GREMLIN Database
PTWCB - PTS system N-acetylglucosamine-specific EIICB component
UniProt: O34521 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 452 (409)
Sequences: 2831 (1603)
Seq/√Len: 79.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
243_V346_Y5.3301.00
236_A338_A5.2141.00
243_V342_F4.7001.00
346_Y350_K4.6661.00
331_L335_I3.8171.00
392_Q406_K3.7091.00
56_I75_A3.6861.00
44_T48_D3.3671.00
23_G309_S3.3101.00
244_T350_K3.2261.00
77_S135_T3.1701.00
355_K361_D3.1691.00
249_K252_A3.1221.00
238_C273_I3.0641.00
291_L344_V3.0211.00
249_K362_D2.9271.00
286_A290_V2.8541.00
407_D410_L2.8291.00
246_K361_D2.7981.00
412_D415_L2.7021.00
335_I339_A2.5931.00
241_M257_M2.5431.00
244_T346_Y2.5431.00
287_V291_L2.4491.00
415_L418_K2.4341.00
232_F334_G2.4251.00
134_L138_I2.4091.00
116_T130_L2.3521.00
384_G415_L2.3331.00
348_L352_L2.3001.00
177_L293_G2.2821.00
231_M265_F2.2201.00
106_A135_T2.2041.00
176_G296_L2.2021.00
302_L333_V2.1841.00
179_N226_F2.1491.00
342_F346_Y2.1201.00
287_V344_V2.0981.00
105_I142_L2.0931.00
299_V333_V2.0661.00
297_F301_W2.0561.00
382_L394_I2.0211.00
283_L352_L2.0021.00
11_S62_I1.9951.00
287_V348_L1.9741.00
242_V254_A1.9731.00
116_T126_S1.9691.00
104_L108_Y1.9591.00
393_T404_T1.9461.00
405_V408_T1.9431.00
102_A139_T1.9391.00
317_Y321_Y1.9271.00
303_G326_K1.9201.00
209_L223_M1.9121.00
344_V348_L1.8811.00
405_V411_V1.8741.00
30_R40_Y1.8541.00
339_A343_I1.8291.00
288_H341_Y1.7861.00
177_L286_A1.7761.00
243_V350_K1.7591.00
413_E417_K1.7231.00
234_L237_A1.6851.00
314_A318_V1.6691.00
343_I346_Y1.6631.00
177_L181_L1.6631.00
342_F350_K1.6571.00
21_A136_A1.6561.00
211_R216_D1.6531.00
10_K395_D1.6371.00
389_E410_L1.6311.00
345_F349_I1.6231.00
31_E35_N1.6231.00
332_L336_C1.5901.00
385_L403_L1.5861.00
178_F191_L1.5851.00
177_L289_A1.5831.00
240_A342_F1.5821.00
392_Q404_T1.5661.00
347_V351_A1.5631.00
207_G211_R1.5550.99
324_A327_P1.5480.99
342_F345_F1.5450.99
144_G148_V1.5390.99
103_G143_A1.5160.99
239_L243_V1.5130.99
254_A258_I1.5010.99
329_L332_L1.5010.99
173_G297_F1.4880.99
365_D368_L1.4860.99
169_G301_W1.4600.99
5_L8_L1.4560.99
13_M189_H1.4530.99
328_L332_L1.4520.99
117_K120_E1.4510.99
137_I141_I1.4400.99
380_I415_L1.4380.99
176_G292_T1.4320.99
299_V304_I1.4300.99
105_I138_I1.4280.99
211_R217_P1.4170.99
211_R215_K1.4140.99
373_V376_V1.4080.99
29_G43_G1.4020.99
50_L96_V1.4000.99
198_Q201_E1.3970.99
55_A69_A1.3940.99
228_P295_S1.3940.99
238_C257_M1.3800.99
251_K254_A1.3700.99
341_Y345_F1.3640.99
343_I347_V1.3480.98
340_V344_V1.3250.98
229_I292_T1.3200.98
291_L340_V1.3190.98
123_G269_I1.3110.98
383_K415_L1.3080.98
