GREMLIN Database
YLBM - UPF0348 protein YlbM
UniProt: O34513 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 415 (375)
Sequences: 1086 (950)
Seq/√Len: 49.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_T26_L6.0881.00
60_L339_G5.8451.00
10_Y20_H4.4311.00
279_R299_T4.3851.00
56_T339_G3.7161.00
87_V98_L3.2321.00
105_G184_T3.2081.00
35_A64_V3.1661.00
56_T60_L3.1251.00
226_L230_S3.1241.00
102_S184_T3.0871.00
7_V86_S2.8991.00
8_V35_A2.7701.00
102_S105_G2.7241.00
110_F170_V2.7081.00
72_Y316_T2.6631.00
57_K61_Q2.6361.00
51_S54_A2.5481.00
5_G90_L2.4351.00
18_L22_Q2.4031.00
32_T347_Y2.3291.00
48_A55_R2.3261.00
298_K304_W2.3081.00
161_P193_H2.3061.00
195_A212_K2.2941.00
65_D341_T2.2921.00
3_A347_Y2.2301.00
342_K345_Q2.1891.00
139_P303_T2.1831.00
2_K96_E2.1471.00
4_V33_A2.1381.00
76_V312_T2.1361.00
68_I337_L2.1301.00
192_Y207_A2.1281.00
106_D109_P2.1121.00
335_I357_V2.0801.00
6_L21_A2.0731.00
272_V314_I2.0721.00
304_W308_Q2.0571.00
222_C226_L2.0401.00
275_G301_R2.0311.00
173_I178_Y2.0061.00
287_S296_L1.9960.99
4_V24_A1.9870.99
25_K33_A1.9800.99
341_T344_G1.9780.99
272_V310_M1.9770.99
40_H378_S1.9620.99
93_L335_I1.9330.99
5_G36_V1.9140.99
20_H24_A1.8950.99
274_E301_R1.8910.99
97_A183_Y1.8520.99
305_T308_Q1.8510.99
68_I335_I1.8360.99
66_L337_L1.8190.99
173_I182_P1.8100.99
124_L128_I1.8070.99
68_I93_L1.8070.99
15_N226_L1.8020.99
257_S260_T1.7960.99
102_S166_G1.7500.99
205_A225_F1.7270.99
197_L225_F1.7140.98
251_F284_I1.6970.98
189_S204_I1.6700.98
115_Q174_L1.6680.98
28_T183_Y1.6670.98
170_V182_P1.6380.98
36_V90_L1.6370.98
91_N178_Y1.6350.98
173_I180_M1.6260.98
337_L361_S1.6090.98
24_A28_T1.5850.97
24_A33_A1.5850.97
289_S292_E1.5840.97
251_F255_K1.5630.97
68_I89_I1.5580.97
93_L351_K1.5550.97
52_K69_E1.5400.97
80_D168_Q1.5400.97
13_F62_S1.5090.96
3_A96_E1.4840.96
170_V174_L1.4840.96
40_H381_Y1.4780.96
197_L213_A1.4770.96
260_T380_I1.4750.96
343_K346_A1.4640.96
50_V58_M1.4620.96
50_V234_L1.4590.96
140_A144_I1.4550.96
121_K125_N1.4380.95
6_L20_H1.4320.95
293_F311_N1.4290.95
267_Q277_E1.4290.95
58_M233_E1.4080.95
274_E302_Y1.3980.95
89_I335_I1.3910.94
8_V20_H1.3900.94
263_A281_I1.3730.94
95_C180_M1.3690.94
268_Q319_K1.3490.93
168_Q171_T1.3460.93
271_E306_R1.3450.93
13_F18_L1.3430.93
351_K355_L1.3430.93
277_E301_R1.3350.93
257_S317_R1.3340.93
22_Q26_L1.3260.93
246_T249_S1.3130.93
