GREMLIN Database
PRKC - Serine/threonine-protein kinase PrkC
UniProt: O34507 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 648 (541)
Sequences: 4556 (4140)
Seq/√Len: 178.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
252_D255_H4.3571.00
108_P238_P4.2661.00
89_E149_K3.9511.00
15_R27_L3.9261.00
92_E144_H3.8501.00
443_K447_K3.7581.00
141_L151_T3.7331.00
505_Y509_A3.7201.00
103_N110_E3.6361.00
392_S424_T3.5451.00
121_A150_V3.3361.00
135_I199_V3.3111.00
444_K448_D3.1751.00
507_K511_S3.1571.00
439_V443_K3.1391.00
12_Q31_I3.0771.00
115_M200_L3.0251.00
368_M376_L3.0201.00
115_M196_L2.9181.00
460_N463_K2.9081.00
259_T262_D2.8611.00
28_A39_I2.8591.00
28_A37_V2.8351.00
13_I39_I2.8151.00
259_T263_M2.8071.00
250_A255_H2.7301.00
123_A127_Q2.7011.00
391_I403_K2.6131.00
511_S515_E2.5951.00
27_L90_Y2.5851.00
512_G516_D2.4601.00
204_L241_V2.4401.00
385_D419_T2.4251.00
27_L36_E2.4081.00
370_Y374_A2.4061.00
193_I248_A2.3961.00
403_K421_Y2.3701.00
463_K467_T2.3391.00
464_N467_T2.3391.00
122_I135_I2.2771.00
369_E372_K2.2691.00
201_F228_P2.2631.00
39_I87_V2.2521.00
178_S191_S2.2391.00
111_A204_L2.2331.00
337_C340_F2.2051.00
30_D33_L2.1981.00
12_Q29_E2.1971.00
505_Y513_Y2.1951.00
437_Q445_A2.1631.00
331_W334_L2.1621.00
391_I402_V2.1531.00
382_L412_V2.1431.00
454_V487_K2.1361.00
143_D147_N2.1211.00
513_Y517_N2.0971.00
67_D73_S2.0841.00
396_I400_L2.0751.00
506_S509_A2.0501.00
29_E36_E2.0361.00
438_T441_Q1.9921.00
458_E461_D1.9801.00
95_T98_E1.9781.00
512_G515_E1.8861.00
458_E470_D1.8751.00
275_R278_E1.8611.00
114_I148_I1.8201.00
553_V558_S1.8111.00
200_L244_I1.8061.00
343_A346_L1.8031.00
97_K138_H1.7951.00
172_G177_L1.7921.00
247_K257_Y1.7771.00
513_Y516_D1.7681.00
502_L510_A1.7501.00
330_P334_L1.7481.00
374_A378_E1.7471.00
198_I209_P1.7391.00
136_K173_S1.7311.00
340_F347_A1.6911.00
463_K469_I1.6771.00
25_V38_A1.6541.00
204_L237_V1.6541.00
502_L521_L1.6501.00
327_K330_P1.6491.00
175_H208_I1.6431.00
111_A200_L1.6381.00
221_K225_A1.6111.00
396_I402_V1.6111.00
547_V551_N1.6101.00
290_T294_P1.6091.00
112_L267_I1.6081.00
201_F229_S1.5951.00
198_I249_T1.5851.00
458_E469_I1.5761.00
432_G442_A1.5751.00
532_P535_Q1.5651.00
140_I199_V1.5471.00
331_W335_T1.5461.00
327_K331_W1.5411.00
375_G379_K1.5391.00
335_T338_L1.5351.00
349_T353_S1.5291.00
325_K329_W1.5281.00
536_V539_Q1.5161.00
289_M292_A1.5131.00
70_N120_S1.4991.00
14_L29_E1.4981.00
550_G554_E1.4941.00
107_H110_E1.4931.00
292_A295_I1.4921.00
