GREMLIN Database
YOCB - Uncharacterized protein YocB
UniProt: O34516 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 260 (247)
Sequences: 196 (167)
Seq/√Len: 10.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_S91_F5.4581.00
42_I45_K3.4670.97
21_I30_M3.1290.95
10_L55_L3.0750.95
142_V242_K2.7520.90
22_L73_M2.6110.88
54_Y114_E2.5690.87
208_A213_W2.4780.85
87_S179_P2.4700.85
196_L200_L2.3520.82
23_S112_Y2.2410.78
28_T130_P2.2020.77
142_V200_L2.1760.76
7_I228_L2.1580.75
167_W183_N2.1270.74
205_D233_N2.1050.74
25_Y91_F2.0900.73
83_D218_I2.0800.73
7_I252_V2.0430.71
172_S181_E2.0060.70
113_W167_W2.0050.70
83_D134_F1.9930.69
143_K232_M1.9280.67
106_P165_E1.9230.66
228_L232_M1.9200.66
111_F130_P1.9040.66
75_Q89_V1.8100.61
216_M247_E1.7890.61
23_S182_E1.7690.60
168_K181_E1.7560.59
38_G41_K1.7390.58
10_L122_L1.7260.58
68_G71_A1.7140.57
11_Q123_K1.6550.54
46_S133_A1.6360.53
69_I93_S1.6290.53
26_L44_L1.6250.53
106_P221_D1.6160.53
208_A216_M1.6100.52
10_L91_F1.5990.52
130_P195_R1.5960.52
77_L89_V1.5940.51
160_Y196_L1.5910.51
136_L249_E1.5870.51
151_K179_P1.5770.51
88_L222_K1.5720.50
172_S175_D1.5400.49
117_A135_I1.5380.49
39_E143_K1.5320.49
82_K88_L1.4900.47
185_M217_V1.4810.46
86_R153_E1.4790.46
133_A162_M1.4780.46
204_L228_L1.4780.46
31_R86_R1.4600.45
28_T113_W1.4580.45
225_A237_H1.4470.45
191_E216_M1.4440.44
132_T138_Q1.4210.43
7_I115_E1.4180.43
113_W198_K1.4160.43
106_P150_G1.4050.43
154_A210_A1.4000.42
206_Q252_V1.3890.42
176_K191_E1.3880.42
7_I10_L1.3800.41
87_S189_V1.3710.41
117_A228_L1.3670.41
120_D161_D1.3320.39
138_Q143_K1.3190.39
119_L236_I1.3150.39
122_L142_V1.3150.39
218_I228_L1.3020.38
22_L43_A1.2980.38
144_I207_K1.2920.37
110_R254_E1.2890.37
121_Q125_L1.2840.37
51_L69_I1.2820.37
107_V244_L1.2650.36
51_L228_L1.2360.35
29_D106_P1.2320.35
6_L134_F1.2310.35
5_S210_A1.2270.35
87_S106_P1.2130.34
129_Y220_G1.2110.34
55_L136_L1.2060.34
52_K70_R1.1910.33
44_L48_F1.1870.33
49_S198_K1.1840.33
121_Q196_L1.1760.33
55_L59_D1.1490.31
50_R53_E1.1390.31
162_M228_L1.1380.31
109_T198_K1.1180.30
143_K178_P1.1170.30
197_Y219_A1.1030.30
77_L206_Q1.1010.29
125_L142_V1.0980.29
18_P104_Q1.0950.29
172_S179_P1.0910.29
144_I253_I1.0810.29
188_H196_L1.0770.29
177_A182_E1.0730.28
137_T204_L1.0730.28
174_V178_P1.0510.28
23_S237_H1.0470.27
135_I254_E1.0450.27
88_L212_R1.0400.27
143_K247_E1.0370.27
63_E153_E1.0360.27
24_L247_E1.0350.27
182_E218_I1.0340.27
157_R223_E1.0320.27
54_Y113_W1.0310.27
43_A48_F1.0280.27
83_D135_I1.0270.27
33_P109_T1.0240.27
28_T158_Y1.0230.27
61_E152_I1.0200.26
24_L73_M1.0130.26
12_Y119_L1.0090.26
185_M196_L1.0070.26
115_E232_M1.0030.26
200_L222_K1.0020.26
104_Q133_A0.9960.26
