YOCS - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

YOCS - Uncharacterized sodium-dependent transporter YocS

UniProt:	O34524	Sequences: MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFLGIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGVILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPGSLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENLLQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAHFSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	321 (296)
Sequences:	6070 (3502)
Seq/√Len:	203.6

ECOLI - YFEH
BACSU - YOCS ARSB YBAS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
49_F	180_V	7.732	1.00
124_N	253_S	7.334	1.00
242_L	246_L	3.943	1.00
61_K	65_R	3.346	1.00
251_Y	255_K	3.229	1.00
158_S	161_S	3.215	1.00
49_F	176_A	3.173	1.00
118_T	123_G	3.114	1.00
250_D	253_S	2.867	1.00
245_K	254_Q	2.866	1.00
102_V	228_V	2.794	1.00
269_G	285_S	2.686	1.00
233_N	295_S	2.635	1.00
77_Q	110_G	2.617	1.00
244_A	254_Q	2.514	1.00
84_V	235_I	2.316	1.00
58_D	61_K	2.249	1.00
107_C	146_L	2.243	1.00
244_A	257_I	2.233	1.00
59_D	62_E	2.217	1.00
75_I	79_T	2.188	1.00
175_I	179_I	2.176	1.00
18_W	22_F	2.169	1.00
104_L	273_A	2.162	1.00
78_Y	142_V	2.135	1.00
22_F	204_V	2.110	1.00
238_L	242_L	2.093	1.00
117_M	259_I	2.074	1.00
81_M	236_G	2.040	1.00
85_A	106_G	2.037	1.00
74_V	138_L	2.027	1.00
241_F	254_Q	1.998	1.00
17_I	21_V	1.992	1.00
86_F	90_F	1.985	1.00
249_M	257_I	1.978	1.00
71_I	75_I	1.958	1.00
128_S	256_A	1.940	1.00
138_L	142_V	1.915	1.00
92_L	228_V	1.843	1.00
89_A	99_A	1.835	1.00
62_E	65_R	1.833	1.00
223_L	227_S	1.820	1.00
230_I	291_W	1.792	1.00
83_L	87_G	1.788	1.00
87_G	91_G	1.775	1.00
20_I	24_V	1.730	1.00
56_Q	181_K	1.726	1.00
118_T	256_A	1.725	1.00
160_G	164_I	1.721	1.00
179_I	183_F	1.719	1.00
291_W	295_S	1.693	1.00
299_L	303_W	1.685	1.00
186_K	190_K	1.628	1.00
302_Y	306_K	1.627	1.00
72_I	247_L	1.610	1.00
184_F	187_Q	1.609	1.00
88_L	228_V	1.576	1.00
301_T	305_K	1.568	1.00
97_E	280_L	1.550	1.00
76_A	240_G	1.548	1.00
118_T	128_S	1.547	1.00
181_K	189_A	1.531	1.00
167_L	172_F	1.511	1.00
108_C	269_G	1.508	1.00
84_V	236_G	1.505	1.00
24_V	27_F	1.455	1.00
56_Q	59_D	1.451	1.00
67_P	71_I	1.437	1.00
266_S	289_S	1.421	1.00
33_F	36_I	1.420	1.00
72_I	257_I	1.411	1.00
124_N	252_P	1.403	1.00
39_Y	42_I	1.403	1.00
249_M	253_S	1.398	1.00
235_I	239_L	1.393	1.00
254_Q	258_A	1.368	1.00
38_S	42_I	1.360	1.00
76_A	261_V	1.360	1.00
18_W	204_V	1.357	1.00
105_V	288_F	1.347	1.00
110_G	132_T	1.345	1.00
258_A	303_W	1.336	1.00
29_F	32_L	1.320	1.00
52_G	177_G	1.314	1.00
78_Y	135_S	1.308	1.00
241_F	251_Y	1.291	1.00
121_A	300_A	1.291	1.00
146_L	150_F	1.288	1.00
21_V	25_L	1.286	1.00
76_A	80_I	1.284	1.00
301_T	304_S	1.283	1.00
180_V	184_F	1.272	1.00
87_G	90_F	1.269	1.00
178_L	182_M	1.260	1.00
255_K	303_W	1.252	1.00
42_I	45_G	1.250	1.00
