GREMLIN Database
SYA - Alanine--tRNA ligase
UniProt: O34526 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 878 (861)
Sequences: 3897 (2304)
Seq/√Len: 78.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
484_A490_V5.9371.00
111_F118_I4.9581.00
465_T554_V4.4521.00
469_A495_D4.2541.00
520_V537_G4.1531.00
15_D18_K3.9991.00
768_K871_E3.9841.00
11_Q15_D3.9581.00
567_T660_V3.8841.00
256_A259_S3.8111.00
102_E143_K3.7881.00
830_H833_K3.7761.00
625_S675_N3.7101.00
565_N701_T3.6881.00
494_L552_A3.4871.00
779_K864_E3.4541.00
274_A314_Y3.3861.00
138_E142_K3.3831.00
606_V614_I3.3441.00
801_S823_D3.2281.00
634_P637_E3.2271.00
558_M562_V3.2021.00
508_G525_V3.1761.00
521_R540_E3.0991.00
606_V611_L3.0551.00
330_P351_A2.9911.00
407_E419_H2.9311.00
476_Q488_E2.9211.00
427_N431_E2.9151.00
418_D421_G2.9131.00
807_G863_L2.8861.00
458_T496_E2.8411.00
460_V467_A2.8001.00
425_E428_Q2.7841.00
719_T734_V2.7541.00
141_A148_E2.7071.00
212_N216_T2.6731.00
621_K624_A2.6541.00
20_K110_E2.6471.00
392_V417_V2.6411.00
392_V403_V2.6291.00
862_K865_E2.5971.00
769_E772_G2.5851.00
741_L744_A2.5581.00
419_H423_E2.5441.00
489_S538_V2.5291.00
578_D617_I2.5081.00
251_V255_K2.4831.00
468_D549_H2.4811.00
12_M111_F2.4631.00
11_Q24_V2.4591.00
769_E774_N2.3961.00
470_N549_H2.3771.00
288_A293_A2.3521.00
212_N218_T2.3321.00
792_V819_G2.3241.00
515_S518_A2.3191.00
637_E640_E2.3111.00
337_A344_K2.3031.00
372_L409_Y2.3001.00
632_L654_I2.2891.00
513_L550_V2.2701.00
14_L24_V2.2571.00
604_G610_E2.2371.00
127_V146_I2.2271.00
385_S416_T2.2171.00
579_V617_I2.2081.00
673_V679_I2.2031.00
387_I410_A2.2031.00
114_S122_K2.2001.00
296_S301_G2.1911.00
521_R538_V2.1771.00
859_Q862_K2.1731.00
625_S677_A2.1631.00
466_K553_E2.1311.00
583_H602_H2.1031.00
211_H217_Y2.0991.00
748_N751_L2.0951.00
28_A47_T2.0891.00
574_Q578_D2.0801.00
134_E153_R2.0771.00
322_R327_D2.0701.00
386_V416_T2.0541.00
428_Q432_R2.0511.00
719_T730_V2.0441.00
470_N495_D2.0411.00
427_N430_R2.0401.00
613_Q616_R2.0401.00
618_V682_F2.0291.00
85_H244_N2.0171.00
110_E114_S2.0151.00
635_I639_K2.0121.00
326_F355_K2.0091.00
631_D641_M1.9901.00
739_A743_D1.9831.00
18_K24_V1.9701.00
784_D787_H1.9631.00
839_A855_A1.9581.00
510_K558_M1.9211.00
360_R363_E1.9121.00
610_E613_Q1.9111.00
519_V541_S1.9081.00
403_V419_H1.8891.00
457_S533_H1.8761.00
869_S872_D1.8751.00
388_S391_D1.8621.00
108_A204_L1.8531.00
514_R553_E1.8531.00
201_V237_V1.8501.00
16_F20_K1.8501.00
841_V862_K1.8461.00
138_E141_A1.8421.00
607_T610_E1.8341.00
805_V818_A1.8291.00