75_A79_L1.3010.98
335_I338_A1.2950.98
321_Y327_P1.2930.98
298_I301_W1.2920.98
52_L75_A1.2890.98
6_Q61_G1.2800.98
355_K360_E1.2770.98
256_M260_F1.2690.98
346_Y349_I1.2600.98
304_I329_L1.2580.98
242_V250_R1.2400.97
245_A253_T1.2330.97
105_I108_Y1.2310.97
247_P250_R1.2240.97
60_I71_G1.2190.97
298_I302_L1.2180.97
230_M264_A1.2170.97
241_M253_T1.2150.97
26_L44_T1.2100.97
181_L289_A1.2090.97
177_L290_V1.2020.97
278_M285_Y1.2020.97
241_M244_T1.1970.97
109_T134_L1.1930.97
208_D223_M1.1780.96
62_I104_L1.1720.96
356_T359_R1.1700.96
258_I261_A1.1690.96
394_I403_L1.1660.96
333_V337_Y1.1610.96
294_L337_Y1.1560.96
175_F224_T1.1520.96
246_K360_E1.1400.96
236_A339_A1.1350.96
172_A300_N1.1330.96
242_V258_I1.1310.96
77_S102_A1.1270.95
109_T138_I1.1250.95
384_G396_H1.1250.95
208_D220_G1.1230.95
414_A418_K1.1200.95
173_G293_G1.1200.95
163_W167_L1.1200.95
348_L354_L1.1190.95
202_Y211_R1.1080.95
208_D211_R1.1060.95
102_A142_L1.0970.95
169_G297_F1.0960.95
156_C160_F1.0840.94
242_V257_M1.0830.94
173_G177_L1.0820.94
333_V338_A1.0810.94
274_E285_Y1.0750.94
209_L213_F1.0720.94
113_F134_L1.0690.94
267_T313_G1.0670.94
339_A342_F1.0670.94
274_E288_H1.0650.94
130_L134_L1.0550.94
379_N383_K1.0530.93
376_V379_N1.0530.93
347_V352_L1.0510.93
389_E406_K1.0500.93
86_K89_D1.0480.93
84_A143_A1.0480.93
134_L137_I1.0400.93
229_I233_G1.0360.93
349_I359_R1.0320.93
109_T113_F1.0310.93
150_W154_Q1.0290.93
349_I356_T1.0260.93
243_V250_R1.0240.92
25_I43_G1.0200.92
374_Q377_N1.0160.92
218_T221_T1.0060.92
305_R325_E1.0020.92
253_T257_M0.9980.91
155_S159_S0.9950.91
295_S337_Y0.9910.91
14_L60_I0.9910.91
114_K134_L0.9860.91
77_S139_T0.9850.91
381_M416_L0.9830.91
105_I139_T0.9810.91
334_G338_A0.9800.91
249_K360_E0.9790.91
65_D115_D0.9760.91
198_Q221_T0.9710.90
405_V413_E0.9670.90
22_V50_L0.9630.90
298_I337_Y0.9590.90
93_N96_V0.9580.90
119_P122_L0.9540.90
49_H79_L0.9520.89
337_Y345_F0.9510.89
406_K410_L0.9480.89
347_V354_L0.9450.89
234_L273_I0.9430.89
56_I70_A0.9410.89
283_L286_A0.9400.89
364_V367_V0.9390.89
302_L329_L0.9380.89
156_C159_S0.9320.88
237_A241_M0.9240.88
102_A106_A0.9240.88
96_V99_G0.9210.88
260_F264_A0.9190.88
234_L278_M0.9180.88
317_Y332_L0.9170.88
196_W311_S0.9170.88
384_G416_L0.9140.87
210_A213_F0.9140.87
208_D213_F0.9120.87
226_F308_F0.9120.87
334_G341_Y0.9100.87
52_L74_G0.9090.87
380_I418_K0.9040.87
221_T300_N0.9040.87
236_A240_A0.8980.87
172_A221_T0.8970.86
116_T134_L0.8970.86
152_P156_C0.8930.86
59_A74_G0.8900.86
391_L394_I0.8880.86
153_I156_C0.8860.86
141_I145_I0.8850.86
65_D110_Y0.8850.86
180_R274_E0.8800.85
26_L47_F0.8750.85
269_I398_A0.8720.85
