PRKC - BACSU - GREMLIN Contacts

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PRKC - Serine/threonine-protein kinase PrkC

UniProt:	O34507	Sequences: MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRFDYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITANGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALSSTTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSIALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRLNEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLLTICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEISDEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQGFNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKEAASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPAKTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQKGYYQVMVNNKVVSYKTIEYPKDE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	648 (541)
Sequences:	4556 (4140)
Seq/√Len:	178.0

ECOLI - YEGI
BACSU - PRKC PKN1
HALSA - Q9HR00
SULSO - Q97U18 Q97U41 Q97WD5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
252_D	255_H	4.357	1.00
108_P	238_P	4.266	1.00
89_E	149_K	3.951	1.00
15_R	27_L	3.926	1.00
92_E	144_H	3.850	1.00
443_K	447_K	3.758	1.00
141_L	151_T	3.733	1.00
505_Y	509_A	3.720	1.00
103_N	110_E	3.636	1.00
392_S	424_T	3.545	1.00
121_A	150_V	3.336	1.00
135_I	199_V	3.311	1.00
444_K	448_D	3.175	1.00
507_K	511_S	3.157	1.00
439_V	443_K	3.139	1.00
12_Q	31_I	3.077	1.00
115_M	200_L	3.025	1.00
368_M	376_L	3.020	1.00
115_M	196_L	2.918	1.00
460_N	463_K	2.908	1.00
259_T	262_D	2.861	1.00
28_A	39_I	2.859	1.00
28_A	37_V	2.835	1.00
13_I	39_I	2.815	1.00
259_T	263_M	2.807	1.00
250_A	255_H	2.730	1.00
123_A	127_Q	2.701	1.00
391_I	403_K	2.613	1.00
511_S	515_E	2.595	1.00
27_L	90_Y	2.585	1.00
512_G	516_D	2.460	1.00
204_L	241_V	2.440	1.00
385_D	419_T	2.425	1.00
27_L	36_E	2.408	1.00
370_Y	374_A	2.406	1.00
193_I	248_A	2.396	1.00
403_K	421_Y	2.370	1.00
463_K	467_T	2.339	1.00
464_N	467_T	2.339	1.00
122_I	135_I	2.277	1.00
369_E	372_K	2.269	1.00
201_F	228_P	2.263	1.00
39_I	87_V	2.252	1.00
178_S	191_S	2.239	1.00
111_A	204_L	2.233	1.00
337_C	340_F	2.205	1.00
30_D	33_L	2.198	1.00
12_Q	29_E	2.197	1.00
505_Y	513_Y	2.195	1.00
437_Q	445_A	2.163	1.00
331_W	334_L	2.162	1.00
391_I	402_V	2.153	1.00
382_L	412_V	2.143	1.00
454_V	487_K	2.136	1.00
143_D	147_N	2.121	1.00
513_Y	517_N	2.097	1.00
67_D	73_S	2.084	1.00
396_I	400_L	2.075	1.00
506_S	509_A	2.050	1.00
29_E	36_E	2.036	1.00
438_T	441_Q	1.992	1.00
458_E	461_D	1.980	1.00
95_T	98_E	1.978	1.00
512_G	515_E	1.886	1.00
458_E	470_D	1.875	1.00