89_V145_I0.9920.25
117_A180_F0.9900.25
90_F198_K0.9890.25
74_N161_D0.9870.25
42_I92_V0.9810.25
130_P243_N0.9800.25
17_P218_I0.9800.25
92_V110_R0.9750.25
23_S118_V0.9720.25
248_N255_H0.9710.25
115_E252_V0.9690.25
176_K180_F0.9650.24
27_N145_I0.9640.24
146_E213_W0.9630.24
55_L65_C0.9550.24
104_Q167_W0.9530.24
162_M170_S0.9490.24
133_A185_M0.9480.24
133_A196_L0.9470.24
44_L109_T0.9460.24
166_S196_L0.9440.24
248_N253_I0.9430.24
93_S113_W0.9350.23
13_V225_A0.9350.23
64_K197_Y0.9320.23
195_R200_L0.9280.23
133_A188_H0.9270.23
174_V177_A0.9260.23
22_L133_A0.9250.23
49_S53_E0.9240.23
25_Y119_L0.9230.23
144_I186_R0.9220.23
38_G219_A0.9220.23
201_A212_R0.9200.23
77_L99_E0.9190.23
133_A213_W0.9190.23
27_N125_L0.9160.23
191_E195_R0.9160.23
172_S176_K0.9130.23
112_Y118_V0.9120.23
139_Q242_K0.9090.23
176_K255_H0.9080.23
17_P20_K0.9020.22
133_A204_L0.9010.22
184_R189_V0.9010.22
195_R243_N0.9000.22
136_L252_V0.8990.22
83_D211_K0.8940.22
72_K194_S0.8920.22
127_Q145_I0.8900.22
203_S206_Q0.8860.22
110_R216_M0.8820.22
65_C134_F0.8820.22
9_K14_Q0.8770.22
66_L135_I0.8760.21
101_I196_L0.8740.21
169_N176_K0.8640.21
71_A231_H0.8590.21
106_P135_I0.8590.21
30_M133_A0.8560.21
47_G132_T0.8550.21
64_K123_K0.8550.21
40_W46_S0.8540.21
219_A236_I0.8510.21
117_A238_S0.8470.21
74_N212_R0.8470.21
73_M254_E0.8430.20
139_Q166_S0.8410.20
90_F155_V0.8380.20
24_L90_F0.8330.20
26_L40_W0.8290.20
18_P75_Q0.8270.20
169_N227_I0.8250.20
130_P147_T0.8190.20
183_N188_H0.8190.20
93_S117_A0.8180.20
21_I248_N0.8120.20
59_D145_I0.8120.20
87_S109_T0.8110.19
110_R119_L0.8080.19
39_E42_I0.8060.19
22_L113_W0.8010.19
60_P226_D0.8010.19
134_F253_I0.8000.19
87_S95_S0.7990.19
170_S189_V0.7960.19
166_S169_N0.7940.19
140_H178_P0.7900.19
103_L164_N0.7900.19
229_D237_H0.7890.19
115_E216_M0.7850.19
180_F186_R0.7840.19
10_L54_Y0.7840.19
125_L130_P0.7840.19
146_E182_E0.7820.19
167_W188_H0.7780.19
199_R252_V0.7760.18
226_D230_Q0.7690.18
99_E161_D0.7670.18
21_I154_A0.7660.18
24_L51_L0.7650.18
143_K251_K0.7640.18
186_R246_N0.7630.18
194_S237_H0.7590.18
173_A181_E0.7580.18
75_Q85_P0.7550.18
31_R217_V0.7470.18
8_N217_V0.7450.18
18_P222_K0.7430.18
136_L209_A0.7420.18
85_P194_S0.7390.17
168_K185_M0.7380.17
121_Q155_V0.7350.17
26_L110_R0.7300.17
133_A191_E0.7300.17
175_D230_Q0.7280.17
138_Q184_R0.7270.17
32_D68_G0.7270.17
74_N125_L0.7230.17
165_E229_D0.7200.17
80_M89_V0.7170.17
36_Q179_P0.7140.17
96_G185_M0.7120.17
71_A252_V0.7110.17
47_G242_K0.7090.17
8_N11_Q0.7040.17
40_W138_Q0.7030.16
14_Q135_I0.6980.16
194_S227_I0.6970.16
137_T190_T0.6890.16
68_G253_I0.6890.16
120_D128_T0.6880.16
181_E184_R0.6870.16
116_T194_S0.6850.16
23_S166_S0.6780.16
