GREMLIN Database
AMYC - Putative ABC transporter permease protein AmyC
UniProt: O34518 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 276 (251)
Sequences: 71180 (46488)
Seq/√Len: 2934.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_K185_T3.9651.00
70_I74_I3.3241.00
173_R182_I3.1711.00
157_S161_R3.0431.00
67_N70_I2.6681.00
68_S228_A2.6121.00
96_R169_V2.5911.00
178_G181_K2.5491.00
172_A182_I2.5321.00
159_F194_I2.4771.00
78_F141_I2.4621.00
34_S56_F2.4521.00
169_V187_V2.4251.00
223_Q231_G2.3841.00
66_G70_I2.3811.00
57_S61_E2.3651.00
179_M182_I2.3431.00
54_H57_S2.3371.00
180_L184_F2.2481.00
80_A199_C2.2431.00
156_Y195_T2.2291.00
99_T102_N2.1831.00
54_H58_E2.1221.00
239_N242_L2.1221.00
82_L145_T2.0721.00
177_A181_K2.0271.00
181_K184_F1.9881.00
168_L190_L1.9721.00
88_S183_F1.9641.00
95_A161_R1.9601.00
152_T198_I1.9561.00
160_I191_L1.9381.00
172_A177_A1.8931.00
32_T36_K1.8781.00
28_Y32_T1.8301.00
106_F157_S1.8121.00
88_S191_L1.8101.00
67_N71_N1.7901.00
169_V182_I1.7881.00
84_I199_C1.7381.00
173_R179_M1.7281.00
74_I78_F1.6981.00
220_Q223_Q1.6951.00
88_S156_Y1.6941.00
87_G152_T1.6931.00
79_S206_I1.6831.00
169_V173_R1.6711.00
76_T203_C1.6671.00
90_A153_V1.6271.00
94_L153_V1.6011.00
58_E242_L1.5491.00
228_A232_F1.5341.00
13_T17_A1.5201.00
25_I29_I1.4931.00
58_E61_E1.4921.00
166_K169_V1.4821.00
152_T202_S1.4591.00
101_L104_A1.4401.00
98_E102_N1.4221.00
91_A156_Y1.4111.00
210_Y214_I1.3941.00
85_I89_L1.3911.00
197_T201_I1.3901.00
75_I224_T1.3731.00
29_I33_T1.3711.00
53_F57_S1.3691.00
160_I187_V1.3671.00
95_A157_S1.3661.00
31_L248_L1.3431.00
52_S55_N1.3431.00
83_L202_S1.3421.00
64_S67_N1.3231.00
166_K170_E1.3021.00
156_Y198_I1.2991.00
135_N139_I1.2821.00
188_F195_T1.2811.00
172_A186_I1.2781.00
96_R166_K1.2611.00
212_F216_F1.2501.00
167_E170_E1.2441.00
223_Q228_A1.2431.00
88_S195_T1.2361.00
104_A107_A1.2331.00
137_H222_V1.2311.00
217_L222_V1.2311.00
71_N74_I1.2291.00
178_G182_I1.2191.00
210_Y230_A1.2081.00
143_I216_F1.2081.00
259_L263_K1.2051.00
232_F239_N1.2051.00
231_G235_E1.1981.00
81_L85_I1.1951.00
164_I190_L1.1901.00
92_Y160_I1.1871.00
140_A213_A1.1851.00
72_T225_L1.1791.00
78_F81_L1.1731.00
219_D222_V1.1661.00
136_T139_I1.1561.00
17_A21_C1.1251.00
84_I195_T1.1131.00
192_K196_A1.1131.00
232_F237_A1.1041.00
224_T227_V1.1031.00
37_A40_D1.0961.00
40_D50_D1.0921.00
169_V179_M1.0891.00
29_I32_T1.0811.00
104_A108_L1.0771.00
30_L248_L1.0741.00
78_F82_L1.0671.00
149_M153_V1.0661.00
95_A160_I1.0591.00
223_Q227_V1.0521.00
79_S83_L1.0501.00
10_R14_L1.0391.00
89_L93_P1.0211.00
156_Y194_I1.0211.00
79_S144_N1.0191.00
126_R130_D1.0171.00
190_L193_P1.0111.00
82_L141_I0.9991.00
60_W66_G0.9991.00
209_D212_F0.9881.00