182_N193_G1.8261.00
125_L172_I1.8111.00
134_E138_E1.8111.00
492_I544_V1.8081.00
258_E275_F1.7981.00
864_E868_A1.7881.00
112_L201_V1.7881.00
118_I238_I1.7811.00
762_A765_S1.7791.00
315_A324_F1.7761.00
333_A347_A1.7761.00
290_S350_I1.7621.00
14_L64_V1.7591.00
612_E616_R1.7531.00
255_K258_E1.7451.00
420_E423_E1.7421.00
483_E545_Q1.7361.00
106_T143_K1.7281.00
43_S46_A1.7241.00
375_M387_I1.7191.00
490_V520_V1.7131.00
474_L492_I1.7101.00
347_A351_A1.7061.00
558_M593_E1.7051.00
805_V870_V1.7021.00
16_F107_W1.6991.00
766_K778_A1.6901.00
375_M391_D1.6781.00
182_N195_N1.6741.00
137_Y153_R1.6691.00
564_K623_W1.6591.00
141_A151_I1.6551.00
103_E106_T1.6551.00
181_G192_G1.6551.00
261_S320_I1.6451.00
577_K585_N1.6371.00
397_D429_Q1.6341.00
102_E106_T1.6261.00
633_K641_M1.6241.00
636_A640_E1.6161.00
545_Q548_L1.6121.00
641_M665_L1.6121.00
431_E435_N1.6051.00
520_V544_V1.6011.00
792_V817_S1.6011.00
841_V869_S1.6001.00
51_Y58_P1.5981.00
820_V824_L1.5951.00
24_V64_V1.5931.00
483_E543_T1.5881.00
252_P335_I1.5811.00
257_T275_F1.5771.00
498_P552_A1.5680.99
241_V246_D1.5650.99
376_I415_M1.5620.99
424_E428_Q1.5620.99
189_L195_N1.5600.99
285_V308_L1.5580.99
19_E115_D1.5570.99
264_T267_K1.5570.99
355_K359_E1.5460.99
469_A496_E1.5330.99
266_G272_D1.5290.99
744_A748_N1.5220.99
114_S119_G1.5150.99
372_L376_I1.5120.99
628_V660_V1.5080.99
420_E424_E1.5060.99
465_T556_D1.5050.99
480_L546_K1.5050.99
330_P347_A1.5040.99
126_S152_I1.5020.99
263_E271_K1.4940.99
816_I842_C1.4940.99
219_P223_K1.4910.99
492_I513_L1.4910.99
468_D551_T1.4860.99
380_K413_E1.4850.99
523_K537_G1.4840.99
256_A331_V1.4730.99
490_V537_G1.4700.99
503_S527_K1.4580.99
799_L802_A1.4560.99
62_R98_D1.4530.99
809_V812_D1.4520.99
129_V153_R1.4490.99
102_E142_K1.4490.99
182_N189_L1.4380.99
489_S523_K1.4320.99
491_Q534_V1.4310.99
659_Q665_L1.4280.99
18_K23_A1.4260.99
577_K644_M1.4260.99
519_V540_E1.4240.99
544_V550_V1.4230.99
80_K411_E1.4170.99
286_A329_V1.4170.99
616_R620_E1.4100.99
494_L513_L1.4080.99
137_Y141_A1.4020.99
111_F238_I1.4000.99
747_E752_L1.3940.99
835_V855_A1.3940.99
380_K385_S1.3920.99
469_A552_A1.3860.99
115_D119_G1.3840.99
522_I537_G1.3790.99
121_D174_Y1.3770.99
840_E845_G1.3740.99
803_V829_L1.3740.99
9_V235_V1.3720.99
308_L354_I1.3680.99
674_R678_E1.3660.99
390_A425_E1.3620.99
16_F110_E1.3620.99
137_Y148_E1.3590.99
703_Q707_V1.3580.99
20_K107_W1.3570.99
494_L550_V1.3540.98
199_L236_S1.3400.98
38_L42_N1.3360.98
612_E714_S1.3340.98
845_G858_K1.3330.98
126_S150_R1.3320.98
514_R519_V1.3320.98