69_Q	249_M	1.235	1.00
186_K	189_A	1.226	1.00
298_M	302_Y	1.221	1.00
189_A	192_V	1.221	1.00
251_Y	306_K	1.220	1.00
244_A	249_M	1.206	1.00
115_N	260_E	1.205	1.00
100_V	151_A	1.184	1.00
73_G	131_V	1.178	1.00
250_D	254_Q	1.176	1.00
26_G	33_F	1.175	1.00
66_K	124_N	1.173	1.00
230_I	295_S	1.165	1.00
69_Q	127_L	1.158	1.00
70_V	134_I	1.152	1.00
114_S	264_Q	1.149	1.00
215_R	219_L	1.146	1.00
139_A	143_T	1.139	1.00
58_D	62_E	1.127	1.00
107_C	147_I	1.123	1.00
48_M	52_G	1.118	1.00
14_T	18_W	1.115	1.00
24_V	28_S	1.108	1.00
122_K	307_V	1.094	1.00
77_Q	264_Q	1.084	1.00
30_P	33_F	1.083	1.00
243_C	247_L	1.082	1.00
130_A	133_T	1.079	1.00
203_I	207_V	1.073	1.00
77_Q	132_T	1.054	1.00
259_I	263_M	1.053	1.00
296_G	300_A	1.048	1.00
93_H	96_A	1.045	1.00
187_Q	191_A	1.042	1.00
142_V	146_L	1.040	1.00
234_G	238_L	1.038	1.00
62_E	130_A	1.038	1.00
254_Q	303_W	1.029	1.00
111_G	114_S	1.029	1.00
187_Q	190_K	1.024	1.00
74_V	134_I	1.019	1.00
185_R	189_A	1.018	1.00
39_Y	209_A	1.014	1.00
142_V	145_L	0.994	1.00
288_F	293_N	0.992	1.00
98_I	225_I	0.988	1.00
164_I	168_Q	0.984	1.00
110_G	115_N	0.984	1.00
159_P	163_F	0.983	1.00
27_F	219_L	0.978	1.00
103_I	150_F	0.976	1.00
103_I	107_C	0.967	1.00
113_A	237_Y	0.957	0.99
269_G	284_P	0.939	0.99
73_G	257_I	0.939	0.99
198_V	202_G	0.936	0.99
32_L	35_W	0.936	0.99
31_S	34_T	0.933	0.99
76_A	243_C	0.933	0.99
13_Q	22_F	0.933	0.99
31_S	35_W	0.932	0.99
72_I	249_M	0.930	0.99
110_G	136_T	0.927	0.99
225_I	229_V	0.924	0.99
66_K	253_S	0.922	0.99
23_A	26_G	0.921	0.99
102_V	229_V	0.921	0.99
116_V	203_I	0.918	0.99
199_S	206_I	0.914	0.99
245_K	248_K	0.910	0.99
75_I	243_C	0.909	0.99
68_W	249_M	0.908	0.99
110_G	259_I	0.906	0.99
57_A	182_M	0.904	0.99
126_A	129_V	0.900	0.99
97_E	278_S	0.898	0.99
289_S	293_N	0.894	0.99
83_L	150_F	0.890	0.99
53_L	170_V	0.888	0.99
95_P	99_A	0.885	0.99
110_G	131_V	0.884	0.99
241_F	258_A	0.879	0.99
241_F	306_K	0.876	0.99
45_G	176_A	0.874	0.99
84_V	87_G	0.872	0.99
110_G	128_S	0.871	0.99
245_K	251_Y	0.869	0.99
161_S	164_I	0.869	0.99
89_A	103_I	0.869	0.99
242_L	245_K	0.868	0.99
104_L	143_T	0.864	0.99
17_I	24_V	0.863	0.99
69_Q	253_S	0.861	0.99
59_D	126_A	0.850	0.99
15_F	19_V	0.850	0.99
122_K	304_S	0.844	0.99
168_Q	172_F	0.842	0.99
12_G	16_G	0.841	0.99
292_H	296_G	0.841	0.99
157_V	162_L	0.839	0.99
209_A	213_G	0.835	0.99
32_L	36_I	0.830	0.98
123_G	255_K	0.823	0.98
183_F	186_K	0.823	0.98
77_Q	128_S	0.816	0.98
115_N	132_T	0.816	0.98
60_F	63_L	0.814	0.98
26_G	215_R	0.812	0.98
179_I	182_M	0.808	0.98
25_L	29_F	0.808	0.98
136_T	268_L	0.807	0.98
37_S	213_G	0.805	0.98
159_P	162_L	0.801	0.98
88_L	235_I	0.799	0.98
114_S	128_S	0.797	0.98
44_L	48_M	0.795	0.98
266_S	292_H	0.794	0.98
208_S	212_S	0.792	0.98
304_S	307_V	0.789	0.98
135_S	264_Q	0.787	0.98
95_P	224_L	0.781	0.98
112_T	117_M	0.770	0.98
237_Y	240_G	0.770	0.98
