HIS1 - BACSU - GREMLIN Contacts

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HIS1 - ATP phosphoribosyltransferase

UniProt:	O34520	Sequences: MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVPEENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGLPNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVSTGQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	213 (202)
Sequences:	2822 (1434)
Seq/√Len:	100.9

ECOLI - HIS1
BACSU - HIS1
HALSA - HIS1
SULSO - HIS1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
174_H	177_D	3.673	1.00
89_D	179_T	3.428	1.00
162_Q	166_E	3.024	1.00
98_A	171_E	3.023	1.00
103_P	168_G	3.019	1.00
126_F	133_V	2.940	1.00
124_S	128_E	2.911	1.00
6_T	49_R	2.715	1.00
84_V	183_I	2.682	1.00
86_E	181_R	2.670	1.00
98_A	158_V	2.567	1.00
18_A	71_I	2.533	1.00
122_A	155_V	2.526	1.00
14_I	180_S	2.518	1.00
103_P	170_V	2.499	1.00
101_G	172_T	2.483	1.00
87_V	184_V	2.482	1.00
83_D	186_P	2.470	1.00
96_H	171_E	2.394	1.00
62_V	183_I	2.303	1.00
74_K	86_E	2.300	1.00
104_N	170_V	2.220	1.00
100_A	164_L	2.069	1.00
123_S	127_R	2.063	1.00
96_H	174_H	2.040	1.00
69_V	182_F	2.025	1.00
78_L	176_C	1.969	1.00
81_E	124_S	1.963	1.00
98_A	174_H	1.898	1.00
17_E	159_S	1.848	1.00
125_Y	173_E	1.801	1.00
120_N	123_S	1.771	1.00
129_Q	173_E	1.759	1.00
99_V	155_V	1.703	1.00
99_V	125_Y	1.698	1.00
68_D	192_K	1.689	1.00
74_K	89_D	1.638	1.00
78_L	124_S	1.627	1.00
114_I	126_F	1.604	1.00
114_I	153_R	1.580	1.00
29_L	50_F	1.573	1.00
171_E	174_H	1.544	1.00
27_Y	43_V	1.490	1.00
4_L	49_R	1.489	1.00
91_N	179_T	1.483	1.00
193_D	197_D	1.449	1.00
159_S	171_E	1.433	1.00
120_N	124_S	1.393	1.00
101_G	153_R	1.385	1.00
145_A	151_A	1.383	1.00
8_A	67_A	1.381	0.99
162_Q	165_K	1.376	0.99
4_L	47_N	1.371	0.99
94_K	177_D	1.354	0.99
21_L	203_L	1.352	0.99
71_I	180_S	1.348	0.99
92_I	180_S	1.325	0.99
42_D	49_R	1.325	0.99
10_P	55_P	1.325	0.99
112_P	153_R	1.296	0.99
7_M	50_F	1.284	0.99
7_M	22_L	1.281	0.99
110_V	125_Y	1.277	0.99
194_D	198_E	1.258	0.99
126_F	155_V	1.253	0.99
185_N	188_S	1.244	0.99
101_G	105_T	1.235	0.99
89_D	181_R	1.228	0.99
182_F	200_A	1.209	0.99
85_Y	186_P	1.204	0.99
144_L	148_I	1.192	0.99
31_E	38_K	1.186	0.98
88_L	200_A	1.178	0.98
87_V	189_Y	1.175	0.98
202_R	205_L	1.172	0.98
74_K	78_L	1.158	0.98
88_L	207_V	1.158	0.98
88_L	204_S	1.148	0.98
94_K	159_S	1.140	0.98
99_V	153_R	1.138	0.98
68_D	188_S	1.136	0.98
101_G	170_V	1.133	0.98
7_M	48_L	1.133	0.98
94_K	179_T	1.132	0.98
22_L	50_F	1.130	0.98
197_D	201_S	1.124	0.98
99_V	122_A	1.119	0.98
47_N	195_V	1.093	0.97
97_L	121_V	1.089	0.97
43_V	46_E	1.080	0.97
81_E	120_N	1.074	0.97
69_V	184_V	1.056	0.97