513_L552_A1.3320.98
103_E107_W1.3310.98
841_V865_E1.3270.98
139_F144_I1.3260.98
868_A871_E1.3190.98
779_K809_V1.3180.98
520_V539_V1.3170.98
691_G694_T1.3160.98
518_A544_V1.3150.98
629_S659_Q1.3130.98
41_I46_A1.3120.98
485_H488_E1.3110.98
12_M118_I1.3100.98
348_D351_A1.3090.98
507_I562_V1.3080.98
822_K851_D1.3020.98
722_E735_A1.2980.98
66_A340_Y1.2930.98
617_I663_Y1.2930.98
634_P654_I1.2900.98
121_D124_L1.2890.98
118_I234_M1.2820.98
571_L618_V1.2820.98
15_D24_V1.2810.98
602_H610_E1.2780.98
515_S550_V1.2780.98
526_Q536_E1.2730.98
573_H644_M1.2680.98
7_A338_D1.2660.98
4_L12_M1.2660.98
471_I492_I1.2640.98
740_E745_Q1.2630.98
767_V776_L1.2610.98
139_F143_K1.2600.98
170_T225_I1.2580.98
256_A260_I1.2580.98
523_K538_V1.2560.98
189_L193_G1.2530.97
466_K551_T1.2470.97
15_D19_E1.2450.97
170_T204_L1.2420.97
833_K836_K1.2410.97
258_E261_S1.2400.97
592_T595_R1.2390.97
822_K826_E1.2380.97
625_S678_E1.2310.97
729_E732_K1.2290.97
837_Q869_S1.2270.97
802_A821_T1.2260.97
471_I544_V1.2230.97
12_M115_D1.2220.97
403_V417_V1.2190.97
136_A170_T1.2190.97
843_G859_Q1.2190.97
486_E541_S1.2180.97
344_K347_A1.2170.97
102_E139_F1.2170.97
41_I47_T1.2160.97
561_G702_G1.2160.97
23_A60_N1.2150.97
764_L767_V1.2130.97
704_G707_V1.2120.97
636_A639_K1.2080.97
621_K626_I1.2080.97
868_A872_D1.2060.97
562_V593_E1.2060.97
814_V860_P1.2020.97
352_K604_G1.2010.97
124_L174_Y1.2000.97
513_L522_I1.1980.97
596_L699_A1.1970.97
681_L709_M1.1940.97
184_P189_L1.1920.97
11_Q18_K1.1910.97
428_Q431_E1.1890.97
460_V496_E1.1870.97
627_P675_N1.1830.96
129_V137_Y1.1780.96
801_S821_T1.1780.96
464_Q554_V1.1760.96
630_I658_V1.1750.96
404_E408_E1.1750.96
794_E797_A1.1750.96
684_I697_I1.1740.96
801_S824_L1.1720.96
865_E868_A1.1710.96
829_L874_V1.1700.96
633_K637_E1.1690.96
587_A601_S1.1680.96
776_L795_L1.1680.96
120_F237_V1.1660.96
775_V874_V1.1640.96
561_G703_Q1.1640.96
65_N94_F1.1630.96
622_I682_F1.1620.96
42_N161_I1.1620.96
426_M429_Q1.1610.96
621_K663_Y1.1550.96
560_S563_I1.1550.96
25_E65_N1.1460.96
830_H850_P1.1430.96
809_V863_L1.1400.96
501_A533_H1.1390.96
379_E384_S1.1340.95
609_E613_Q1.1340.95
792_V804_I1.1310.95
112_L125_L1.1290.95
518_A550_V1.1280.95
836_K840_E1.1270.95
210_N218_T1.1270.95
57_V61_P1.1210.95
842_C862_K1.1210.95
421_G425_E1.1200.95
258_E264_T1.1180.95
824_L829_L1.1120.95
308_L312_V1.1100.95
539_V544_V1.1070.95
660_V676_T1.1070.95
836_K845_G1.1030.95
247_T252_P1.1030.95
429_Q432_R1.1000.95
282_I328_L1.0990.95
23_A63_I1.0940.95
492_I537_G1.0930.94
471_I550_V1.0920.94
