GREMLIN Database
YRVN - Uncharacterized AAA domain-containing protein YrvN
UniProt: O34528 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 421 (356)
Sequences: 9235 (6195)
Seq/√Len: 328.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_Q153_L4.9131.00
159_E178_D3.6961.00
155_K182_E3.5241.00
160_R164_D3.2961.00
150_T153_L3.1281.00
159_E181_M3.0011.00
155_K159_E2.9361.00
30_G34_Q2.9291.00
20_Q156_Q2.7191.00
218_L222_E2.7141.00
250_I281_I2.7131.00
149_L192_V2.6831.00
16_I57_A2.5971.00
16_I54_I2.5021.00
217_T220_T2.4881.00
12_K15_D2.4551.00
177_D215_H2.3761.00
159_E163_H2.3371.00
175_S215_H2.2931.00
158_L195_A2.2691.00
74_N103_D2.2351.00
77_K81_I2.1981.00
157_A192_V2.1971.00
292_Q295_P2.1611.00
176_I181_M2.1581.00
16_I23_V2.1201.00
154_I195_A2.1101.00
155_K181_M2.0921.00
302_Q306_R2.0841.00
74_N105_G2.0771.00
232_H235_D2.0761.00
259_L262_L2.0391.00
247_Q250_I2.0131.00
56_T68_K1.8951.00
260_H264_R1.8871.00
335_A340_L1.8761.00
247_Q253_S1.8631.00
257_A262_L1.8441.00
157_A160_R1.8111.00
257_A264_R1.7781.00
158_L181_M1.7671.00
219_E222_E1.7651.00
335_A339_A1.7531.00
14_E30_G1.7421.00
232_H237_D1.6891.00
188_C195_A1.6801.00
174_V203_V1.6721.00
84_Q87_K1.6711.00
81_I85_E1.6691.00
22_L144_F1.6621.00
185_A195_A1.6591.00
249_S253_S1.6421.00
332_A339_A1.6341.00
177_D180_A1.6151.00
250_I253_S1.6101.00
244_S247_Q1.5941.00
267_E344_R1.5941.00
264_R268_A1.5891.00
43_L146_L1.5841.00
295_P299_N1.5801.00
298_L301_I1.5671.00
305_E308_G1.5621.00
154_I192_V1.5501.00
151_P182_E1.5501.00
247_Q252_G1.5371.00
257_A263_A1.5031.00
155_K185_A1.5021.00
42_I141_T1.4951.00
11_T15_D1.4911.00
91_Q120_I1.4861.00
249_S254_D1.4741.00
341_A345_A1.4681.00
65_A85_E1.4611.00
336_I340_L1.4581.00
99_V121_L1.4471.00
235_D238_A1.4381.00
283_Y287_G1.4331.00
7_R165_E1.4321.00
290_S326_S1.4321.00
259_L263_A1.4301.00
292_Q296_R1.4291.00
301_I306_R1.4281.00
44_Y145_E1.4221.00
287_G291_P1.4211.00
65_A90_G1.4061.00
339_A342_D1.4041.00
360_Y363_A1.4011.00
260_H263_A1.3961.00
127_A131_H1.3921.00
62_T120_I1.3911.00
238_A241_D1.3701.00
179_Q218_L1.3661.00
262_L265_L1.3661.00
300_A319_A1.3511.00
162_L199_L1.3441.00
346_G349_G1.3361.00
161_A196_L1.3261.00
241_D245_A1.3251.00
279_L282_A1.3181.00
75_N78_D1.3151.00
76_K105_G1.3151.00
353_K356_K1.3131.00
67_R85_E1.3061.00
76_K80_E1.3061.00
219_E223_E1.3011.00
15_D160_R1.2961.00
233_D236_G1.2941.00
79_M83_A1.2911.00
282_A285_D1.2851.00
298_L302_Q1.2821.00
302_Q305_E1.2781.00
312_A315_P1.2761.00
151_P185_A1.2731.00
251_R254_D1.2701.00
243_L247_Q1.2461.00
83_A113_Y1.2421.00
333_I337_D1.2411.00
357_D363_A1.2401.00
183_H218_L1.2351.00
54_I146_L1.2341.00
295_P298_L1.2291.00
261_Y265_L1.2281.00
261_Y264_R1.2181.00
152_E156_Q1.2151.00
220_T223_E1.2141.00
357_D360_Y1.2141.00
240_Y250_I1.2101.00
336_I339_A1.2081.00
262_L268_A1.2041.00
263_A267_E1.2001.00
256_N260_H1.1841.00
17_I157_A1.1821.00
