GREMLIN Database
YCEB - Uncharacterized protein YceB
UniProt: O34504 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (286)
Sequences: 16496 (10429)
Seq/√Len: 616.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
232_D290_T5.1491.00
30_Q66_Q3.3421.00
149_D154_G3.2711.00
71_R103_D2.7731.00
232_D287_S2.7161.00
132_N182_H2.6321.00
294_Q297_D2.5351.00
33_E69_T2.5311.00
31_L34_Q2.5241.00
178_R208_S2.4781.00
203_R207_E2.4731.00
64_A98_Y2.4711.00
232_D236_E2.4181.00
231_T234_E2.3551.00
60_I72_V2.3471.00
287_S290_T2.2591.00
229_A234_E2.2571.00
136_Q183_Q2.2511.00
296_L300_G2.2291.00
202_F206_R2.1881.00
177_A204_I2.1661.00
207_E211_P2.1661.00
129_T151_P2.1401.00
23_Q99_P2.1011.00
202_F220_A2.0761.00
209_F218_P2.0581.00
30_Q34_Q2.0511.00
26_V30_Q2.0361.00
199_E203_R2.0241.00
204_I208_S2.0031.00
29_A63_I1.9991.00
233_E237_E1.9481.00
143_T164_A1.9161.00
40_Y70_I1.9041.00
123_G126_K1.8961.00
95_E100_N1.8861.00
27_E30_Q1.8791.00
91_F102_I1.8721.00
284_V291_V1.8631.00
41_W73_G1.8471.00
55_A90_T1.8081.00
114_T118_L1.8011.00
64_A72_V1.7951.00
26_V66_Q1.7871.00
181_A208_S1.7861.00
240_L244_L1.7431.00
139_S164_A1.7001.00
126_K151_P1.6631.00
31_L35_W1.6461.00
208_S211_P1.6201.00
171_G187_Y1.6111.00
91_F104_L1.6051.00
178_R211_P1.6031.00
63_I72_V1.6001.00
29_A40_Y1.5941.00
290_T293_Q1.5791.00
204_I207_E1.5601.00
228_C291_V1.5441.00
200_N203_R1.5291.00
274_K277_E1.5261.00
289_T293_Q1.5191.00
136_Q140_Y1.5111.00
129_T152_Y1.5101.00
139_S183_Q1.4921.00
17_S20_T1.4591.00
292_K296_L1.4401.00
33_E67_T1.4111.00
29_A67_T1.4031.00
26_V62_R1.4011.00
34_Q68_N1.3981.00
178_R182_H1.3941.00
296_L299_T1.3851.00
62_R65_A1.3841.00
139_S167_L1.3671.00
234_E238_L1.3561.00
62_R97_L1.3461.00
222_F304_T1.3181.00
23_Q27_E1.3161.00
20_T24_H1.3151.00
132_N183_Q1.3031.00
293_Q297_D1.3011.00
290_T294_Q1.2991.00
55_A58_I1.2971.00
136_Q148_P1.2961.00
42_F60_I1.2901.00
82_Y90_T1.2881.00
126_K129_T1.2871.00
140_Y145_S1.2771.00
140_Y144_D1.2731.00
228_C288_P1.2711.00
174_E204_I1.2661.00
229_A235_A1.2611.00
168_W221_L1.2431.00
261_E264_K1.2281.00
227_I238_L1.2261.00
27_E31_L1.2251.00
297_D300_G1.2241.00
178_R204_I1.2021.00
87_V134_Q1.1991.00
237_E240_L1.1941.00
168_W186_G1.1911.00
219_S305_N1.1901.00
209_F214_H1.1881.00
33_E68_N1.1871.00
234_E237_E1.1861.00
132_N136_Q1.1781.00
60_I74_S1.1731.00
139_S185_I1.1681.00
239_A243_D1.1581.00
73_G103_D1.1571.00
135_L183_Q1.1551.00
29_A70_I1.1531.00
137_D148_P1.1451.00
126_K152_Y1.1431.00
237_E241_S1.1291.00
286_G291_V1.1271.00
94_L102_I1.1251.00
182_H212_S1.1241.00
157_A160_L1.1241.00
197_R200_N1.1211.00
272_D275_L1.1201.00
104_L138_V1.1191.00
140_Y148_P1.1151.00
138_V142_L1.1141.00
42_F63_I1.1131.00
111_G116_T1.1121.00
77_V87_V1.1101.00
175_N178_R1.1081.00
236_E240_L1.1021.00
259_S262_E1.1011.00
95_E162_G1.0921.00
181_A212_S1.0901.00
58_I61_A1.0851.00
112_G116_T1.0821.00
54_T93_Q1.0801.00
57_E90_T1.0801.00
178_R212_S1.0791.00
137_D153_A1.0751.00
230_K234_E1.0741.00
76_G170_L1.0731.00
161_I164_A1.0711.00
199_E302_Y1.0681.00
24_H27_E1.0671.00
76_G107_G1.0621.00
106_V135_L1.0591.00
