GREMLIN Database
YOCS - Uncharacterized sodium-dependent transporter YocS
UniProt: O34524 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 321 (296)
Sequences: 6070 (3502)
Seq/√Len: 203.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_F180_V7.7321.00
124_N253_S7.3341.00
242_L246_L3.9431.00
61_K65_R3.3461.00
251_Y255_K3.2291.00
158_S161_S3.2151.00
49_F176_A3.1731.00
118_T123_G3.1141.00
250_D253_S2.8671.00
245_K254_Q2.8661.00
102_V228_V2.7941.00
269_G285_S2.6861.00
233_N295_S2.6351.00
77_Q110_G2.6171.00
244_A254_Q2.5141.00
84_V235_I2.3161.00
58_D61_K2.2491.00
107_C146_L2.2431.00
244_A257_I2.2331.00
59_D62_E2.2171.00
75_I79_T2.1881.00
175_I179_I2.1761.00
18_W22_F2.1691.00
104_L273_A2.1621.00
78_Y142_V2.1351.00
22_F204_V2.1101.00
238_L242_L2.0931.00
117_M259_I2.0741.00
81_M236_G2.0401.00
85_A106_G2.0371.00
74_V138_L2.0271.00
241_F254_Q1.9981.00
17_I21_V1.9921.00
86_F90_F1.9851.00
249_M257_I1.9781.00
71_I75_I1.9581.00
128_S256_A1.9401.00
138_L142_V1.9151.00
92_L228_V1.8431.00
89_A99_A1.8351.00
62_E65_R1.8331.00
223_L227_S1.8201.00
230_I291_W1.7921.00
83_L87_G1.7881.00
87_G91_G1.7751.00
20_I24_V1.7301.00
56_Q181_K1.7261.00
118_T256_A1.7251.00
160_G164_I1.7211.00
179_I183_F1.7191.00
291_W295_S1.6931.00
299_L303_W1.6851.00
186_K190_K1.6281.00
302_Y306_K1.6271.00
72_I247_L1.6101.00
184_F187_Q1.6091.00
88_L228_V1.5761.00
301_T305_K1.5681.00
97_E280_L1.5501.00
76_A240_G1.5481.00
118_T128_S1.5471.00
181_K189_A1.5311.00
167_L172_F1.5111.00
108_C269_G1.5081.00
84_V236_G1.5051.00
24_V27_F1.4551.00
56_Q59_D1.4511.00
67_P71_I1.4371.00
266_S289_S1.4211.00
33_F36_I1.4201.00
72_I257_I1.4111.00
124_N252_P1.4031.00
39_Y42_I1.4031.00
249_M253_S1.3981.00
235_I239_L1.3931.00
254_Q258_A1.3681.00
38_S42_I1.3601.00
76_A261_V1.3601.00
18_W204_V1.3571.00
105_V288_F1.3471.00
110_G132_T1.3451.00
258_A303_W1.3361.00
29_F32_L1.3201.00
52_G177_G1.3141.00
78_Y135_S1.3081.00
241_F251_Y1.2911.00
121_A300_A1.2911.00
146_L150_F1.2881.00
21_V25_L1.2861.00
76_A80_I1.2841.00
301_T304_S1.2831.00
180_V184_F1.2721.00
87_G90_F1.2691.00
178_L182_M1.2601.00
255_K303_W1.2521.00
42_I45_G1.2501.00
69_Q249_M1.2351.00
186_K189_A1.2261.00
298_M302_Y1.2211.00
189_A192_V1.2211.00
251_Y306_K1.2201.00
244_A249_M1.2061.00
115_N260_E1.2051.00
100_V151_A1.1841.00
73_G131_V1.1781.00
250_D254_Q1.1761.00
26_G33_F1.1751.00
66_K124_N1.1731.00
230_I295_S1.1651.00