18_A	92_I	1.056	0.97
107_W	110_V	1.042	0.96
204_S	208_E	1.039	0.96
69_V	196_I	1.039	0.96
85_Y	184_V	1.008	0.96
77_M	84_V	1.007	0.96
100_A	146_P	0.996	0.95
14_I	92_I	0.993	0.95
91_N	94_K	0.989	0.95
57_D	138_L	0.982	0.95
97_L	157_I	0.971	0.95
4_L	195_V	0.968	0.95
20_G	24_Q	0.967	0.95
4_L	192_K	0.964	0.95
24_Q	206_V	0.959	0.94
101_G	107_W	0.950	0.94
9_M	50_F	0.946	0.94
121_V	176_C	0.945	0.94
115_A	138_L	0.942	0.94
63_E	82_R	0.935	0.94
125_Y	128_E	0.915	0.93
10_P	72_A	0.909	0.93
70_G	183_I	0.909	0.93
158_V	171_E	0.893	0.92
155_V	175_I	0.887	0.92
59_T	80_E	0.885	0.92
116_T	119_P	0.881	0.91
76_V	97_L	0.872	0.91
17_E	20_G	0.872	0.91
124_S	127_R	0.872	0.91
53_A	58_V	0.871	0.91
197_D	200_A	0.871	0.91
201_S	204_S	0.863	0.91
10_P	75_D	0.858	0.90
54_K	141_S	0.841	0.89
138_L	145_A	0.835	0.89
9_M	71_I	0.835	0.89
198_E	202_R	0.832	0.89
126_F	153_R	0.825	0.89
25_A	206_V	0.817	0.88
141_S	148_I	0.816	0.88
200_A	204_S	0.814	0.88
78_L	121_V	0.812	0.88
93_S	157_I	0.812	0.88
184_V	200_A	0.802	0.87
68_D	152_D	0.800	0.87
199_M	202_R	0.799	0.87
55_P	72_A	0.797	0.87
63_E	84_V	0.796	0.87
100_A	154_I	0.792	0.86
58_V	156_D	0.789	0.86
138_L	142_I	0.787	0.86
51_I	61_Y	0.783	0.86
113_R	134_E	0.779	0.86
69_V	199_M	0.774	0.85
99_V	175_I	0.774	0.85
40_I	147_L	0.771	0.85
195_V	198_E	0.770	0.85
56_M	139_N	0.770	0.85
74_K	178_I	0.765	0.85
95_C	157_I	0.764	0.84
182_F	199_M	0.762	0.84
102_L	172_T	0.761	0.84
56_M	76_V	0.756	0.84
54_K	133_V	0.755	0.84
87_V	200_A	0.754	0.84
20_G	23_R	0.754	0.84
43_V	48_L	0.752	0.84
194_D	197_D	0.751	0.83
23_R	28_R	0.750	0.83
97_L	142_I	0.743	0.83
18_A	54_K	0.742	0.83
119_P	135_I	0.741	0.83
69_V	200_A	0.739	0.82
78_L	86_E	0.737	0.82
38_K	166_E	0.732	0.82
39_L	43_V	0.730	0.82
78_L	81_E	0.727	0.81
74_K	176_C	0.722	0.81
123_S	132_Q	0.721	0.81
192_K	195_V	0.720	0.81
39_L	138_L	0.719	0.81
106_D	109_G	0.717	0.81
99_V	126_F	0.715	0.80
164_L	167_N	0.712	0.80
110_V	173_E	0.710	0.80
10_P	56_M	0.708	0.80
119_P	137_K	0.707	0.80
146_P	167_N	0.699	0.79
13_R	54_K	0.693	0.78
125_Y	129_Q	0.693	0.78
146_P	154_I	0.691	0.78
5_L	195_V	0.688	0.78
96_H	177_D	0.684	0.77
125_Y	175_I	0.684	0.77
108_S	170_V	0.678	0.77
71_I	90_L	0.678	0.77
84_V	186_P	0.674	0.76
59_T	97_L	0.674	0.76
55_P	92_I	0.667	0.76
15_F	159_S	0.667	0.76
63_E	83_D	0.666	0.75
54_K	139_N	0.663	0.75
138_L	158_V	0.662	0.75
74_K	181_R	0.657	0.74
11_K	75_D	0.654	0.74
58_V	70_G	0.654	0.74
54_K	178_I	0.652	0.74
28_R	44_P	0.651	0.74
31_E	199_M	0.647	0.73
62_V	70_G	0.647	0.73
74_K	179_T	0.647	0.73
97_L	139_N	0.641	0.73
43_V	50_F	0.640	0.73
11_K	37_R	0.639	0.72
55_P	75_D	0.638	0.72
112_P	152_D	0.636	0.72
