GREMLIN Database
HIS1 - ATP phosphoribosyltransferase
UniProt: O34520 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (202)
Sequences: 2822 (1434)
Seq/√Len: 100.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_H177_D3.6731.00
89_D179_T3.4281.00
162_Q166_E3.0241.00
98_A171_E3.0231.00
103_P168_G3.0191.00
126_F133_V2.9401.00
124_S128_E2.9111.00
6_T49_R2.7151.00
84_V183_I2.6821.00
86_E181_R2.6701.00
98_A158_V2.5671.00
18_A71_I2.5331.00
122_A155_V2.5261.00
14_I180_S2.5181.00
103_P170_V2.4991.00
101_G172_T2.4831.00
87_V184_V2.4821.00
83_D186_P2.4701.00
96_H171_E2.3941.00
62_V183_I2.3031.00
74_K86_E2.3001.00
104_N170_V2.2201.00
100_A164_L2.0691.00
123_S127_R2.0631.00
96_H174_H2.0401.00
69_V182_F2.0251.00
78_L176_C1.9691.00
81_E124_S1.9631.00
98_A174_H1.8981.00
17_E159_S1.8481.00
125_Y173_E1.8011.00
120_N123_S1.7711.00
129_Q173_E1.7591.00
99_V155_V1.7031.00
99_V125_Y1.6981.00
68_D192_K1.6891.00
74_K89_D1.6381.00
78_L124_S1.6271.00
114_I126_F1.6041.00
114_I153_R1.5801.00
29_L50_F1.5731.00
171_E174_H1.5441.00
27_Y43_V1.4901.00
4_L49_R1.4891.00
91_N179_T1.4831.00
193_D197_D1.4491.00
159_S171_E1.4331.00
120_N124_S1.3931.00
101_G153_R1.3851.00
145_A151_A1.3831.00
8_A67_A1.3810.99
162_Q165_K1.3760.99
4_L47_N1.3710.99
94_K177_D1.3540.99
21_L203_L1.3520.99
71_I180_S1.3480.99
92_I180_S1.3250.99
42_D49_R1.3250.99
10_P55_P1.3250.99
112_P153_R1.2960.99
7_M50_F1.2840.99
7_M22_L1.2810.99
110_V125_Y1.2770.99
194_D198_E1.2580.99
126_F155_V1.2530.99
185_N188_S1.2440.99
101_G105_T1.2350.99
89_D181_R1.2280.99
182_F200_A1.2090.99
85_Y186_P1.2040.99
144_L148_I1.1920.99
31_E38_K1.1860.98
88_L200_A1.1780.98
87_V189_Y1.1750.98
202_R205_L1.1720.98
74_K78_L1.1580.98
88_L207_V1.1580.98
88_L204_S1.1480.98
94_K159_S1.1400.98
99_V153_R1.1380.98
68_D188_S1.1360.98
101_G170_V1.1330.98
7_M48_L1.1330.98
94_K179_T1.1320.98
22_L50_F1.1300.98
197_D201_S1.1240.98
99_V122_A1.1190.98
47_N195_V1.0930.97
97_L121_V1.0890.97
43_V46_E1.0800.97
81_E120_N1.0740.97
69_V184_V1.0560.97
18_A92_I1.0560.97
107_W110_V1.0420.96
204_S208_E1.0390.96
69_V196_I1.0390.96
85_Y184_V1.0080.96
77_M84_V1.0070.96
100_A146_P0.9960.95
14_I92_I0.9930.95
91_N94_K0.9890.95
57_D138_L0.9820.95
97_L157_I0.9710.95
4_L195_V0.9680.95
20_G24_Q0.9670.95
4_L192_K0.9640.95
24_Q206_V0.9590.94
101_G107_W0.9500.94
9_M50_F0.9460.94
121_V176_C0.9450.94
115_A138_L0.9420.94
63_E82_R0.9350.94
125_Y128_E0.9150.93
10_P72_A0.9090.93
70_G183_I0.9090.93
158_V171_E0.8930.92
155_V175_I0.8870.92
59_T80_E0.8850.92
116_T119_P0.8810.91
76_V97_L0.8720.91
17_E20_G0.8720.91
124_S127_R0.8720.91
53_A58_V0.8710.91
197_D200_A0.8710.91
201_S204_S0.8630.91
10_P75_D0.8580.90
54_K141_S0.8410.89
138_L145_A0.8350.89
9_M71_I0.8350.89
198_E202_R0.8320.89
126_F153_R0.8250.89
25_A206_V0.8170.88
141_S148_I0.8160.88
200_A204_S0.8140.88
78_L121_V0.8120.88
93_S157_I0.8120.88
184_V200_A0.8020.87
68_D152_D0.8000.87
199_M202_R0.7990.87
55_P72_A0.7970.87
63_E84_V0.7960.87
100_A154_I0.7920.86
58_V156_D0.7890.86
138_L142_I0.7870.86
51_I61_Y0.7830.86
113_R134_E0.7790.86
69_V199_M0.7740.85
99_V175_I0.7740.85
40_I147_L0.7710.85
195_V198_E0.7700.85
56_M139_N0.7700.85
74_K178_I0.7650.85
95_C157_I0.7640.84
182_F199_M0.7620.84
102_L172_T0.7610.84
56_M76_V0.7560.84
54_K133_V0.7550.84
87_V200_A0.7540.84
20_G23_R0.7540.84