208_S212_S1.0411.00
27_E316_F1.0391.00
226_V309_V1.0381.00
86_K90_T1.0311.00
233_E236_E1.0291.00
157_A161_I1.0261.00
62_R66_Q1.0211.00
195_P297_D1.0171.00
30_Q68_N1.0151.00
139_S143_T1.0121.00
284_V294_Q1.0121.00
24_H316_F1.0081.00
275_L278_E1.0071.00
194_N197_R1.0031.00
219_S306_E0.9991.00
158_A161_I0.9891.00
57_E77_V0.9851.00
58_I94_L0.9781.00
180_A187_Y0.9651.00
200_N204_I0.9631.00
130_E133_R0.9571.00
137_D140_Y0.9551.00
39_R73_G0.9541.00
132_N179_R0.9521.00
129_T175_N0.9511.00
224_I284_V0.9501.00
179_R183_Q0.9391.00
19_V23_Q0.9331.00
126_K130_E0.9331.00
133_R151_P0.9301.00
239_A285_I0.9301.00
133_R150_H0.9231.00
229_A238_L0.9201.00
241_S244_L0.9191.00
95_E163_T0.9141.00
247_L250_G0.9141.00
188_V221_L0.9091.00
272_D277_E0.9061.00
274_K278_E0.9061.00
195_P199_E0.9051.00
177_A208_S0.8951.00
113_T116_T0.8931.00
258_P262_E0.8911.00
148_P153_A0.8891.00
22_L97_L0.8861.00
27_E34_Q0.8851.00
148_P151_P0.8831.00
140_Y146_L0.8821.00
150_H153_A0.8801.00
23_Q26_V0.8761.00
272_D276_I0.8741.00
130_E134_Q0.8711.00
257_V260_I0.8661.00
206_R220_A0.8661.00
84_P137_D0.8521.00
231_T235_A0.8451.00
95_E164_A0.8421.00
224_I295_L0.8421.00
61_A65_A0.8331.00
133_R137_D0.8301.00
39_R306_E0.8261.00
293_Q296_L0.8221.00
134_Q138_V0.8211.00
64_A102_I0.8211.00
169_V180_A0.8191.00
245_W248_R0.8151.00
177_A181_A0.8121.00
187_Y205_Y0.8101.00
79_L134_Q0.8091.00
240_L243_D0.8051.00
115_K118_L0.8041.00
142_L165_P0.8021.00
209_F215_F0.8001.00
209_F212_S0.7931.00
212_S215_F0.7921.00
260_I264_K0.7911.00
273_K277_E0.7901.00
262_E271_S0.7901.00
96_A163_T0.7901.00
236_E239_A0.7891.00
65_A98_Y0.7871.00
21_T24_H0.7861.00
60_I64_A0.7861.00
205_Y209_F0.7841.00
79_L87_V0.7771.00
236_E280_R0.7761.00
258_P261_E0.7601.00
60_I94_L0.7531.00
60_I102_I0.7471.00
202_F205_Y0.7461.00
260_I263_A0.7461.00
132_N175_N0.7431.00
22_L62_R0.7431.00
103_D168_W0.7411.00
169_V176_S0.7411.00
174_E178_R0.7411.00
238_L241_S0.7401.00
244_L248_R0.7401.00
169_V184_G0.7381.00
64_A94_L0.7361.00
257_V263_A0.7361.00
252_G258_P0.7351.00
203_R303_E0.7351.00
95_E161_I0.7341.00
41_W75_G0.7321.00
141_F146_L0.7291.00
264_K271_S0.7281.00
133_R152_Y0.7281.00
177_A187_Y0.7271.00
209_F216_S0.7231.00
182_H208_S0.7221.00
117_R121_T0.7201.00
174_E208_S0.7191.00
257_V261_E0.7151.00
247_L251_K0.7141.00
205_Y218_P0.7141.00
209_F217_N0.7091.00
189_F201_A0.7091.00
241_S245_W0.7091.00
108_R127_S0.7081.00
87_V138_V0.7081.00
44_E82_Y0.7041.00
24_H28_L0.7011.00
128_L175_N0.7001.00
84_P134_Q0.6991.00
149_D152_Y0.6981.00
178_R207_E0.6971.00
221_L306_E0.6971.00
26_V63_I0.6951.00
46_H89_E0.6941.00
140_Y143_T0.6941.00
83_S86_K0.6931.00
155_I158_A0.6931.00
206_R209_F0.6921.00
91_F142_L0.6921.00
220_A304_T0.6881.00
125_K175_N0.6871.00
74_S102_I0.6831.00
26_V65_A0.6831.00
38_K69_T0.6821.00
202_F302_Y0.6801.00
133_R148_P0.6781.00
71_R166_E0.6771.00
39_R308_M0.6741.00
42_F59_M0.6701.00
136_Q182_H0.6701.00
82_Y86_K0.6681.00
92_R155_I0.6671.00
263_A271_S0.6591.00
171_G176_S0.6571.00
73_G168_W0.6551.00
61_A98_Y0.6531.00
156_K160_L0.6521.00
257_V264_K0.6501.00
57_E91_F0.6491.00
