GREMLIN Database
6PGL - 6-phosphogluconolactonase
UniProt: O34499 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 349 (260)
Sequences: 7767 (6218)
Seq/√Len: 385.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_D106_T3.0621.00
94_H107_A2.9341.00
290_E308_A2.8531.00
308_A319_F2.7851.00
45_Y58_I2.7811.00
150_Y164_D2.7441.00
105_L153_F2.7321.00
105_L161_V2.7231.00
163_V173_Y2.7171.00
56_Y97_V2.6441.00
106_T117_F2.5711.00
57_S70_Y2.5031.00
249_A263_N2.4901.00
39_K57_S2.4501.00
56_Y104_V2.4451.00
67_V106_T2.4171.00
310_N313_T2.3711.00
243_D262_A2.3411.00
144_E163_V2.2821.00
105_L116_V2.2201.00
108_N111_S2.2031.00
162_A199_F2.0671.00
262_A272_F2.0661.00
56_Y69_A2.0381.00
269_I308_A2.0141.00
59_E64_Q2.0011.00
216_V262_A1.9721.00
96_S152_G1.9341.00
296_D309_S1.9311.00
114_V163_V1.9261.00
95_V106_T1.8781.00
307_V318_L1.8661.00
162_A197_I1.8541.00
261_V299_F1.8411.00
217_I230_E1.8181.00
162_A206_A1.7421.00
107_A148_T1.7421.00
190_P213_S1.7341.00
71_Q74_K1.7331.00
108_N113_K1.6891.00
270_A286_R1.6831.00
162_A172_T1.6811.00
261_V306_L1.6531.00
152_G198_A1.6331.00
49_N53_T1.6271.00
164_D194_P1.6271.00
251_H298_V1.6121.00
154_T199_F1.5841.00
58_I92_P1.5821.00
68_A81_F1.5761.00
88_D108_N1.5721.00
47_A96_S1.5661.00
201_P252_V1.5351.00
217_I233_V1.5281.00
144_E167_I1.4991.00
290_E310_N1.4771.00
220_E223_P1.4751.00
207_Y218_A1.4741.00
81_F84_H1.4701.00
200_H252_V1.4451.00
67_V95_V1.4141.00
249_A296_D1.4131.00
88_D111_S1.4101.00
253_T299_F1.4001.00
50_K101_N1.3981.00
208_V211_E1.3821.00
98_D153_F1.3711.00
144_E165_L1.3651.00
165_L169_K1.3641.00
209_M219_L1.3621.00
207_Y252_V1.3441.00
198_A251_H1.3381.00
48_T55_L1.3351.00
230_E233_V1.3211.00
56_Y95_V1.3151.00
170_L208_V1.3081.00
49_N54_I1.2971.00
270_A283_F1.2861.00
105_L151_A1.2831.00
213_S217_I1.2721.00
190_P209_M1.2671.00
208_V219_L1.2661.00
310_N315_N1.2601.00
292_N312_E1.2581.00
261_V271_V1.2511.00
144_E148_T1.2401.00
66_G84_H1.2311.00
254_Q303_E1.2291.00
99_D157_H1.2281.00
289_T319_F1.2241.00
59_E66_G1.2051.00
320_E323_K1.2041.00
155_P199_F1.2021.00
207_Y250_I1.1861.00
149_H166_G1.1841.00
262_A270_A1.1811.00
95_V104_V1.1791.00
118_P121_E1.1781.00
107_A151_A1.1751.00
290_E313_T1.1661.00
48_T72_I1.1571.00
198_A250_I1.1561.00
190_P208_V1.1541.00
299_F306_L1.1301.00
243_D266_H1.1251.00
163_V171_Y1.1071.00
267_D292_N1.1011.00
264_R268_S1.0981.00
88_D92_P1.0981.00
201_P256_G1.0941.00
308_A317_V1.0941.00
177_D180_L1.0861.00
308_A313_T1.0851.00
54_I69_A1.0841.00
263_N267_D1.0841.00
220_E231_I1.0821.00
297_F308_A1.0811.00
87_I115_H1.0791.00
283_F286_R1.0781.00
210_T213_S1.0771.00
152_G197_I1.0741.00
300_D303_E1.0721.00
39_K43_P1.0711.00
295_R312_E1.0621.00
251_H297_F1.0581.00
290_E319_F1.0521.00
196_H210_T1.0491.00
261_V297_F1.0491.00
68_A84_H1.0481.00
263_N297_F1.0461.00
190_P194_P1.0441.00