121_A125_A1.4821.00
328_K336_I1.4771.00
347_A351_F1.4751.00
551_N555_V1.4731.00
368_M372_K1.4661.00
548_K551_N1.4551.00
504_T507_K1.4401.00
244_I262_D1.4281.00
343_A347_A1.4191.00
346_L350_V1.4191.00
351_F355_F1.4171.00
470_D489_T1.4141.00
326_R341_I1.4101.00
557_F561_P1.4101.00
281_F285_E1.4021.00
390_E424_T1.3901.00
557_F560_G1.3891.00
509_A513_Y1.3861.00
548_K560_G1.3821.00
119_V196_L1.3751.00
194_Y222_H1.3711.00
328_K334_L1.3711.00
227_T249_T1.3681.00
117_Q147_N1.3661.00
459_V492_I1.3641.00
346_L349_T1.3591.00
339_V342_T1.3561.00
129_Q189_K1.3461.00
397_E400_L1.3381.00
479_L484_D1.3371.00
198_I208_I1.3361.00
508_E512_G1.3341.00
554_E557_F1.3341.00
528_S531_V1.3261.00
499_L502_L1.3171.00
280_R283_I1.3071.00
113_N117_Q1.3051.00
138_H155_I1.3001.00
217_S220_L1.2951.00
294_P298_D1.2951.00
331_W337_C1.2931.00
393_D396_I1.2931.00
326_R329_W1.2931.00
118_I140_I1.2921.00
204_L245_I1.2831.00
502_L519_L1.2811.00
337_C341_I1.2751.00
324_G334_L1.2741.00
508_E511_S1.2721.00
553_V557_F1.2711.00
437_Q441_Q1.2651.00
297_K300_E1.2591.00
509_A512_G1.2561.00
535_Q539_Q1.2501.00
332_V338_L1.2491.00
330_P337_C1.2481.00
331_W336_I1.2421.00
332_V335_T1.2381.00
234_N237_V1.2351.00
326_R333_L1.2341.00
94_M102_A1.2311.00
439_V455_T1.2301.00
553_V556_T1.2291.00
451_F479_L1.2281.00
77_L198_I1.2281.00
330_P333_L1.2271.00
468_V488_L1.2151.00
334_L338_L1.2141.00
225_A251_K1.2101.00
137_P176_Y1.2031.00
556_T560_G1.2021.00
260_A263_M1.2001.00
289_M293_I1.1971.00
16_V24_N1.1931.00
243_N265_A1.1911.00
543_A546_A1.1901.00
335_T339_V1.1881.00
279_K283_I1.1801.00
551_N560_G1.1791.00
392_S396_I1.1771.00
190_K258_E1.1761.00
10_R30_D1.1761.00
328_K335_T1.1761.00
11_Y76_D1.1751.00
546_A553_V1.1681.00
136_K172_G1.1641.00
515_E521_L1.1471.00
350_V353_S1.1471.00
541_P544_G1.1451.00
552_E555_V1.1451.00
434_V442_A1.1441.00
327_K332_V1.1421.00
459_V463_K1.1411.00
275_R279_K1.1371.00
522_V525_E1.1351.00
295_I298_D1.1331.00
21_G187_A1.1281.00
441_Q445_A1.1251.00
289_M295_I1.1201.00
407_K410_T1.1181.00
448_D452_N1.1181.00
329_W332_V1.1151.00
35_R75_Y1.1121.00
329_W333_L1.1101.00
515_E523_E1.1081.00
538_K541_P1.1071.00
550_G553_V1.1071.00
445_A448_D1.1031.00
332_V342_T1.1021.00
333_L337_C1.0971.00
342_T347_A1.0961.00
551_N554_E1.0961.00
551_N556_T1.0941.00
510_A517_N1.0931.00
541_P553_V1.0901.00
281_F284_Q1.0881.00
321_K325_K1.0771.00
507_K523_E1.0741.00
110_E113_N1.0681.00
344_G347_A1.0661.00
205_T230_A1.0661.00