275_R	278_E	1.861	1.00
114_I	148_I	1.820	1.00
553_V	558_S	1.811	1.00
200_L	244_I	1.806	1.00
343_A	346_L	1.803	1.00
97_K	138_H	1.795	1.00
172_G	177_L	1.792	1.00
247_K	257_Y	1.777	1.00
513_Y	516_D	1.768	1.00
502_L	510_A	1.750	1.00
330_P	334_L	1.748	1.00
374_A	378_E	1.747	1.00
198_I	209_P	1.739	1.00
136_K	173_S	1.731	1.00
340_F	347_A	1.691	1.00
463_K	469_I	1.677	1.00
25_V	38_A	1.654	1.00
204_L	237_V	1.654	1.00
502_L	521_L	1.650	1.00
327_K	330_P	1.649	1.00
175_H	208_I	1.643	1.00
111_A	200_L	1.638	1.00
221_K	225_A	1.611	1.00
396_I	402_V	1.611	1.00
547_V	551_N	1.610	1.00
290_T	294_P	1.609	1.00
112_L	267_I	1.608	1.00
201_F	229_S	1.595	1.00
198_I	249_T	1.585	1.00
458_E	469_I	1.576	1.00
432_G	442_A	1.575	1.00
532_P	535_Q	1.565	1.00
140_I	199_V	1.547	1.00
331_W	335_T	1.546	1.00
327_K	331_W	1.541	1.00
375_G	379_K	1.539	1.00
335_T	338_L	1.535	1.00
349_T	353_S	1.529	1.00
325_K	329_W	1.528	1.00
536_V	539_Q	1.516	1.00
289_M	292_A	1.513	1.00
70_N	120_S	1.499	1.00
14_L	29_E	1.498	1.00
550_G	554_E	1.494	1.00
107_H	110_E	1.493	1.00
292_A	295_I	1.492	1.00
121_A	125_A	1.482	1.00
328_K	336_I	1.477	1.00
347_A	351_F	1.475	1.00
551_N	555_V	1.473	1.00
368_M	372_K	1.466	1.00
548_K	551_N	1.455	1.00
504_T	507_K	1.440	1.00
244_I	262_D	1.428	1.00
343_A	347_A	1.419	1.00
346_L	350_V	1.419	1.00
351_F	355_F	1.417	1.00
470_D	489_T	1.414	1.00
326_R	341_I	1.410	1.00
557_F	561_P	1.410	1.00
281_F	285_E	1.402	1.00
390_E	424_T	1.390	1.00
557_F	560_G	1.389	1.00
509_A	513_Y	1.386	1.00
548_K	560_G	1.382	1.00
119_V	196_L	1.375	1.00
194_Y	222_H	1.371	1.00
328_K	334_L	1.371	1.00
227_T	249_T	1.368	1.00
117_Q	147_N	1.366	1.00
459_V	492_I	1.364	1.00
346_L	349_T	1.359	1.00
339_V	342_T	1.356	1.00
129_Q	189_K	1.346	1.00
397_E	400_L	1.338	1.00
479_L	484_D	1.337	1.00
198_I	208_I	1.336	1.00
508_E	512_G	1.334	1.00
554_E	557_F	1.334	1.00
528_S	531_V	1.326	1.00
499_L	502_L	1.317	1.00
280_R	283_I	1.307	1.00
113_N	117_Q	1.305	1.00
138_H	155_I	1.300	1.00
217_S	220_L	1.295	1.00
294_P	298_D	1.295	1.00
331_W	337_C	1.293	1.00
393_D	396_I	1.293	1.00
326_R	329_W	1.293	1.00
118_I	140_I	1.292	1.00
204_L	245_I	1.283	1.00
502_L	519_L	1.281	1.00
337_C	341_I	1.275	1.00
324_G	334_L	1.274	1.00
508_E	511_S	1.272	1.00
553_V	557_F	1.271	1.00
437_Q	441_Q	1.265	1.00
297_K	300_E	1.259	1.00
509_A	512_G	1.256	1.00
535_Q	539_Q	1.250	1.00
332_V	338_L	1.249	1.00
330_P	337_C	1.248	1.00
331_W	336_I	1.242	1.00
332_V	335_T	1.238	1.00
234_N	237_V	1.235	1.00
326_R	333_L	1.234	1.00
94_M	102_A	1.231	1.00
439_V	455_T	1.230	1.00
553_V	556_T	1.229	1.00
451_F	479_L	1.228	1.00
