GREMLIN Database
YFMM - Uncharacterized ABC transporter ATP-binding protein YfmM
UniProt: O34512 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 518 (406)
Sequences: 3453 (2282)
Seq/√Len: 113.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
223_N245_H5.1501.00
100_E122_E4.6271.00
330_D342_P3.8011.00
328_T331_L3.7801.00
102_N105_Y3.6351.00
8_D21_N3.3281.00
46_M215_I3.2011.00
134_D137_V3.1391.00
328_T345_L3.0211.00
329_K380_S2.9931.00
333_I377_L2.8541.00
293_Q297_D2.6861.00
6_V9_L2.6641.00
333_I369_S2.6611.00
347_M353_I2.6371.00
334_G377_L2.5411.00
82_S85_D2.5241.00
330_D344_N2.5161.00
92_H96_A2.4681.00
273_K301_M2.4541.00
228_L239_R2.4491.00
130_L135_F2.4141.00
238_T254_K2.3661.00
246_Q250_V2.3241.00
30_E228_L2.2241.00
87_L90_A2.2221.00
6_V49_I2.2101.00
103_E107_K2.1741.00
246_Q249_E2.1681.00
273_K277_A2.1501.00
33_G229_I2.1451.00
129_A133_N2.1331.00
158_R162_D2.1031.00
338_P341_R2.0951.00
104_I119_L2.0661.00
100_E103_E2.0391.00
141_K180_K2.0121.00
85_D88_K1.9871.00
97_M126_I1.9451.00
117_E121_E1.9441.00
17_A20_N1.9331.00
402_N407_E1.9071.00
112_D115_E1.8931.00
6_V24_F1.8811.00
49_I213_I1.8411.00
332_V378_E1.8401.00
240_Y254_K1.8371.00
206_Q224_S1.8361.00
226_I229_I1.8351.00
396_V399_T1.8311.00
262_Y266_Q1.8181.00
180_K209_E1.8081.00
282_R285_T1.8021.00
99_E102_N1.7991.00
9_L55_P1.7731.00
280_K293_Q1.7671.00
10_S57_E1.7631.00
113_P116_L1.7371.00
93_Y96_A1.7121.00
364_T368_K1.7091.00
369_S381_V1.7021.00
20_N236_E1.7001.00
7_K59_K1.6901.00
98_E102_N1.6631.00
368_K373_E1.6601.00
30_E227_N1.6581.00
202_K224_S1.6491.00
101_M105_Y1.6271.00
324_L327_E1.6271.00
84_R87_L1.6251.00
290_M293_Q1.6241.00
327_E382_E1.6101.00
86_V89_D1.5951.00
331_L376_P1.5851.00
276_V296_L1.5821.00
249_E253_V1.5631.00
84_R90_A1.5441.00
250_V254_K1.5371.00
231_H251_Y1.5331.00
47_N52_K1.5251.00
33_G222_L1.5151.00
26_L183_I1.5121.00
19_F22_V1.5061.00
80_G159_D1.4911.00
327_E346_R1.4701.00
232_V237_L1.4611.00
223_N243_D1.4591.00
86_V90_A1.4571.00
257_Q261_A1.4571.00
268_E271_E1.4511.00
291_S294_K1.4401.00
276_V293_Q1.4261.00
100_E104_I1.4231.00
203_R207_E1.4141.00
34_L232_V1.4131.00
283_V286_R1.4071.00
85_D90_A1.4021.00
250_V253_V1.3991.00
87_L91_F1.3981.00
369_S376_P1.3981.00
62_W66_V1.3961.00
134_D141_K1.3941.00
275_F288_M1.3901.00
46_M185_L1.3821.00
101_M104_I1.3731.00
168_R395_E1.3691.00
43_S47_N1.3671.00
340_S343_L1.3661.00
333_I374_I1.3631.00
98_E105_Y1.3631.00
329_K344_N1.3481.00
279_N285_T1.3471.00
159_D162_D1.3441.00
328_T370_L1.3421.00
98_E101_M1.3391.00
396_V400_N1.3201.00
282_R286_R1.3121.00