155_L198_I0.9881.00
228_A231_G0.9841.00
92_Y179_M0.9841.00
12_I16_A0.9781.00
260_A264_Y0.9781.00
92_Y183_F0.9751.00
58_E62_R0.9731.00
177_A182_I0.9691.00
73_M77_G0.9601.00
9_M13_T0.9601.00
133_M138_A0.9591.00
10_R13_T0.9491.00
213_A224_T0.9471.00
33_T36_K0.9441.00
124_L216_F0.9341.00
102_N161_R0.9271.00
209_D213_A0.9271.00
124_L143_I0.9191.00
74_I137_H0.9191.00
77_G81_L0.9171.00
141_I145_T0.9141.00
182_I185_T0.9131.00
81_L199_C0.9111.00
34_S38_K0.9071.00
74_I77_G0.9061.00
20_A24_F0.9061.00
100_K103_K0.9061.00
94_L106_F0.9051.00
91_A95_A0.9051.00
152_T156_Y0.8961.00
228_A246_A0.8931.00
55_N241_H0.8931.00
56_F248_L0.8921.00
69_F225_L0.8911.00
233_F243_V0.8891.00
110_I154_F0.8851.00
87_G153_V0.8741.00
230_A234_G0.8731.00
214_I227_V0.8681.00
144_N206_I0.8651.00
156_Y191_L0.8651.00
159_F191_L0.8611.00
79_S141_I0.8601.00
36_K40_D0.8601.00
82_L85_I0.8591.00
83_L87_G0.8571.00
135_N219_D0.8571.00
69_F73_M0.8541.00
47_F50_D0.8511.00
179_M183_F0.8451.00
183_F188_F0.8431.00
103_K106_F0.8421.00
191_L194_I0.8401.00
33_T37_A0.8351.00
70_I73_M0.8281.00
83_L148_Y0.8171.00
184_F188_F0.8161.00
91_A160_I0.8141.00
182_I187_V0.8131.00
227_V231_G0.8111.00
35_L51_I0.8111.00
244_A248_L0.8091.00
192_K195_T0.8091.00
75_I144_N0.8071.00
202_S206_I0.8041.00
91_A153_V0.8021.00
65_L246_A0.8021.00
117_P147_A0.8001.00
51_I54_H0.7961.00
30_L244_A0.7941.00
93_P99_T0.7941.00
53_F56_F0.7921.00
256_V260_A0.7881.00
192_K264_Y0.7851.00
83_L152_T0.7851.00
143_I212_F0.7791.00
177_A185_T0.7771.00
50_D53_F0.7761.00
90_A149_M0.7751.00
125_Y129_V0.7751.00
254_M258_F0.7691.00
33_T244_A0.7651.00
87_G156_Y0.7631.00
64_S220_Q0.7631.00
183_F187_V0.7581.00
140_A144_N0.7481.00
38_K42_S0.7441.00
250_A254_M0.7441.00
129_V134_V0.7431.00
168_L186_I0.7381.00
39_G42_S0.7341.00
86_F145_T0.7331.00
58_E239_N0.7331.00
121_M211_Q0.7311.00
242_L246_A0.7291.00
59_A249_M0.7291.00
68_S71_N0.7291.00
241_H244_A0.7281.00
166_K173_R0.7241.00
232_F246_A0.7221.00
255_V259_L0.7221.00
121_M215_F0.7191.00
217_L223_Q0.7191.00
84_I156_Y0.7181.00
194_I198_I0.7171.00
25_I28_Y0.7151.00
62_R66_G0.7131.00
94_L105_V0.7091.00
171_A175_D0.7091.00
66_G69_F0.7051.00
40_D49_A0.7001.00
232_F242_L0.7001.00
135_N138_A0.6971.00
131_A134_V0.6971.00
80_A203_C0.6941.00
63_A67_N0.6931.00
75_I140_A0.6931.00
11_I15_L0.6901.00
94_L157_S0.6891.00
83_L206_I0.6881.00
100_K104_A0.6861.00
171_A174_I0.6861.00
79_S145_T0.6851.00
261_L264_Y0.6821.00
19_V23_H0.6801.00
124_L127_M0.6771.00
35_L52_S0.6761.00
11_I14_L0.6721.00
14_L17_A0.6711.00
76_T80_A0.6711.00
55_N58_E0.6701.00
140_A217_L0.6701.00
36_K48_P0.6661.00
117_P211_Q0.6661.00
156_Y160_I0.6641.00
187_V190_L0.6631.00
57_S60_W0.6621.00
37_A49_A0.6621.00
195_T198_I0.6591.00