77_L	198_I	1.228	1.00
330_P	333_L	1.227	1.00
468_V	488_L	1.215	1.00
334_L	338_L	1.214	1.00
225_A	251_K	1.210	1.00
137_P	176_Y	1.203	1.00
556_T	560_G	1.202	1.00
260_A	263_M	1.200	1.00
289_M	293_I	1.197	1.00
16_V	24_N	1.193	1.00
243_N	265_A	1.191	1.00
543_A	546_A	1.190	1.00
335_T	339_V	1.188	1.00
279_K	283_I	1.180	1.00
551_N	560_G	1.179	1.00
392_S	396_I	1.177	1.00
190_K	258_E	1.176	1.00
10_R	30_D	1.176	1.00
328_K	335_T	1.176	1.00
11_Y	76_D	1.175	1.00
546_A	553_V	1.168	1.00
136_K	172_G	1.164	1.00
515_E	521_L	1.147	1.00
350_V	353_S	1.147	1.00
541_P	544_G	1.145	1.00
552_E	555_V	1.145	1.00
434_V	442_A	1.144	1.00
327_K	332_V	1.142	1.00
459_V	463_K	1.141	1.00
275_R	279_K	1.137	1.00
522_V	525_E	1.135	1.00
295_I	298_D	1.133	1.00
21_G	187_A	1.128	1.00
441_Q	445_A	1.125	1.00
289_M	295_I	1.120	1.00
407_K	410_T	1.118	1.00
448_D	452_N	1.118	1.00
329_W	332_V	1.115	1.00
35_R	75_Y	1.112	1.00
329_W	333_L	1.110	1.00
515_E	523_E	1.108	1.00
538_K	541_P	1.107	1.00
550_G	553_V	1.107	1.00
445_A	448_D	1.103	1.00
332_V	342_T	1.102	1.00
333_L	337_C	1.097	1.00
342_T	347_A	1.096	1.00
551_N	554_E	1.096	1.00
551_N	556_T	1.094	1.00
510_A	517_N	1.093	1.00
541_P	553_V	1.090	1.00
281_F	284_Q	1.088	1.00
321_K	325_K	1.077	1.00
507_K	523_E	1.074	1.00
110_E	113_N	1.068	1.00
344_G	347_A	1.066	1.00
205_T	230_A	1.066	1.00
551_N	557_F	1.064	1.00
290_T	293_I	1.061	1.00
278_E	282_T	1.059	1.00
307_E	317_E	1.057	1.00
551_N	558_S	1.053	1.00
130_I	156_A	1.048	1.00
215_A	218_I	1.047	1.00
344_G	350_V	1.039	1.00
461_D	464_N	1.039	1.00
550_G	556_T	1.030	0.99
553_V	561_P	1.023	0.99
334_L	340_F	1.020	0.99
324_G	336_I	1.020	0.99
436_G	440_D	1.019	0.99
337_C	343_A	1.018	0.99
375_G	378_E	1.017	0.99
260_A	264_E	1.016	0.99
536_V	541_P	1.011	0.99
288_E	292_A	1.010	0.99
344_G	348_V	1.008	0.99
212_G	221_K	1.005	0.99
329_W	336_I	1.005	0.99
547_V	553_V	1.003	0.99
291_K	294_P	1.002	0.99
340_F	343_A	1.001	0.99
540_K	554_E	0.998	0.99
450_G	455_T	0.998	0.99
343_A	350_V	0.998	0.99
36_E	90_Y	0.995	0.99
14_L	27_L	0.992	0.99
75_Y	89_E	0.991	0.99
402_V	422_K	0.991	0.99
471_Q	474_S	0.990	0.99
551_N	559_L	0.990	0.99
527_Y	531_V	0.989	0.99
338_L	350_V	0.988	0.99
277_N	282_T	0.985	0.99
385_D	388_V	0.983	0.99
556_T	559_L	0.982	0.99
549_P	558_S	0.982	0.99
450_G	453_H	0.974	0.99
497_I	519_L	0.974	0.99
438_T	442_A	0.973	0.99
29_E	34_D	0.971	0.99
550_G	560_G	0.969	0.99
74_I	77_L	0.968	0.99
550_G	557_F	0.962	0.99
388_V	419_T	0.959	0.99
545_T	554_E	0.958	0.99
237_V	241_V	0.951	0.99
332_V	340_F	0.950	0.99
335_T	340_F	0.947	0.99
555_V	558_S	0.946	0.99
