GREMLIN Database
MNTD - Manganese transport system membrane protein MntD
UniProt: O34500 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 295 (257)
Sequences: 5157 (3211)
Seq/√Len: 200.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
222_L270_A4.2381.00
11_G241_A3.9271.00
144_W148_S3.7191.00
240_S266_C3.2391.00
95_S264_G2.9211.00
243_M262_M2.9041.00
240_S263_T2.7861.00
225_R228_Y2.7321.00
232_L236_I2.7321.00
10_T126_V2.6801.00
223_T229_M2.6371.00
253_V258_A2.6181.00
231_I235_L2.5221.00
223_T228_Y2.4371.00
13_L150_L2.4231.00
12_V238_G2.3551.00
218_A236_I2.2851.00
156_L187_V2.2651.00
218_A270_A2.2421.00
223_T232_L2.2011.00
180_P183_L2.1261.00
13_L147_A2.1191.00
87_A217_A2.1051.00
224_D228_Y2.0861.00
22_G216_P2.0581.00
220_H229_M1.9791.00
102_I261_A1.9281.00
48_A63_G1.8511.00
219_A232_L1.8091.00
183_L187_V1.8081.00
10_T146_L1.7911.00
218_A266_C1.7831.00
240_S262_M1.7671.00
210_A260_A1.7631.00
17_S150_L1.7571.00
247_F262_M1.7461.00
247_F251_L1.7391.00
166_I173_M1.7361.00
20_L154_V1.6951.00
20_L157_I1.6931.00
10_T143_F1.6851.00
15_G241_A1.6791.00
248_A255_I1.6721.00
269_S273_F1.6681.00
175_L182_L1.6601.00
173_M177_L1.6571.00
236_I240_S1.6481.00
160_C163_E1.6471.00
236_I266_C1.6101.00
16_V234_A1.5941.00
11_G123_I1.5851.00
156_L191_M1.5731.00
151_V155_V1.5651.00
140_P144_W1.5061.00
23_T229_M1.5041.00
69_L190_G1.5031.00
171_P185_H1.4971.00
239_L266_C1.4741.00
239_L243_M1.4641.00
149_V198_A1.4611.00
156_L160_C1.4481.00
254_S257_G1.4411.00
145_M148_S1.4371.00
246_F250_W1.4261.00
261_A265_V1.4121.00
218_A263_T1.3941.00
34_A212_L1.3771.00
167_A181_V1.3731.00
164_F188_Q1.3301.00
40_T71_T1.3291.00
80_S182_L1.3241.00
97_F206_V1.3231.00
73_F190_G1.3221.00
6_W140_P1.3211.00
272_L276_A1.3101.00
142_A201_D1.3101.00
174_A181_V1.3031.00
160_C187_V1.3011.00
160_C184_I1.3001.00
4_E249_T1.3001.00
224_D276_A1.2961.00
12_V242_V1.2941.00
161_Y230_L1.2791.00
23_T230_L1.2761.00
228_Y231_I1.2671.00
65_A194_L1.2661.00
43_L100_G1.2651.00
273_F276_A1.2581.00
228_Y232_L1.2421.00
221_L270_A1.2401.00
73_F77_L1.2331.00
234_A238_G1.2221.00
221_L274_S1.2161.00
231_I234_A1.2061.00
148_S152_L1.2031.00
83_V267_Y1.1981.00
50_L103_L1.1921.00
165_K226_L1.1901.00
8_I242_V1.1751.00
245_Y255_I1.1741.00
268_A272_L1.1671.00
28_R171_P1.1541.00
35_D93_F1.1531.00
174_A179_I1.1511.00
211_M263_T1.1461.00
19_G233_S1.1331.00
154_V158_S1.1291.00
28_R168_S1.1271.00
156_L164_F1.1261.00
218_A240_S1.1231.00
14_V18_C1.1221.00
265_V269_S1.1151.00
11_G259_M1.1081.00
219_A236_I1.1001.00
23_T233_S1.0981.00
35_D39_H1.0861.00
91_V217_A1.0801.00
179_I184_I1.0791.00
127_P140_P1.0731.00
180_P184_I1.0711.00
161_Y227_L1.0701.00
24_F157_I1.0701.00
266_C270_A1.0671.00
155_V159_V1.0491.00
7_I245_Y1.0491.00
244_G259_M1.0471.00
140_P143_F1.0471.00