250_Y384_P1.3110.92
291_Q304_W1.3040.92
37_M55_R1.2940.92
80_D171_T1.2900.92
34_V95_C1.2870.92
23_T27_Q1.2850.92
3_A32_T1.2730.91
57_K236_A1.2700.91
24_A99_F1.2690.91
315_L380_I1.2620.91
62_S229_A1.2610.91
84_R176_G1.2480.90
223_L231_A1.2430.90
288_S292_E1.2430.90
163_N184_T1.2390.90
36_V86_S1.2360.90
247_P290_Y1.2330.90
178_Y182_P1.2240.90
110_F167_Y1.2230.90
298_K305_T1.2230.90
107_I170_V1.2160.89
70_L86_S1.2110.89
212_K216_G1.2100.89
215_I246_T1.2080.89
66_L341_T1.2010.89
355_L359_L1.1940.88
255_K259_S1.1940.88
6_L24_A1.1940.88
78_K81_I1.1870.88
21_A64_V1.1810.88
4_V28_T1.1770.88
269_V314_I1.1760.88
270_Y323_M1.1750.88
131_E134_K1.1530.87
166_G184_T1.1510.86
24_A30_C1.1460.86
8_V64_V1.1460.86
84_R175_T1.1390.86
50_V54_A1.1360.86
53_W378_S1.1360.86
374_D378_S1.1360.86
121_K149_I1.1320.86
279_R283_S1.1260.85
262_T265_E1.1240.85
276_L297_L1.1220.85
294_M307_L1.1160.85
42_L305_T1.1150.85
120_H125_N1.1120.85
54_A233_E1.0990.84
125_N128_I1.0990.84
341_T345_Q1.0960.84
256_Y260_T1.0940.84
73_L374_D1.0910.83
280_I297_L1.0910.83
72_Y75_A1.0860.83
140_A143_A1.0850.83
210_I225_F1.0810.83
38_S75_A1.0740.82
15_N18_L1.0690.82
49_V214_M1.0600.82
19_Y23_T1.0510.81
266_L277_E1.0500.81
363_L371_L1.0390.80
128_I132_L1.0340.80
257_S261_V1.0310.80
286_K296_L1.0170.79
40_H75_A1.0140.79
131_E148_S1.0060.78
104_N109_P1.0030.78
39_G374_D0.9990.78
2_K97_A0.9940.77
373_L376_K0.9920.77
138_Y142_A0.9880.77
251_F259_S0.9870.77
283_S297_L0.9840.76
118_D171_T0.9830.76
99_F185_T0.9740.76
334_Y358_P0.9720.76
292_E296_L0.9710.76
131_E136_A0.9700.75
91_N176_G0.9700.75
54_A237_Y0.9690.75
4_V25_K0.9680.75
19_Y22_Q0.9670.75
269_V310_M0.9650.75
107_I184_T0.9640.75
188_I204_I0.9610.75
66_L93_L0.9570.74
319_K322_D0.9560.74
248_E291_Q0.9410.73
274_E277_E0.9400.73
197_L205_A0.9380.73
298_K303_T0.9360.73
136_A144_I0.9340.73
70_L85_G0.9330.73
192_Y208_T0.9320.72
141_A145_A0.9320.72
251_F290_Y0.9300.72
280_I311_N0.9290.72
102_S163_N0.9270.72
297_L307_L0.9240.72
79_A168_Q0.9130.71
36_V70_L0.9090.71
8_V99_F0.9080.70
245_H250_Y0.9070.70
111_L170_V0.9010.70
20_H35_A0.9000.70
350_E354_A0.8940.69
362_K365_S0.8920.69
37_M48_A0.8900.69
208_T305_T0.8890.69
259_S379_R0.8810.68
76_V313_H0.8810.68
273_E306_R0.8800.68
191_D194_D0.8790.68
105_G166_G0.8780.68
77_Q81_I0.8780.68
132_L135_G0.8760.68
360_V363_L0.8700.67