337_Y341_Y0.8710.85
377_N380_I0.8700.85
249_K363_D0.8690.85
338_A341_Y0.8660.84
371_N374_Q0.8620.84
56_I66_S0.8570.84
23_G263_T0.8540.84
12_F128_R0.8500.83
4_F8_L0.8490.83
332_L335_I0.8480.83
129_R132_P0.8480.83
118_L130_L0.8450.83
380_I383_K0.8370.82
197_F209_L0.8360.82
291_L341_Y0.8350.82
172_A297_F0.8340.82
227_F230_M0.8340.82
392_Q405_V0.8330.82
213_F223_M0.8330.82
27_A30_R0.8330.82
168_G171_G0.8330.82
243_V247_P0.8330.82
326_K329_L0.8320.82
404_T408_T0.8240.81
353_N359_R0.8230.81
345_F350_K0.8220.81
265_F314_A0.8210.81
179_N292_T0.8180.81
78_Y82_D0.8180.81
380_I388_K0.8090.80
162_E166_G0.8050.80
341_Y344_V0.8020.80
298_I329_L0.8020.80
208_D215_K0.8010.80
63_S69_A0.7970.79
198_Q202_Y0.7970.79
409_A418_K0.7970.79
41_Q87_T0.7950.79
173_G294_L0.7940.79
216_D219_A0.7940.79
157_I182_L0.7930.79
353_N356_T0.7870.78
211_R219_A0.7860.78
194_I199_F0.7820.78
109_T130_L0.7810.78
337_Y342_F0.7790.78
3_S377_N0.7790.78
381_M384_G0.7770.77
170_I174_I0.7770.77
294_L326_K0.7700.77
3_S404_T0.7670.77
383_K410_L0.7670.77
169_G300_N0.7660.76
333_V345_F0.7650.76
391_L405_V0.7650.76
238_C261_A0.7650.76
196_W310_F0.7640.76
46_V53_I0.7640.76
245_A250_R0.7590.76
179_N308_F0.7580.76
321_Y328_L0.7560.76
372_T376_V0.7550.75
29_G36_I0.7510.75
220_G305_R0.7510.75
72_L100_I0.7500.75
338_A349_I0.7480.75
259_G263_T0.7480.75
374_Q396_H0.7470.75
233_G291_L0.7430.74
338_A345_F0.7420.74
340_V343_I0.7420.74
64_K111_N0.7400.74
228_P299_V0.7390.74
233_G288_H0.7370.74
210_A214_A0.7370.74
240_A349_I0.7360.74
229_I337_Y0.7350.73
309_S313_G0.7350.73
93_N99_G0.7330.73
347_V350_K0.7310.73
121_Y262_L0.7290.73
397_C400_R0.7290.73
230_M312_A0.7290.73
337_Y343_I0.7260.73
119_P125_F0.7250.72
136_A139_T0.7240.72
317_Y327_P0.7240.72
291_L295_S0.7230.72
82_D85_T0.7210.72
21_A137_I0.7200.72
55_A73_S0.7200.72
110_Y220_G0.7170.72
226_F292_T0.7140.71
372_T375_D0.7140.71
42_A140_I0.7120.71
52_L70_A0.7120.71
237_A288_H0.7110.71
4_F108_Y0.7090.71
202_Y220_G0.7090.71
185_L278_M0.7090.71
338_A343_I0.7080.71
283_L287_V0.7080.71
107_G135_T0.7060.70
349_I353_N0.7050.70
92_N96_V0.7040.70
294_L298_I0.7040.70
394_I408_T0.7030.70
245_A356_T0.7020.70
17_A278_M0.7010.70
207_G210_A0.6990.70
163_W166_G0.6980.70
228_P316_D0.6980.70
180_R231_M0.6970.69
306_S320_S0.6960.69
94_M98_G0.6940.69
90_K93_N0.6940.69
54_F100_I0.6940.69
397_C402_R0.6940.69
349_I357_P0.6920.69
92_N98_G0.6900.69
377_N381_M0.6900.69
249_K368_L0.6860.68
145_I149_V0.6860.68
222_Y225_G0.6850.68
384_G403_L0.6830.68
239_L244_T0.6830.68
231_M334_G0.6820.68
149_V152_P0.6810.68
37_P40_Y0.6800.68
379_N388_K0.6780.67
47_F213_F0.6770.67