69_Q127_L1.1581.00
70_V134_I1.1521.00
114_S264_Q1.1491.00
215_R219_L1.1461.00
139_A143_T1.1391.00
58_D62_E1.1271.00
107_C147_I1.1231.00
48_M52_G1.1181.00
14_T18_W1.1151.00
24_V28_S1.1081.00
122_K307_V1.0941.00
77_Q264_Q1.0841.00
30_P33_F1.0831.00
243_C247_L1.0821.00
130_A133_T1.0791.00
203_I207_V1.0731.00
77_Q132_T1.0541.00
259_I263_M1.0531.00
296_G300_A1.0481.00
93_H96_A1.0451.00
187_Q191_A1.0421.00
142_V146_L1.0401.00
234_G238_L1.0381.00
62_E130_A1.0381.00
254_Q303_W1.0291.00
111_G114_S1.0291.00
187_Q190_K1.0241.00
74_V134_I1.0191.00
185_R189_A1.0181.00
39_Y209_A1.0141.00
142_V145_L0.9941.00
288_F293_N0.9921.00
98_I225_I0.9881.00
164_I168_Q0.9841.00
110_G115_N0.9841.00
159_P163_F0.9831.00
27_F219_L0.9781.00
103_I150_F0.9761.00
103_I107_C0.9671.00
113_A237_Y0.9570.99
269_G284_P0.9390.99
73_G257_I0.9390.99
198_V202_G0.9360.99
32_L35_W0.9360.99
31_S34_T0.9330.99
76_A243_C0.9330.99
13_Q22_F0.9330.99
31_S35_W0.9320.99
72_I249_M0.9300.99
110_G136_T0.9270.99
225_I229_V0.9240.99
66_K253_S0.9220.99
23_A26_G0.9210.99
102_V229_V0.9210.99
116_V203_I0.9180.99
199_S206_I0.9140.99
245_K248_K0.9100.99
75_I243_C0.9090.99
68_W249_M0.9080.99
110_G259_I0.9060.99
57_A182_M0.9040.99
126_A129_V0.9000.99
97_E278_S0.8980.99
289_S293_N0.8940.99
83_L150_F0.8900.99
53_L170_V0.8880.99
95_P99_A0.8850.99
110_G131_V0.8840.99
241_F258_A0.8790.99
241_F306_K0.8760.99
45_G176_A0.8740.99
84_V87_G0.8720.99
110_G128_S0.8710.99
245_K251_Y0.8690.99
161_S164_I0.8690.99
89_A103_I0.8690.99
242_L245_K0.8680.99
104_L143_T0.8640.99
17_I24_V0.8630.99
69_Q253_S0.8610.99
59_D126_A0.8500.99
15_F19_V0.8500.99
122_K304_S0.8440.99
168_Q172_F0.8420.99
12_G16_G0.8410.99
292_H296_G0.8410.99
157_V162_L0.8390.99
209_A213_G0.8350.99
32_L36_I0.8300.98
123_G255_K0.8230.98
183_F186_K0.8230.98
77_Q128_S0.8160.98
115_N132_T0.8160.98
60_F63_L0.8140.98
26_G215_R0.8120.98
179_I182_M0.8080.98
25_L29_F0.8080.98
136_T268_L0.8070.98
37_S213_G0.8050.98
159_P162_L0.8010.98
88_L235_I0.7990.98
114_S128_S0.7970.98
44_L48_M0.7950.98
266_S292_H0.7940.98
208_S212_S0.7920.98
304_S307_V0.7890.98
135_S264_Q0.7870.98
95_P224_L0.7810.98
112_T117_M0.7700.98
237_Y240_G0.7700.98
74_V130_A0.7680.97
73_G260_E0.7670.97
128_S260_E0.7650.97
261_V264_Q0.7650.97
43_F202_G0.7630.97
18_W21_V0.7610.97
117_M210_V0.7600.97
157_V161_S0.7550.97
191_A194_A0.7540.97
270_A274_T0.7520.97