227_L231_I1.0451.00
222_L232_L1.0441.00
197_V206_V1.0381.00
235_L239_L1.0371.00
9_A143_F1.0361.00
214_V263_T1.0351.00
46_V103_L1.0291.00
25_L192_L1.0271.00
219_A223_T1.0151.00
42_L100_G1.0121.00
164_F184_I0.9881.00
46_V104_L0.9741.00
149_V153_N0.9720.99
24_F230_L0.9590.99
70_L74_L0.9580.99
144_W147_A0.9570.99
247_F258_A0.9510.99
127_P141_K0.9490.99
62_I66_A0.9350.99
163_E184_I0.9320.99
183_L186_Y0.9300.99
218_A221_L0.9270.99
152_L155_V0.9240.99
59_Y62_I0.9220.99
36_A89_I0.9190.99
166_I174_A0.9180.99
102_I253_V0.9150.99
64_A68_G0.9120.99
272_L275_P0.9110.99
9_A13_L0.9030.99
221_L271_F0.8970.99
25_L32_M0.8920.99
40_T43_L0.8910.99
5_A9_A0.8840.99
47_G67_T0.8840.99
237_G241_A0.8830.99
17_S195_T0.8780.99
11_G245_Y0.8660.99
167_A184_I0.8600.99
122_E257_G0.8590.99
105_S254_S0.8570.99
76_Q189_M0.8570.99
160_C188_Q0.8560.99
122_E205_A0.8550.99
42_L104_L0.8540.99
111_V114_D0.8520.99
147_A151_V0.8490.99
123_I255_I0.8380.98
22_G263_T0.8320.98
150_L154_V0.8310.98
182_L185_H0.8310.98
34_A120_M0.8260.98
27_L168_S0.8250.98
230_L234_A0.8140.98
173_M176_A0.8110.98
19_G234_A0.8110.98
164_F167_A0.8110.98
63_G67_T0.8100.98
38_S169_F0.8060.98
19_G216_P0.7990.98
10_T202_S0.7990.98
50_L107_Y0.7990.98
142_A145_M0.7990.98
83_V88_A0.7940.98
161_Y165_K0.7940.98
78_L92_V0.7900.98
83_V87_A0.7900.98
141_K144_W0.7900.98
214_V264_G0.7880.98
35_D213_I0.7880.98
31_A213_I0.7850.98
46_V96_L0.7810.98
24_F161_Y0.7790.98
90_G213_I0.7750.97
77_L186_Y0.7740.97
218_A267_Y0.7720.97
166_I177_L0.7670.97
51_V57_G0.7650.97
8_I245_Y0.7600.97
20_L230_L0.7560.97
17_S198_A0.7550.97
24_F28_R0.7520.97
270_A274_S0.7520.97
171_P175_L0.7510.97
95_S99_I0.7490.97
230_L233_S0.7440.97
38_S84_Q0.7370.97
232_L235_L0.7320.96
218_A222_L0.7320.96
47_G103_L0.7300.96
270_A273_F0.7300.96
236_I270_A0.7290.96
12_V15_G0.7270.96
199_S208_V0.7260.96
67_T70_L0.7250.96
15_G238_G0.7250.96
24_F164_F0.7220.96
41_V68_G0.7210.96
153_N195_T0.7210.96
28_R185_H0.7180.96
102_I257_G0.7150.96
157_I230_L0.7140.96
258_A262_M0.7140.96
192_L212_L0.7140.96
242_V246_F0.7090.96
26_V31_A0.7080.96
58_I63_G0.7080.96
47_G66_A0.7050.96
188_Q192_L0.7030.96
143_F147_A0.7000.95
58_I62_I0.7000.95
17_S153_N0.6990.95
11_G15_G0.6980.95
62_I65_A0.6980.95
159_V163_E0.6970.95
141_K151_V0.6950.95
34_A213_I0.6890.95
127_P142_A0.6880.95
79_H85_S0.6880.95
153_N191_M0.6860.95
170_D173_M0.6860.95
144_W247_F0.6830.95
21_I191_M0.6830.95
158_S231_I0.6820.95
224_D277_N0.6810.95
114_D117_H0.6800.95
13_L143_F0.6780.95
158_S162_K0.6780.95
271_F274_S0.6720.94
146_L198_A0.6710.94
16_V238_G0.6690.94
36_A42_L0.6670.94
99_I102_I0.6660.94
7_I124_A0.6650.94
35_D209_V0.6640.94
126_V202_S0.6630.94
124_A237_G0.6630.94
15_G256_S0.6620.94
19_G23_T0.6580.94
189_M200_F0.6570.94
66_A70_L0.6560.94
190_G194_L0.6490.93