252_E256_Q1.3051.00
11_H56_D1.3020.99
334_G338_P1.3020.99
96_A100_E1.3010.99
84_R89_D1.3000.99
26_L32_V1.2980.99
294_K297_D1.2950.99
368_K374_I1.2830.99
329_K382_E1.2770.99
333_I365_T1.2770.99
84_R88_K1.2760.99
8_D23_S1.2740.99
11_H44_T1.2730.99
205_L225_V1.2660.99
69_G176_L1.2660.99
253_V256_Q1.2610.99
326_F383_R1.2610.99
323_K348_E1.2510.99
146_A156_L1.2500.99
112_D116_L1.2460.99
253_V257_Q1.2420.99
127_Q131_T1.2420.99
81_K89_D1.2420.99
11_H53_L1.2400.99
105_Y108_M1.2390.99
10_S21_N1.2370.99
9_L48_I1.2320.99
242_G246_Q1.2260.99
275_F292_R1.2250.99
95_F98_E1.2220.99
82_S86_V1.2210.99
11_H48_I1.2180.99
77_L82_S1.2150.99
231_H247_F1.2090.99
279_N282_R1.2060.99
185_L213_I1.1960.99
22_V237_L1.1950.99
80_G161_T1.1900.99
24_F230_Y1.1900.99
214_L226_I1.1860.99
369_S377_L1.1800.99
163_L171_V1.1740.99
321_S325_I1.1670.99
48_I60_V1.1660.99
267_Q270_A1.1660.99
63_S66_V1.1560.99
268_E272_L1.1520.99
160_V171_V1.1500.99
97_M100_E1.1490.99
105_Y123_V1.1330.99
243_D246_Q1.1270.99
331_L369_S1.1260.99
376_P381_V1.1260.99
122_E126_I1.1250.99
259_E263_K1.1230.98
33_G226_I1.1220.98
48_I55_P1.1220.98
274_D278_R1.1180.98
97_M101_M1.1170.98
125_V129_A1.1170.98
79_K82_S1.1080.98
205_L212_F1.1010.98
86_V91_F1.0990.98
81_K86_V1.0980.98
82_S87_L1.0920.98
121_E125_V1.0920.98
128_D131_T1.0830.98
256_Q260_A1.0810.98
31_H227_N1.0750.98
183_I213_I1.0740.98
111_A115_E1.0730.98
107_K110_E1.0700.98
8_D57_E1.0670.98
100_E107_K1.0650.98
258_L302_I1.0640.98
265_Q302_I1.0610.98
249_E252_E1.0600.98
230_Y237_L1.0590.98
185_L215_I1.0530.98
275_F279_N1.0400.98
52_K72_D1.0400.98
99_E103_E1.0400.98
256_Q259_E1.0390.98
262_Y265_Q1.0350.97
334_G369_S1.0320.97
122_E125_V1.0320.97
88_K95_F1.0300.97
4_L62_W1.0300.97
81_K85_D1.0270.97
128_D132_N1.0250.97
183_I211_A1.0210.97
93_Y133_N1.0200.97
230_Y239_R1.0140.97
299_M302_I1.0120.97
78_E82_S1.0030.97
294_K298_K1.0030.97
289_A293_Q0.9960.97
302_I305_A0.9960.97
107_K115_E0.9900.97
103_E106_N0.9900.97
62_W68_V0.9870.97
91_F98_E0.9840.97
340_S369_S0.9840.97
277_A280_K0.9810.96
6_V60_V0.9770.96
216_S222_L0.9750.96
151_L155_G0.9730.96
46_M50_T0.9730.96
328_T381_V0.9710.96
330_D378_E0.9650.96
319_R388_Y0.9650.96
152_S155_G0.9640.96
66_V183_I0.9640.96
335_Y374_I0.9630.96
67_R182_E0.9600.96
324_L382_E0.9560.96
281_A285_T0.9550.96
22_V232_V0.9510.96
289_A294_K0.9510.96
29_G211_A0.9500.96
81_K84_R0.9480.96
155_G158_R0.9480.96
34_L237_L0.9450.96
270_A274_D0.9380.95
272_L295_K0.9340.95
332_V340_S0.9320.95
155_G163_L0.9310.95
266_Q269_V0.9280.95
151_L163_L0.9240.95
30_E239_R0.9230.95