339_A343_I1.1801.00
8_M165_E1.1791.00
359_H362_G1.1791.00
162_L176_I1.1761.00
74_N78_D1.1761.00
270_D275_A1.1751.00
240_Y251_R1.1741.00
244_S250_I1.1731.00
337_D340_L1.1701.00
259_L264_R1.1691.00
247_Q254_D1.1631.00
154_I185_A1.1581.00
342_D346_G1.1531.00
297_V300_A1.1521.00
359_H363_A1.1481.00
225_L229_S1.1471.00
278_L281_I1.1401.00
257_A261_Y1.1341.00
262_L269_G1.1331.00
286_I289_A1.1311.00
293_A297_V1.1301.00
66_F95_I1.1301.00
294_G297_V1.1291.00
242_V245_A1.1271.00
226_Q229_S1.1211.00
286_I290_S1.1161.00
151_P186_H1.1141.00
246_F254_D1.1111.00
343_I346_G1.1031.00
248_K251_R1.1031.00
334_L337_D1.1011.00
21_H147_E1.0981.00
248_K252_G1.0921.00
254_D257_A1.0911.00
11_T60_G1.0891.00
163_H176_I1.0831.00
8_M164_D1.0641.00
255_A262_L1.0641.00
181_M185_A1.0641.00
182_E186_H1.0631.00
246_F253_S1.0611.00
95_I124_A1.0551.00
244_S252_G1.0511.00
221_A226_Q1.0511.00
175_S178_D1.0501.00
249_S252_G1.0491.00
296_R300_A1.0481.00
271_L275_A1.0481.00
261_Y268_A1.0471.00
363_A368_R1.0311.00
24_A30_G1.0281.00
76_K109_F1.0251.00
239_H253_S1.0211.00
81_I84_Q1.0211.00
245_A249_S1.0191.00
278_L320_V1.0181.00
36_K62_T1.0171.00
154_I158_L1.0131.00
44_Y143_I1.0121.00
132_A234_K1.0101.00
247_Q251_R1.0091.00
218_L221_A0.9891.00
78_D81_I0.9881.00
52_T97_D0.9821.00
237_D247_Q0.9751.00
178_D182_E0.9751.00
151_P155_K0.9731.00
338_E342_D0.9721.00
317_A321_I0.9721.00
257_A260_H0.9701.00
214_I220_T0.9681.00
158_L199_L0.9631.00
76_K103_D0.9521.00
304_A312_A0.9521.00
260_H265_L0.9471.00
300_A303_T0.9471.00
294_G300_A0.9401.00
285_D289_A0.9361.00
256_N262_L0.9361.00
148_P189_G0.9361.00
266_I309_F0.9341.00
313_R337_D0.9321.00
246_F251_R0.9261.00
290_S293_A0.9241.00
263_A268_A0.9211.00
265_L269_G0.9211.00
313_R317_A0.9201.00
240_Y247_Q0.9171.00
240_Y246_F0.9151.00
263_A269_G0.9111.00
234_K237_D0.9101.00
156_Q159_E0.9101.00
285_D288_L0.9071.00
318_N322_E0.9061.00
360_Y366_L0.9061.00
275_A278_L0.9031.00
259_L266_I0.8991.00
192_V195_A0.8991.00
337_D341_A0.8991.00
362_G366_L0.8951.00
355_L362_G0.8931.00
338_E341_A0.8891.00
221_A224_C0.8881.00
239_H251_R0.8871.00
258_A263_A0.8861.00
300_A308_G0.8841.00
283_Y318_N0.8811.00
299_N303_T0.8791.00
220_T224_C0.8781.00
184_F195_A0.8761.00
250_I323_L0.8751.00
340_L344_R0.8731.00
244_S248_K0.8721.00
356_K362_G0.8711.00
259_L269_G0.8701.00
258_A262_L0.8681.00
262_L266_I0.8651.00
357_D362_G0.8641.00
214_I226_Q0.8641.00
287_G290_S0.8631.00
340_L343_I0.8601.00
28_I144_F0.8531.00
283_Y286_I0.8521.00
206_T220_T0.8521.00
293_A296_R0.8501.00
360_Y364_Q0.8501.00
239_H242_V0.8441.00
215_H224_C0.8381.00
57_A61_S0.8361.00
272_E275_A0.8361.00
235_D239_H0.8341.00
358_A369_G0.8331.00
257_A268_A0.8321.00
87_K116_N0.8311.00
297_V305_E0.8311.00
367_G370_I0.8281.00
242_V246_F0.8271.00
183_H186_H0.8261.00
152_E155_K0.8241.00
232_H236_G0.8221.00
263_A266_I0.8211.00
335_A343_I0.8181.00