244_A248_K0.7510.97
234_G298_M0.7490.97
46_I198_V0.7480.97
229_V233_N0.7460.97
80_I239_L0.7460.97
25_L28_S0.7440.97
167_L171_L0.7440.97
211_V289_S0.7420.97
77_Q260_E0.7320.97
237_Y299_L0.7310.97
190_K194_A0.7290.97
136_T265_N0.7280.97
216_E220_Q0.7280.97
164_I167_L0.7250.96
40_I262_G0.7230.96
101_G284_P0.7230.96
271_A275_A0.7230.96
111_G260_E0.7210.96
211_V290_V0.7190.96
19_V23_A0.7180.96
260_E264_Q0.7150.96
19_V207_V0.7140.96
41_T45_G0.7090.96
21_V24_V0.7070.96
251_Y254_Q0.7050.96
81_M106_G0.7000.96
127_L253_S0.6960.96
22_F25_L0.6960.96
131_V257_I0.6940.95
77_Q131_V0.6930.95
105_V292_H0.6850.95
112_T266_S0.6830.95
97_E281_S0.6820.95
132_T260_E0.6800.95
99_A103_I0.6800.95
145_L148_M0.6790.95
237_Y258_A0.6790.95
43_F205_A0.6760.95
121_A259_I0.6750.95
189_A193_H0.6750.95
203_I210_V0.6730.95
214_N217_N0.6730.95
160_G163_F0.6710.95
108_C139_A0.6650.94
252_P256_A0.6630.94
31_S36_I0.6620.94
145_L149_L0.6610.94
89_A92_L0.6600.94
139_A146_L0.6580.94
47_I113_A0.6580.94
258_A262_G0.6560.94
113_A293_N0.6550.94
135_S142_V0.6550.94
117_M263_M0.6530.94
50_G199_S0.6500.94
13_Q17_I0.6480.93
111_G265_N0.6470.93
111_G115_N0.6470.93
188_V192_V0.6470.93
274_T282_A0.6460.93
130_A134_I0.6460.93
42_I46_I0.6460.93
64_V130_A0.6450.93
14_T17_I0.6440.93
99_A102_V0.6440.93
90_F99_A0.6420.93
119_F122_K0.6420.93
207_V210_V0.6370.93
288_F292_H0.6360.93
104_L272_L0.6350.93
237_Y241_F0.6340.93
118_T270_A0.6340.93
241_F245_K0.6330.93
27_F217_N0.6320.93
119_F125_T0.6320.93
89_A154_W0.6320.93
108_C143_T0.6290.92
286_A290_V0.6280.92
65_R71_I0.6270.92
37_S42_I0.6260.92
181_K185_R0.6260.92
105_V289_S0.6250.92
188_V196_P0.6240.92
95_P98_I0.6230.92
62_E66_K0.6220.92
85_A102_V0.6210.92
182_M186_K0.6200.92
194_A197_L0.6190.92
264_Q292_H0.6130.91
116_V293_N0.6130.91
77_Q115_N0.6130.91
22_F26_G0.6090.91
85_A89_A0.6080.91
12_G15_F0.6050.91
270_A282_A0.6050.91
111_G289_S0.6030.91
263_M296_G0.6030.91
179_I226_F0.6020.91
40_I267_G0.5990.91
44_L127_L0.5950.90
33_F212_S0.5940.90
166_I171_L0.5920.90
15_F18_W0.5910.90
110_G260_E0.5910.90
47_I52_G0.5910.90
141_V145_L0.5910.90
100_V281_S0.5890.90
193_H197_L0.5890.90
180_V190_K0.5890.90
239_L243_C0.5880.90
129_V132_T0.5850.89
195_L198_V0.5840.89
17_I20_I0.5820.89
133_T166_I0.5820.89
245_K250_D0.5820.89
117_M292_H0.5810.89
92_L231_L0.5800.89
89_A102_V0.5790.89
234_G295_S0.5780.89
13_Q16_G0.5760.89
