MENC - BACSU - GREMLIN Contacts

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MENC - o-succinylbenzoate synthase

UniProt:	O34514	Sequences: MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVTGWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAKAGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQRIKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKIHDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIRIDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	371 (310)
Sequences:	12549 (7463)
Seq/√Len:	423.9

ECOLI - GUDD GUDX RHMD RSPA DGOD AEEP MENC
BACSU - MENC AEEP YITF GUDD
HALSA - Q9HS20 Q9HP25 Q9HQN7
SULSO - GAD Q97VG1 ARAD Q97YL9 Q97YR3 Q97UK8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
80_R	91_S	3.481	1.00
131_K	339_F	3.331	1.00
250_R	254_L	3.189	1.00
229_Q	258_K	3.096	1.00
195_E	198_D	3.046	1.00
84_H	87_E	2.932	1.00
226_R	230_K	2.792	1.00
35_V	104_G	2.765	1.00
221_D	224_D	2.741	1.00
38_I	44_T	2.672	1.00
36_E	44_T	2.554	1.00
249_R	253_E	2.527	1.00
43_V	112_I	2.527	1.00
39_D	112_I	2.404	1.00
227_H	230_K	2.286	1.00
203_K	206_D	2.272	1.00
36_E	46_W	2.235	1.00
245_V	272_E	2.232	1.00
151_E	180_R	2.218	1.00
86_S	275_K	2.209	1.00
226_R	254_L	2.206	1.00
106_E	271_T	2.168	1.00
67_H	71_D	2.143	1.00
185_P	211_M	2.129	1.00
39_D	43_V	2.110	1.00
227_H	231_H	2.105	1.00
66_L	70_K	2.086	1.00
336_D	341_S	2.023	1.00
172_E	175_K	1.991	1.00
267_V	276_I	1.969	1.00
252_I	285_M	1.954	1.00
223_V	254_L	1.953	1.00
259_I	286_Q	1.947	1.00
151_E	155_K	1.925	1.00
41_S	116_K	1.885	1.00
200_S	231_H	1.863	1.00
175_K	208_Y	1.861	1.00
147_L	180_R	1.824	1.00
43_V	116_K	1.818	1.00
279_L	283_H	1.803	1.00
80_R	87_E	1.801	1.00
114_A	121_L	1.794	1.00
133_P	159_Q	1.778	1.00
49_V	104_G	1.774	1.00
248_A	276_I	1.767	1.00
143_L	147_L	1.760	1.00
120_S	123_E	1.733	1.00
206_D	233_K	1.726	1.00
152_S	156_E	1.701	1.00
253_E	283_H	1.691	1.00
154_Q	184_I	1.687	1.00
147_L	151_E	1.687	1.00
37_A	109_V	1.673	1.00
88_V	109_V	1.671	1.00
119_V	123_E	1.665	1.00
176_A	179_S	1.661	1.00
177_I	181_F	1.624	1.00
204_E	207_D	1.610	1.00
171_V	204_E	1.601	1.00
278_D	281_K	1.594	1.00
197_K	227_H	1.582	1.00
217_L	228_L	1.577	1.00
202_L	205_L	1.555	1.00
43_V	115_K	1.555	1.00
142_P	145_D	1.551	1.00
140_L	187_M	1.545	1.00
252_I	279_L	1.544	1.00
175_K	179_S	1.532	1.00
169_Q	172_E	1.529	1.00
274_L	278_D	1.522	1.00
196_L	227_H	1.501	1.00