316_L323_L0.8131.00
297_V308_G0.8081.00
267_E340_L0.8071.00
353_K371_D0.8061.00
239_H243_L0.8041.00
246_F252_G0.8041.00
264_R269_G0.8041.00
248_K253_S0.8011.00
237_D250_I0.8001.00
69_L83_A0.8001.00
282_A289_A0.8001.00
288_L318_N0.8001.00
184_F198_A0.8001.00
148_P191_D0.7961.00
342_D345_A0.7951.00
217_T222_E0.7951.00
245_A253_S0.7931.00
20_Q24_A0.7921.00
243_L248_K0.7901.00
298_L303_T0.7871.00
275_A279_L0.7861.00
96_L110_L0.7831.00
58_I122_I0.7811.00
239_H250_I0.7781.00
239_H244_S0.7771.00
233_D237_D0.7741.00
248_K254_D0.7701.00
332_A335_A0.7701.00
177_D217_T0.7681.00
217_T229_S0.7681.00
153_L156_Q0.7661.00
41_M144_F0.7651.00
57_A60_G0.7631.00
301_I305_E0.7591.00
301_I304_A0.7581.00
255_A259_L0.7571.00
224_C227_K0.7540.99
112_P116_N0.7530.99
67_R82_V0.7520.99
241_D247_Q0.7520.99
67_R92_V0.7520.99
334_L338_E0.7510.99
333_I339_A0.7500.99
312_A316_L0.7490.99
351_V357_D0.7490.99
39_S120_I0.7470.99
244_S251_R0.7460.99
360_Y368_R0.7370.99
79_M102_L0.7340.99
282_A286_I0.7340.99
56_T116_N0.7330.99
216_I228_K0.7330.99
321_I325_L0.7320.99
352_P358_A0.7300.99
246_F250_I0.7290.99
240_Y249_S0.7290.99
214_I217_T0.7270.99
239_H254_D0.7250.99
293_A308_G0.7230.99
244_S253_S0.7230.99
329_S332_A0.7220.99
69_L78_D0.7220.99
352_P356_K0.7170.99
280_V283_Y0.7160.99
8_M161_A0.7160.99
259_L268_A0.7160.99
215_H218_L0.7130.99
326_S329_S0.7120.99
293_A307_V0.7100.99
49_I146_L0.7100.99
222_E229_S0.7080.99
297_V304_A0.7080.99
240_Y254_D0.7050.99
187_G225_L0.7050.99
336_I346_G0.7020.99
318_N321_I0.7000.99
346_G350_D0.7000.99
298_L306_R0.6980.99
215_H226_Q0.6970.99
222_E226_Q0.6970.99
75_N79_M0.6960.99
224_C228_K0.6950.99
250_I254_D0.6930.99
238_A242_V0.6920.99
149_L153_L0.6910.99
115_E136_A0.6870.99
264_R267_E0.6870.99
243_L273_S0.6860.99
369_G372_Y0.6850.99
242_V247_Q0.6840.99
240_Y248_K0.6830.99
335_A342_D0.6830.99
250_I278_L0.6820.99
281_I286_I0.6820.99
284_E287_G0.6810.99
292_Q297_V0.6810.99
279_L283_Y0.6790.99
73_I113_Y0.6780.99
93_I122_I0.6780.99
245_A251_R0.6760.99
83_A119_I0.6730.99
281_I284_E0.6700.99
216_I222_E0.6700.99
272_E301_I0.6690.99
294_G303_T0.6680.99
310_P314_I0.6670.99
256_N264_R0.6660.99
280_V284_E0.6620.99
245_A250_I0.6610.99
361_K365_E0.6610.99
222_E225_L0.6590.99
239_H249_S0.6570.99
23_V30_G0.6550.99
363_A366_L0.6540.99
273_S277_R0.6540.99
247_Q280_V0.6540.99
44_Y130_Y0.6530.99
181_M195_A0.6520.99
281_I285_D0.6510.98
259_L335_A0.6490.98
255_A263_A0.6470.98
315_P318_N0.6460.98
243_L253_S0.6460.98
217_T226_Q0.6450.98
270_D273_S0.6380.98
259_L265_L0.6380.98
188_C191_D0.6370.98
46_P49_I0.6360.98
293_A301_I0.6330.98
271_L274_I0.6330.98
296_R307_V0.6300.98
284_E288_L0.6300.98
275_A282_A0.6270.98
101_R108_D0.6250.98
279_L286_I0.6240.98
130_Y145_E0.6240.98
102_L106_K0.6240.98
277_R282_A0.6240.98
33_V58_I0.6230.98
242_V252_G0.6220.98
221_A229_S0.6190.98
342_D347_K0.6180.98
303_T306_R0.6170.98