254_I258_E1.0910.94
484_A520_V1.0900.94
143_K146_I1.0900.94
268_D271_K1.0870.94
25_E63_I1.0840.94
29_S33_H1.0830.94
388_S392_V1.0820.94
865_E869_S1.0810.94
4_L8_E1.0780.94
207_S224_N1.0770.94
329_V333_A1.0760.94
229_M234_M1.0730.94
66_A91_L1.0650.94
683_K713_I1.0650.94
631_D637_E1.0620.94
820_V831_A1.0570.93
512_Y519_V1.0550.93
606_V610_E1.0530.93
313_R412_D1.0500.93
471_I494_L1.0470.93
130_H155_E1.0440.93
578_D663_Y1.0430.93
738_Q741_L1.0420.93
11_Q338_D1.0400.93
107_W110_E1.0380.93
700_V708_E1.0370.93
700_V705_A1.0360.93
333_A344_K1.0350.93
112_L172_I1.0340.93
555_E558_M1.0330.93
569_T596_L1.0320.93
34_E56_V1.0300.93
616_R710_N1.0280.92
256_A327_D1.0280.92
261_S275_F1.0270.92
767_V774_N1.0260.92
507_I593_E1.0250.92
346_K349_F1.0250.92
373_S377_K1.0220.92
734_V737_L1.0220.92
176_R199_L1.0200.92
72_T75_I1.0190.92
730_V734_V1.0190.92
628_V673_V1.0170.92
453_V480_L1.0150.92
431_E434_R1.0130.92
818_A838_A1.0110.92
489_S536_E1.0090.92
687_E695_R1.0090.92
425_E432_R1.0090.92
807_G867_L1.0070.92
386_V418_D1.0060.92
719_T723_L1.0050.92
780_V791_M1.0050.92
373_S413_E1.0040.92
8_E12_M1.0040.92
845_G855_A1.0010.91
160_D211_H1.0010.91
176_R236_S0.9960.91
62_R107_W0.9960.91
575_A617_I0.9950.91
631_D659_Q0.9930.91
182_N188_E0.9920.91
75_I307_L0.9900.91
574_Q644_M0.9890.91
176_R242_P0.9890.91
578_D613_Q0.9860.91
466_K556_D0.9850.91
401_F406_T0.9830.91
426_M433_A0.9820.91
512_Y553_E0.9810.91
790_T794_E0.9810.91
184_P188_E0.9800.91
727_I731_P0.9800.91
743_D747_E0.9790.90
410_A417_V0.9790.90
289_V353_V0.9760.90
816_I835_V0.9760.90
23_A59_E0.9750.90
870_V874_V0.9730.90
746_R749_E0.9720.90
796_K819_G0.9710.90
410_A415_M0.9710.90
834_L873_W0.9700.90
353_V603_F0.9670.90
816_I838_A0.9670.90
286_A332_V0.9670.90
6_S247_T0.9670.90
820_V825_I0.9660.90
423_E427_N0.9650.90
126_S198_Y0.9650.90
256_A328_L0.9620.90
70_I284_T0.9610.90
316_K366_N0.9610.90
510_K562_V0.9610.90
378_K391_D0.9600.90
779_K867_L0.9570.89
5_T8_E0.9550.89
329_V351_A0.9540.89
707_V711_S0.9520.89
750_S753_A0.9480.89
375_M378_K0.9480.89
613_Q617_I0.9470.89
177_G197_R0.9450.89
805_V838_A0.9440.89
506_Q671_C0.9440.89
837_Q840_E0.9420.89
175_D197_R0.9380.89
134_E137_Y0.9370.88
565_N704_G0.9370.88
253_I332_V0.9350.88
785_M815_N0.9350.88
838_A870_V0.9330.88
379_E388_S0.9330.88
50_K55_R0.9330.88
30_L288_A0.9300.88
484_A488_E0.9300.88
508_G524_D0.9290.88
492_I520_V0.9260.88
747_E750_S0.9240.88
777_A867_L0.9200.88
263_E275_F0.9200.88
514_R551_T0.9170.87
490_V539_V0.9170.87
43_S69_A0.9160.87
539_V542_G0.9140.87