454_V	457_N	0.946	0.99
267_I	270_A	0.944	0.99
514_L	517_N	0.941	0.99
385_D	417_T	0.938	0.99
369_E	373_A	0.937	0.99
341_I	351_F	0.936	0.99
520_K	523_E	0.936	0.99
327_K	342_T	0.935	0.99
346_L	351_F	0.934	0.99
341_I	345_I	0.931	0.99
278_E	285_E	0.930	0.99
546_A	549_P	0.928	0.99
447_K	453_H	0.928	0.99
338_L	342_T	0.927	0.99
339_V	349_T	0.926	0.99
321_K	324_G	0.924	0.99
226_E	251_K	0.924	0.99
324_G	331_W	0.922	0.99
176_Y	213_E	0.919	0.99
324_G	339_V	0.919	0.99
328_K	332_V	0.919	0.99
501_D	508_E	0.917	0.99
539_Q	543_A	0.917	0.99
16_V	19_G	0.916	0.99
412_V	415_G	0.916	0.99
437_Q	442_A	0.914	0.99
330_P	343_A	0.912	0.99
502_L	513_Y	0.912	0.99
318_N	321_K	0.910	0.99
538_K	556_T	0.910	0.99
553_V	559_L	0.909	0.99
323_N	330_P	0.908	0.99
122_I	196_L	0.907	0.99
515_E	519_L	0.907	0.99
276_L	280_R	0.905	0.99
328_K	331_W	0.905	0.99
277_N	281_F	0.904	0.99
531_V	537_V	0.902	0.99
326_R	342_T	0.900	0.99
343_A	349_T	0.897	0.99
431_I	442_A	0.896	0.99
336_I	339_V	0.896	0.99
328_K	337_C	0.893	0.99
53_I	151_T	0.892	0.99
155_I	175_H	0.892	0.99
201_F	209_P	0.890	0.98
347_A	352_P	0.885	0.98
429_T	432_G	0.885	0.98
347_A	350_V	0.884	0.98
370_Y	386_S	0.882	0.98
322_K	325_K	0.880	0.98
176_Y	202_E	0.878	0.98
543_A	547_V	0.878	0.98
100_I	203_L	0.873	0.98
99_Y	114_I	0.872	0.98
323_N	327_K	0.872	0.98
70_N	147_N	0.871	0.98
516_D	522_V	0.870	0.98
365_V	380_E	0.867	0.98
522_V	529_D	0.865	0.98
329_W	337_C	0.860	0.98
112_L	241_V	0.860	0.98
445_A	449_Q	0.857	0.98
471_Q	478_E	0.856	0.98
292_A	302_A	0.856	0.98
325_K	335_T	0.856	0.98
542_A	546_A	0.854	0.98
403_K	407_K	0.853	0.98
524_K	527_Y	0.853	0.98
295_I	299_E	0.853	0.98
323_N	338_L	0.852	0.98
368_M	380_E	0.852	0.98
378_E	383_Q	0.851	0.98
350_V	355_F	0.850	0.98
539_Q	556_T	0.848	0.98
377_L	380_E	0.847	0.98
482_S	485_Q	0.847	0.98
434_V	453_H	0.846	0.98
396_I	403_K	0.846	0.98
118_I	199_V	0.844	0.98
378_E	384_V	0.843	0.98
244_I	248_A	0.842	0.98
201_F	210_F	0.841	0.98
239_Q	243_N	0.837	0.98
342_T	352_P	0.836	0.98
293_I	297_K	0.836	0.98
430_E	433_D	0.835	0.98
430_E	478_E	0.834	0.98
538_K	552_E	0.834	0.98
546_A	561_P	0.834	0.98
544_G	560_G	0.833	0.98
551_N	561_P	0.833	0.98
394_E	400_L	0.832	0.98
298_D	302_A	0.828	0.98
540_K	543_A	0.828	0.98
290_T	297_K	0.827	0.98
266_D	270_A	0.826	0.98
137_P	202_E	0.825	0.98
459_V	462_E	0.825	0.98
540_K	546_A	0.821	0.97
362_I	365_V	0.818	0.97
326_R	330_P	0.817	0.97
333_L	336_I	0.815	0.97
290_T	296_I	0.815	0.97
178_S	181_Q	0.813	0.97
536_V	540_K	0.810	0.97
527_Y	532_P	0.808	0.97
507_K	525_E	0.807	0.97
302_A	305_A	0.807	0.97
376_L	380_E	0.804	0.97
