GREMLIN Database
MENC - o-succinylbenzoate synthase
UniProt: O34514 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (310)
Sequences: 12549 (7463)
Seq/√Len: 423.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_R91_S3.4811.00
131_K339_F3.3311.00
250_R254_L3.1891.00
229_Q258_K3.0961.00
195_E198_D3.0461.00
84_H87_E2.9321.00
226_R230_K2.7921.00
35_V104_G2.7651.00
221_D224_D2.7411.00
38_I44_T2.6721.00
36_E44_T2.5541.00
249_R253_E2.5271.00
43_V112_I2.5271.00
39_D112_I2.4041.00
227_H230_K2.2861.00
203_K206_D2.2721.00
36_E46_W2.2351.00
245_V272_E2.2321.00
151_E180_R2.2181.00
86_S275_K2.2091.00
226_R254_L2.2061.00
106_E271_T2.1681.00
67_H71_D2.1431.00
185_P211_M2.1291.00
39_D43_V2.1101.00
227_H231_H2.1051.00
66_L70_K2.0861.00
336_D341_S2.0231.00
172_E175_K1.9911.00
267_V276_I1.9691.00
252_I285_M1.9541.00
223_V254_L1.9531.00
259_I286_Q1.9471.00
151_E155_K1.9251.00
41_S116_K1.8851.00
200_S231_H1.8631.00
175_K208_Y1.8611.00
147_L180_R1.8241.00
43_V116_K1.8181.00
279_L283_H1.8031.00
80_R87_E1.8011.00
114_A121_L1.7941.00
133_P159_Q1.7781.00
49_V104_G1.7741.00
248_A276_I1.7671.00
143_L147_L1.7601.00
120_S123_E1.7331.00
206_D233_K1.7261.00
152_S156_E1.7011.00
253_E283_H1.6911.00
154_Q184_I1.6871.00
147_L151_E1.6871.00
37_A109_V1.6731.00
88_V109_V1.6711.00
119_V123_E1.6651.00
176_A179_S1.6611.00
177_I181_F1.6241.00
204_E207_D1.6101.00
171_V204_E1.6011.00
278_D281_K1.5941.00
197_K227_H1.5821.00
217_L228_L1.5771.00
202_L205_L1.5551.00
43_V115_K1.5551.00
142_P145_D1.5511.00
140_L187_M1.5451.00
252_I279_L1.5441.00
175_K179_S1.5321.00
169_Q172_E1.5291.00
274_L278_D1.5221.00
196_L227_H1.5011.00
74_I78_V1.4971.00
249_R279_L1.4731.00
251_A257_C1.4731.00
70_K74_I1.4701.00
106_E110_W1.4671.00
131_K341_S1.4391.00
157_G184_I1.4331.00
34_I46_W1.4241.00
307_S342_V1.3781.00
200_S227_H1.3741.00
111_D115_K1.3721.00
252_I283_H1.3711.00
247_D250_R1.3431.00
83_N116_K1.3361.00
161_I184_I1.3321.00
220_D247_D1.3151.00
107_S270_L1.3111.00
237_C259_I1.3061.00
196_L228_L1.3061.00
170_D173_L1.3001.00
250_R253_E1.2951.00
141_A145_D1.2921.00
217_L224_D1.2921.00
196_L224_D1.2821.00
149_E152_S1.2811.00
148_K151_E1.2811.00
90_D94_R1.2801.00
87_E91_S1.2801.00
133_P339_F1.2781.00
166_Q169_Q1.2631.00
187_M211_M1.2631.00
272_E275_K1.2611.00
226_R256_S1.2611.00
119_V124_A1.2531.00
188_A210_L1.2531.00
113_Y117_K1.2491.00
151_E154_Q1.2451.00
71_D75_P1.2421.00
175_K207_D1.2381.00
164_K191_N1.2221.00
39_D116_K1.2131.00
178_R182_P1.2131.00
203_K207_D1.2111.00
