GREMLIN Database
AEEP - L-Ala-D/L-Glu epimerase
UniProt: O34508 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 366 (313)
Sequences: 12514 (7327)
Seq/√Len: 414.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_T343_T3.4441.00
77_K88_D3.2581.00
255_E259_T3.0651.00
234_T263_D3.0491.00
197_R200_E2.9641.00
81_G84_A2.9111.00
231_K235_D2.7761.00
34_V102_A2.6911.00
226_D229_G2.6271.00
254_F258_Q2.5251.00
37_T43_V2.5241.00
42_A110_G2.4471.00
35_R43_V2.4271.00
38_Y110_G2.4031.00
232_K235_D2.1961.00
250_P277_G2.1801.00
149_E181_R2.1471.00
63_E67_H2.1421.00
35_R45_W2.1411.00
83_E280_K2.1321.00
231_K259_T2.1131.00
187_K216_E2.0901.00
64_S68_H2.0641.00
205_I218_V2.0321.00
206_R236_A2.0191.00
104_E276_S2.0091.00
38_Y42_A2.0071.00
232_K236_A2.0021.00
206_R209_E1.9911.00
149_E153_K1.9871.00
228_A259_T1.9651.00
173_A176_Q1.9381.00
340_S345_S1.9271.00
257_L290_V1.9071.00
272_A281_I1.8861.00
77_K84_A1.8511.00
202_V236_A1.8471.00
40_S114_M1.8441.00
264_L291_E1.8331.00
205_I237_T1.8321.00
209_E238_D1.8011.00
42_A114_M1.7881.00
131_E157_Q1.7611.00
112_A119_L1.7481.00
118_P121_Q1.7251.00
284_M288_C1.7211.00
253_A281_I1.7171.00
204_A208_M1.7151.00
176_Q213_L1.7121.00
145_A181_R1.6861.00
36_I107_L1.6551.00
48_A102_A1.6521.00
146_A149_E1.6511.00
117_L121_Q1.6511.00
85_I107_L1.6441.00
207_K210_D1.6361.00
258_Q288_C1.5981.00
143_E146_A1.5871.00
141_P145_A1.5741.00
129_T345_S1.5711.00
172_I207_K1.5621.00
42_A113_Q1.5511.00
170_T173_A1.5491.00
222_V233_V1.5411.00
149_E152_L1.5401.00
150_N153_K1.5251.00
283_A286_E1.5161.00
257_L284_M1.4971.00
199_K232_K1.4851.00
279_E283_A1.4831.00
140_S143_E1.4491.00
67_H71_K1.4431.00
146_A150_N1.4421.00
152_L186_V1.4401.00
312_A346_M1.4381.00
33_I45_W1.4121.00
210_D213_L1.4101.00
162_K166_D1.4101.00
177_E180_K1.4091.00
71_K75_L1.4031.00
104_E108_Y1.3941.00
176_Q180_K1.3871.00
255_E258_Q1.3841.00
198_P232_K1.3831.00
38_Y114_M1.3831.00
247_V256_V1.3821.00
254_F284_M1.3821.00
209_E239_T1.3701.00
109_D113_Q1.3671.00
135_T171_D1.3571.00
256_V262_A1.3471.00
80_A114_M1.3461.00
173_A177_E1.3421.00
150_N154_Q1.3421.00
202_V232_K1.3411.00
257_L288_C1.3411.00
198_P233_V1.3371.00
282_N314_K1.3001.00
242_M264_L1.2981.00
206_R210_D1.2971.00
203_T206_R1.2791.00
222_V229_G1.2721.00
77_K85_I1.2701.00
68_H72_P1.2611.00
84_A88_D1.2591.00
225_D252_Q1.2501.00
111_W115_C1.2421.00
198_P229_G1.2421.00
105_M275_I1.2381.00
252_Q255_E1.2361.00
277_G280_K1.2301.00
189_R217_L1.2281.00
159_L186_V1.2251.00
145_A149_E1.2131.00
249_T252_Q1.2101.00
278_A310_F1.2091.00