551_N557_F1.0641.00
290_T293_I1.0611.00
278_E282_T1.0591.00
307_E317_E1.0571.00
551_N558_S1.0531.00
130_I156_A1.0481.00
215_A218_I1.0471.00
344_G350_V1.0391.00
461_D464_N1.0391.00
550_G556_T1.0300.99
553_V561_P1.0230.99
334_L340_F1.0200.99
324_G336_I1.0200.99
436_G440_D1.0190.99
337_C343_A1.0180.99
375_G378_E1.0170.99
260_A264_E1.0160.99
536_V541_P1.0110.99
288_E292_A1.0100.99
344_G348_V1.0080.99
212_G221_K1.0050.99
329_W336_I1.0050.99
547_V553_V1.0030.99
291_K294_P1.0020.99
340_F343_A1.0010.99
540_K554_E0.9980.99
450_G455_T0.9980.99
343_A350_V0.9980.99
36_E90_Y0.9950.99
14_L27_L0.9920.99
75_Y89_E0.9910.99
402_V422_K0.9910.99
471_Q474_S0.9900.99
551_N559_L0.9900.99
527_Y531_V0.9890.99
338_L350_V0.9880.99
277_N282_T0.9850.99
385_D388_V0.9830.99
556_T559_L0.9820.99
549_P558_S0.9820.99
450_G453_H0.9740.99
497_I519_L0.9740.99
438_T442_A0.9730.99
29_E34_D0.9710.99
550_G560_G0.9690.99
74_I77_L0.9680.99
550_G557_F0.9620.99
388_V419_T0.9590.99
545_T554_E0.9580.99
237_V241_V0.9510.99
332_V340_F0.9500.99
335_T340_F0.9470.99
555_V558_S0.9460.99
454_V457_N0.9460.99
267_I270_A0.9440.99
514_L517_N0.9410.99
385_D417_T0.9380.99
369_E373_A0.9370.99
341_I351_F0.9360.99
520_K523_E0.9360.99
327_K342_T0.9350.99
346_L351_F0.9340.99
341_I345_I0.9310.99
278_E285_E0.9300.99
546_A549_P0.9280.99
447_K453_H0.9280.99
338_L342_T0.9270.99
339_V349_T0.9260.99
321_K324_G0.9240.99
226_E251_K0.9240.99
324_G331_W0.9220.99
176_Y213_E0.9190.99
324_G339_V0.9190.99
328_K332_V0.9190.99
501_D508_E0.9170.99
539_Q543_A0.9170.99
16_V19_G0.9160.99
412_V415_G0.9160.99
437_Q442_A0.9140.99
330_P343_A0.9120.99
502_L513_Y0.9120.99
318_N321_K0.9100.99
538_K556_T0.9100.99
553_V559_L0.9090.99
323_N330_P0.9080.99
122_I196_L0.9070.99
515_E519_L0.9070.99
276_L280_R0.9050.99
328_K331_W0.9050.99
277_N281_F0.9040.99
531_V537_V0.9020.99
326_R342_T0.9000.99
343_A349_T0.8970.99
431_I442_A0.8960.99
336_I339_V0.8960.99
328_K337_C0.8930.99
53_I151_T0.8920.99
155_I175_H0.8920.99
201_F209_P0.8900.98
347_A352_P0.8850.98
429_T432_G0.8850.98
347_A350_V0.8840.98
370_Y386_S0.8820.98
322_K325_K0.8800.98
176_Y202_E0.8780.98
543_A547_V0.8780.98
100_I203_L0.8730.98
99_Y114_I0.8720.98
323_N327_K0.8720.98
70_N147_N0.8710.98
516_D522_V0.8700.98
365_V380_E0.8670.98
522_V529_D0.8650.98
329_W337_C0.8600.98
112_L241_V0.8600.98
445_A449_Q0.8570.98
471_Q478_E0.8560.98
292_A302_A0.8560.98
325_K335_T0.8560.98
542_A546_A0.8540.98
403_K407_K0.8530.98