74_I	78_V	1.497	1.00
249_R	279_L	1.473	1.00
251_A	257_C	1.473	1.00
70_K	74_I	1.470	1.00
106_E	110_W	1.467	1.00
131_K	341_S	1.439	1.00
157_G	184_I	1.433	1.00
34_I	46_W	1.424	1.00
307_S	342_V	1.378	1.00
200_S	227_H	1.374	1.00
111_D	115_K	1.372	1.00
252_I	283_H	1.371	1.00
247_D	250_R	1.343	1.00
83_N	116_K	1.336	1.00
161_I	184_I	1.332	1.00
220_D	247_D	1.315	1.00
107_S	270_L	1.311	1.00
237_C	259_I	1.306	1.00
196_L	228_L	1.306	1.00
170_D	173_L	1.300	1.00
250_R	253_E	1.295	1.00
141_A	145_D	1.292	1.00
217_L	224_D	1.292	1.00
196_L	224_D	1.282	1.00
149_E	152_S	1.281	1.00
148_K	151_E	1.281	1.00
90_D	94_R	1.280	1.00
87_E	91_S	1.280	1.00
133_P	339_F	1.278	1.00
166_Q	169_Q	1.263	1.00
187_M	211_M	1.263	1.00
272_E	275_K	1.261	1.00
226_R	256_S	1.261	1.00
119_V	124_A	1.253	1.00
188_A	210_L	1.253	1.00
113_Y	117_K	1.249	1.00
151_E	154_Q	1.245	1.00
71_D	75_P	1.242	1.00
175_K	207_D	1.238	1.00
164_K	191_N	1.222	1.00
39_D	116_K	1.213	1.00
178_R	182_P	1.213	1.00
203_K	207_D	1.211	1.00
244_S	247_D	1.204	1.00
198_D	201_R	1.202	1.00
92_L	102_K	1.200	1.00
80_R	88_V	1.200	1.00
187_M	212_M	1.198	1.00
275_K	278_D	1.191	1.00
64_T	67_H	1.174	1.00
190_A	213_I	1.171	1.00
181_F	186_L	1.164	1.00
278_D	282_E	1.162	1.00
248_A	260_I	1.153	1.00
73_F	105_L	1.151	1.00
273_A	305_L	1.141	1.00
245_V	279_L	1.133	1.00
200_S	228_L	1.133	1.00
114_A	124_A	1.133	1.00
171_V	208_Y	1.132	1.00
48_E	295_T	1.125	1.00
260_I	280_C	1.121	1.00
206_D	234_T	1.114	1.00
264_P	273_A	1.110	1.00
216_P	236_I	1.093	1.00
142_P	185_P	1.090	1.00
81_E	84_H	1.088	1.00
274_L	307_S	1.085	1.00
172_E	176_A	1.080	1.00
194_Y	199_I	1.079	1.00
238_L	251_A	1.078	1.00
279_L	282_E	1.076	1.00
229_Q	255_G	1.072	1.00
76_N	91_S	1.069	1.00
145_D	148_K	1.068	1.00
111_D	299_R	1.067	1.00
315_G	318_S	1.066	1.00
255_G	285_M	1.063	1.00
144_D	153_Y	1.060	1.00
176_A	180_R	1.051	1.00
83_N	113_Y	1.046	1.00
216_P	228_L	1.043	1.00
83_N	117_K	1.040	1.00
215_Q	261_N	1.038	1.00
110_W	271_T	1.038	1.00
163_I	177_I	1.036	1.00
154_Q	161_I	1.029	1.00
85_P	113_Y	1.021	1.00
237_C	261_N	1.017	1.00
117_K	124_A	1.016	1.00
150_I	181_F	1.015	1.00
33_L	66_L	1.011	1.00
150_I	161_I	1.009	1.00
201_R	204_E	1.000	1.00
152_S	155_K	1.000	1.00
86_S	274_L	1.000	1.00
148_K	152_S	0.991	1.00
263_K	290_G	0.981	1.00
252_I	260_I	0.979	1.00
147_L	179_S	0.978	1.00
249_R	283_H	0.977	1.00
34_I	297_I	0.975	1.00
69_L	105_L	0.967	1.00
40_T	82_F	0.964	1.00