37_A50_D0.6581.00
110_I113_M0.6561.00
50_D54_H0.6551.00
20_A23_H0.6511.00
148_Y202_S0.6481.00
164_I191_L0.6471.00
75_I141_I0.6401.00
52_S56_F0.6391.00
80_A84_I0.6381.00
209_D224_T0.6371.00
98_E103_K0.6361.00
244_A247_A0.6361.00
240_L244_A0.6351.00
232_F235_E0.6321.00
260_A263_K0.6311.00
204_V208_N0.6301.00
225_L250_A0.6291.00
259_L262_Q0.6271.00
68_S225_L0.6271.00
24_F28_Y0.6231.00
21_C25_I0.6211.00
15_L19_V0.6201.00
72_T226_T0.6171.00
247_A250_A0.6171.00
126_R129_V0.6161.00
195_T199_C0.6151.00
90_A109_L0.6131.00
101_L105_V0.6131.00
75_I137_H0.6091.00
211_Q214_I0.6071.00
30_L247_A0.6071.00
99_T105_V0.6071.00
106_F154_F0.6061.00
26_P30_L0.6021.00
26_P33_T0.6021.00
78_F145_T0.5991.00
80_A206_I0.5991.00
117_P121_M0.5991.00
16_A20_A0.5971.00
72_T207_W0.5971.00
205_F208_N0.5961.00
120_S146_A0.5931.00
184_F187_V0.5921.00
109_L150_P0.5911.00
229_M246_A0.5891.00
75_I79_S0.5871.00
86_F149_M0.5871.00
113_M150_P0.5861.00
63_A66_G0.5861.00
148_Y205_F0.5781.00
258_F262_Q0.5761.00
93_P97_R0.5761.00
9_M12_I0.5751.00
211_Q215_F0.5751.00
48_P51_I0.5731.00
155_L194_I0.5721.00
199_C202_S0.5721.00
118_L215_F0.5711.00
13_T16_A0.5701.00
91_A157_S0.5691.00
196_A199_C0.5691.00
83_L145_T0.5681.00
76_T207_W0.5651.00
76_T206_I0.5641.00
242_L245_A0.5631.00
33_T38_K0.5611.00
182_I186_I0.5581.00
240_L243_V0.5571.00
226_T250_A0.5571.00
97_R179_M0.5561.00
92_Y187_V0.5551.00
22_A26_P0.5551.00
103_K107_A0.5551.00
144_N209_D0.5511.00
71_N222_V0.5501.00
107_A111_S0.5501.00
115_I120_S0.5501.00
67_N74_I0.5471.00
106_F161_R0.5431.00
170_E173_R0.5431.00
128_V134_V0.5421.00
59_A246_A0.5421.00
38_K48_P0.5411.00
64_S228_A0.5411.00
85_I88_S0.5401.00
113_M151_L0.5391.00
121_M125_Y0.5381.00
36_K50_D0.5381.00
59_A242_L0.5331.00
90_A93_P0.5291.00
226_T229_M0.5271.00
133_M136_T0.5261.00
108_L112_I0.5251.00
105_V109_L0.5241.00
26_P29_I0.5211.00
102_N106_F0.5191.00
202_S205_F0.5181.00
227_V230_A0.5161.00
112_I150_P0.5151.00
62_R242_L0.5131.00
198_I202_S0.5111.00
187_V191_L0.5091.00
206_I209_D0.5091.00
98_E166_K0.5081.00
253_P256_V0.5081.00
36_K49_A0.5081.00
256_V259_L0.5081.00
34_S245_A0.5031.00
60_W63_A0.5031.00
47_F51_I0.5031.00
98_E101_L0.5001.00
109_L153_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlfG 1 0.9674 100 0.23 Contact Map
4tquN 1 0.9493 100 0.247 Contact Map
2onkC 2 0.8768 100 0.277 Contact Map
4tquM 1 0.9203 100 0.301 Contact Map
3d31C 2 0.8587 100 0.306 Contact Map
3rlfF 1 0.9203 100 0.357 Contact Map
4ymuD 2 0.7717 99.9 0.455 Contact Map
3tuiA 2 0.7536 99.9 0.504 Contact Map
4hfiA 3 0.4348 9.4 0.946 Contact Map
3hd7A 1 0.1196 7.3 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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