524_K527_Y0.8530.98
295_I299_E0.8530.98
323_N338_L0.8520.98
368_M380_E0.8520.98
378_E383_Q0.8510.98
350_V355_F0.8500.98
539_Q556_T0.8480.98
377_L380_E0.8470.98
482_S485_Q0.8470.98
434_V453_H0.8460.98
396_I403_K0.8460.98
118_I199_V0.8440.98
378_E384_V0.8430.98
244_I248_A0.8420.98
201_F210_F0.8410.98
239_Q243_N0.8370.98
342_T352_P0.8360.98
293_I297_K0.8360.98
430_E433_D0.8350.98
430_E478_E0.8340.98
538_K552_E0.8340.98
546_A561_P0.8340.98
544_G560_G0.8330.98
551_N561_P0.8330.98
394_E400_L0.8320.98
298_D302_A0.8280.98
540_K543_A0.8280.98
290_T297_K0.8270.98
266_D270_A0.8260.98
137_P202_E0.8250.98
459_V462_E0.8250.98
540_K546_A0.8210.97
362_I365_V0.8180.97
326_R330_P0.8170.97
333_L336_I0.8150.97
290_T296_I0.8150.97
178_S181_Q0.8130.97
536_V540_K0.8100.97
527_Y532_P0.8080.97
507_K525_E0.8070.97
302_A305_A0.8070.97
376_L380_E0.8040.97
540_K553_V0.8030.97
99_Y103_N0.8010.97
338_L341_I0.7990.97
531_V534_G0.7980.97
326_R338_L0.7970.97
74_I86_I0.7970.97
133_R187_A0.7950.97
544_G548_K0.7910.97
339_V346_L0.7870.97
55_R86_I0.7860.97
299_E302_A0.7840.97
171_L215_A0.7820.97
544_G554_E0.7800.97
541_P546_A0.7800.97
552_E556_T0.7800.97
554_E559_L0.7790.96
540_K544_G0.7760.96
336_I342_T0.7750.96
544_G552_E0.7750.96
488_L491_S0.7740.96
270_A273_A0.7730.96
542_A549_P0.7730.96
549_P553_V0.7710.96
388_V391_I0.7710.96
367_G400_L0.7710.96
72_V91_V0.7690.96
344_G351_F0.7690.96
501_D504_T0.7690.96
370_Y390_E0.7680.96
334_L342_T0.7680.96
467_T478_E0.7660.96
435_T438_T0.7660.96
338_L344_G0.7660.96
324_G327_K0.7650.96
548_K555_V0.7650.96
523_E528_S0.7650.96
549_P561_P0.7640.96
525_E529_D0.7630.96
525_E528_S0.7620.96
330_P344_G0.7610.96
546_A550_G0.7610.96
136_K152_D0.7610.96
336_I348_V0.7600.96
526_A532_P0.7590.96
330_P340_F0.7580.96
115_M122_I0.7560.96
259_T264_E0.7530.96
119_V124_H0.7530.96
335_T344_G0.7530.96
342_T345_I0.7520.96
14_L36_E0.7520.96
325_K333_L0.7500.96
437_Q448_D0.7500.96
453_H488_L0.7470.96
341_I344_G0.7450.95
68_H124_H0.7450.95
333_L340_F0.7430.95
418_V422_K0.7430.95
344_G349_T0.7420.95
533_E558_S0.7410.95
340_F345_I0.7410.95
326_R337_C0.7390.95
544_G550_G0.7390.95
336_I340_F0.7370.95
452_N456_V0.7360.95
263_M267_I0.7350.95
534_G540_K0.7340.95
373_A377_L0.7340.95
537_V548_K0.7330.95
459_V465_A0.7310.95
353_S356_M0.7300.95
300_E304_A0.7280.95
535_Q542_A0.7270.95
326_R331_W0.7270.95
550_G558_S0.7270.95
339_V350_V0.7250.95
431_I434_V0.7250.95
470_D473_P0.7240.95
545_T548_K0.7230.95