174_V	181_F	0.959	1.00
228_L	236_I	0.957	1.00
275_K	281_K	0.953	1.00
224_D	227_H	0.952	1.00
178_R	183_T	0.952	1.00
267_V	273_A	0.950	1.00
190_A	202_L	0.947	1.00
235_A	310_Q	0.934	1.00
171_V	175_K	0.933	1.00
289_C	308_L	0.927	1.00
121_L	125_L	0.923	1.00
277_H	287_V	0.900	1.00
178_R	186_L	0.899	1.00
277_H	281_K	0.898	1.00
80_R	84_H	0.897	1.00
110_W	270_L	0.894	1.00
153_Y	156_E	0.893	1.00
281_K	309_P	0.890	1.00
37_A	45_G	0.890	1.00
82_F	109_V	0.890	1.00
147_L	181_F	0.887	1.00
196_L	200_S	0.886	1.00
217_L	225_H	0.885	1.00
239_D	263_K	0.883	1.00
190_A	194_Y	0.883	1.00
203_K	233_K	0.881	1.00
223_V	226_R	0.881	1.00
144_D	148_K	0.879	1.00
223_V	250_R	0.878	1.00
143_L	176_A	0.874	1.00
121_L	270_L	0.873	1.00
88_V	91_S	0.873	1.00
245_V	275_K	0.873	1.00
335_I	340_I	0.871	1.00
210_L	234_T	0.871	1.00
222_I	256_S	0.867	1.00
197_K	201_R	0.865	1.00
257_C	260_I	0.863	1.00
169_Q	173_L	0.860	1.00
199_I	217_L	0.859	1.00
143_L	172_E	0.857	1.00
160_R	187_M	0.853	1.00
230_K	255_G	0.852	1.00
125_L	274_L	0.849	1.00
277_H	308_L	0.847	1.00
176_A	181_F	0.847	1.00
86_S	90_D	0.846	1.00
238_L	257_C	0.842	1.00
117_K	120_S	0.841	1.00
196_L	217_L	0.840	1.00
173_L	181_F	0.837	1.00
243_C	247_D	0.836	1.00
82_F	113_Y	0.831	1.00
38_I	42_G	0.829	1.00
113_Y	124_A	0.829	1.00
181_F	184_I	0.826	1.00
174_V	208_Y	0.821	1.00
122_A	342_V	0.814	1.00
63_G	67_H	0.808	1.00
93_A	272_E	0.806	1.00
89_P	106_E	0.802	1.00
165_I	190_A	0.800	1.00
242_I	248_A	0.800	1.00
262_I	273_A	0.797	1.00
39_D	82_F	0.797	1.00
277_H	289_C	0.797	1.00
107_S	301_Q	0.794	1.00
88_V	92_L	0.794	1.00
148_K	180_R	0.793	1.00
194_Y	213_I	0.790	1.00
225_H	236_I	0.790	1.00
174_V	188_A	0.789	1.00
38_I	46_W	0.787	1.00
242_I	251_A	0.783	1.00
225_H	238_L	0.783	1.00
77_V	80_R	0.781	1.00
242_I	247_D	0.780	1.00
336_D	339_F	0.779	1.00
200_S	217_L	0.776	1.00
45_G	108_A	0.776	1.00
136_V	140_L	0.775	1.00
206_D	232_L	0.773	1.00
67_H	70_K	0.768	1.00
262_I	277_H	0.766	1.00
136_V	158_Y	0.766	1.00
91_S	94_R	0.763	1.00
222_I	251_A	0.762	1.00
199_I	228_L	0.761	1.00
222_I	250_R	0.760	1.00
270_L	274_L	0.756	1.00
178_R	209_H	0.752	1.00
260_I	285_M	0.751	1.00
46_W	297_I	0.750	1.00
299_R	303_V	0.749	1.00
76_N	80_R	0.748	1.00
84_H	123_E	0.745	1.00
171_V	207_D	0.744	1.00
173_L	177_I	0.740	1.00
158_Y	315_G	0.735	1.00
174_V	205_L	0.727	1.00
246_D	249_R	0.726	1.00
123_E	128_T	0.723	1.00
82_F	116_K	0.722	1.00
199_I	202_L	0.721	1.00
