
114_C158_I1.1571.00
50_Y58_G1.1531.00
148_S154_S1.1331.00
181_L219_V1.1271.00
25_K29_C1.1261.00
238_L288_M1.1121.00
239_G245_I1.1051.00
269_Q272_E1.1041.00
178_S190_L1.0921.00
29_C32_R1.0831.00
68_N79_D1.0761.00
86_S175_V1.0720.99
244_D276_L1.0620.99
270_A275_E1.0530.99
95_A286_E1.0520.99
118_M146_L1.0510.99
101_L142_Y1.0490.99
43_L69_E1.0440.99
284_Y288_M1.0370.99
248_K275_E1.0360.99
15_Y26_V1.0340.99
268_K281_Y1.0330.99
28_Q33_G1.0300.99
162_F167_T1.0280.99
182_N190_L1.0220.99
160_P163_Q1.0170.99
4_G50_Y1.0150.99
233_I238_L1.0150.99
84_V116_T1.0100.99
89_Q195_I1.0040.99
279_Y283_H1.0030.99
249_S267_V0.9990.99
80_Q161_H0.9970.99
272_E278_Q0.9970.99
102_V242_F0.9960.99
82_V162_F0.9880.99
17_L26_V0.9880.99
164_D216_G0.9850.99
186_P189_G0.9820.99
134_A146_L0.9810.99
254_F263_P0.9760.99
26_V33_G0.9680.99
86_S92_F0.9670.99
18_D27_I0.9660.99
86_S195_I0.9620.99
155_L159_I0.9600.99
163_Q216_G0.9580.99
105_E246_R0.9520.99
147_T179_S0.9520.99
47_Y166_T0.9510.99
267_V281_Y0.9480.99
48_V60_L0.9420.99
4_G58_G0.9370.99
68_N78_V0.9350.99
100_F170_A0.9290.99
8_K208_H0.9280.99
4_G29_C0.9280.99
80_Q110_Q0.9240.98
136_D279_Y0.9210.98
74_P209_V0.9210.98
116_T180_L0.9180.98
238_L291_I0.9150.98
149_S183_A0.9130.98
168_V222_T0.9080.98
84_V180_L0.9050.98
94_T133_Y0.8990.98
250_S266_A0.8930.98
143_D157_D0.8910.98
271_V278_Q0.8870.98
4_G18_D0.8860.98
88_V91_S0.8860.98
250_S267_V0.8800.98
112_I145_Y0.8700.98
17_L218_L0.8700.98
155_L183_A0.8650.98
19_E24_D0.8630.98
82_V161_H0.8630.98
246_R249_S0.8630.98
130_I134_A0.8590.98
102_V241_T0.8560.98
211_L218_L0.8510.97
51_Q59_Y0.8500.97
118_M153_D0.8470.97
95_A99_R0.8430.97
92_F172_Q0.8410.97
7_I26_V0.8410.97
283_H287_F0.8370.97
114_C147_T0.8360.97
71_I231_T0.8360.97
131_Q146_L0.8340.97
242_F283_H0.8270.97
70_L168_V0.8260.97
138_R143_D0.8210.97
99_R290_E0.8170.97
106_A241_T0.8170.97
270_A276_L0.8170.97
86_S90_P0.8150.97
27_I52_A0.8130.97
121_I125_D0.8100.97
245_I267_V0.8100.97
261_K268_K0.8100.97
116_T147_T0.8090.97
169_F180_L0.8080.96
86_S172_Q0.8010.96
95_A201_R0.7940.96
97_L133_Y0.7850.96
155_L180_L0.7850.96
89_Q197_E0.7840.96
253_K263_P0.7830.96
195_I199_L0.7820.96
114_C145_Y0.7800.96
145_Y157_D0.7800.96
96_L172_Q0.7800.96
48_V63_I0.7770.96
245_I276_L0.7760.96
53_E57_E0.7720.95
235_E292_K0.7700.95
162_F217_G0.7670.95
282_D285_V0.7660.95
132_A136_D0.7660.95
87_A121_I0.7630.95
93_S201_R0.7550.95
237_E240_Y0.7500.95
262_E268_K0.7500.95
245_I250_S0.7490.95
113_I142_Y0.7400.94
136_D139_N0.7380.94
53_E56_K0.7330.94
209_V220_A0.7330.94
260_L289_T0.7330.94
240_Y246_R0.7330.94
83_L170_A0.7280.94
85_F172_Q0.7270.94
95_A279_Y0.7260.94
260_L268_K0.7250.94
92_F133_Y0.7240.94
152_Q155_L0.7240.94
113_I137_Y0.7210.94
93_S172_Q0.7180.93
19_E47_Y0.7170.93
147_T180_L0.7140.93
28_Q31_G0.7060.93
230_F291_I0.7040.93
101_L243_P0.7030.93
88_V121_I0.7020.93
134_A144_V0.6990.92
285_V288_M0.6990.92
101_L105_E0.6970.92
138_R146_L0.6970.92
166_T218_L0.6950.92
113_I144_V0.6950.92
31_G42_P0.6940.92
264_K268_K0.6940.92
5_K218_L0.6860.92
230_F287_F0.6840.92
24_D33_G0.6820.91
131_Q138_R0.6790.91
132_A135_E0.6790.91
99_R204_H0.6790.91
239_G246_R0.6780.91
238_L287_F0.6760.91
149_S154_S0.6750.91
237_E241_T0.6750.91
214_T217_G0.6740.91
167_T217_G0.6720.91
70_L104_V0.6710.91
90_P200_G0.6700.91
19_E25_K0.6690.91
43_L76_C0.6660.91