291_S295_K0.9200.95
55_P60_V0.9200.95
403_T406_E0.9160.95
399_T407_E0.9160.95
121_E124_G0.9110.95
203_R206_Q0.9060.95
108_M116_L0.9030.94
286_R290_M0.8980.94
322_G384_G0.8960.94
94_L98_E0.8910.94
12_G17_A0.8910.94
322_G325_I0.8900.94
264_K267_Q0.8900.94
77_L83_I0.8890.94
11_H55_P0.8860.94
370_L383_R0.8830.94
21_N236_E0.8810.94
275_F282_R0.8790.94
383_R387_I0.8780.94
104_I126_I0.8760.93
196_Q358_A0.8740.93
275_F281_A0.8730.93
13_F53_L0.8720.93
102_N106_N0.8690.93
370_L381_V0.8660.93
124_G128_D0.8660.93
97_M105_Y0.8650.93
104_I107_K0.8650.93
110_E113_P0.8650.93
326_F347_M0.8580.93
280_K285_T0.8550.93
96_A99_E0.8550.93
321_S387_I0.8510.92
332_V341_R0.8490.92
291_S296_L0.8480.92
111_A116_L0.8480.92
296_L302_I0.8470.92
97_M129_A0.8470.92
290_M294_K0.8470.92
283_V290_M0.8470.92
357_G363_K0.8470.92
325_I387_I0.8460.92
399_T402_N0.8430.92
332_V342_P0.8430.92
275_F283_V0.8380.92
83_I90_A0.8360.92
277_A282_R0.8350.92
106_N109_G0.8340.92
94_L97_M0.8260.91
363_K394_Q0.8230.91
107_K119_L0.8220.91
75_T168_R0.8200.91
89_D92_H0.8190.91
242_G250_V0.8170.91
291_S298_K0.8150.91
4_L183_I0.8100.90
291_S299_M0.8090.90
140_S144_E0.8090.90
287_N291_S0.8090.90
113_P117_E0.8070.90
279_N288_M0.8050.90
138_I142_V0.8020.90
104_I108_M0.7990.90
78_E83_I0.7950.90
269_V296_L0.7940.90
371_L389_T0.7930.90
281_A284_S0.7930.90
34_L213_I0.7920.89
84_R91_F0.7900.89
83_I163_L0.7890.89
9_L19_F0.7880.89
117_E120_L0.7870.89
384_G387_I0.7850.89
279_N283_V0.7750.88
282_R288_M0.7730.88
303_E306_A0.7730.88
255_K259_E0.7720.88
26_L213_I0.7710.88
84_R142_V0.7690.88
138_I178_L0.7690.88
78_E81_K0.7680.88
114_D117_E0.7680.88
330_D333_I0.7670.88
115_E119_L0.7590.87
166_G360_G0.7570.87
334_G339_L0.7560.87
32_V230_Y0.7520.87
106_N110_E0.7520.87
295_K299_M0.7510.87
97_M104_I0.7510.87
290_M298_K0.7510.87
288_M291_S0.7490.87
202_K219_I0.7490.87
335_Y365_T0.7450.86
277_A281_A0.7440.86
93_Y129_A0.7430.86
264_K268_E0.7400.86
402_N406_E0.7390.86
358_A361_I0.7380.86
76_V79_K0.7370.86
69_G73_Q0.7360.86
124_G127_Q0.7340.86
258_L304_L0.7330.86
258_L261_A0.7330.86
160_V168_R0.7320.85
10_S17_A0.7320.85
110_E114_D0.7290.85
332_V338_P0.7280.85
116_L119_L0.7280.85
357_G360_G0.7260.85
80_G83_I0.7250.85
405_I408_V0.7220.85
98_E108_M0.7180.84
348_E351_Q0.7170.84
77_L81_K0.7160.84
77_L86_V0.7160.84
300_D303_E0.7160.84
80_G87_L0.7160.84
98_E104_I0.7150.84
319_R386_H0.7140.84
141_K144_E0.7130.84
298_K301_M0.7130.84
284_S290_M0.7120.84
143_E156_L0.7110.84
158_R163_L0.7110.84
83_I171_V0.7110.84
154_I158_R0.7100.84
347_M351_Q0.7090.84
272_L282_R0.7070.83