248_A	285_M	0.721	1.00
75_P	78_V	0.719	1.00
170_D	181_F	0.718	1.00
89_P	92_L	0.710	1.00
179_S	182_P	0.708	1.00
89_P	271_T	0.701	1.00
167_P	171_V	0.700	1.00
89_P	93_A	0.700	1.00
178_R	181_F	0.700	1.00
229_Q	236_I	0.699	1.00
316_D	319_S	0.698	1.00
227_H	255_G	0.697	1.00
308_L	311_F	0.696	1.00
110_W	121_L	0.694	1.00
203_K	231_H	0.694	1.00
334_R	341_S	0.694	1.00
201_R	231_H	0.694	1.00
45_G	115_K	0.693	1.00
136_V	153_Y	0.693	1.00
37_A	77_V	0.691	1.00
150_I	154_Q	0.690	1.00
102_K	269_G	0.690	1.00
66_L	69_L	0.689	1.00
85_P	88_V	0.689	1.00
303_V	340_I	0.687	1.00
86_S	130_D	0.686	1.00
281_K	310_Q	0.686	1.00
86_S	271_T	0.686	1.00
150_I	177_I	0.683	1.00
262_I	287_V	0.683	1.00
222_I	254_L	0.681	1.00
194_Y	202_L	0.680	1.00
110_W	125_L	0.680	1.00
280_C	285_M	0.679	1.00
182_P	209_H	0.676	1.00
73_F	95_Y	0.675	1.00
38_I	41_S	0.672	1.00
68_M	101_A	0.669	1.00
150_I	176_A	0.665	1.00
69_L	74_I	0.664	0.99
77_V	105_L	0.664	0.99
145_D	149_E	0.662	0.99
90_D	93_A	0.661	0.99
204_E	208_Y	0.659	0.99
160_R	185_P	0.657	0.99
245_V	276_I	0.657	0.99
121_L	124_A	0.654	0.99
281_K	287_V	0.654	0.99
35_V	69_L	0.654	0.99
125_L	270_L	0.649	0.99
47_G	104_G	0.648	0.99
45_G	111_D	0.648	0.99
177_I	180_R	0.647	0.99
200_S	203_K	0.646	0.99
90_D	275_K	0.646	0.99
248_A	280_C	0.646	0.99
131_K	337_N	0.645	0.99
228_L	232_L	0.644	0.99
170_D	178_R	0.642	0.99
200_S	232_L	0.641	0.99
326_E	330_T	0.641	0.99
303_V	342_V	0.639	0.99
113_Y	116_K	0.637	0.99
114_A	119_V	0.637	0.99
261_N	290_G	0.637	0.99
171_V	181_F	0.633	0.99
147_L	176_A	0.630	0.99
33_L	62_I	0.627	0.99
63_G	71_D	0.627	0.99
167_P	202_L	0.626	0.99
62_I	66_L	0.623	0.99
138_V	153_Y	0.623	0.99
248_A	262_I	0.623	0.99
280_C	287_V	0.623	0.99
81_E	123_E	0.622	0.99
163_I	174_V	0.622	0.99
215_Q	241_S	0.621	0.99
149_E	153_Y	0.620	0.99
260_I	276_I	0.620	0.99
225_H	228_L	0.619	0.99
245_V	249_R	0.619	0.99
310_Q	315_G	0.618	0.99
314_P	318_S	0.618	0.99
154_Q	180_R	0.617	0.99
174_V	210_L	0.614	0.99
274_L	308_L	0.613	0.99
119_V	127_G	0.612	0.99
82_F	112_I	0.612	0.99
277_H	307_S	0.611	0.99
215_Q	239_D	0.610	0.99
273_A	289_C	0.608	0.99
317_I	320_S	0.605	0.99
212_M	288_W	0.604	0.99
327_D	330_T	0.604	0.99
131_K	336_D	0.604	0.99
112_I	116_K	0.601	0.99
256_S	285_M	0.600	0.99
44_T	115_K	0.600	0.99
173_L	179_S	0.599	0.99
170_D	194_Y	0.598	0.99
173_L	178_R	0.597	0.99
161_I	181_F	0.597	0.99
257_C	285_M	0.596	0.99
60_E	64_T	0.594	0.99