36_A43_L0.6480.93
265_V272_L0.6420.93
14_V202_S0.6410.93
15_G19_G0.6390.93
14_V199_S0.6390.93
4_E245_Y0.6370.93
262_M266_C0.6350.92
77_L80_S0.6350.92
73_F186_Y0.6340.92
243_M247_F0.6310.92
5_A8_I0.6270.92
46_V97_F0.6270.92
274_S277_N0.6260.92
76_Q216_P0.6260.92
225_R229_M0.6260.92
271_F275_P0.6250.92
6_W26_V0.6220.92
37_I68_G0.6210.92
32_M81_K0.6190.92
80_S185_H0.6140.91
83_V86_D0.6130.91
264_G268_A0.6130.91
48_A59_Y0.6120.91
90_G217_A0.6110.91
69_L73_F0.6080.91
123_I259_M0.6070.91
44_G63_G0.6060.91
24_F188_Q0.6050.91
164_F172_Q0.6030.90
85_S189_M0.6030.90
10_T123_I0.6020.90
23_T26_V0.6010.90
16_V154_V0.6000.90
185_H189_M0.5950.90
48_A58_I0.5950.90
163_E180_P0.5940.90
20_L234_A0.5930.90
34_A38_S0.5870.89
161_Y226_L0.5870.89
142_A254_S0.5850.89
76_Q185_H0.5840.89
51_V58_I0.5790.89
149_V194_L0.5770.88
115_I260_A0.5750.88
4_E7_I0.5730.88
184_I187_V0.5730.88
141_K145_M0.5710.88
232_L270_A0.5710.88
19_G212_L0.5700.88
38_S41_V0.5690.88
8_I246_F0.5680.88
14_V206_V0.5670.88
255_I258_A0.5650.87
18_C207_L0.5650.87
94_T98_A0.5640.87
24_F168_S0.5640.87
100_G255_I0.5610.87
243_M273_F0.5600.87
72_A193_S0.5600.87
38_S42_L0.5590.87
39_H42_L0.5590.87
49_F113_L0.5570.87
64_A93_F0.5530.86
41_V118_S0.5530.86
148_S151_V0.5520.86
107_Y237_G0.5500.86
147_A150_L0.5490.86
61_F65_A0.5490.86
71_T75_V0.5490.86
117_H122_E0.5480.86
27_L34_A0.5470.86
104_L113_L0.5470.86
155_V158_S0.5440.85
41_V200_F0.5430.85
247_F250_W0.5420.85
79_H185_H0.5410.85
16_V237_G0.5400.85
40_T96_L0.5390.85
146_L202_S0.5380.85
169_F213_I0.5370.85
74_L92_V0.5370.85
7_I10_T0.5350.84
4_E246_F0.5330.84
64_A188_Q0.5280.84
43_L93_F0.5250.83
43_L97_F0.5250.83
43_L89_I0.5250.83
112_H202_S0.5250.83
113_L116_E0.5250.83
228_Y265_V0.5230.83
165_K168_S0.5230.83
104_L116_E0.5220.83
243_M266_C0.5220.83
33_L169_F0.5200.83
158_S161_Y0.5200.83
22_G28_R0.5190.83
273_F277_N0.5190.83
40_T254_S0.5180.83
74_L77_L0.5180.83
22_G30_M0.5150.82
32_M40_T0.5130.82
69_L194_L0.5130.82
22_G237_G0.5120.82
193_S199_S0.5120.82
175_L183_L0.5110.82
34_A209_V0.5100.82
105_S122_E0.5100.82
158_S265_V0.5080.81
211_M241_A0.5080.81
123_I249_T0.5080.81
195_T208_V0.5070.81
142_A200_F0.5060.81
71_T96_L0.5060.81
89_I208_V0.5040.81
262_M265_V0.5020.81
92_V96_L0.5010.80
96_L122_E0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qi9A 2 0.8746 100 0.574 Contact Map
2nq2A 2 0.8644 100 0.578 Contact Map
4g1uA 2 0.8542 100 0.595 Contact Map
2zy9A 2 0.2983 44.2 0.95 Contact Map
4p6vB 1 0.7186 15.5 0.96 Contact Map
3zuxA 1 0.9017 12.8 0.962 Contact Map
4n7wA 2 0.9322 11.4 0.963 Contact Map
2m20A 2 0.1661 10.9 0.963 Contact Map
2kluA 1 0.1593 6.3 0.967 Contact Map
4czbA 2 0.6915 5.6 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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