43_V48_L0.7520.84
194_D197_D0.7510.83
23_R28_R0.7500.83
97_L142_I0.7430.83
18_A54_K0.7420.83
119_P135_I0.7410.83
69_V200_A0.7390.82
78_L86_E0.7370.82
38_K166_E0.7320.82
39_L43_V0.7300.82
78_L81_E0.7270.81
74_K176_C0.7220.81
123_S132_Q0.7210.81
192_K195_V0.7200.81
39_L138_L0.7190.81
106_D109_G0.7170.81
99_V126_F0.7150.80
164_L167_N0.7120.80
110_V173_E0.7100.80
10_P56_M0.7080.80
119_P137_K0.7070.80
146_P167_N0.6990.79
13_R54_K0.6930.78
125_Y129_Q0.6930.78
146_P154_I0.6910.78
5_L195_V0.6880.78
96_H177_D0.6840.77
125_Y175_I0.6840.77
108_S170_V0.6780.77
71_I90_L0.6780.77
84_V186_P0.6740.76
59_T97_L0.6740.76
55_P92_I0.6670.76
15_F159_S0.6670.76
63_E83_D0.6660.75
54_K139_N0.6630.75
138_L158_V0.6620.75
74_K181_R0.6570.74
11_K75_D0.6540.74
58_V70_G0.6540.74
54_K178_I0.6520.74
28_R44_P0.6510.74
31_E199_M0.6470.73
62_V70_G0.6470.73
74_K179_T0.6470.73
97_L139_N0.6410.73
43_V50_F0.6400.73
11_K37_R0.6390.72
55_P75_D0.6380.72
112_P152_D0.6360.72
106_D170_V0.6340.72
154_I167_N0.6330.72
109_G172_T0.6320.72
142_I158_V0.6280.71
55_P76_V0.6280.71
76_V95_C0.6280.71
22_L199_M0.6250.71
5_L206_V0.6230.71
29_L113_R0.6190.70
13_R27_Y0.6140.69
100_A159_S0.6130.69
53_A189_Y0.6130.69
81_E84_V0.6120.69
59_T76_V0.6050.68
62_V185_N0.6030.68
97_L118_Y0.6010.68
56_M121_V0.5990.68
14_I93_S0.5980.67
111_A133_V0.5970.67
85_Y187_V0.5960.67
97_L174_H0.5960.67
102_L105_T0.5940.67
39_L57_D0.5940.67
10_P59_T0.5910.66
15_F138_L0.5900.66
62_V67_A0.5900.66
21_L206_V0.5890.66
184_V189_Y0.5880.66
75_D93_S0.5880.66
66_V150_L0.5880.66
106_D127_R0.5860.66
108_S123_S0.5860.66
40_I149_G0.5840.66
57_D142_I0.5840.66
60_T64_H0.5830.65
51_I67_A0.5810.65
102_L168_G0.5800.65
123_S135_I0.5800.65
149_G163_T0.5790.65
14_I175_I0.5790.65
117_K142_I0.5750.64
20_G44_P0.5720.64
105_T108_S0.5720.64
10_P178_I0.5700.64
27_Y59_T0.5700.64
52_L148_I0.5690.64
156_D161_G0.5640.63
90_L180_S0.5610.62
24_Q194_D0.5600.62
26_G91_N0.5570.62
198_E201_S0.5540.62
14_I178_I0.5530.61
61_Y157_I0.5490.61
121_V124_S0.5470.61
4_L31_E0.5460.60
167_N208_E0.5410.60
22_L71_I0.5400.60
83_D160_T0.5380.59
120_N128_E0.5370.59
92_I142_I0.5350.59
8_A62_V0.5340.59
10_P76_V0.5330.59
198_E207_V0.5330.59
82_R109_G0.5270.58
85_Y190_R0.5270.58
201_S205_L0.5270.58
10_P93_S0.5240.57
121_V157_I0.5230.57
42_D69_V0.5220.57
55_P159_S0.5220.57
52_L157_I0.5220.57
15_F22_L0.5200.57
19_A29_L0.5200.57
199_M203_L0.5200.57
192_K197_D0.5200.57
147_L160_T0.5160.56
51_I178_I0.5150.56
156_D163_T0.5150.56
13_R145_A0.5150.56
151_A195_V0.5150.56
64_H134_E0.5140.56
6_T51_I0.5120.56
98_A178_I0.5100.55
26_G153_R0.5090.55
146_P151_A0.5090.55
28_R71_I0.5070.55
11_K25_A0.5050.55
88_L203_L0.5040.54
110_V131_E0.5030.54
115_A151_A0.5030.54
53_A56_M0.5030.54
54_K159_S0.5010.54
37_R65_G0.5010.54
79_E146_P0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vd2A 2 0.9906 100 0.034 Contact Map
2vd3A 5 0.9906 100 0.053 Contact Map
1nh8A 5 0.939 100 0.058 Contact Map
1z7mE 2 0.9531 100 0.06 Contact Map
1o63A 2 0.9531 100 0.063 Contact Map
1ve4A 1 0.939 100 0.064 Contact Map
1h3dA 4 0.9765 100 0.065 Contact Map
3qslA 1 0.9437 97.4 0.891 Contact Map
3ix1A 2 0.9249 97.3 0.893 Contact Map
2nxoA 2 0.8967 97.1 0.896 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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