GREMLIN Database
YNGL - UPF0713 protein YngL
UniProt: O34506 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 130 (106)
Sequences: 135 (110)
Seq/√Len: 10.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_F66_Y4.7681.00
19_L95_L4.3000.99
80_G88_A3.7950.99
35_P63_L3.6330.98
44_D48_H2.3440.82
22_L28_I2.0450.72
30_E45_Q1.9220.67
74_A108_V1.9060.66
59_F99_G1.8560.64
41_R49_V1.8320.63
21_H39_K1.7910.61
4_L21_H1.7680.60
11_M92_I1.7650.60
4_L12_L1.6840.56
34_K91_L1.6760.56
21_H61_Y1.6740.56
35_P90_P1.5880.51
31_F35_P1.5750.51
50_D56_A1.5470.50
44_D47_G1.4980.47
9_F96_A1.4860.47
39_K94_I1.3950.42
5_S95_L1.3890.42
78_G90_P1.3800.42
83_F108_V1.3680.41
93_F97_I1.3670.41
76_L108_V1.3650.41
9_F100_A1.3430.40
31_F94_I1.2880.38
103_I108_V1.2400.35
38_K79_L1.2300.35
43_V47_G1.2260.35
5_S106_T1.2210.35
95_L98_A1.2160.34
71_V76_L1.2090.34
66_Y83_F1.1880.33
17_Y61_Y1.1860.33
13_I101_Q1.1740.33
21_H44_D1.1520.32
74_A97_I1.1430.31
6_F99_G1.1380.31
58_N106_T1.1330.31
13_I89_I1.1280.31
22_L29_T1.1160.30
56_A64_N1.1140.30
27_K103_I1.1050.30
43_V51_E1.0880.29
12_L54_V1.0840.29
76_L92_I1.0700.28
38_K94_I1.0600.28
27_K61_Y1.0560.28
52_K69_A1.0510.28
25_F102_A1.0230.27
17_Y64_N1.0020.26
16_S74_A0.9990.26
32_I106_T0.9900.25
25_F46_N0.9880.25
27_K31_F0.9740.25
12_L88_A0.9630.24
37_M78_G0.9620.24
37_M64_N0.9580.24
7_L74_A0.9530.24
25_F105_E0.9440.24
13_I80_G0.9370.24
17_Y60_G0.9290.23
39_K52_K0.9190.23
29_T63_L0.9020.22
14_L105_E0.8970.22
62_M90_P0.8930.22
56_A83_F0.8900.22
8_T30_E0.8730.21
92_I95_L0.8710.21
45_Q76_L0.8630.21
57_S84_L0.8630.21
29_T32_I0.8630.21
76_L104_L0.8600.21
21_H52_K0.8360.20
12_L79_L0.8180.20
47_G50_D0.8180.20
59_F96_A0.8170.20
41_R77_I0.8140.20
11_M51_E0.8040.19
8_T103_I0.8040.19
23_I81_Y0.7980.19
13_I99_G0.7810.19
11_M50_D0.7690.18
71_V97_I0.7650.18
21_H41_R0.7630.18
10_I34_K0.7610.18
42_I64_N0.7320.17
7_L32_I0.7250.17
64_N109_G0.7210.17
10_I45_Q0.7160.17
71_V95_L0.7150.17
50_D102_A0.7070.17
47_G51_E0.7050.17
21_H38_K0.7020.17
47_G52_K0.6880.16
32_I82_L0.6870.16
75_I95_L0.6860.16
34_K66_Y0.6820.16
5_S91_L0.6820.16
37_M61_Y0.6820.16
8_T45_Q0.6790.16
11_M61_Y0.6790.16
47_G70_G0.6770.16
30_E55_P0.6770.16
75_I94_I0.6760.16
77_I92_I0.6710.16
66_Y105_E0.6650.16
39_K51_E0.6550.15
43_V79_L0.6530.15
94_I107_A0.6480.15
43_V66_Y0.6470.15
43_V48_H0.6460.15
20_T35_P0.6430.15
32_I76_L0.6380.15
23_I104_L0.6350.15
58_N104_L0.6350.15
80_G89_I0.6340.15
96_A104_L0.6320.15
76_L83_F0.6150.14
43_V46_N0.6110.14
60_G64_N0.6050.14
20_T36_F0.6040.14
41_R86_R0.6010.14
27_K79_L0.5870.14
46_N76_L0.5860.14
56_A97_I0.5860.14
75_I97_I0.5790.14
17_Y96_A0.5770.14
32_I77_I0.5770.14
6_F84_L0.5750.13
19_L102_A0.5690.13
23_I73_C0.5690.13
63_L70_G0.5640.13
16_S84_L0.5620.13
14_L100_A0.5610.13
76_L96_A0.5610.13
13_I16_S0.5600.13
69_A91_L0.5510.13
16_S55_P0.5490.13
45_Q75_I0.5480.13
37_M55_P0.5450.13
74_A101_Q0.5430.13
11_M64_N0.5410.13
4_L8_T0.5370.13
23_I58_N0.5360.13
51_E59_F0.5310.13
58_N82_L0.5310.13
35_P70_G0.5290.12
64_N69_A0.5140.12
30_E100_A0.5090.12
7_L78_G0.5070.12
102_A106_T0.5060.12
101_Q109_G0.5060.12
7_L23_I0.5030.12
6_F56_A0.5030.12
8_T50_D0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zxeA 1 0.3385 8.7 0.958 Contact Map
3ixzA 1 0.3385 8 0.959 Contact Map
3j01B 1 0.5385 7.2 0.96 Contact Map
1q90L 1 0.2462 4.5 0.964 Contact Map
3tx3A 2 0.8615 4.5 0.964 Contact Map
4xk8I 1 0.2231 3.9 0.965 Contact Map
4nv5A 1 0.9462 3.8 0.965 Contact Map
2mfrA 1 0.3 2.8 0.967 Contact Map
4q9hA 1 0.9846 2.6 0.968 Contact Map
4f4cA 1 0.9615 2.3 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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