227_T230_A0.7220.95
442_A446_L0.7210.95
469_I489_T0.7210.95
343_A351_F0.7200.95
332_V346_L0.7200.95
318_N326_R0.7180.95
339_V347_A0.7180.95
176_Y201_F0.7180.95
171_L187_A0.7170.94
348_V351_F0.7170.94
138_H175_H0.7160.94
325_K334_L0.7140.94
411_T414_E0.7140.94
333_L343_A0.7110.94
510_A514_L0.7110.94
220_L223_L0.7100.94
526_A533_E0.7090.94
347_A353_S0.7080.94
299_E303_K0.7060.94
157_T173_S0.7050.94
517_N523_E0.7050.94
53_I141_L0.7020.94
384_V420_L0.7010.94
523_E527_Y0.7000.94
370_Y373_A0.6990.94
531_V535_Q0.6990.94
340_F351_F0.6980.94
323_N328_K0.6980.94
558_S561_P0.6980.94
338_L348_V0.6980.94
537_V543_A0.6970.94
361_K364_D0.6970.94
452_N485_Q0.6960.94
289_M299_E0.6940.93
502_L506_S0.6940.93
319_K322_K0.6930.93
58_R90_Y0.6920.93
202_E208_I0.6900.93
522_V526_A0.6900.93
460_N467_T0.6890.93
453_H456_V0.6890.93
342_T348_V0.6880.93
554_E558_S0.6870.93
337_C345_I0.6860.93
290_T295_I0.6860.93
268_K271_F0.6840.93
432_G438_T0.6830.93
208_I211_D0.6830.93
549_P552_E0.6820.93
345_I350_V0.6820.93
406_P418_V0.6780.93
187_A195_A0.6780.93
552_E559_L0.6760.93
372_K376_L0.6750.92
328_K340_F0.6750.92
516_D520_K0.6750.92
95_T202_E0.6740.92
418_V425_G0.6740.92
510_A519_L0.6740.92
282_T285_E0.6730.92
368_M373_A0.6730.92
13_I16_V0.6730.92
266_D269_T0.6730.92
486_V490_V0.6720.92
65_S128_N0.6720.92
284_Q287_E0.6720.92
535_Q538_K0.6690.92
507_K513_Y0.6690.92
444_K447_K0.6680.92
485_Q489_T0.6670.92
507_K512_G0.6670.92
549_P555_V0.6660.92
326_R334_L0.6640.92
373_A382_L0.6640.92
371_E374_A0.6630.92
137_P199_V0.6630.92
517_N521_L0.6620.92
398_E408_A0.6610.92
331_W341_I0.6610.92
393_D400_L0.6600.92
545_T550_G0.6570.91
341_I346_L0.6560.91
396_I414_E0.6550.91
26_Y41_I0.6540.91
539_Q546_A0.6540.91
499_L517_N0.6530.91
451_F454_V0.6530.91
296_I300_E0.6530.91
85_Y181_Q0.6530.91
333_L341_I0.6520.91
537_V544_G0.6520.91
291_K296_I0.6510.91
548_K552_E0.6480.91
62_S156_A0.6470.91
429_T434_V0.6460.91
372_K375_G0.6460.91
459_V495_E0.6430.91
468_V473_P0.6420.91
500_R505_Y0.6420.91
548_K554_E0.6420.91
378_E381_G0.6400.90
500_R513_Y0.6400.90
244_I257_Y0.6390.90
366_S377_L0.6380.90
229_S242_E0.6370.90
498_T501_D0.6370.90
340_F346_L0.6360.90
556_T561_P0.6360.90
517_N524_K0.6360.90
336_I349_T0.6350.90
322_K326_R0.6340.90
95_T138_H0.6340.90
134_D152_D0.6330.90
328_K341_I0.6330.90
91_V149_K0.6320.90
518_G521_L0.6320.90
365_V369_E0.6320.90
438_T467_T0.6320.90
337_C349_T0.6310.90
555_V560_G0.6310.90
547_V558_S0.6290.90