131_E343_T1.2021.00
89_I100_K1.1991.00
189_R216_E1.1951.00
172_I213_L1.1921.00
117_L122_M1.1831.00
87_H91_H1.1831.00
203_T207_K1.1811.00
190_L215_I1.1801.00
231_K261_S1.1781.00
279_E314_K1.1771.00
167_D170_T1.1751.00
139_N143_E1.1671.00
162_K193_N1.1661.00
175_I213_L1.1641.00
147_D150_N1.1581.00
283_A287_A1.1531.00
112_A122_M1.1481.00
286_E315_R1.1461.00
221_P233_V1.1371.00
47_E302_L1.1361.00
200_E203_T1.1331.00
182_V188_L1.1321.00
78_S81_G1.1321.00
109_D306_A1.1281.00
250_P284_M1.1271.00
202_V233_V1.1221.00
70_L103_V1.1201.00
172_I176_Q1.1111.00
82_Y111_W1.1091.00
253_A265_I1.1031.00
39_D79_L1.0951.00
280_K283_A1.0911.00
181_R184_S1.0911.00
105_M306_A1.0871.00
148_A152_L1.0811.00
161_I178_I1.0801.00
80_A115_C1.0771.00
206_R238_D1.0761.00
192_A218_V1.0741.00
269_L278_A1.0721.00
201_A205_I1.0681.00
265_I285_A1.0651.00
209_E237_T1.0621.00
148_A182_V1.0561.00
221_P241_I1.0391.00
80_A111_W1.0351.00
85_I88_D1.0351.00
61_S64_S1.0311.00
115_C122_M1.0281.00
291_E318_T1.0271.00
284_M287_A1.0231.00
196_W204_A1.0191.00
234_T260_R1.0181.00
196_W201_A1.0181.00
152_L159_L1.0161.00
145_A180_K1.0141.00
243_A256_V1.0121.00
108_Y276_S1.0111.00
176_Q210_D1.0091.00
260_R290_V0.9991.00
108_Y275_I0.9981.00
77_K81_G0.9961.00
179_R183_G0.9911.00
33_I302_L0.9841.00
66_I103_V0.9821.00
220_Q266_N0.9821.00
242_M266_N0.9731.00
169_A173_A0.9731.00
147_D151_Y0.9711.00
294_V316_N0.9701.00
145_A182_V0.9661.00
280_K286_E0.9661.00
268_K295_G0.9511.00
148_A159_L0.9411.00
32_V63_E0.9391.00
192_A205_I0.9381.00
198_P202_V0.9291.00
83_E279_E0.9291.00
229_G232_K0.9271.00
79_L107_L0.9261.00
73_A88_D0.9251.00
247_V253_A0.9241.00
184_S214_G0.9161.00
254_F288_C0.9151.00
119_L123_L0.9061.00
233_V241_I0.9021.00
164_G171_D0.9011.00
201_A222_V0.8981.00
142_E146_A0.8951.00
257_L265_I0.8881.00
178_I182_V0.8841.00
70_L93_L0.8811.00
141_P177_E0.8811.00
272_A278_A0.8781.00
175_I208_M0.8781.00
151_Y154_Q0.8771.00
141_P173_A0.8731.00
228_A231_K0.8671.00
175_I190_L0.8651.00
240_P318_T0.8621.00
279_E313_S0.8611.00
158_T189_R0.8611.00
168_I172_I0.8601.00
37_T41_G0.8591.00
179_R188_L0.8571.00
36_I44_G0.8551.00
262_A265_I0.8541.00
210_D238_D0.8531.00
123_L279_E0.8471.00
250_P280_K0.8401.00
199_K203_T0.8401.00
227_L261_S0.8381.00
74_L77_K0.8371.00
215_I239_T0.8341.00
222_V230_L0.8341.00
177_E181_R0.8341.00
235_D260_R0.8321.00
282_N286_E0.8321.00
111_W122_M0.8311.00
86_L276_S0.8251.00
90_Q277_G0.8251.00
282_N292_C0.8241.00
38_Y79_L0.8201.00
168_I204_A0.8161.00
339_Y344_I0.8121.00
248_F252_Q0.8111.00