540_K	553_V	0.803	0.97
99_Y	103_N	0.801	0.97
338_L	341_I	0.799	0.97
531_V	534_G	0.798	0.97
326_R	338_L	0.797	0.97
74_I	86_I	0.797	0.97
133_R	187_A	0.795	0.97
544_G	548_K	0.791	0.97
339_V	346_L	0.787	0.97
55_R	86_I	0.786	0.97
299_E	302_A	0.784	0.97
171_L	215_A	0.782	0.97
544_G	554_E	0.780	0.97
541_P	546_A	0.780	0.97
552_E	556_T	0.780	0.97
554_E	559_L	0.779	0.96
540_K	544_G	0.776	0.96
336_I	342_T	0.775	0.96
544_G	552_E	0.775	0.96
488_L	491_S	0.774	0.96
270_A	273_A	0.773	0.96
542_A	549_P	0.773	0.96
549_P	553_V	0.771	0.96
388_V	391_I	0.771	0.96
367_G	400_L	0.771	0.96
72_V	91_V	0.769	0.96
344_G	351_F	0.769	0.96
501_D	504_T	0.769	0.96
370_Y	390_E	0.768	0.96
334_L	342_T	0.768	0.96
467_T	478_E	0.766	0.96
435_T	438_T	0.766	0.96
338_L	344_G	0.766	0.96
324_G	327_K	0.765	0.96
548_K	555_V	0.765	0.96
523_E	528_S	0.765	0.96
549_P	561_P	0.764	0.96
525_E	529_D	0.763	0.96
525_E	528_S	0.762	0.96
330_P	344_G	0.761	0.96
546_A	550_G	0.761	0.96
136_K	152_D	0.761	0.96
336_I	348_V	0.760	0.96
526_A	532_P	0.759	0.96
330_P	340_F	0.758	0.96
115_M	122_I	0.756	0.96
259_T	264_E	0.753	0.96
119_V	124_H	0.753	0.96
335_T	344_G	0.753	0.96
342_T	345_I	0.752	0.96
14_L	36_E	0.752	0.96
325_K	333_L	0.750	0.96
437_Q	448_D	0.750	0.96
453_H	488_L	0.747	0.96
341_I	344_G	0.745	0.95
68_H	124_H	0.745	0.95
333_L	340_F	0.743	0.95
418_V	422_K	0.743	0.95
344_G	349_T	0.742	0.95
533_E	558_S	0.741	0.95
340_F	345_I	0.741	0.95
326_R	337_C	0.739	0.95
544_G	550_G	0.739	0.95
336_I	340_F	0.737	0.95
452_N	456_V	0.736	0.95
263_M	267_I	0.735	0.95
534_G	540_K	0.734	0.95
373_A	377_L	0.734	0.95
537_V	548_K	0.733	0.95
459_V	465_A	0.731	0.95
353_S	356_M	0.730	0.95
300_E	304_A	0.728	0.95
535_Q	542_A	0.727	0.95
326_R	331_W	0.727	0.95
550_G	558_S	0.727	0.95
339_V	350_V	0.725	0.95
431_I	434_V	0.725	0.95
470_D	473_P	0.724	0.95
545_T	548_K	0.723	0.95
227_T	230_A	0.722	0.95
442_A	446_L	0.721	0.95
469_I	489_T	0.721	0.95
343_A	351_F	0.720	0.95
332_V	346_L	0.720	0.95
318_N	326_R	0.718	0.95
339_V	347_A	0.718	0.95
176_Y	201_F	0.718	0.95
171_L	187_A	0.717	0.94
348_V	351_F	0.717	0.94
138_H	175_H	0.716	0.94
325_K	334_L	0.714	0.94
411_T	414_E	0.714	0.94
333_L	343_A	0.711	0.94
510_A	514_L	0.711	0.94
220_L	223_L	0.710	0.94
526_A	533_E	0.709	0.94
347_A	353_S	0.708	0.94
299_E	303_K	0.706	0.94
157_T	173_S	0.705	0.94
517_N	523_E	0.705	0.94
53_I	141_L	0.702	0.94
384_V	420_L	0.701	0.94
523_E	527_Y	0.700	0.94
370_Y	373_A	0.699	0.94
531_V	535_Q	0.699	0.94
340_F	351_F	0.698	0.94
323_N	328_K	0.698	0.94
558_S	561_P	0.698	0.94
338_L	348_V	0.698	0.94
537_V	543_A	0.697	0.94