74_V	130_A	0.768	0.97
73_G	260_E	0.767	0.97
128_S	260_E	0.765	0.97
261_V	264_Q	0.765	0.97
43_F	202_G	0.763	0.97
18_W	21_V	0.761	0.97
117_M	210_V	0.760	0.97
157_V	161_S	0.755	0.97
191_A	194_A	0.754	0.97
270_A	274_T	0.752	0.97
244_A	248_K	0.751	0.97
234_G	298_M	0.749	0.97
46_I	198_V	0.748	0.97
229_V	233_N	0.746	0.97
80_I	239_L	0.746	0.97
25_L	28_S	0.744	0.97
167_L	171_L	0.744	0.97
211_V	289_S	0.742	0.97
77_Q	260_E	0.732	0.97
237_Y	299_L	0.731	0.97
190_K	194_A	0.729	0.97
136_T	265_N	0.728	0.97
216_E	220_Q	0.728	0.97
164_I	167_L	0.725	0.96
40_I	262_G	0.723	0.96
101_G	284_P	0.723	0.96
271_A	275_A	0.723	0.96
111_G	260_E	0.721	0.96
211_V	290_V	0.719	0.96
19_V	23_A	0.718	0.96
260_E	264_Q	0.715	0.96
19_V	207_V	0.714	0.96
41_T	45_G	0.709	0.96
21_V	24_V	0.707	0.96
251_Y	254_Q	0.705	0.96
81_M	106_G	0.700	0.96
127_L	253_S	0.696	0.96
22_F	25_L	0.696	0.96
131_V	257_I	0.694	0.95
77_Q	131_V	0.693	0.95
105_V	292_H	0.685	0.95
112_T	266_S	0.683	0.95
97_E	281_S	0.682	0.95
132_T	260_E	0.680	0.95
99_A	103_I	0.680	0.95
145_L	148_M	0.679	0.95
237_Y	258_A	0.679	0.95
43_F	205_A	0.676	0.95
121_A	259_I	0.675	0.95
189_A	193_H	0.675	0.95
203_I	210_V	0.673	0.95
214_N	217_N	0.673	0.95
160_G	163_F	0.671	0.95
108_C	139_A	0.665	0.94
252_P	256_A	0.663	0.94
31_S	36_I	0.662	0.94
145_L	149_L	0.661	0.94
89_A	92_L	0.660	0.94
139_A	146_L	0.658	0.94
47_I	113_A	0.658	0.94
258_A	262_G	0.656	0.94
113_A	293_N	0.655	0.94
135_S	142_V	0.655	0.94
117_M	263_M	0.653	0.94
50_G	199_S	0.650	0.94
13_Q	17_I	0.648	0.93
111_G	265_N	0.647	0.93
111_G	115_N	0.647	0.93
188_V	192_V	0.647	0.93
274_T	282_A	0.646	0.93
130_A	134_I	0.646	0.93
42_I	46_I	0.646	0.93
64_V	130_A	0.645	0.93
14_T	17_I	0.644	0.93
99_A	102_V	0.644	0.93
90_F	99_A	0.642	0.93
119_F	122_K	0.642	0.93
207_V	210_V	0.637	0.93
288_F	292_H	0.636	0.93
104_L	272_L	0.635	0.93
237_Y	241_F	0.634	0.93
118_T	270_A	0.634	0.93
241_F	245_K	0.633	0.93
27_F	217_N	0.632	0.93
119_F	125_T	0.632	0.93
89_A	154_W	0.632	0.93
108_C	143_T	0.629	0.92
286_A	290_V	0.628	0.92
65_R	71_I	0.627	0.92
37_S	42_I	0.626	0.92
181_K	185_R	0.626	0.92
105_V	289_S	0.625	0.92
188_V	196_P	0.624	0.92
95_P	98_I	0.623	0.92
62_E	66_K	0.622	0.92
85_A	102_V	0.621	0.92
182_M	186_K	0.620	0.92
194_A	197_L	0.619	0.92
264_Q	292_H	0.613	0.91
116_V	293_N	0.613	0.91
77_Q	115_N	0.613	0.91
22_F	26_G	0.609	0.91
85_A	89_A	0.608	0.91
12_G	15_F	0.605	0.91
270_A	282_A	0.605	0.91
111_G	289_S	0.603	0.91
263_M	296_G	0.603	0.91
179_I	226_F	0.602	0.91
40_I	267_G	0.599	0.91
44_L	127_L	0.595	0.90
33_F	212_S	0.594	0.90
166_I	171_L	0.592	0.90
15_F	18_W	0.591	0.90
110_G	260_E	0.591	0.90
47_I	52_G	0.591	0.90
141_V	145_L	0.591	0.90
100_V	281_S	0.589	0.90
193_H	197_L	0.589	0.90
180_V	190_K	0.589	0.90
239_L	243_C	0.588	0.90
129_V	132_T	0.585	0.89
195_L	198_V	0.584	0.89
17_I	20_I	0.582	0.89