97_V104_V1.0411.00
115_H124_S1.0401.00
39_K59_E1.0351.00
243_D264_R1.0311.00
103_F116_V1.0271.00
43_P57_S1.0221.00
47_A95_V1.0211.00
93_C110_H1.0201.00
88_D117_F1.0171.00
216_V250_I1.0151.00
59_E68_A1.0101.00
253_T256_G1.0001.00
150_Y197_I0.9951.00
273_E276_Q0.9821.00
91_S110_H0.9791.00
87_I117_F0.9631.00
190_P219_L0.9551.00
165_L168_D0.9551.00
249_A297_F0.9521.00
300_D304_G0.9481.00
47_A97_V0.9451.00
92_P106_T0.9431.00
49_N52_N0.9411.00
293_W312_E0.9401.00
290_E294_P0.9381.00
144_E173_Y0.9381.00
58_I65_G0.9351.00
210_T215_E0.9311.00
69_A97_V0.9221.00
55_L72_I0.9211.00
174_K177_D0.9201.00
304_G320_E0.9171.00
49_N97_V0.9121.00
122_D125_L0.9111.00
299_F321_R0.9101.00
236_A272_F0.9081.00
264_R267_D0.9051.00
210_T217_I0.9011.00
170_L209_M0.8921.00
198_A252_V0.8901.00
57_S68_A0.8831.00
111_S115_H0.8831.00
143_Q173_Y0.8801.00
59_E65_G0.8771.00
300_D305_F0.8741.00
154_T157_H0.8731.00
202_K205_Y0.8711.00
252_V299_F0.8701.00
219_L230_E0.8691.00
215_E233_V0.8671.00
218_A252_V0.8651.00
165_L171_Y0.8611.00
263_N294_P0.8591.00
289_T317_V0.8581.00
71_Q80_T0.8571.00
167_I171_Y0.8541.00
310_N319_F0.8531.00
98_D103_F0.8501.00
149_H193_G0.8431.00
164_D170_L0.8431.00
148_T163_V0.8411.00
269_I294_P0.8401.00
32_S35_K0.8381.00
98_D105_L0.8321.00
97_V119_V0.8321.00
147_H166_G0.8301.00
243_D272_F0.8251.00
310_N314_G0.8251.00
273_E282_A0.8181.00
121_E124_S0.8131.00
193_G212_L0.8101.00
49_N101_N0.8101.00
88_D115_H0.8041.00
309_S316_L0.8021.00
211_E215_E0.8011.00
165_L173_Y0.8001.00
94_H151_A0.7971.00
209_M247_G0.7901.00
54_I57_S0.7861.00
58_I95_V0.7861.00
116_V175_L0.7831.00
272_F283_F0.7801.00
106_T115_H0.7791.00
208_V260_Y0.7791.00
149_H195_R0.7761.00
246_Q265_G0.7751.00
290_E317_V0.7741.00
98_D102_Q0.7731.00
170_L197_I0.7731.00
44_T60_K0.7691.00
204_K222_N0.7631.00
47_A56_Y0.7571.00
67_V92_P0.7531.00
107_A112_G0.7531.00
164_D168_D0.7481.00
250_I262_A0.7471.00
254_Q299_F0.7461.00
47_A50_K0.7451.00
252_V274_V0.7411.00
195_R212_L0.7321.00
269_I306_L0.7301.00
96_S105_L0.7261.00
197_I206_A0.7251.00
148_T151_A0.7241.00
190_P211_E0.7231.00
79_L82_L0.7191.00
105_L175_L0.7181.00
155_P203_E0.7171.00
205_Y218_A0.7161.00
46_V57_S0.7161.00
171_Y186_H0.7131.00
205_Y231_I0.7111.00
120_Q124_S0.7111.00
50_K97_V0.7051.00
56_Y60_K0.7021.00
236_A243_D0.7011.00
192_A213_S0.7001.00
220_E229_R0.6950.99
168_D193_G0.6940.99
96_S151_A0.6910.99
248_S262_A0.6910.99
96_S99_D0.6900.99
207_Y260_Y0.6880.99
196_H249_A0.6840.99
269_I297_F0.6830.99
158_N176_K0.6830.99
190_P210_T0.6830.99
30_A34_P0.6810.99
268_S286_R0.6790.99
305_F320_E0.6790.99
313_T317_V0.6770.99
200_H207_Y0.6740.99
252_V259_V0.6730.99
196_H250_I0.6720.99
44_T93_C0.6710.99
305_F309_S0.6710.99
172_T199_F0.6690.99
216_V234_V0.6670.99
162_A170_L0.6610.99
243_D247_G0.6600.99
54_I97_V0.6560.99
96_S153_F0.6510.99
273_E281_L0.6500.99