263_M288_F0.5760.89
43_F206_I0.5750.89
180_V187_Q0.5750.89
23_A27_F0.5740.89
100_V147_I0.5730.89
72_I244_A0.5730.89
79_T83_L0.5720.88
24_V35_W0.5710.88
69_Q73_G0.5710.88
111_G263_M0.5700.88
113_A203_I0.5690.88
282_A286_A0.5670.88
105_V283_V0.5660.88
64_V67_P0.5650.88
179_I184_F0.5650.88
20_I23_A0.5640.88
48_M51_M0.5630.88
15_F27_F0.5620.88
217_N220_Q0.5620.88
241_F255_K0.5610.87
237_Y296_G0.5610.87
289_S292_H0.5610.87
255_K307_V0.5590.87
273_A277_F0.5580.87
26_G30_P0.5570.87
112_T269_G0.5530.87
259_I297_S0.5530.87
297_S301_T0.5520.87
76_A79_T0.5520.87
232_H292_H0.5520.87
69_Q131_V0.5520.87
233_N236_G0.5490.86
53_L195_L0.5460.86
129_V174_I0.5460.86
266_S293_N0.5460.86
34_T38_S0.5450.86
77_Q135_S0.5440.86
169_A271_A0.5440.86
221_S225_I0.5430.86
186_K305_K0.5410.86
74_V131_V0.5410.86
147_I151_A0.5400.85
176_A180_V0.5390.85
187_Q193_H0.5380.85
267_G271_A0.5380.85
107_C136_T0.5380.85
241_F303_W0.5370.85
282_A285_S0.5350.85
24_V238_L0.5350.85
271_A276_H0.5320.85
128_S259_I0.5310.84
78_Y146_L0.5300.84
28_S239_L0.5290.84
23_A211_V0.5280.84
196_P200_V0.5270.84
299_L302_Y0.5270.84
14_T22_F0.5270.84
12_G18_W0.5270.84
120_L300_A0.5250.84
265_N268_L0.5240.84
137_L171_L0.5230.84
156_P160_G0.5230.84
114_S260_E0.5220.83
203_I267_G0.5210.83
107_C150_F0.5200.83
105_V266_S0.5200.83
80_I84_V0.5190.83
111_G136_T0.5190.83
175_I230_I0.5180.83
226_F291_W0.5180.83
192_V196_P0.5180.83
104_L147_I0.5170.83
35_W38_S0.5170.83
131_V135_S0.5170.83
51_M110_G0.5170.83
72_I243_C0.5160.83
271_A293_N0.5140.83
109_P139_A0.5130.82
107_C143_T0.5120.82
96_A100_V0.5110.82
15_F22_F0.5110.82
127_L256_A0.5100.82
131_V260_E0.5090.82
124_N250_D0.5090.82
57_A61_K0.5090.82
113_A135_S0.5060.82
283_V286_A0.5060.82
61_K243_C0.5060.82
47_I112_T0.5060.82
69_Q257_I0.5050.81
82_P264_Q0.5040.81
158_S163_F0.5030.81
189_A246_L0.5030.81
88_L102_V0.5020.81
263_M292_H0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.9533 100 0.208 Contact Map
4n7wA 2 0.9564 100 0.234 Contact Map
4bwzA 2 0.947 97.7 0.868 Contact Map
4czbA 2 0.9346 97.2 0.879 Contact Map
4cz8A 2 0.9377 92.4 0.912 Contact Map
1zcdA 1 0.8972 69.3 0.934 Contact Map
3w4tA 1 0.9533 43.4 0.943 Contact Map
2cfqA 1 0.6199 43.1 0.944 Contact Map
3l1lA 2 0.8505 40.6 0.945 Contact Map
4q65A 1 0.5826 31 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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