129_T341_G0.8091.00
228_A255_E0.8081.00
179_R214_G0.8031.00
247_V262_A0.8021.00
244_D268_K0.7991.00
132_T135_T0.7981.00
179_R185_A0.7971.00
198_P222_V0.7971.00
86_L104_E0.7941.00
294_V311_A0.7921.00
282_N294_V0.7901.00
230_L243_A0.7891.00
243_A262_A0.7881.00
269_L310_F0.7861.00
79_L111_W0.7841.00
119_L275_I0.7841.00
60_D64_S0.7811.00
146_A153_K0.7791.00
64_S67_H0.7781.00
192_A196_W0.7771.00
227_L256_V0.7761.00
308_A346_M0.7731.00
45_W302_L0.7711.00
269_L307_A0.7711.00
338_T345_S0.7681.00
120_Y309_H0.7671.00
172_I210_D0.7631.00
37_T45_W0.7611.00
134_Y156_F0.7611.00
117_L125_G0.7571.00
83_E87_H0.7551.00
227_L255_E0.7521.00
182_V186_V0.7521.00
267_I278_A0.7501.00
172_I182_V0.7491.00
145_A148_A0.7441.00
134_Y151_Y0.7441.00
340_S343_T0.7401.00
275_I306_A0.7401.00
115_C118_P0.7391.00
247_V252_Q0.7361.00
306_A310_F0.7331.00
36_I74_L0.7311.00
253_A290_V0.7301.00
267_I282_N0.7281.00
202_V237_T0.7221.00
66_I71_K0.7201.00
163_V192_A0.7171.00
146_A181_R0.7161.00
73_A77_K0.7121.00
201_A233_V0.7111.00
265_I290_V0.7101.00
120_Y346_M0.7071.00
79_L114_M0.7051.00
44_G113_Q0.7051.00
143_E147_D0.7051.00
171_D196_W0.7041.00
230_L241_I0.7001.00
169_A207_K0.6961.00
129_T340_S0.6941.00
72_P75_L0.6931.00
196_W218_V0.6921.00
156_F159_L0.6891.00
148_A151_Y0.6881.00
34_V66_I0.6861.00
86_L90_Q0.6851.00
115_C125_G0.6851.00
285_A290_V0.6821.00
232_K260_R0.6821.00
279_E310_F0.6811.00
81_G121_Q0.6811.00
100_K274_G0.6811.00
305_T309_H0.6801.00
308_A344_I0.6791.00
108_Y119_L0.6781.00
275_I279_E0.6751.00
37_T40_S0.6690.99
250_P281_I0.6690.99
227_L259_T0.6670.99
202_V222_V0.6660.99
251_R254_F0.6650.99
86_L89_I0.6650.99
164_G167_D0.6630.99
170_T174_R0.6630.99
88_D91_H0.6620.99
144_M148_A0.6610.99
253_A285_A0.6590.99
78_S121_Q0.6580.99
267_I292_C0.6560.99
123_L275_I0.6550.99
44_G106_A0.6550.99
145_A177_E0.6480.99
144_M147_D0.6480.99
250_P254_F0.6450.99
175_I188_L0.6430.99
63_E66_I0.6420.99
234_T241_I0.6410.99
233_V237_T0.6380.99
132_T293_M0.6370.99
144_M177_E0.6340.99
85_I89_I0.6310.99
44_G109_D0.6310.99
286_E292_C0.6290.99
158_T187_K0.6270.99
123_L313_S0.6270.99
83_E276_S0.6270.99
148_A178_I0.6260.99
266_N295_G0.6230.99
32_V59_M0.6230.99
202_V206_R0.6200.99
176_Q181_R0.6200.99
292_C316_N0.6190.99
87_H90_Q0.6160.99
110_G114_M0.6140.99
144_M150_N0.6140.99
82_Y85_I0.6140.99
38_Y41_G0.6120.99
286_E316_N0.6090.99
112_A117_L0.6090.99
217_L293_M0.6070.99
205_I239_T0.6070.99
108_Y123_L0.6040.99
175_I182_V0.6030.99
157_Q341_G0.6020.99
79_L82_Y0.6020.99
43_V113_Q0.6010.99
230_L233_V0.6000.99