296_L305_A0.7040.83
149_L174_A0.7030.83
105_Y109_G0.7010.83
308_K311_P0.7010.83
275_F286_R0.6990.83
82_S90_A0.6970.83
275_F285_T0.6950.82
82_S89_D0.6930.82
265_Q296_L0.6900.82
93_Y100_E0.6890.82
166_G359_N0.6890.82
273_K296_L0.6870.82
137_V141_K0.6870.82
272_L275_F0.6850.81
265_Q269_V0.6850.81
274_D277_A0.6840.81
269_V272_L0.6830.81
333_I340_S0.6820.81
362_G394_Q0.6820.81
76_V81_K0.6780.81
324_L346_R0.6770.81
91_F94_L0.6740.80
268_E299_M0.6740.80
160_V172_L0.6740.80
323_K327_E0.6720.80
47_N53_L0.6700.80
58_G73_Q0.6680.80
286_R291_S0.6670.80
110_E117_E0.6660.80
82_S91_F0.6660.80
280_K286_R0.6640.79
331_L370_L0.6640.79
143_E153_D0.6640.79
369_S374_I0.6630.79
269_V301_M0.6620.79
164_S360_G0.6610.79
293_Q296_L0.6570.79
88_K98_E0.6570.79
372_G381_V0.6550.79
360_G363_K0.6530.78
111_A114_D0.6530.78
221_F225_V0.6520.78
101_M126_I0.6500.78
279_N286_R0.6450.77
90_A101_M0.6450.77
27_L30_E0.6440.77
164_S363_K0.6430.77
166_G362_G0.6420.77
279_N284_S0.6420.77
322_G385_E0.6410.77
94_L133_N0.6400.77
78_E89_D0.6400.77
151_L154_I0.6390.77
130_L134_D0.6380.77
83_I87_L0.6370.77
318_A388_Y0.6360.76
97_M102_N0.6360.76
38_N217_H0.6320.76
306_A311_P0.6320.76
7_K61_E0.6310.76
342_P378_E0.6300.76
393_E396_V0.6270.75
360_G365_T0.6270.75
359_N365_T0.6250.75
272_L286_R0.6250.75
294_K300_D0.6240.75
118_K122_E0.6240.75
214_L225_V0.6240.75
32_V228_L0.6230.75
357_G362_G0.6230.75
108_M123_V0.6200.75
50_T70_Y0.6190.75
44_T53_L0.6190.75
118_K121_E0.6180.74
62_W65_N0.6180.74
79_K83_I0.6160.74
100_E126_I0.6160.74
281_A293_Q0.6130.74
294_K302_I0.6130.74
88_K139_D0.6130.74
289_A296_L0.6090.73
288_M292_R0.6090.73
3_I63_S0.6080.73
37_A40_E0.6060.73
92_H97_M0.6030.73
355_L358_A0.6030.73
101_M108_M0.6020.72
261_A302_I0.6000.72
126_I129_A0.6000.72
164_S394_Q0.5990.72
298_K305_A0.5970.72
69_G181_P0.5970.72
244_Y247_F0.5970.72
369_S375_Q0.5960.72
95_F102_N0.5950.72
29_G209_E0.5950.72
397_K400_N0.5940.71
349_R392_F0.5940.71
281_A286_R0.5930.71
83_I89_D0.5920.71
276_V305_A0.5910.71
34_L230_Y0.5900.71
325_I384_G0.5890.71
118_K336_D0.5890.71
281_A289_A0.5890.71
130_L136_Y0.5890.71
176_L184_L0.5870.71
374_I377_L0.5860.70
3_I211_A0.5850.70
228_L241_V0.5840.70
220_P224_S0.5800.70
5_S61_E0.5800.70
60_V183_I0.5790.70
115_E118_K0.5780.69
51_G58_G0.5770.69
279_N293_Q0.5770.69
170_K231_H0.5760.69
14_G17_A0.5760.69
240_Y247_F0.5750.69
298_K302_I0.5750.69
372_G389_T0.5730.69
166_G394_Q0.5720.69
325_I349_R0.5700.68
404_C407_E0.5700.68
123_V130_L0.5700.68
104_I122_E0.5700.68
19_F232_V0.5700.68
293_Q299_M0.5680.68
328_T344_N0.5660.68