108_D237_E0.6660.91
110_Q243_P0.6640.90
78_V109_I0.6630.90
102_V291_I0.6630.90
28_Q57_E0.6610.90
87_A146_L0.6600.90
246_R250_S0.6590.90
105_E141_G0.6590.90
199_L283_H0.6580.90
240_Y249_S0.6570.90
13_F30_R0.6540.90
153_D156_A0.6540.90
260_L292_K0.6530.90
54_N57_E0.6520.90
271_V276_L0.6500.89
133_Y137_Y0.6470.89
94_T279_Y0.6460.89
31_G41_T0.6460.89
115_I118_M0.6460.89
195_I200_G0.6440.89
108_D112_I0.6410.89
213_H217_G0.6360.88
150_K154_S0.6350.88
28_Q32_R0.6350.88
116_T148_S0.6300.88
148_S155_L0.6290.88
114_C227_S0.6230.87
88_V125_D0.6200.87
73_P225_F0.6190.87
33_G262_E0.6190.87
13_F28_Q0.6190.87
247_E250_S0.6180.87
154_S183_A0.6150.87
159_I184_I0.6150.87
85_F96_L0.6140.87
281_Y284_Y0.6140.87
243_P248_K0.6140.87
140_I244_D0.6130.87
102_V287_F0.6130.87
24_D29_C0.6120.86
75_I78_V0.6110.86
185_S189_G0.6110.86
201_R222_T0.6090.86
10_L13_F0.6050.86
166_T211_L0.6050.86
197_E200_G0.6040.86
17_L24_D0.6040.86
96_L209_V0.6030.86
172_Q175_V0.6030.86
156_A160_P0.6010.85
181_L212_I0.6010.85
188_L212_I0.6010.85
9_A13_F0.5980.85
121_I124_Q0.5970.85
142_Y243_P0.5970.85
99_R226_S0.5950.85
148_S183_A0.5920.85
260_L271_V0.5900.84
124_Q146_L0.5880.84
288_M292_K0.5870.84
186_P190_L0.5870.84
100_F228_L0.5860.84
11_S209_V0.5860.84
100_F207_R0.5850.84
254_F264_K0.5850.84
91_S172_Q0.5840.84
96_L256_G0.5830.84
115_I144_V0.5830.84
9_A14_Y0.5820.84
103_L287_F0.5820.84
99_R182_N0.5810.84
101_L111_P0.5780.83
47_Y64_K0.5770.83
86_S116_T0.5770.83
68_N107_N0.5760.83
199_L226_S0.5750.83
175_V179_S0.5740.83
16_V60_L0.5710.82
190_L207_R0.5700.82
233_I241_T0.5670.82
43_L225_F0.5630.82
148_S151_D0.5620.81
145_Y162_F0.5620.81
152_Q157_D0.5620.81
235_E288_M0.5600.81
238_L284_Y0.5600.81
136_D140_I0.5600.81
164_D215_S0.5590.81
75_I168_V0.5590.81
73_P226_S0.5550.81
18_D24_D0.5550.81
182_N189_G0.5540.81
163_Q215_S0.5530.80
195_I204_H0.5520.80
248_K271_V0.5510.80
269_Q275_E0.5500.80
67_T215_S0.5500.80
248_K251_S0.5500.80
258_L262_E0.5500.80
116_T179_S0.5500.80
52_A58_G0.5500.80
151_D156_A0.5480.80
147_T154_S0.5460.80
103_L242_F0.5460.80
105_E111_P0.5440.79
239_G249_S0.5410.79
5_K17_L0.5410.79
27_I56_K0.5410.79
9_A12_G0.5390.79
118_M130_I0.5390.79
158_I161_H0.5380.79
41_T63_I0.5350.78
25_K33_G0.5340.78
201_R226_S0.5340.78
182_N212_I0.5340.78
10_L15_Y0.5340.78
282_D286_E0.5330.78
209_V225_F0.5320.78
42_P97_L0.5320.78
100_F172_Q0.5310.78
158_I184_I0.5260.77
285_V289_T0.5250.77
184_I214_T0.5220.77
85_F92_F0.5220.77
116_T222_T0.5210.76
201_R207_R0.5200.76
149_S155_L0.5170.76
70_L200_G0.5150.76
14_Y208_H0.5150.76
70_L218_L0.5130.75
26_V29_C0.5130.75
119_D164_D0.5130.75
262_E267_V0.5120.75
243_P247_E0.5120.75
32_R61_M0.5110.75
108_D240_Y0.5100.75
288_M291_I0.5090.75
159_I163_Q0.5090.75
110_Q141_G0.5060.74
94_T137_Y0.5050.74
73_P207_R0.5030.74
268_K285_V0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t9hA 1 0.9362 100 0.298 Contact Map
2rcnA 2 0.896 100 0.299 Contact Map
1u0lA 1 0.9228 100 0.323 Contact Map
2yv5A 1 0.9463 100 0.339 Contact Map
3cnlA 1 0.651 99.9 0.783 Contact Map
3ec1A 1 0.7383 99.9 0.784 Contact Map
1pujA 1 0.6812 99.9 0.788 Contact Map
3h2yA 1 0.7517 99.9 0.794 Contact Map
4tmxA 1 0.8557 99.7 0.825 Contact Map
4dcuA 1 0.8121 99.7 0.826 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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