193_H208_T0.8690.67
4_V97_A0.8690.67
10_Y99_F0.8670.67
265_E317_R0.8620.66
237_Y242_G0.8600.66
253_Y256_Y0.8580.66
104_N184_T0.8560.66
261_V265_E0.8510.65
349_S359_L0.8510.65
20_H28_T0.8500.65
294_M308_Q0.8380.64
42_L204_I0.8380.64
72_Y318_T0.8340.64
255_K284_I0.8290.63
294_M304_W0.8270.63
248_E289_S0.8250.63
114_A167_Y0.8230.63
42_L161_P0.8230.63
131_E144_I0.8230.63
98_L173_I0.8210.63
89_I357_V0.8210.63
251_F287_S0.8200.63
129_K133_K0.8160.62
3_A94_E0.8150.62
287_S293_F0.8130.62
77_Q270_Y0.8120.62
111_L174_L0.8070.61
160_K191_D0.8050.61
270_Y313_H0.8030.61
275_G302_Y0.8020.61
275_G344_G0.8020.61
74_Y85_G0.7980.60
128_I138_Y0.7980.60
277_E302_Y0.7960.60
20_H99_F0.7960.60
250_Y315_L0.7950.60
335_I355_L0.7940.60
132_L141_A0.7900.60
30_C33_A0.7890.60
8_V166_G0.7880.59
275_G310_M0.7830.59
158_L167_Y0.7800.59
91_N179_P0.7800.59
272_V280_I0.7790.59
20_H86_S0.7780.58
66_L347_Y0.7760.58
40_H52_K0.7740.58
42_L230_S0.7740.58
8_V37_M0.7710.58
60_L298_K0.7700.58
118_D174_L0.7650.57
332_A357_V0.7600.57
72_Y377_A0.7570.56
10_Y18_L0.7560.56
161_P191_D0.7550.56
205_A210_I0.7550.56
46_E247_P0.7530.56
287_S292_E0.7530.56
80_D182_P0.7490.56
15_N227_P0.7470.55
58_M230_S0.7440.55
274_E278_H0.7430.55
34_V317_R0.7390.55
347_Y355_L0.7360.54
127_R131_E0.7350.54
7_V36_V0.7340.54
117_I142_A0.7300.54
334_Y374_D0.7250.53
290_Y294_M0.7220.53
120_H128_I0.7220.53
72_Y76_V0.7220.53
127_R149_I0.7210.53
76_V269_V0.7210.53
28_T31_D0.7200.53
258_L293_F0.7180.52
158_L163_N0.7140.52
77_Q250_Y0.7130.52
190_S205_A0.7120.52
142_A168_Q0.7120.52
261_V269_V0.7090.52
86_S95_C0.7090.52
170_V173_I0.7080.51
295_E304_W0.7050.51
363_L378_S0.7050.51
344_G352_K0.7040.51
41_F47_P0.7010.51
9_E16_G0.7010.51
9_E17_H0.7010.51
9_E14_H0.7010.51
14_H17_H0.7010.51
276_L307_L0.7000.51
307_L311_N0.6980.50
254_L314_I0.6970.50
5_G98_L0.6970.50
32_T344_G0.6950.50
70_L82_F0.6940.50
51_S237_Y0.6940.50
120_H124_L0.6940.50
135_G170_V0.6930.50
335_I359_L0.6920.50
280_I310_M0.6910.50
72_Y313_H0.6910.50
99_F139_P0.6900.50
259_S383_L0.6890.50
245_H249_S0.6890.50
98_L180_M0.6830.49
66_L344_G0.6830.49
110_F113_T0.6820.49
46_E308_Q0.6820.49
134_K139_P0.6810.49
374_D377_A0.6800.49
24_A29_G0.6780.48
20_H36_V0.6770.48
254_L311_N0.6750.48
77_Q142_A0.6720.48
276_L280_I0.6710.48
108_K111_L0.6690.47
271_E313_H0.6680.47
21_A62_S0.6670.47
99_F183_Y0.6640.47