61_A94_L0.6481.00
273_K276_I0.6481.00
23_Q65_A0.6471.00
108_R131_F0.6471.00
130_E153_A0.6471.00
77_V91_F0.6451.00
99_P160_L0.6441.00
206_R305_N0.6431.00
206_R210_R0.6391.00
245_W249_V0.6381.00
299_T304_T0.6381.00
232_D235_A0.6351.00
259_S263_A0.6351.00
196_E199_E0.6341.00
236_E285_I0.6341.00
133_R136_Q0.6331.00
122_D130_E0.6311.00
78_L111_G0.6281.00
18_P21_T0.6271.00
136_Q139_S0.6261.00
169_V179_R0.6251.00
118_L121_T0.6251.00
295_L307_I0.6231.00
230_K288_P0.6221.00
23_Q68_N0.6211.00
243_D246_L0.6181.00
22_L26_V0.6171.00
32_S70_I0.6161.00
38_K71_R0.6141.00
92_R157_A0.6131.00
67_T101_R0.6071.00
282_R294_Q0.6061.00
182_H211_P0.6061.00
289_T292_K0.6051.00
294_Q298_L0.6051.00
156_K161_I0.6001.00
215_F218_P0.5971.00
271_S274_K0.5971.00
85_F141_F0.5951.00
40_Y63_I0.5931.00
62_R98_Y0.5921.00
82_Y87_V0.5901.00
20_T23_Q0.5901.00
106_V138_V0.5891.00
95_E98_Y0.5891.00
26_V29_A0.5891.00
33_E70_I0.5881.00
175_N179_R0.5871.00
59_M93_Q0.5861.00
248_R251_K0.5861.00
226_V284_V0.5851.00
174_E200_N0.5851.00
72_V98_Y0.5821.00
211_P215_F0.5811.00
206_R303_E0.5811.00
92_R142_L0.5811.00
223_T308_M0.5781.00
114_T117_R0.5771.00
207_E210_R0.5751.00
177_A205_Y0.5741.00
111_G117_R0.5731.00
246_L249_V0.5721.00
272_D278_E0.5711.00
56_P74_S0.5701.00
156_K159_P0.5691.00
58_I90_T0.5681.00
235_A239_A0.5671.00
197_R201_A0.5661.00
231_T237_E0.5641.00
105_G170_L0.5631.00
295_L309_V0.5621.00
88_A142_L0.5601.00
168_W306_E0.5581.00
75_G188_V0.5561.00
160_L163_T0.5561.00
225_F310_L0.5551.00
95_E165_P0.5551.00
271_S276_I0.5541.00
172_L191_H0.5541.00
288_P292_K0.5531.00
172_L201_A0.5531.00
112_G117_R0.5460.99
228_C287_S0.5460.99
217_N305_N0.5450.99
166_E219_S0.5440.99
181_A209_F0.5440.99
198_G201_A0.5430.99
206_R216_S0.5430.99
25_S28_L0.5430.99
106_V167_L0.5400.99
298_L302_Y0.5400.99
135_L169_V0.5390.99
112_G115_K0.5390.99
113_T117_R0.5380.99
203_R206_R0.5340.99
155_I160_L0.5330.99
143_T146_L0.5330.99
67_T70_I0.5310.99
84_P138_V0.5310.99
79_L106_V0.5310.99
168_W219_S0.5310.99
243_D248_R0.5300.99
259_S264_K0.5290.99
111_G121_T0.5280.99
227_I239_A0.5280.99
246_L250_G0.5270.99
27_E317_E0.5270.99
258_P271_S0.5260.99
148_P154_G0.5250.99
195_P302_Y0.5230.99
172_L190_G0.5200.99
196_E200_N0.5190.99
273_K278_E0.5190.99
61_A64_A0.5160.99
244_L247_L0.5150.99
92_R96_A0.5150.99
84_P153_A0.5130.99
206_R217_N0.5110.99
98_Y102_I0.5110.99
131_F169_V0.5100.99
176_S179_R0.5090.99
242_Q247_L0.5080.99
114_T121_T0.5080.99
127_S130_E0.5030.99
58_I97_L0.5020.99
205_Y220_A0.5020.99
179_R182_H0.5020.99
74_S77_V0.5010.99
111_G119_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lucA 1 0.9396 100 0.201 Contact Map
4us5A 3 0.9668 100 0.202 Contact Map
2wgkA 2 0.9728 100 0.205 Contact Map
1lucB 1 0.9426 100 0.206 Contact Map
2i7gA 2 0.9637 100 0.229 Contact Map
1rhcA 2 0.9305 100 0.247 Contact Map
3raoA 2 0.9607 100 0.249 Contact Map
1z69A 4 0.9366 100 0.251 Contact Map
1ezwA 3 0.9366 100 0.252 Contact Map
3b9oA 2 0.9728 100 0.258 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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