536_V555_V0.6290.90
278_E281_F0.6270.89
343_A348_V0.6270.89
522_V554_E0.6240.89
330_P336_I0.6230.89
472_N476_G0.6230.89
14_L26_Y0.6230.89
500_R510_A0.6210.89
504_T508_E0.6210.89
517_N520_K0.6210.89
55_R155_I0.6200.89
385_D389_L0.6190.89
436_G442_A0.6190.89
373_A380_E0.6180.89
207_R233_W0.6180.89
329_W340_F0.6170.89
289_M298_D0.6150.89
329_W341_I0.6150.89
63_A74_I0.6150.89
550_G555_V0.6140.88
295_I304_A0.6140.88
139_N152_D0.6130.88
516_D519_L0.6120.88
413_K418_V0.6120.88
510_A513_Y0.6110.88
297_K301_L0.6100.88
555_V559_L0.6090.88
362_I366_S0.6080.88
184_G195_A0.6070.88
376_L379_K0.6070.88
504_T519_L0.6070.88
327_K336_I0.6050.88
279_K282_T0.6040.88
346_L354_L0.6040.88
126_H173_S0.6040.88
155_I251_K0.6030.88
502_L505_Y0.6030.88
276_L283_I0.6030.88
41_I206_G0.6020.88
324_G333_L0.6020.88
303_K306_G0.6020.88
555_V561_P0.6010.87
330_P349_T0.6000.87
549_P559_L0.6000.87
512_G520_K0.5990.87
545_T560_G0.5980.87
177_L211_D0.5980.87
18_G25_V0.5980.87
369_E378_E0.5970.87
518_G522_V0.5960.87
294_P302_A0.5950.87
324_G328_K0.5940.87
526_A531_V0.5930.87
201_F232_R0.5910.87
346_L352_P0.5910.87
427_A430_E0.5910.87
367_G373_A0.5890.86
278_E284_Q0.5890.86
16_V26_Y0.5870.86
334_L344_G0.5870.86
329_W335_T0.5870.86
351_F354_L0.5860.86
243_N247_K0.5860.86
366_S403_K0.5840.86
377_L382_L0.5820.86
526_A538_K0.5820.86
500_R517_N0.5810.86
332_V336_I0.5800.86
539_Q544_G0.5800.86
548_K558_S0.5790.85
541_P545_T0.5790.85
382_L385_D0.5790.85
401_M404_T0.5790.85
19_G114_I0.5780.85
466_G472_N0.5780.85
201_F207_R0.5780.85
540_K545_T0.5770.85
544_G551_N0.5760.85
13_I28_A0.5750.85
515_E520_K0.5740.85
134_D139_N0.5740.85
382_L418_V0.5740.85
298_D301_L0.5730.85
410_T416_A0.5730.85
530_D533_E0.5720.85
334_L341_I0.5710.85
124_H223_L0.5690.84
370_Y382_L0.5680.84
511_S521_L0.5680.84
276_L284_Q0.5680.84
490_V493_G0.5680.84
507_K514_L0.5670.84
302_A306_G0.5660.84
336_I343_A0.5660.84
543_A550_G0.5650.84
515_E518_G0.5650.84
331_W345_I0.5630.84
529_D533_E0.5620.84
275_R283_I0.5610.84
517_N522_V0.5610.84
177_L182_A0.5600.84
337_C346_L0.5600.84
323_N331_W0.5590.83
100_I199_V0.5570.83
402_V421_Y0.5570.83
331_W338_L0.5570.83
379_K407_K0.5570.83
325_K340_F0.5570.83
433_D437_Q0.5560.83
337_C359_D0.5550.83
11_Y78_G0.5540.83
345_I353_S0.5540.83
344_G352_P0.5540.83
325_K341_I0.5530.83
44_F79_E0.5520.83
336_I344_G0.5520.83
540_K551_N0.5500.82
541_P551_N0.5500.82
277_N280_R0.5490.82
72_V151_T0.5490.82
391_I394_E0.5490.82