91_N356_S0.6630.47
118_D175_T0.6630.47
25_K216_G0.6630.47
301_R310_M0.6620.47
247_P254_L0.6610.47
12_P17_H0.6610.47
12_P16_G0.6610.47
9_E12_P0.6610.47
276_L310_M0.6610.47
54_A57_K0.6610.47
40_H53_W0.6590.46
248_E251_F0.6560.46
78_K168_Q0.6560.46
313_H318_T0.6550.46
298_K307_L0.6550.46
263_A278_H0.6540.46
57_K233_E0.6530.46
98_L386_E0.6520.46
36_V68_I0.6470.45
13_F229_A0.6450.45
275_G278_H0.6440.45
41_F336_R0.6420.45
91_N180_M0.6420.45
164_I171_T0.6410.45
92_E357_V0.6400.45
104_N163_N0.6390.44
83_A86_S0.6380.44
111_L181_K0.6380.44
135_G141_A0.6350.44
20_H102_S0.6350.44
8_V42_L0.6340.44
135_G163_N0.6340.44
6_L33_A0.6330.44
6_L64_V0.6330.44
128_I171_T0.6320.44
18_L21_A0.6270.43
60_L341_T0.6270.43
126_D221_A0.6260.43
30_C163_N0.6240.43
56_T61_Q0.6240.43
146_F149_I0.6220.43
88_S332_A0.6200.43
20_H33_A0.6190.42
135_G182_P0.6190.42
340_M345_Q0.6180.42
53_W382_S0.6180.42
78_K164_I0.6180.42
92_E335_I0.6160.42
93_L347_Y0.6160.42
34_V67_V0.6150.42
84_R88_S0.6140.42
30_C96_E0.6140.42
270_Y314_I0.6130.42
4_V30_C0.6120.42
24_A31_D0.6110.42
214_M244_W0.6090.41
272_V277_E0.6040.41
144_I147_S0.6040.41
15_N205_A0.6040.41
262_T281_I0.6020.41
24_A184_T0.6010.41
136_A141_A0.5980.40
264_R268_Q0.5960.40
39_G52_K0.5960.40
263_A267_Q0.5940.40
255_K293_F0.5930.40
283_S296_L0.5920.40
78_K270_Y0.5910.40
271_E323_M0.5900.40
387_E390_R0.5900.40
222_C231_A0.5900.40
80_D271_E0.5900.40
297_L311_N0.5890.40
127_R148_S0.5880.39
4_V34_V0.5850.39
351_K359_L0.5850.39
164_I168_Q0.5840.39
333_P370_A0.5840.39
93_L355_L0.5840.39
172_S176_G0.5830.39
322_D376_K0.5810.39
183_Y195_A0.5810.39
20_H139_P0.5790.39
349_S352_K0.5770.38
77_Q157_D0.5770.38
79_A141_A0.5770.38
375_V379_R0.5760.38
48_A339_G0.5750.38
13_F21_A0.5740.38
94_E355_L0.5720.38
116_L150_L0.5710.38
261_V314_I0.5710.38
197_L209_S0.5690.38
113_T117_I0.5690.38
299_T302_Y0.5690.38
315_L318_T0.5690.38
116_L120_H0.5670.37
301_R344_G0.5670.37
21_A33_A0.5650.37
5_G99_F0.5640.37
290_Y293_F0.5630.37
91_N264_R0.5630.37
334_Y371_L0.5620.37
332_A370_A0.5610.37
99_F166_G0.5610.37
138_Y380_I0.5570.36
237_Y244_W0.5570.36
113_T116_L0.5550.36
39_G69_E0.5540.36
117_I163_N0.5530.36
251_F258_L0.5530.36
28_T97_A0.5530.36
128_I142_A0.5520.36
254_L258_L0.5490.36
10_Y163_N0.5480.36
20_H317_R0.5470.36
262_T266_L0.5460.35
114_A174_L0.5460.35
68_I99_F0.5450.35
78_K142_A0.5450.35