311_E316_L0.6160.98
158_L185_A0.6160.98
352_P366_L0.6150.98
367_G373_K0.6130.98
162_L181_M0.6130.98
279_L306_R0.6110.98
222_E227_K0.6080.98
103_D106_K0.6080.98
297_V301_I0.6070.98
330_N334_L0.6070.98
31_R34_Q0.6060.98
20_Q23_V0.6040.98
75_N86_A0.6020.98
280_V314_I0.5990.97
356_K364_Q0.5980.97
258_A267_E0.5970.97
31_R35_A0.5900.97
357_D365_E0.5900.97
361_K364_Q0.5880.97
198_A225_L0.5880.97
278_L284_E0.5870.97
216_I220_T0.5860.97
363_A367_G0.5840.97
243_L246_F0.5830.97
255_A269_G0.5820.97
367_G371_D0.5810.97
265_L268_A0.5810.97
20_Q152_E0.5790.97
368_R372_Y0.5740.97
340_L346_G0.5730.97
237_D244_S0.5720.97
246_F249_S0.5720.97
339_A346_G0.5700.97
241_D244_S0.5690.97
273_S276_R0.5690.97
138_R143_I0.5680.96
17_I160_R0.5660.96
74_N102_L0.5640.96
354_H359_H0.5620.96
218_L224_C0.5610.96
297_V303_T0.5610.96
300_A304_A0.5610.96
262_L320_V0.5600.96
358_A361_K0.5590.96
347_K358_A0.5590.96
345_A351_V0.5580.96
294_G308_G0.5580.96
41_M146_L0.5560.96
224_C229_S0.5550.96
313_R340_L0.5550.96
256_N268_A0.5550.96
203_V206_T0.5550.96
59_A93_I0.5530.96
136_A140_R0.5530.96
368_R371_D0.5520.96
115_E140_R0.5520.96
294_G298_L0.5500.96
258_A261_Y0.5500.96
296_R308_G0.5480.96
114_L141_T0.5470.96
180_A202_A0.5470.96
53_S57_A0.5440.96
215_H222_E0.5430.95
355_L361_K0.5420.95
274_I277_R0.5420.95
370_I373_K0.5420.95
288_L321_I0.5410.95
161_A165_E0.5410.95
309_F313_R0.5410.95
39_S144_F0.5410.95
130_Y143_I0.5400.95
275_A286_I0.5390.95
260_H269_G0.5370.95
321_I332_A0.5370.95
258_A264_R0.5360.95
226_Q230_F0.5360.95
72_V112_P0.5360.95
309_F315_P0.5340.95
237_D241_D0.5320.95
256_N265_L0.5300.95
328_K331_S0.5290.95
361_K366_L0.5290.95
312_A322_E0.5280.95
366_L370_I0.5280.95
83_A87_K0.5280.95
315_P319_A0.5270.95
51_K97_D0.5260.95
365_E372_Y0.5250.95
175_S213_E0.5240.95
237_D249_S0.5240.95
354_H357_D0.5220.94
279_L303_T0.5210.94
347_K351_V0.5190.94
156_Q160_R0.5180.94
336_I342_D0.5180.94
242_V253_S0.5180.94
257_A269_G0.5160.94
46_P191_D0.5150.94
214_I224_C0.5150.94
17_I153_L0.5150.94
355_L360_Y0.5150.94
349_G353_K0.5150.94
326_S330_N0.5140.94
366_L369_G0.5130.94
239_H252_G0.5120.94
240_Y252_G0.5110.94
157_A161_A0.5100.94
255_A264_R0.5090.94
162_L203_V0.5080.94
221_A231_S0.5070.94
352_P359_H0.5070.94
239_H247_Q0.5030.93
363_A369_G0.5030.93
179_Q182_E0.5020.93
239_H248_K0.5010.93
352_P360_Y0.5010.93
221_A225_L0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pvsA 4 0.9952 100 0.369 Contact Map
3vkgA 2 0.9002 100 0.49 Contact Map
4rh7A 1 0.8907 100 0.522 Contact Map
1sxjD 1 0.7102 100 0.532 Contact Map
2chqA 3 0.7007 100 0.546 Contact Map
1sxjC 1 0.7197 100 0.56 Contact Map
1iqpA 5 0.7055 100 0.561 Contact Map
1sxjE 1 0.6912 100 0.564 Contact Map
4akgA 2 0.6081 100 0.581 Contact Map
4cr2H 1 0.5202 100 0.583 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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