361_K	364_D	0.697	0.94
452_N	485_Q	0.696	0.94
289_M	299_E	0.694	0.93
502_L	506_S	0.694	0.93
319_K	322_K	0.693	0.93
58_R	90_Y	0.692	0.93
202_E	208_I	0.690	0.93
522_V	526_A	0.690	0.93
460_N	467_T	0.689	0.93
453_H	456_V	0.689	0.93
342_T	348_V	0.688	0.93
554_E	558_S	0.687	0.93
337_C	345_I	0.686	0.93
290_T	295_I	0.686	0.93
268_K	271_F	0.684	0.93
432_G	438_T	0.683	0.93
208_I	211_D	0.683	0.93
549_P	552_E	0.682	0.93
345_I	350_V	0.682	0.93
406_P	418_V	0.678	0.93
187_A	195_A	0.678	0.93
552_E	559_L	0.676	0.93
372_K	376_L	0.675	0.92
328_K	340_F	0.675	0.92
516_D	520_K	0.675	0.92
95_T	202_E	0.674	0.92
418_V	425_G	0.674	0.92
510_A	519_L	0.674	0.92
282_T	285_E	0.673	0.92
368_M	373_A	0.673	0.92
13_I	16_V	0.673	0.92
266_D	269_T	0.673	0.92
486_V	490_V	0.672	0.92
65_S	128_N	0.672	0.92
284_Q	287_E	0.672	0.92
535_Q	538_K	0.669	0.92
507_K	513_Y	0.669	0.92
444_K	447_K	0.668	0.92
485_Q	489_T	0.667	0.92
507_K	512_G	0.667	0.92
549_P	555_V	0.666	0.92
326_R	334_L	0.664	0.92
373_A	382_L	0.664	0.92
371_E	374_A	0.663	0.92
137_P	199_V	0.663	0.92
517_N	521_L	0.662	0.92
398_E	408_A	0.661	0.92
331_W	341_I	0.661	0.92
393_D	400_L	0.660	0.92
545_T	550_G	0.657	0.91
341_I	346_L	0.656	0.91
396_I	414_E	0.655	0.91
26_Y	41_I	0.654	0.91
539_Q	546_A	0.654	0.91
499_L	517_N	0.653	0.91
451_F	454_V	0.653	0.91
296_I	300_E	0.653	0.91
85_Y	181_Q	0.653	0.91
333_L	341_I	0.652	0.91
537_V	544_G	0.652	0.91
291_K	296_I	0.651	0.91
548_K	552_E	0.648	0.91
62_S	156_A	0.647	0.91
429_T	434_V	0.646	0.91
372_K	375_G	0.646	0.91
459_V	495_E	0.643	0.91
468_V	473_P	0.642	0.91
500_R	505_Y	0.642	0.91
548_K	554_E	0.642	0.91
378_E	381_G	0.640	0.90
500_R	513_Y	0.640	0.90
244_I	257_Y	0.639	0.90
366_S	377_L	0.638	0.90
229_S	242_E	0.637	0.90
498_T	501_D	0.637	0.90
340_F	346_L	0.636	0.90
556_T	561_P	0.636	0.90
517_N	524_K	0.636	0.90
336_I	349_T	0.635	0.90
322_K	326_R	0.634	0.90
95_T	138_H	0.634	0.90
134_D	152_D	0.633	0.90
328_K	341_I	0.633	0.90
91_V	149_K	0.632	0.90
518_G	521_L	0.632	0.90
365_V	369_E	0.632	0.90
438_T	467_T	0.632	0.90
337_C	349_T	0.631	0.90
555_V	560_G	0.631	0.90
547_V	558_S	0.629	0.90
536_V	555_V	0.629	0.90
278_E	281_F	0.627	0.89
343_A	348_V	0.627	0.89
522_V	554_E	0.624	0.89
330_P	336_I	0.623	0.89
472_N	476_G	0.623	0.89
14_L	26_Y	0.623	0.89
500_R	510_A	0.621	0.89
504_T	508_E	0.621	0.89
517_N	520_K	0.621	0.89
55_R	155_I	0.620	0.89
385_D	389_L	0.619	0.89
436_G	442_A	0.619	0.89
373_A	380_E	0.618	0.89
207_R	233_W	0.618	0.89
329_W	340_F	0.617	0.89
289_M	298_D	0.615	0.89
329_W	341_I	0.615	0.89
63_A	74_I	0.615	0.89
550_G	555_V	0.614	0.88