247_P312_T0.5450.35
126_D179_P0.5450.35
81_I86_S0.5440.35
52_K378_S0.5430.35
300_K307_L0.5430.35
41_F374_D0.5430.35
130_E148_S0.5430.35
21_A91_N0.5420.35
35_A277_E0.5410.35
87_V147_S0.5410.35
88_S176_G0.5400.35
40_H51_S0.5400.35
130_E134_K0.5390.35
120_H132_L0.5370.35
263_A282_R0.5370.35
217_Q291_Q0.5370.35
87_V178_Y0.5370.35
212_K229_A0.5360.35
54_A58_M0.5360.35
42_L48_A0.5350.34
106_D112_E0.5350.34
72_Y85_G0.5350.34
270_Y318_T0.5340.34
5_G358_P0.5340.34
31_D293_F0.5340.34
112_E115_Q0.5330.34
290_Y384_P0.5330.34
258_L272_V0.5330.34
98_L182_P0.5320.34
285_R379_R0.5320.34
337_L359_L0.5320.34
132_L142_A0.5310.34
124_L145_A0.5310.34
8_V24_A0.5290.34
166_G170_V0.5290.34
53_W383_L0.5270.34
181_K235_A0.5260.34
295_E356_S0.5250.34
337_L340_M0.5250.34
216_G220_E0.5250.34
110_F166_G0.5230.33
251_F384_P0.5230.33
193_H209_S0.5220.33
8_V192_Y0.5210.33
27_Q183_Y0.5210.33
106_D286_K0.5210.33
47_P312_T0.5210.33
213_A225_F0.5210.33
53_W344_G0.5200.33
105_G163_N0.5190.33
11_N14_H0.5190.33
11_N17_H0.5190.33
11_N16_G0.5190.33
228_A232_R0.5180.33
251_F293_F0.5170.33
310_M314_I0.5160.33
113_T121_K0.5160.33
163_N375_V0.5150.33
294_M301_R0.5140.33
364_S367_S0.5140.33
230_S234_L0.5140.33
87_V182_P0.5130.32
363_L366_F0.5110.32
77_Q86_S0.5100.32
85_G300_K0.5100.32
277_E310_M0.5090.32
103_E163_N0.5090.32
269_V317_R0.5080.32
10_Y135_G0.5080.32
78_K146_F0.5080.32
85_G207_A0.5080.32
204_I210_I0.5080.32
125_N129_K0.5070.32
50_V226_L0.5060.32
252_S255_K0.5060.32
300_K306_R0.5060.32
117_I120_H0.5050.32
123_I365_S0.5050.32
134_K181_K0.5040.32
210_I223_L0.5040.32
6_L137_S0.5040.32
75_A133_K0.5020.31
331_K370_A0.5020.31
142_A146_F0.5020.31
24_A258_L0.5020.31
210_I248_E0.5020.31
266_L314_I0.5020.31
161_P299_T0.5020.31
62_S352_K0.5010.31
353_K359_L0.5010.31
114_A209_S0.5000.31
252_S290_Y0.5000.31
337_L355_L0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gmiA 1 0.7012 100 0.553 Contact Map
2h29A 2 0.4361 99.9 0.853 Contact Map
2qtrA 2 0.4386 99.9 0.855 Contact Map
2qjoA 3 0.6843 99.5 0.893 Contact Map
1kamA 3 0.4193 99.4 0.899 Contact Map
4mvcA 2 0.3735 99.4 0.9 Contact Map
4natA 5 0.3663 99.4 0.9 Contact Map
1o6bA 5 0.388 99.4 0.902 Contact Map
3k9wA 5 0.3831 99.4 0.902 Contact Map
3op1A 4 0.6337 99.3 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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