272_L283_V0.5660.68
301_M305_A0.5660.68
87_L146_A0.5640.68
91_F101_M0.5630.67
79_K161_T0.5630.67
131_T136_Y0.5610.67
298_K303_E0.5600.67
286_R292_R0.5590.67
120_L124_G0.5590.67
198_I395_E0.5530.66
149_L200_W0.5520.66
94_L101_M0.5510.66
85_D100_E0.5490.65
48_I232_V0.5480.65
164_S362_G0.5480.65
360_G394_Q0.5470.65
101_M123_V0.5470.65
216_S354_A0.5460.65
169_T279_N0.5460.65
139_D143_E0.5460.65
248_M252_E0.5460.65
335_Y369_S0.5460.65
95_F99_E0.5450.65
102_N108_M0.5450.65
291_S297_D0.5440.65
212_F225_V0.5430.65
293_Q300_D0.5420.65
80_G85_D0.5410.64
257_Q260_A0.5400.64
19_F45_F0.5390.64
166_G365_T0.5380.64
107_K122_E0.5380.64
285_T293_Q0.5380.64
269_V299_M0.5380.64
120_L127_Q0.5370.64
71_L176_L0.5360.64
49_I230_Y0.5350.64
70_Y73_Q0.5350.64
107_K114_D0.5340.63
3_I393_E0.5340.63
142_V352_K0.5320.63
110_E116_L0.5310.63
226_I230_Y0.5280.63
22_V45_F0.5280.63
335_Y339_L0.5280.63
85_D89_D0.5270.62
149_L197_H0.5270.62
165_G394_Q0.5260.62
289_A292_R0.5260.62
166_G357_G0.5250.62
208_Y212_F0.5250.62
191_N218_D0.5250.62
220_P223_N0.5250.62
283_V291_S0.5240.62
403_T407_E0.5240.62
11_H18_I0.5240.62
299_M305_A0.5230.62
294_K299_M0.5210.61
151_L171_V0.5200.61
83_I86_V0.5200.61
271_E275_F0.5200.61
79_K89_D0.5190.61
280_K284_S0.5190.61
278_R281_A0.5180.61
167_Q395_E0.5180.61
33_G230_Y0.5180.61
291_S300_D0.5170.61
375_Q383_R0.5170.61
7_K23_S0.5160.61
93_Y97_M0.5160.61
320_T349_R0.5150.61
85_D157_E0.5150.61
86_V175_K0.5150.61
119_L123_V0.5150.61
265_Q276_V0.5150.61
260_A264_K0.5140.60
3_I32_V0.5130.60
180_K208_Y0.5130.60
317_P320_T0.5130.60
92_H95_F0.5120.60
109_G113_P0.5120.60
272_L276_V0.5100.60
22_V29_G0.5100.60
108_M115_E0.5090.60
265_Q301_M0.5080.60
43_S46_M0.5080.60
170_K197_H0.5060.59
38_N191_N0.5060.59
3_I66_V0.5060.59
62_W183_I0.5050.59
109_G115_E0.5050.59
99_E107_K0.5050.59
163_L282_R0.5050.59
76_V213_I0.5050.59
110_E115_E0.5040.59
146_A151_L0.5040.59
114_D119_L0.5040.59
294_K305_A0.5030.59
52_K203_R0.5030.59
85_D91_F0.5030.59
365_T394_Q0.5030.59
11_H168_R0.5020.59
6_V19_F0.5000.58
259_E304_L0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4finA 2 0.9459 100 0.275 Contact Map
2iw3A 2 0.834 100 0.342 Contact Map
4q9hA 1 0.9189 100 0.347 Contact Map
4f4cA 1 0.9054 100 0.354 Contact Map
1yqtA 1 0.8514 100 0.367 Contact Map
3bk7A 1 0.8668 100 0.367 Contact Map
3ozxA 1 0.861 100 0.373 Contact Map
3j16B 1 0.8803 100 0.398 Contact Map
3ux8A 2 0.7529 100 0.425 Contact Map
2vf7A 2 0.8378 100 0.526 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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