106_D	170_V	0.634	0.72
154_I	167_N	0.633	0.72
109_G	172_T	0.632	0.72
142_I	158_V	0.628	0.71
55_P	76_V	0.628	0.71
76_V	95_C	0.628	0.71
22_L	199_M	0.625	0.71
5_L	206_V	0.623	0.71
29_L	113_R	0.619	0.70
13_R	27_Y	0.614	0.69
100_A	159_S	0.613	0.69
53_A	189_Y	0.613	0.69
81_E	84_V	0.612	0.69
59_T	76_V	0.605	0.68
62_V	185_N	0.603	0.68
97_L	118_Y	0.601	0.68
56_M	121_V	0.599	0.68
14_I	93_S	0.598	0.67
111_A	133_V	0.597	0.67
85_Y	187_V	0.596	0.67
97_L	174_H	0.596	0.67
102_L	105_T	0.594	0.67
39_L	57_D	0.594	0.67
10_P	59_T	0.591	0.66
15_F	138_L	0.590	0.66
62_V	67_A	0.590	0.66
21_L	206_V	0.589	0.66
184_V	189_Y	0.588	0.66
75_D	93_S	0.588	0.66
66_V	150_L	0.588	0.66
106_D	127_R	0.586	0.66
108_S	123_S	0.586	0.66
40_I	149_G	0.584	0.66
57_D	142_I	0.584	0.66
60_T	64_H	0.583	0.65
51_I	67_A	0.581	0.65
102_L	168_G	0.580	0.65
123_S	135_I	0.580	0.65
149_G	163_T	0.579	0.65
14_I	175_I	0.579	0.65
117_K	142_I	0.575	0.64
20_G	44_P	0.572	0.64
105_T	108_S	0.572	0.64
10_P	178_I	0.570	0.64
27_Y	59_T	0.570	0.64
52_L	148_I	0.569	0.64
156_D	161_G	0.564	0.63
90_L	180_S	0.561	0.62
24_Q	194_D	0.560	0.62
26_G	91_N	0.557	0.62
198_E	201_S	0.554	0.62
14_I	178_I	0.553	0.61
61_Y	157_I	0.549	0.61
121_V	124_S	0.547	0.61
4_L	31_E	0.546	0.60
167_N	208_E	0.541	0.60
22_L	71_I	0.540	0.60
83_D	160_T	0.538	0.59
120_N	128_E	0.537	0.59
92_I	142_I	0.535	0.59
8_A	62_V	0.534	0.59
10_P	76_V	0.533	0.59
198_E	207_V	0.533	0.59
82_R	109_G	0.527	0.58
85_Y	190_R	0.527	0.58
201_S	205_L	0.527	0.58
10_P	93_S	0.524	0.57
121_V	157_I	0.523	0.57
42_D	69_V	0.522	0.57
55_P	159_S	0.522	0.57
52_L	157_I	0.522	0.57
15_F	22_L	0.520	0.57
19_A	29_L	0.520	0.57
199_M	203_L	0.520	0.57
192_K	197_D	0.520	0.57
147_L	160_T	0.516	0.56
51_I	178_I	0.515	0.56
156_D	163_T	0.515	0.56
13_R	145_A	0.515	0.56
151_A	195_V	0.515	0.56
64_H	134_E	0.514	0.56
6_T	51_I	0.512	0.56
98_A	178_I	0.510	0.55
26_G	153_R	0.509	0.55
146_P	151_A	0.509	0.55
28_R	71_I	0.507	0.55
11_K	25_A	0.505	0.55
88_L	203_L	0.504	0.54
110_V	131_E	0.503	0.54
115_A	151_A	0.503	0.54
53_A	56_M	0.503	0.54
54_K	159_S	0.501	0.54
37_R	65_G	0.501	0.54
79_E	146_P	0.500	0.54

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vd2A	2	0.9906	100	0.034	Contact Map
2vd3A	5	0.9906	100	0.053	Contact Map
1nh8A	5	0.939	100	0.058	Contact Map
1z7mE	2	0.9531	100	0.06	Contact Map
1o63A	2	0.9531	100	0.063	Contact Map
1ve4A	1	0.939	100	0.064	Contact Map
1h3dA	4	0.9765	100	0.065	Contact Map
3qslA	1	0.9437	97.4	0.891	Contact Map
3ix1A	2	0.9249	97.3	0.893	Contact Map
2nxoA	2	0.8967	97.1	0.896	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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