302_T305_F0.6490.99
211_E214_N0.6490.99
114_V151_A0.6470.99
261_V265_G0.6460.99
102_Q118_P0.6420.99
259_V274_V0.6410.99
57_S64_Q0.6410.99
210_T247_G0.6380.99
60_K91_S0.6380.99
164_D197_I0.6350.99
185_S189_A0.6350.99
214_N245_S0.6340.99
214_N246_Q0.6330.99
92_P108_N0.6310.99
172_T221_Y0.6310.99
303_E321_R0.6290.99
89_G108_N0.6290.99
257_R275_N0.6280.99
285_E288_S0.6270.99
36_L39_K0.6270.99
94_H150_Y0.6240.99
236_A270_A0.6230.99
281_L287_V0.6220.99
164_D209_M0.6180.99
252_V260_Y0.6180.99
58_I106_T0.6170.99
305_F318_L0.6170.99
189_A230_E0.6130.99
115_H127_S0.6110.99
219_L228_F0.6110.99
53_T71_Q0.6090.99
251_H299_F0.6090.99
163_V167_I0.6080.99
108_N112_G0.6040.99
257_R273_E0.6020.99
169_K187_S0.5990.98
287_V319_F0.5990.98
169_K185_S0.5970.98
247_G250_I0.5960.98
234_V272_F0.5960.98
205_Y208_V0.5940.98
162_A207_Y0.5920.98
54_I82_L0.5920.98
303_E307_V0.5900.98
119_V122_D0.5890.98
263_N308_A0.5880.98
170_L194_P0.5880.98
90_P110_H0.5880.98
106_T111_S0.5880.98
142_R145_K0.5870.98
178_G181_T0.5840.98
194_P211_E0.5830.98
116_V153_F0.5830.98
268_S288_S0.5810.98
195_R248_S0.5800.98
264_R272_F0.5800.98
192_A210_T0.5780.98
174_K222_N0.5770.98
57_S60_K0.5740.98
196_H209_M0.5730.98
64_Q68_A0.5730.98
276_Q281_L0.5730.98
276_Q282_A0.5720.98
111_S145_K0.5680.98
228_F231_I0.5660.98
29_K33_E0.5650.98
45_Y95_V0.5650.98
110_H147_H0.5610.98
45_Y249_A0.5600.98
231_I234_V0.5580.98
67_V70_Y0.5580.98
103_F175_L0.5570.98
69_A85_Q0.5540.97
39_K70_Y0.5540.97
161_V199_F0.5530.97
54_I119_V0.5530.97
41_G64_Q0.5510.97
33_E40_L0.5500.97
41_G60_K0.5470.97
166_G193_G0.5470.97
267_D289_T0.5460.97
300_D307_V0.5450.97
154_T158_N0.5420.97
186_H189_A0.5420.97
54_I71_Q0.5370.97
253_T271_V0.5340.97
106_T113_K0.5340.97
261_V264_R0.5330.97
107_A163_V0.5320.97
266_H270_A0.5280.97
46_V55_L0.5280.97
53_T72_I0.5270.97
260_Y265_G0.5250.97
200_H205_Y0.5250.97
296_D307_V0.5250.97
128_P132_A0.5240.97
186_H192_A0.5240.97
42_N60_K0.5240.97
102_Q158_N0.5230.96
77_G80_T0.5230.96
39_K68_A0.5210.96
274_V281_L0.5200.96
150_Y196_H0.5200.96
271_V287_V0.5200.96
146_P166_G0.5190.96
171_Y180_L0.5180.96
64_Q70_Y0.5170.96
236_A264_R0.5160.96
253_T258_F0.5160.96
114_V148_T0.5150.96
118_P123_G0.5130.96
221_Y228_F0.5100.96
205_Y220_E0.5060.96
273_E284_V0.5060.96
255_D258_F0.5030.96
112_G147_H0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vyhC 1 0.8052 100 0.217 Contact Map
4u1eI 1 0.7908 100 0.234 Contact Map
2xyiA 1 0.8682 100 0.24 Contact Map
4j87A 1 0.7994 100 0.251 Contact Map
4j73A 1 0.7908 100 0.254 Contact Map
3sfzA 1 0.894 100 0.257 Contact Map
3ow8A 3 0.7908 100 0.258 Contact Map
3w15A 1 0.8138 100 0.259 Contact Map
4pswB 1 0.8539 100 0.26 Contact Map
1gotB 1 0.7937 100 0.266 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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