264_P	302_N	0.591	0.99
323_Y	327_D	0.590	0.99
109_V	113_Y	0.589	0.99
122_A	304_A	0.588	0.99
246_D	250_R	0.588	0.99
197_K	200_S	0.582	0.99
291_G	299_R	0.582	0.99
88_V	105_L	0.581	0.99
106_E	269_G	0.581	0.99
188_A	205_L	0.580	0.99
69_L	101_A	0.579	0.99
333_I	340_I	0.575	0.99
135_G	187_M	0.574	0.99
145_D	153_Y	0.572	0.99
215_Q	240_E	0.571	0.98
39_D	42_G	0.570	0.98
137_V	140_L	0.568	0.98
159_Q	337_N	0.567	0.98
33_L	65_C	0.567	0.98
150_I	180_R	0.567	0.98
47_G	108_A	0.563	0.98
211_M	235_A	0.562	0.98
73_F	77_V	0.560	0.98
226_R	255_G	0.560	0.98
115_K	118_G	0.559	0.98
69_L	104_G	0.555	0.98
37_A	108_A	0.551	0.98
229_Q	256_S	0.550	0.98
307_S	343_S	0.549	0.98
192_S	219_A	0.549	0.98
110_W	124_A	0.540	0.98
122_A	128_T	0.539	0.98
74_I	105_L	0.536	0.98
247_D	256_S	0.536	0.98
35_V	105_L	0.536	0.98
64_T	68_M	0.535	0.98
165_I	194_Y	0.534	0.98
84_H	88_V	0.534	0.98
329_V	332_D	0.534	0.98
170_D	180_R	0.534	0.98
87_E	90_D	0.533	0.98
154_Q	181_F	0.533	0.98
88_V	93_A	0.531	0.98
73_F	92_L	0.531	0.98
232_L	236_I	0.531	0.98
77_V	109_V	0.531	0.98
192_S	241_S	0.529	0.98
89_P	102_K	0.529	0.98
168_G	201_R	0.528	0.98
51_A	100_M	0.527	0.97
178_R	208_Y	0.525	0.97
40_T	43_V	0.525	0.97
134_A	340_I	0.525	0.97
93_A	102_K	0.524	0.97
169_Q	181_F	0.524	0.97
146_M	173_L	0.523	0.97
41_S	82_F	0.521	0.97
270_L	305_L	0.521	0.97
64_T	71_D	0.521	0.97
286_Q	312_T	0.520	0.97
49_V	100_M	0.518	0.97
107_S	297_I	0.517	0.97
117_K	126_G	0.516	0.97
175_K	178_R	0.516	0.97
300_A	303_V	0.515	0.97
159_Q	183_T	0.514	0.97
85_P	109_V	0.514	0.97
235_A	259_I	0.514	0.97
223_V	227_H	0.514	0.97
85_P	124_A	0.513	0.97
120_S	126_G	0.512	0.97
306_A	311_F	0.511	0.97
225_H	256_S	0.509	0.97
171_V	174_V	0.509	0.97
309_P	312_T	0.507	0.97
151_E	181_F	0.506	0.97
92_L	105_L	0.506	0.97
170_D	179_S	0.506	0.97
114_A	117_K	0.505	0.97
107_S	265_S	0.501	0.97
120_S	124_A	0.501	0.97
128_T	131_K	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1wufA	2	0.9973	100	0.108	Contact Map
3qldA	2	0.9946	100	0.115	Contact Map
1wueA	2	0.9892	100	0.119	Contact Map
1r0mA	2	0.965	100	0.123	Contact Map
2zc8A	5	0.9892	100	0.13	Contact Map
1sjdA	5	0.9865	100	0.135	Contact Map
3s5sA	2	0.9542	100	0.145	Contact Map
3u9iA	2	0.9137	100	0.16	Contact Map
3dgbA	5	0.973	100	0.16	Contact Map
3fcpA	5	0.938	100	0.161	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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