485_H543_T0.9140.87
659_Q662_D0.9130.87
16_F114_S0.9110.87
388_S421_G0.9090.87
569_T589_S0.9080.87
465_T563_I0.9080.87
675_N678_E0.9080.87
711_S714_S0.9050.87
734_V738_Q0.9030.87
286_A343_V0.9030.87
726_N729_E0.9030.87
260_I320_I0.9020.87
780_V783_K0.9020.87
169_N173_F0.9000.86
469_A550_V0.8990.86
747_E751_L0.8980.86
491_Q536_E0.8950.86
70_I288_A0.8940.86
9_V118_I0.8940.86
718_Q735_A0.8920.86
837_Q841_V0.8910.86
510_K523_K0.8910.86
28_A41_I0.8890.86
503_S567_T0.8890.86
120_F124_L0.8880.86
718_Q731_P0.8860.86
842_C855_A0.8840.85
106_T110_E0.8810.85
775_V871_E0.8800.85
781_N809_V0.8800.85
14_L18_K0.8770.85
188_E195_N0.8740.85
109_W113_T0.8730.85
482_E546_K0.8710.85
188_E191_P0.8700.84
255_K259_S0.8700.84
499_F552_A0.8680.84
464_Q467_A0.8670.84
239_Q248_D0.8670.84
572_L596_L0.8660.84
173_F192_G0.8650.84
386_V420_E0.8650.84
568_A682_F0.8640.84
786_N845_G0.8610.84
563_I671_C0.8600.84
474_L546_K0.8600.84
528_A534_V0.8590.84
183_D189_L0.8590.84
390_A421_G0.8590.84
131_P134_E0.8580.84
427_N434_R0.8570.84
85_H250_F0.8530.83
188_E193_G0.8520.83
714_S718_Q0.8520.83
115_D118_I0.8500.83
138_E143_K0.8490.83
287_F336_M0.8490.83
585_N644_M0.8470.83
816_I855_A0.8470.83
331_V334_E0.8460.83
471_I548_L0.8460.83
814_V858_K0.8420.82
616_R707_V0.8420.82
793_D796_K0.8410.82
842_C857_G0.8410.82
211_H214_D0.8410.82
761_G794_E0.8400.82
838_A866_A0.8400.82
148_E151_I0.8380.82
484_A537_G0.8380.82
241_V251_V0.8380.82
106_T144_I0.8370.82
201_V234_M0.8370.82
72_T307_L0.8360.82
104_A108_A0.8360.82
620_E624_A0.8350.82
108_A172_I0.8350.82
673_V678_E0.8350.82
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192_G199_L0.5400.50
209_F219_P0.5400.50
531_G652_G0.5400.50
152_I193_G0.5400.50
770_V773_V0.5400.50
446_Q450_L0.5390.50
688_S698_E0.5390.50
76_E273_T0.5390.50
128_T144_I0.5390.50
562_V592_T0.5380.50
176_R225_I0.5380.50
247_T251_V0.5380.50
791_M794_E0.5380.50
274_A277_V0.5380.50
390_A424_E0.5370.50
600_F606_V0.5370.50
338_D341_P0.5370.50
109_W127_V0.5370.50
434_R437_R0.5370.50
70_I304_L0.5370.50
306_R401_F0.5360.49
13_F37_S0.5360.49
329_V347_A0.5360.49
577_K584_V0.5360.49
182_N190_Y0.5350.49
126_S154_L0.5350.49
179_A242_P0.5350.49
610_E614_I0.5350.49
160_D191_P0.5350.49
501_A527_K0.5350.49
193_G199_L0.5340.49
42_N73_N0.5340.49
767_V799_L0.5340.49
761_G764_L0.5340.49
53_D161_I0.5330.49
184_P193_G0.5320.49
752_L787_H0.5320.49
748_N755_L0.5320.49
118_I201_V0.5320.49
561_G565_N0.5320.49
573_H646_L0.5310.49
537_G542_G0.5310.49
134_E139_F0.5310.49
43_S66_A0.5310.49