21_I143_K0.6740.16
173_A200_L0.6730.16
181_E185_M0.6690.16
91_F128_T0.6660.16
45_K69_I0.6650.16
86_R207_K0.6640.15
42_I195_R0.6610.15
134_F245_L0.6590.15
224_T253_I0.6590.15
44_L207_K0.6570.15
64_K119_L0.6570.15
137_T228_L0.6570.15
24_L101_I0.6540.15
79_A201_A0.6530.15
114_E142_V0.6530.15
81_G197_Y0.6500.15
86_R136_L0.6480.15
88_L162_M0.6450.15
233_N240_I0.6450.15
225_A236_I0.6450.15
45_K152_I0.6440.15
67_D75_Q0.6420.15
184_R187_E0.6380.15
171_H184_R0.6370.15
8_N12_Y0.6370.15
48_F82_K0.6320.15
88_L145_I0.6310.15
50_R186_R0.6280.15
65_C194_S0.6270.15
176_K238_S0.6270.15
188_H195_R0.6270.15
131_S148_V0.6250.15
7_I187_E0.6230.15
142_V196_L0.6230.15
122_L166_S0.6200.14
188_H192_N0.6190.14
121_Q201_A0.6180.14
174_V179_P0.6170.14
222_K225_A0.6160.14
163_I196_L0.6160.14
24_L236_I0.6090.14
108_D119_L0.6070.14
200_L215_R0.6060.14
165_E178_P0.6060.14
98_W109_T0.6030.14
77_L239_K0.5970.14
80_M86_R0.5950.14
183_N200_L0.5900.14
163_I176_K0.5890.14
28_T136_L0.5870.14
244_L253_I0.5820.14
26_L210_A0.5810.14
40_W167_W0.5800.14
6_L103_L0.5800.14
61_E64_K0.5760.13
65_C129_Y0.5750.13
46_S256_L0.5690.13
24_L32_D0.5690.13
127_Q254_E0.5640.13
10_L98_W0.5630.13
22_L206_Q0.5590.13
134_F226_D0.5580.13
20_K86_R0.5560.13
18_P245_L0.5560.13
27_N197_Y0.5550.13
229_D243_N0.5550.13
220_G228_L0.5550.13
126_R140_H0.5550.13
18_P230_Q0.5520.13
145_I251_K0.5470.13
40_W47_G0.5440.13
146_E214_E0.5420.13
39_E170_S0.5410.13
26_L209_A0.5390.13
23_S45_K0.5390.13
74_N170_S0.5390.13
45_K94_D0.5390.13
7_I179_P0.5380.13
81_G245_L0.5370.13
28_T149_L0.5360.13
30_M39_E0.5350.13
126_R188_H0.5340.13
49_S231_H0.5340.13
32_D91_F0.5340.13
48_F66_L0.5320.12
104_Q213_W0.5320.12
52_K119_L0.5310.12
59_D116_T0.5310.12
61_E230_Q0.5290.12
116_T240_I0.5280.12
44_L147_T0.5250.12
91_F227_I0.5230.12
135_I151_K0.5220.12
103_L190_T0.5170.12
127_Q238_S0.5160.12
233_N252_V0.5160.12
22_L93_S0.5160.12
69_I73_M0.5140.12
59_D109_T0.5120.12
197_Y224_T0.5080.12
165_E225_A0.5080.12
78_N234_K0.5060.12
149_L220_G0.5060.12
15_L53_E0.5030.12
97_I100_P0.5030.12
40_W242_K0.5020.12
173_A176_K0.5010.12
214_E242_K0.5010.12
30_M143_K0.5000.12
10_L13_V0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3agkA 1 0.8769 100 0.598 Contact Map
4af1A 1 0.9308 100 0.627 Contact Map
1dt9A 1 0.9192 99.9 0.658 Contact Map
3e20C 1 0.4462 99.9 0.676 Contact Map
4crnX 1 0.9192 99.9 0.679 Contact Map
3j15A 1 0.85 99.6 0.771 Contact Map
3obwA 2 0.7385 99.5 0.783 Contact Map
3wxmB 1 0.8462 99.5 0.784 Contact Map
2vgnA 1 0.8115 99.4 0.798 Contact Map
3obyA 1 0.7615 99.3 0.802 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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