202_Y219_A0.6770.67
63_S66_S0.6770.67
151_P189_H0.6760.67
379_N409_A0.6760.67
336_C418_K0.6760.67
209_L215_K0.6760.67
41_Q44_T0.6760.67
290_V347_V0.6750.67
349_I358_G0.6750.67
248_S362_D0.6730.67
142_L145_I0.6700.66
69_A73_S0.6690.66
59_A70_A0.6680.66
97_F148_V0.6670.66
27_A267_T0.6670.66
269_I312_A0.6670.66
92_N95_A0.6660.66
338_A342_F0.6640.66
374_Q382_L0.6630.66
160_F163_W0.6620.66
412_D416_L0.6610.65
334_G345_F0.6610.65
291_L294_L0.6570.65
179_N296_L0.6560.65
341_Y349_I0.6540.65
306_S330_L0.6540.65
382_L391_L0.6520.64
375_D379_N0.6480.64
298_I333_V0.6480.64
163_W174_I0.6480.64
107_G111_N0.6470.64
396_H403_L0.6470.64
369_D373_V0.6440.63
93_N97_F0.6430.63
345_F353_N0.6410.63
62_I105_I0.6410.63
255_G259_G0.6410.63
334_G337_Y0.6400.63
24_I118_L0.6390.63
234_L288_H0.6390.63
176_G293_G0.6370.63
245_A358_G0.6370.63
105_I109_T0.6360.62
331_L338_A0.6340.62
17_A20_P0.6330.62
234_L260_F0.6330.62
23_G270_T0.6320.62
406_K418_K0.6310.62
337_Y346_Y0.6290.62
122_L130_L0.6290.62
85_T94_M0.6280.61
16_I30_R0.6280.61
260_F276_A0.6270.61
22_V46_V0.6270.61
307_G316_D0.6270.61
385_L405_V0.6260.61
142_L146_F0.6250.61
257_M276_A0.6240.61
392_Q409_A0.6240.61
41_Q48_D0.6240.61
384_G412_D0.6230.61
24_I28_L0.6230.61
369_D372_T0.6220.61
363_D366_E0.6220.61
266_I315_I0.6210.61
232_F235_P0.6210.61
39_V140_I0.6200.60
331_L336_C0.6180.60
233_G237_A0.6160.60
396_H404_T0.6150.60
369_D389_E0.6130.60
226_F296_L0.6130.60
227_F311_S0.6130.60
209_L212_F0.6120.59
372_T379_N0.6120.59
238_C242_V0.6110.59
231_M288_H0.6110.59
306_S321_Y0.6090.59
243_V343_I0.6090.59
393_T403_L0.6080.59
16_I382_L0.6080.59
338_A344_V0.6080.59
370_E375_D0.6070.59
354_L358_G0.6070.59
384_G418_K0.6050.59
383_K392_Q0.6050.59
392_Q410_L0.6050.59
199_F202_Y0.6050.59
211_R324_A0.6030.58
15_P57_G0.6020.58
166_G364_V0.6000.58
81_L98_G0.6000.58
404_T409_A0.5990.58
264_A343_I0.5990.58
95_A139_T0.5960.57
125_F240_A0.5960.57
317_Y328_L0.5940.57
373_V414_A0.5900.57
364_V418_K0.5890.57
211_R218_T0.5880.56
59_A64_K0.5880.56
154_Q187_L0.5860.56
101_I146_F0.5850.56
304_I332_L0.5850.56
369_D383_K0.5840.56
97_F194_I0.5840.56
371_N414_A0.5820.56
113_F116_T0.5810.56
77_S106_A0.5800.55
93_N98_G0.5800.55
379_N392_Q0.5780.55
81_L146_F0.5780.55
164_M194_I0.5780.55
222_Y228_P0.5780.55
375_D378_E0.5770.55
60_I67_N0.5760.55
191_L195_F0.5760.55
388_K394_I0.5750.55
403_L408_T0.5740.55
284_L345_F0.5730.55
102_A150_W0.5730.55
115_D123_G0.5720.54
409_A414_A0.5720.54
113_F130_L0.5710.54
343_I351_A0.5700.54
202_Y217_P0.5700.54
360_E364_V0.5700.54
262_L266_I0.5680.54
83_A86_K0.5670.54
379_N414_A0.5650.54
59_A107_G0.5650.54