366_S376_L0.5480.82
507_K517_N0.5480.82
176_Y248_A0.5470.82
293_I302_A0.5470.82
503_K507_K0.5470.82
539_Q542_A0.5470.82
507_K521_L0.5460.82
348_V352_P0.5440.82
300_E306_G0.5440.82
391_I421_Y0.5440.82
462_E465_A0.5430.82
334_L348_V0.5430.82
167_T177_L0.5420.82
511_S514_L0.5420.82
329_W342_T0.5410.81
546_A554_E0.5410.81
332_V339_V0.5410.81
169_S177_L0.5390.81
535_Q559_L0.5380.81
447_K455_T0.5380.81
539_Q559_L0.5380.81
438_T443_K0.5370.81
276_L282_T0.5370.81
547_V557_F0.5360.81
544_G555_V0.5340.81
283_I286_D0.5330.80
535_Q551_N0.5330.80
434_V451_F0.5330.80
292_A303_K0.5320.80
177_L202_E0.5320.80
138_H176_Y0.5310.80
295_I300_E0.5300.80
334_L337_C0.5300.80
412_V419_T0.5290.80
545_T551_N0.5280.80
529_D532_P0.5280.80
516_D524_K0.5280.80
337_C350_V0.5270.80
435_T439_V0.5270.80
504_T511_S0.5260.80
241_V244_I0.5260.80
513_Y520_K0.5220.79
74_I88_M0.5220.79
361_K411_T0.5210.79
372_K377_L0.5200.79
340_F350_V0.5200.79
393_D425_G0.5200.79
365_V401_M0.5200.79
288_E293_I0.5200.79
535_Q540_K0.5190.79
361_K365_V0.5190.79
319_K325_K0.5180.79
537_V556_T0.5180.79
371_E376_L0.5180.79
442_A453_H0.5160.78
327_K340_F0.5160.78
533_E537_V0.5160.78
535_Q553_V0.5150.78
499_L510_A0.5150.78
516_D523_E0.5150.78
332_V337_C0.5150.78
119_V262_D0.5140.78
468_V471_Q0.5140.78
365_V377_L0.5130.78
366_S370_Y0.5130.78
339_V355_F0.5130.78
470_D475_A0.5120.78
519_L553_V0.5120.78
322_K333_L0.5120.78
548_K561_P0.5120.78
318_N337_C0.5110.78
538_K542_A0.5100.77
170_V177_L0.5100.77
539_Q558_S0.5100.77
539_Q545_T0.5090.77
389_L419_T0.5090.77
330_P335_T0.5090.77
79_E218_I0.5080.77
174_V177_L0.5080.77
248_A262_D0.5070.77
523_E526_A0.5070.77
545_T553_V0.5070.77
473_P478_E0.5060.77
138_H173_S0.5060.77
370_Y376_L0.5060.77
534_G541_P0.5040.77
413_K416_A0.5030.77
331_W344_G0.5030.77
274_D278_E0.5030.77
549_P556_T0.5030.77
543_A552_E0.5020.76
177_L251_K0.5010.76
439_V448_D0.5010.76
469_I490_V0.5010.76
366_S372_K0.5000.76
544_G547_V0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lqsA 1 0.4614 100 0.375 Contact Map
4ejnA 1 0.4105 100 0.388 Contact Map
4gv1A 1 0.4907 100 0.392 Contact Map
4aw2A 2 0.4923 100 0.392 Contact Map
2bdwA 2 0.4769 100 0.401 Contact Map
4dc2A 1 0.483 100 0.401 Contact Map
3pfqA 1 0.4938 100 0.401 Contact Map
3v8sA 2 0.5 100 0.404 Contact Map
4ic7A 1 0.4846 100 0.406 Contact Map
2yabA 2 0.4506 100 0.406 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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