127_V151_I0.5310.49
575_A579_V0.5310.49
763_I778_A0.5300.49
716_L731_P0.5300.49
182_N196_D0.5290.49
391_D394_K0.5280.48
457_S522_I0.5280.48
460_V498_P0.5280.48
326_F351_A0.5270.48
69_A169_N0.5270.48
34_E434_R0.5270.48
453_V473_V0.5270.48
389_G422_F0.5260.48
715_V718_Q0.5260.48
740_E743_D0.5250.48
192_G196_D0.5250.48
128_T173_F0.5250.48
595_R685_V0.5250.48
82_A243_T0.5240.48
554_V563_I0.5240.48
183_D195_N0.5240.48
254_I279_A0.5240.48
348_D582_T0.5230.48
42_N46_A0.5220.48
241_V255_K0.5220.48
745_Q749_E0.5210.47
429_Q436_A0.5210.47
152_I184_P0.5200.47
152_I155_E0.5190.47
66_A73_N0.5190.47
595_R698_E0.5190.47
510_K525_V0.5180.47
264_T271_K0.5180.47
822_K825_I0.5180.47
49_K52_F0.5180.47
126_S175_D0.5170.47
638_A642_G0.5170.47
403_V423_E0.5170.47
152_I192_G0.5160.47
66_A339_F0.5160.47
45_V96_I0.5150.47
252_P331_V0.5150.47
40_W217_Y0.5150.47
182_N194_E0.5150.47
120_F238_I0.5140.47
312_V366_N0.5140.47
845_G856_G0.5130.46
184_P198_Y0.5130.46
163_E224_N0.5130.46
416_T496_E0.5130.46
177_G180_Y0.5130.46
235_V238_I0.5130.46
235_V247_T0.5130.46
287_F602_H0.5130.46
31_V293_A0.5120.46
20_K114_S0.5110.46
776_L805_V0.5110.46
180_Y240_N0.5110.46
142_K146_I0.5110.46
176_R196_D0.5110.46
85_H247_T0.5110.46
134_E148_E0.5110.46
48_L65_N0.5100.46
42_N163_E0.5100.46
83_R177_G0.5090.46
129_V132_E0.5090.46
457_S460_V0.5090.46
558_M592_T0.5080.46
805_V867_L0.5080.46
154_L173_F0.5070.46
273_T276_K0.5070.46
559_R671_C0.5070.46
457_S461_G0.5070.46
42_N160_D0.5050.45
557_H561_G0.5050.45
683_K700_V0.5050.45
41_I49_K0.5050.45
572_L682_F0.5040.45
712_Q727_I0.5040.45
51_Y72_T0.5040.45
774_N801_S0.5040.45
679_I701_T0.5040.45
110_E113_T0.5040.45
66_A231_L0.5030.45
613_Q620_E0.5030.45
563_I674_R0.5030.45
94_F107_W0.5030.45
514_R518_A0.5030.45
48_L176_R0.5020.45
380_K384_S0.5020.45
715_V730_V0.5020.45
46_A68_K0.5020.45
608_K612_E0.5010.45
618_V699_A0.5010.45
123_E149_E0.5010.45
126_S146_I0.5010.45
50_K58_P0.5000.45
82_A276_K0.5000.45
630_I656_R0.5000.45
141_A145_G0.5000.45
244_N247_T0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wqyA 2 0.8872 100 0.252 Contact Map
2zzeA 1 0.672 100 0.344 Contact Map
2ztgA 1 0.7027 100 0.354 Contact Map
1yfsA 1 0.5011 100 0.441 Contact Map
3hy0A 1 0.4863 100 0.45 Contact Map
3kewA 1 0.2574 100 0.83 Contact Map
2e1bA 1 0.2415 100 0.841 Contact Map
1nyrA 2 0.4077 100 0.912 Contact Map
1v4pA 2 0.1617 100 0.912 Contact Map
1tkeA 1 0.2358 100 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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