235_P238_C0.5640.53
391_L403_L0.5630.53
6_Q10_K0.5620.53
296_L300_N0.5620.53
196_W227_F0.5620.53
139_T143_A0.5610.53
137_I409_A0.5580.53
233_G341_Y0.5570.52
370_E374_Q0.5560.52
108_Y112_R0.5560.52
202_Y216_D0.5550.52
161_G222_Y0.5550.52
363_D368_L0.5550.52
406_K415_L0.5540.52
244_T250_R0.5540.52
207_G213_F0.5520.52
378_E381_M0.5510.52
211_R323_I0.5510.52
7_K62_I0.5500.52
339_A345_F0.5500.52
55_A99_G0.5490.51
364_V368_L0.5490.51
99_G103_G0.5480.51
373_V377_N0.5480.51
409_A413_E0.5470.51
376_V380_I0.5470.51
346_Y351_A0.5470.51
392_Q408_T0.5470.51
364_V371_N0.5450.51
304_I333_V0.5450.51
167_L174_I0.5440.51
345_F351_A0.5440.51
196_W312_A0.5440.51
410_L418_K0.5430.51
27_A313_G0.5430.51
220_G226_F0.5420.51
67_N128_R0.5410.50
95_A98_G0.5400.50
389_E393_T0.5400.50
120_E123_G0.5400.50
201_E221_T0.5390.50
375_D412_D0.5390.50
241_M245_A0.5380.50
369_D375_D0.5380.50
174_I178_F0.5380.50
92_N154_Q0.5370.50
239_L261_A0.5370.50
322_G328_L0.5360.50
380_I409_A0.5360.50
47_F209_L0.5360.50
394_I414_A0.5340.50
373_V396_H0.5340.50
281_S284_L0.5320.49
231_M264_A0.5320.49
6_Q9_G0.5320.49
51_P55_A0.5320.49
170_I365_D0.5320.49
283_L348_L0.5300.49
274_E277_F0.5300.49
102_A109_T0.5280.49
82_D86_K0.5270.49
323_I327_P0.5270.49
349_I354_L0.5270.49
22_V25_I0.5250.48
97_F101_I0.5240.48
161_G201_E0.5230.48
393_T408_T0.5230.48
247_P251_K0.5220.48
293_G297_F0.5210.48
246_K355_K0.5210.48
56_I71_G0.5210.48
342_F349_I0.5200.48
383_K389_E0.5200.48
62_I123_G0.5190.48
26_L315_I0.5160.47
222_Y306_S0.5160.47
391_L411_V0.5160.47
278_M288_H0.5150.47
383_K388_K0.5150.47
45_A74_G0.5150.47
102_A146_F0.5150.47
40_Y44_T0.5150.47
363_D414_A0.5150.47
108_Y409_A0.5140.47
184_P274_E0.5140.47
152_P155_S0.5140.47
84_A88_I0.5120.47
180_R316_D0.5120.47
37_P41_Q0.5110.47
159_S163_W0.5110.47
211_R321_Y0.5090.46
172_A306_S0.5080.46
172_A177_L0.5080.46
389_E411_V0.5080.46
43_G311_S0.5070.46
392_Q403_L0.5060.46
195_F233_G0.5060.46
57_G100_I0.5040.46
408_T411_V0.5040.46
379_N393_T0.5030.46
223_M227_F0.5020.45
408_T418_K0.5020.45
215_K218_T0.5020.45
158_N162_E0.5000.45
100_I238_C0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.792 100 0.655 Contact Map
1ibaA 1 0.1659 99.9 0.821 Contact Map
3bp3A 1 0.177 99.9 0.824 Contact Map
3ipjA 1 0.1792 99.8 0.837 Contact Map
3wdoA 1 0.7876 59.5 0.969 Contact Map
4pypA 1 0.7257 37.8 0.973 Contact Map
4ea3A 2 0.1814 37.3 0.973 Contact Map
3cw2K 1 0.2168 33.6 0.974 Contact Map
2d74B 1 0.2102 27.8 0.975 Contact Map
4mt1A 3 0.2854 25.7 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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