244_S247_D1.2041.00
198_D201_R1.2021.00
92_L102_K1.2001.00
80_R88_V1.2001.00
187_M212_M1.1981.00
275_K278_D1.1911.00
64_T67_H1.1741.00
190_A213_I1.1711.00
181_F186_L1.1641.00
278_D282_E1.1621.00
248_A260_I1.1531.00
73_F105_L1.1511.00
273_A305_L1.1411.00
245_V279_L1.1331.00
200_S228_L1.1331.00
114_A124_A1.1331.00
171_V208_Y1.1321.00
48_E295_T1.1251.00
260_I280_C1.1211.00
206_D234_T1.1141.00
264_P273_A1.1101.00
216_P236_I1.0931.00
142_P185_P1.0901.00
81_E84_H1.0881.00
274_L307_S1.0851.00
172_E176_A1.0801.00
194_Y199_I1.0791.00
238_L251_A1.0781.00
279_L282_E1.0761.00
229_Q255_G1.0721.00
76_N91_S1.0691.00
145_D148_K1.0681.00
111_D299_R1.0671.00
315_G318_S1.0661.00
255_G285_M1.0631.00
144_D153_Y1.0601.00
176_A180_R1.0511.00
83_N113_Y1.0461.00
216_P228_L1.0431.00
83_N117_K1.0401.00
215_Q261_N1.0381.00
110_W271_T1.0381.00
163_I177_I1.0361.00
154_Q161_I1.0291.00
85_P113_Y1.0211.00
237_C261_N1.0171.00
117_K124_A1.0161.00
150_I181_F1.0151.00
33_L66_L1.0111.00
150_I161_I1.0091.00
201_R204_E1.0001.00
152_S155_K1.0001.00
86_S274_L1.0001.00
148_K152_S0.9911.00
263_K290_G0.9811.00
252_I260_I0.9791.00
147_L179_S0.9781.00
249_R283_H0.9771.00
34_I297_I0.9751.00
69_L105_L0.9671.00
40_T82_F0.9641.00
174_V181_F0.9591.00
228_L236_I0.9571.00
275_K281_K0.9531.00
224_D227_H0.9521.00
178_R183_T0.9521.00
267_V273_A0.9501.00
190_A202_L0.9471.00
235_A310_Q0.9341.00
171_V175_K0.9331.00
289_C308_L0.9271.00
121_L125_L0.9231.00
277_H287_V0.9001.00
178_R186_L0.8991.00
277_H281_K0.8981.00
80_R84_H0.8971.00
110_W270_L0.8941.00
153_Y156_E0.8931.00
281_K309_P0.8901.00
37_A45_G0.8901.00
82_F109_V0.8901.00
147_L181_F0.8871.00
196_L200_S0.8861.00
217_L225_H0.8851.00
239_D263_K0.8831.00
190_A194_Y0.8831.00
203_K233_K0.8811.00
223_V226_R0.8811.00
144_D148_K0.8791.00
223_V250_R0.8781.00
143_L176_A0.8741.00
121_L270_L0.8731.00
88_V91_S0.8731.00
245_V275_K0.8731.00
335_I340_I0.8711.00
210_L234_T0.8711.00
222_I256_S0.8671.00
197_K201_R0.8651.00
257_C260_I0.8631.00
169_Q173_L0.8601.00
199_I217_L0.8591.00
143_L172_E0.8571.00
160_R187_M0.8531.00
230_K255_G0.8521.00
125_L274_L0.8491.00
277_H308_L0.8471.00
176_A181_F0.8471.00
86_S90_D0.8461.00
238_L257_C0.8421.00
117_K120_S0.8411.00
196_L217_L0.8401.00
173_L181_F0.8371.00
243_C247_D0.8361.00
82_F113_Y0.8311.00
38_I42_G0.8291.00
113_Y124_A0.8291.00
181_F184_I0.8261.00
174_V208_Y0.8211.00
122_A342_V0.8141.00
63_G67_H0.8081.00
93_A272_E0.8061.00
89_P106_E0.8021.00
165_I190_A0.8001.00
242_I248_A0.8001.00
262_I273_A0.7971.00