133_T	166_I	0.582	0.89
245_K	250_D	0.582	0.89
117_M	292_H	0.581	0.89
92_L	231_L	0.580	0.89
89_A	102_V	0.579	0.89
234_G	295_S	0.578	0.89
13_Q	16_G	0.576	0.89
263_M	288_F	0.576	0.89
43_F	206_I	0.575	0.89
180_V	187_Q	0.575	0.89
23_A	27_F	0.574	0.89
100_V	147_I	0.573	0.89
72_I	244_A	0.573	0.89
79_T	83_L	0.572	0.88
24_V	35_W	0.571	0.88
69_Q	73_G	0.571	0.88
111_G	263_M	0.570	0.88
113_A	203_I	0.569	0.88
282_A	286_A	0.567	0.88
105_V	283_V	0.566	0.88
64_V	67_P	0.565	0.88
179_I	184_F	0.565	0.88
20_I	23_A	0.564	0.88
48_M	51_M	0.563	0.88
15_F	27_F	0.562	0.88
217_N	220_Q	0.562	0.88
241_F	255_K	0.561	0.87
237_Y	296_G	0.561	0.87
289_S	292_H	0.561	0.87
255_K	307_V	0.559	0.87
273_A	277_F	0.558	0.87
26_G	30_P	0.557	0.87
112_T	269_G	0.553	0.87
259_I	297_S	0.553	0.87
297_S	301_T	0.552	0.87
76_A	79_T	0.552	0.87
232_H	292_H	0.552	0.87
69_Q	131_V	0.552	0.87
233_N	236_G	0.549	0.86
53_L	195_L	0.546	0.86
129_V	174_I	0.546	0.86
266_S	293_N	0.546	0.86
34_T	38_S	0.545	0.86
77_Q	135_S	0.544	0.86
169_A	271_A	0.544	0.86
221_S	225_I	0.543	0.86
186_K	305_K	0.541	0.86
74_V	131_V	0.541	0.86
147_I	151_A	0.540	0.85
176_A	180_V	0.539	0.85
187_Q	193_H	0.538	0.85
267_G	271_A	0.538	0.85
107_C	136_T	0.538	0.85
241_F	303_W	0.537	0.85
282_A	285_S	0.535	0.85
24_V	238_L	0.535	0.85
271_A	276_H	0.532	0.85
128_S	259_I	0.531	0.84
78_Y	146_L	0.530	0.84
28_S	239_L	0.529	0.84
23_A	211_V	0.528	0.84
196_P	200_V	0.527	0.84
299_L	302_Y	0.527	0.84
14_T	22_F	0.527	0.84
12_G	18_W	0.527	0.84
120_L	300_A	0.525	0.84
265_N	268_L	0.524	0.84
137_L	171_L	0.523	0.84
156_P	160_G	0.523	0.84
114_S	260_E	0.522	0.83
203_I	267_G	0.521	0.83
107_C	150_F	0.520	0.83
105_V	266_S	0.520	0.83
80_I	84_V	0.519	0.83
111_G	136_T	0.519	0.83
175_I	230_I	0.518	0.83
226_F	291_W	0.518	0.83
192_V	196_P	0.518	0.83
104_L	147_I	0.517	0.83
35_W	38_S	0.517	0.83
131_V	135_S	0.517	0.83
51_M	110_G	0.517	0.83
72_I	243_C	0.516	0.83
271_A	293_N	0.514	0.83
109_P	139_A	0.513	0.82
107_C	143_T	0.512	0.82
96_A	100_V	0.511	0.82
15_F	22_F	0.511	0.82
127_L	256_A	0.510	0.82
131_V	260_E	0.509	0.82
124_N	250_D	0.509	0.82
57_A	61_K	0.509	0.82
113_A	135_S	0.506	0.82
283_V	286_A	0.506	0.82
61_K	243_C	0.506	0.82
47_I	112_T	0.506	0.82
69_Q	257_I	0.505	0.81
82_P	264_Q	0.504	0.81
158_S	163_F	0.503	0.81
189_A	246_L	0.503	0.81
88_L	102_V	0.502	0.81
263_M	292_H	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zuxA	1	0.9533	100	0.208	Contact Map
4n7wA	2	0.9564	100	0.234	Contact Map
4bwzA	2	0.947	97.7	0.868	Contact Map
4czbA	2	0.9346	97.2	0.879	Contact Map
4cz8A	2	0.9377	92.4	0.912	Contact Map
1zcdA	1	0.8972	69.3	0.934	Contact Map
3w4tA	1	0.9533	43.4	0.943	Contact Map
2cfqA	1	0.6199	43.1	0.944	Contact Map
3l1lA	2	0.8505	40.6	0.945	Contact Map
4q65A	1	0.5826	31	0.948	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.01 seconds.