295_I	304_A	0.614	0.88
139_N	152_D	0.613	0.88
516_D	519_L	0.612	0.88
413_K	418_V	0.612	0.88
510_A	513_Y	0.611	0.88
297_K	301_L	0.610	0.88
555_V	559_L	0.609	0.88
362_I	366_S	0.608	0.88
184_G	195_A	0.607	0.88
376_L	379_K	0.607	0.88
504_T	519_L	0.607	0.88
327_K	336_I	0.605	0.88
279_K	282_T	0.604	0.88
346_L	354_L	0.604	0.88
126_H	173_S	0.604	0.88
155_I	251_K	0.603	0.88
502_L	505_Y	0.603	0.88
276_L	283_I	0.603	0.88
41_I	206_G	0.602	0.88
324_G	333_L	0.602	0.88
303_K	306_G	0.602	0.88
555_V	561_P	0.601	0.87
330_P	349_T	0.600	0.87
549_P	559_L	0.600	0.87
512_G	520_K	0.599	0.87
545_T	560_G	0.598	0.87
177_L	211_D	0.598	0.87
18_G	25_V	0.598	0.87
369_E	378_E	0.597	0.87
518_G	522_V	0.596	0.87
294_P	302_A	0.595	0.87
324_G	328_K	0.594	0.87
526_A	531_V	0.593	0.87
201_F	232_R	0.591	0.87
346_L	352_P	0.591	0.87
427_A	430_E	0.591	0.87
367_G	373_A	0.589	0.86
278_E	284_Q	0.589	0.86
16_V	26_Y	0.587	0.86
334_L	344_G	0.587	0.86
329_W	335_T	0.587	0.86
351_F	354_L	0.586	0.86
243_N	247_K	0.586	0.86
366_S	403_K	0.584	0.86
377_L	382_L	0.582	0.86
526_A	538_K	0.582	0.86
500_R	517_N	0.581	0.86
332_V	336_I	0.580	0.86
539_Q	544_G	0.580	0.86
548_K	558_S	0.579	0.85
541_P	545_T	0.579	0.85
382_L	385_D	0.579	0.85
401_M	404_T	0.579	0.85
19_G	114_I	0.578	0.85
466_G	472_N	0.578	0.85
201_F	207_R	0.578	0.85
540_K	545_T	0.577	0.85
544_G	551_N	0.576	0.85
13_I	28_A	0.575	0.85
515_E	520_K	0.574	0.85
134_D	139_N	0.574	0.85
382_L	418_V	0.574	0.85
298_D	301_L	0.573	0.85
410_T	416_A	0.573	0.85
530_D	533_E	0.572	0.85
334_L	341_I	0.571	0.85
124_H	223_L	0.569	0.84
370_Y	382_L	0.568	0.84
511_S	521_L	0.568	0.84
276_L	284_Q	0.568	0.84
490_V	493_G	0.568	0.84
507_K	514_L	0.567	0.84
302_A	306_G	0.566	0.84
336_I	343_A	0.566	0.84
543_A	550_G	0.565	0.84
515_E	518_G	0.565	0.84
331_W	345_I	0.563	0.84
529_D	533_E	0.562	0.84
275_R	283_I	0.561	0.84
517_N	522_V	0.561	0.84
177_L	182_A	0.560	0.84
337_C	346_L	0.560	0.84
323_N	331_W	0.559	0.83
100_I	199_V	0.557	0.83
402_V	421_Y	0.557	0.83
331_W	338_L	0.557	0.83
379_K	407_K	0.557	0.83
325_K	340_F	0.557	0.83
433_D	437_Q	0.556	0.83
337_C	359_D	0.555	0.83
11_Y	78_G	0.554	0.83
345_I	353_S	0.554	0.83
344_G	352_P	0.554	0.83
325_K	341_I	0.553	0.83
44_F	79_E	0.552	0.83
336_I	344_G	0.552	0.83
540_K	551_N	0.550	0.82
541_P	551_N	0.550	0.82
277_N	280_R	0.549	0.82
72_V	151_T	0.549	0.82
391_I	394_E	0.549	0.82
366_S	376_L	0.548	0.82
507_K	517_N	0.548	0.82
176_Y	248_A	0.547	0.82
293_I	302_A	0.547	0.82
503_K	507_K	0.547	0.82
539_Q	542_A	0.547	0.82
507_K	521_L	0.546	0.82
348_V	352_P	0.544	0.82
300_E	306_G	0.544	0.82