65_A99_A0.6000.99
144_M174_R0.6000.99
285_A292_C0.5990.99
265_I281_I0.5980.99
133_D189_R0.5950.99
311_A320_F0.5950.99
39_D42_A0.5920.99
112_A115_C0.5920.99
220_Q245_E0.5910.99
203_T236_A0.5910.99
60_D68_H0.5900.99
66_I99_A0.5890.99
216_E240_P0.5880.99
130_L133_D0.5870.99
180_K184_S0.5850.99
148_A181_R0.5850.99
111_W114_M0.5840.99
46_G102_A0.5840.99
161_I175_I0.5840.99
144_M151_Y0.5830.99
107_L111_W0.5810.99
296_S304_I0.5800.99
79_L110_G0.5800.99
32_V62_I0.5790.99
163_V166_D0.5780.98
253_A267_I0.5770.98
61_S65_A0.5760.98
129_T133_D0.5740.98
220_Q244_D0.5740.98
328_L331_D0.5720.98
159_L182_V0.5720.98
109_D305_T0.5710.98
220_Q246_S0.5690.98
46_G106_A0.5640.98
204_A207_K0.5630.98
156_F160_K0.5620.98
161_I167_D0.5590.98
252_Q261_S0.5590.98
270_M297_M0.5540.98
183_G186_V0.5540.98
122_M125_G0.5510.98
179_R184_S0.5500.98
146_A151_Y0.5480.98
36_I106_A0.5480.98
205_I233_V0.5480.98
119_L122_M0.5470.98
157_Q185_A0.5470.98
144_M149_E0.5450.98
269_L275_I0.5450.98
172_I175_I0.5450.98
194_Q246_S0.5450.98
119_L309_H0.5430.98
160_K163_V0.5420.98
82_Y276_S0.5410.98
145_A151_Y0.5410.98
152_L182_V0.5400.98
113_Q116_G0.5390.98
261_S290_V0.5370.98
145_A153_K0.5370.98
175_I215_I0.5360.98
82_Y107_L0.5360.98
304_I308_A0.5350.98
199_K202_V0.5350.98
234_T261_S0.5350.98
231_K260_R0.5340.97
159_L163_V0.5310.97
194_Q224_K0.5310.97
59_M63_E0.5300.97
163_V196_W0.5300.97
198_P226_D0.5300.97
142_E145_A0.5300.97
87_H280_K0.5290.97
146_A152_L0.5290.97
160_K164_G0.5270.97
66_I102_A0.5260.97
131_E187_K0.5250.97
179_R213_L0.5230.97
176_Q207_K0.5220.97
237_T241_I0.5210.97
86_L100_K0.5190.97
278_A294_V0.5180.97
192_A201_A0.5180.97
251_R255_E0.5170.97
262_A290_V0.5160.97
71_K103_V0.5160.97
205_I208_M0.5160.97
322_F325_P0.5140.97
74_L103_V0.5140.97
85_I103_V0.5110.97
74_L107_L0.5110.97
144_M153_K0.5100.97
70_L89_I0.5090.97
97_M101_A0.5070.97
230_L261_S0.5070.97
172_I208_M0.5060.97
311_A317_I0.5050.97
190_L208_M0.5040.96
148_A153_K0.5020.96
89_I274_G0.5010.96
143_E151_Y0.5010.96
50_P62_I0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s5sA 2 0.9699 100 0.071 Contact Map
3u9iA 2 0.9372 100 0.084 Contact Map
3i4kA 4 0.9945 100 0.088 Contact Map
2p8bA 5 0.9863 100 0.089 Contact Map
3dgbA 5 0.9945 100 0.089 Contact Map
3fcpA 5 0.9536 100 0.091 Contact Map
3q45A 3 0.9891 100 0.093 Contact Map
4m0xA 5 0.9945 100 0.097 Contact Map
2qdeA 5 0.9617 100 0.098 Contact Map
3r0uA 2 0.9891 100 0.099 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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