39_D82_F0.7971.00
277_H289_C0.7971.00
107_S301_Q0.7941.00
88_V92_L0.7941.00
148_K180_R0.7931.00
194_Y213_I0.7901.00
225_H236_I0.7901.00
174_V188_A0.7891.00
38_I46_W0.7871.00
242_I251_A0.7831.00
225_H238_L0.7831.00
77_V80_R0.7811.00
242_I247_D0.7801.00
336_D339_F0.7791.00
200_S217_L0.7761.00
45_G108_A0.7761.00
136_V140_L0.7751.00
206_D232_L0.7731.00
67_H70_K0.7681.00
262_I277_H0.7661.00
136_V158_Y0.7661.00
91_S94_R0.7631.00
222_I251_A0.7621.00
199_I228_L0.7611.00
222_I250_R0.7601.00
270_L274_L0.7561.00
178_R209_H0.7521.00
260_I285_M0.7511.00
46_W297_I0.7501.00
299_R303_V0.7491.00
76_N80_R0.7481.00
84_H123_E0.7451.00
171_V207_D0.7441.00
173_L177_I0.7401.00
158_Y315_G0.7351.00
174_V205_L0.7271.00
246_D249_R0.7261.00
123_E128_T0.7231.00
82_F116_K0.7221.00
199_I202_L0.7211.00
248_A285_M0.7211.00
75_P78_V0.7191.00
170_D181_F0.7181.00
89_P92_L0.7101.00
179_S182_P0.7081.00
89_P271_T0.7011.00
167_P171_V0.7001.00
89_P93_A0.7001.00
178_R181_F0.7001.00
229_Q236_I0.6991.00
316_D319_S0.6981.00
227_H255_G0.6971.00
308_L311_F0.6961.00
110_W121_L0.6941.00
203_K231_H0.6941.00
334_R341_S0.6941.00
201_R231_H0.6941.00
45_G115_K0.6931.00
136_V153_Y0.6931.00
37_A77_V0.6911.00
150_I154_Q0.6901.00
102_K269_G0.6901.00
66_L69_L0.6891.00
85_P88_V0.6891.00
303_V340_I0.6871.00
86_S130_D0.6861.00
281_K310_Q0.6861.00
86_S271_T0.6861.00
150_I177_I0.6831.00
262_I287_V0.6831.00
222_I254_L0.6811.00
194_Y202_L0.6801.00
110_W125_L0.6801.00
280_C285_M0.6791.00
182_P209_H0.6761.00
73_F95_Y0.6751.00
38_I41_S0.6721.00
68_M101_A0.6691.00
150_I176_A0.6651.00
69_L74_I0.6640.99
77_V105_L0.6640.99
145_D149_E0.6620.99
90_D93_A0.6610.99
204_E208_Y0.6590.99
160_R185_P0.6570.99
245_V276_I0.6570.99
121_L124_A0.6540.99
281_K287_V0.6540.99
35_V69_L0.6540.99
125_L270_L0.6490.99
47_G104_G0.6480.99
45_G111_D0.6480.99
177_I180_R0.6470.99
200_S203_K0.6460.99
90_D275_K0.6460.99
248_A280_C0.6460.99
131_K337_N0.6450.99
228_L232_L0.6440.99
170_D178_R0.6420.99
200_S232_L0.6410.99
326_E330_T0.6410.99
303_V342_V0.6390.99
113_Y116_K0.6370.99
114_A119_V0.6370.99
261_N290_G0.6370.99
171_V181_F0.6330.99
147_L176_A0.6300.99
33_L62_I0.6270.99
63_G71_D0.6270.99
167_P202_L0.6260.99
62_I66_L0.6230.99
138_V153_Y0.6230.99
248_A262_I0.6230.99
280_C287_V0.6230.99
81_E123_E0.6220.99
163_I174_V0.6220.99
215_Q241_S0.6210.99
149_E153_Y0.6200.99
260_I276_I0.6200.99
225_H228_L0.6190.99
245_V249_R0.6190.99
310_Q315_G0.6180.99
314_P318_S0.6180.99
154_Q180_R0.6170.99
174_V210_L0.6140.99
274_L308_L0.6130.99