391_I	421_Y	0.544	0.82
462_E	465_A	0.543	0.82
334_L	348_V	0.543	0.82
167_T	177_L	0.542	0.82
511_S	514_L	0.542	0.82
329_W	342_T	0.541	0.81
546_A	554_E	0.541	0.81
332_V	339_V	0.541	0.81
169_S	177_L	0.539	0.81
535_Q	559_L	0.538	0.81
447_K	455_T	0.538	0.81
539_Q	559_L	0.538	0.81
438_T	443_K	0.537	0.81
276_L	282_T	0.537	0.81
547_V	557_F	0.536	0.81
544_G	555_V	0.534	0.81
283_I	286_D	0.533	0.80
535_Q	551_N	0.533	0.80
434_V	451_F	0.533	0.80
292_A	303_K	0.532	0.80
177_L	202_E	0.532	0.80
138_H	176_Y	0.531	0.80
295_I	300_E	0.530	0.80
334_L	337_C	0.530	0.80
412_V	419_T	0.529	0.80
545_T	551_N	0.528	0.80
529_D	532_P	0.528	0.80
516_D	524_K	0.528	0.80
337_C	350_V	0.527	0.80
435_T	439_V	0.527	0.80
504_T	511_S	0.526	0.80
241_V	244_I	0.526	0.80
513_Y	520_K	0.522	0.79
74_I	88_M	0.522	0.79
361_K	411_T	0.521	0.79
372_K	377_L	0.520	0.79
340_F	350_V	0.520	0.79
393_D	425_G	0.520	0.79
365_V	401_M	0.520	0.79
288_E	293_I	0.520	0.79
535_Q	540_K	0.519	0.79
361_K	365_V	0.519	0.79
319_K	325_K	0.518	0.79
537_V	556_T	0.518	0.79
371_E	376_L	0.518	0.79
442_A	453_H	0.516	0.78
327_K	340_F	0.516	0.78
533_E	537_V	0.516	0.78
535_Q	553_V	0.515	0.78
499_L	510_A	0.515	0.78
516_D	523_E	0.515	0.78
332_V	337_C	0.515	0.78
119_V	262_D	0.514	0.78
468_V	471_Q	0.514	0.78
365_V	377_L	0.513	0.78
366_S	370_Y	0.513	0.78
339_V	355_F	0.513	0.78
470_D	475_A	0.512	0.78
519_L	553_V	0.512	0.78
322_K	333_L	0.512	0.78
548_K	561_P	0.512	0.78
318_N	337_C	0.511	0.78
538_K	542_A	0.510	0.77
170_V	177_L	0.510	0.77
539_Q	558_S	0.510	0.77
539_Q	545_T	0.509	0.77
389_L	419_T	0.509	0.77
330_P	335_T	0.509	0.77
79_E	218_I	0.508	0.77
174_V	177_L	0.508	0.77
248_A	262_D	0.507	0.77
523_E	526_A	0.507	0.77
545_T	553_V	0.507	0.77
473_P	478_E	0.506	0.77
138_H	173_S	0.506	0.77
370_Y	376_L	0.506	0.77
534_G	541_P	0.504	0.77
413_K	416_A	0.503	0.77
331_W	344_G	0.503	0.77
274_D	278_E	0.503	0.77
549_P	556_T	0.503	0.77
543_A	552_E	0.502	0.76
177_L	251_K	0.501	0.76
439_V	448_D	0.501	0.76
469_I	490_V	0.501	0.76
366_S	372_K	0.500	0.76
544_G	547_V	0.500	0.76

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4lqsA	1	0.4614	100	0.375	Contact Map
4ejnA	1	0.4105	100	0.388	Contact Map
4gv1A	1	0.4907	100	0.392	Contact Map
4aw2A	2	0.4923	100	0.392	Contact Map
2bdwA	2	0.4769	100	0.401	Contact Map
4dc2A	1	0.483	100	0.401	Contact Map
3pfqA	1	0.4938	100	0.401	Contact Map
3v8sA	2	0.5	100	0.404	Contact Map
4ic7A	1	0.4846	100	0.406	Contact Map
2yabA	2	0.4506	100	0.406	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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