119_V127_G0.6120.99
82_F112_I0.6120.99
277_H307_S0.6110.99
215_Q239_D0.6100.99
273_A289_C0.6080.99
317_I320_S0.6050.99
212_M288_W0.6040.99
327_D330_T0.6040.99
131_K336_D0.6040.99
112_I116_K0.6010.99
256_S285_M0.6000.99
44_T115_K0.6000.99
173_L179_S0.5990.99
170_D194_Y0.5980.99
173_L178_R0.5970.99
161_I181_F0.5970.99
257_C285_M0.5960.99
60_E64_T0.5940.99
264_P302_N0.5910.99
323_Y327_D0.5900.99
109_V113_Y0.5890.99
122_A304_A0.5880.99
246_D250_R0.5880.99
197_K200_S0.5820.99
291_G299_R0.5820.99
88_V105_L0.5810.99
106_E269_G0.5810.99
188_A205_L0.5800.99
69_L101_A0.5790.99
333_I340_I0.5750.99
135_G187_M0.5740.99
145_D153_Y0.5720.99
215_Q240_E0.5710.98
39_D42_G0.5700.98
137_V140_L0.5680.98
159_Q337_N0.5670.98
33_L65_C0.5670.98
150_I180_R0.5670.98
47_G108_A0.5630.98
211_M235_A0.5620.98
73_F77_V0.5600.98
226_R255_G0.5600.98
115_K118_G0.5590.98
69_L104_G0.5550.98
37_A108_A0.5510.98
229_Q256_S0.5500.98
307_S343_S0.5490.98
192_S219_A0.5490.98
110_W124_A0.5400.98
122_A128_T0.5390.98
74_I105_L0.5360.98
247_D256_S0.5360.98
35_V105_L0.5360.98
64_T68_M0.5350.98
165_I194_Y0.5340.98
84_H88_V0.5340.98
329_V332_D0.5340.98
170_D180_R0.5340.98
87_E90_D0.5330.98
154_Q181_F0.5330.98
88_V93_A0.5310.98
73_F92_L0.5310.98
232_L236_I0.5310.98
77_V109_V0.5310.98
192_S241_S0.5290.98
89_P102_K0.5290.98
168_G201_R0.5280.98
51_A100_M0.5270.97
178_R208_Y0.5250.97
40_T43_V0.5250.97
134_A340_I0.5250.97
93_A102_K0.5240.97
169_Q181_F0.5240.97
146_M173_L0.5230.97
41_S82_F0.5210.97
270_L305_L0.5210.97
64_T71_D0.5210.97
286_Q312_T0.5200.97
49_V100_M0.5180.97
107_S297_I0.5170.97
117_K126_G0.5160.97
175_K178_R0.5160.97
300_A303_V0.5150.97
159_Q183_T0.5140.97
85_P109_V0.5140.97
235_A259_I0.5140.97
223_V227_H0.5140.97
85_P124_A0.5130.97
120_S126_G0.5120.97
306_A311_F0.5110.97
225_H256_S0.5090.97
171_V174_V0.5090.97
309_P312_T0.5070.97
151_E181_F0.5060.97
92_L105_L0.5060.97
170_D179_S0.5060.97
114_A117_K0.5050.97
107_S265_S0.5010.97
120_S124_A0.5010.97
128_T131_K0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wufA 2 0.9973 100 0.108 Contact Map
3qldA 2 0.9946 100 0.115 Contact Map
1wueA 2 0.9892 100 0.119 Contact Map
1r0mA 2 0.965 100 0.123 Contact Map
2zc8A 5 0.9892 100 0.13 Contact Map
1sjdA 5 0.9865 100 0.135 Contact Map
3s5sA 2 0.9542 100 0.145 Contact Map
3u9iA 2 0.9137 100 0.16 Contact Map
3dgbA 5 0.973 100 0.16 Contact Map
3fcpA 5 0.938 100 0.161 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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