GREMLIN Database
YKGA - Uncharacterized protein YkgA
UniProt: O34497 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (263)
Sequences: 3112 (1985)
Seq/√Len: 122.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_E68_S4.1101.00
28_K60_S3.5611.00
145_D170_Y3.5061.00
23_K72_E3.1351.00
250_N254_S3.0991.00
54_T57_D2.9491.00
267_E270_K2.9071.00
26_L63_V2.8511.00
251_Q255_K2.6821.00
117_K121_H2.6131.00
254_S262_E2.5711.00
251_Q254_S2.5211.00
64_E67_R2.4471.00
233_L279_T2.4371.00
65_A263_I2.4351.00
25_I282_L2.4161.00
58_Q266_S2.4121.00
216_D256_R2.3961.00
149_V163_L2.3691.00
157_I161_G2.2891.00
239_T261_I2.2431.00
63_V67_R2.2261.00
61_R64_E2.1251.00
87_F271_S2.0851.00
239_T259_H2.0791.00
109_R112_E2.0061.00
244_P262_E2.0051.00
192_S195_E1.9661.00
23_K74_V1.9541.00
92_G280_M1.8871.00
252_Q256_R1.8711.00
191_I258_Y1.8431.00
146_I173_V1.8011.00
139_D155_T1.7941.00
63_V75_L1.7891.00
56_N60_S1.7881.00
149_V155_T1.7751.00
62_L279_T1.7691.00
244_P264_D1.7641.00
252_Q255_K1.7471.00
61_R264_D1.7051.00
92_G120_F1.6751.00
69_H259_H1.6601.00
100_F167_L1.6471.00
248_H252_Q1.6431.00
195_E258_Y1.6381.00
250_N262_E1.6151.00
208_A212_A1.5931.00
52_V56_N1.5381.00
82_L111_G1.5291.00
89_R185_D1.5121.00
22_Q283_I1.5001.00
88_T116_I1.4981.00
265_L278_C1.4971.00
60_S64_E1.4861.00
146_I171_T1.4811.00
209_D212_A1.4691.00
54_T266_S1.4621.00
57_D61_R1.4561.00
100_F163_L1.4561.00
51_H54_T1.4381.00
65_A261_I1.4321.00
67_R72_E1.4081.00
243_L246_N1.4001.00
188_F196_A1.3941.00
200_S219_E1.3781.00
117_K129_R1.3771.00
265_L275_F1.3751.00
119_F123_Q1.3671.00
24_V279_T1.3671.00
65_A69_H1.3581.00
126_S131_L1.3481.00
99_A120_F1.3411.00
238_K259_H1.3391.00
54_T264_D1.3231.00
93_F102_S1.3181.00
231_N277_C1.3161.00
239_T242_S1.3161.00
151_I160_I1.3141.00
62_L241_I1.3141.00
133_T159_A1.3091.00
23_K283_I1.3021.00
70_N73_V1.2771.00
149_V160_I1.2731.00
69_H239_T1.2711.00
160_I174_P1.2691.00
248_H251_Q1.2661.00
163_L167_L1.2651.00
151_I157_I1.2631.00
158_S161_G1.2631.00
240_I260_I1.2510.99
61_R65_A1.2320.99
26_L279_T1.2280.99
101_L113_E1.2020.99
103_S110_Q1.1900.99
69_H261_I1.1890.99
156_D159_A1.1830.99
107_P110_Q1.1770.99
127_Y130_M1.1740.99
151_I176_K1.1730.99
209_D256_R1.1720.99
221_P248_H1.1680.99
164_E174_P1.1680.99
54_T58_Q1.1380.99
94_V280_M1.1380.99
198_I217_L1.1310.99
133_T162_Q1.1240.99
209_D213_K1.1230.99
189_N232_V1.1220.99
268_I278_C1.1170.99
98_K126_S1.1100.99
236_G239_T1.1060.99
58_Q264_D1.0990.99
134_S156_D1.0980.99
249_V253_L1.0970.99
143_D146_I1.0950.99
161_G165_E1.0930.99
68_S261_I1.0910.99
69_H235_I1.0840.99
21_L24_V1.0810.99
89_R276_R1.0770.98
58_Q267_E1.0770.98
26_L66_L1.0620.98
66_L235_I1.0570.98
183_H277_C1.0480.98
118_D122_S1.0470.98
220_V230_T1.0450.98
38_I41_T1.0440.98
93_F100_F1.0320.98
126_S130_M1.0310.98
161_G164_E1.0280.98
176_K207_A1.0170.98
167_L172_I1.0100.98
93_F140_V1.0080.98
132_D162_Q1.0030.98
143_D148_Y0.9990.98
71_V235_I0.9940.97
254_S260_I0.9880.97
61_R68_S0.9830.97
273_G277_C0.9750.97
268_I271_S0.9690.97
84_E154_R0.9570.97
249_V254_S0.9560.97
237_K259_H0.9540.97
27_C32_M0.9530.97
191_I253_L0.9530.97
125_I131_L0.9520.97
208_A211_L0.9470.97
126_S129_R0.9420.96
191_I195_E0.9410.96
195_E216_D0.9370.96
53_K57_D0.9360.96
201_Q222_E0.9360.96
233_L276_R0.9300.96
234_S237_K0.9280.96
151_I174_P0.9250.96
66_L233_L0.9240.96
98_K166_A0.9230.96
197_L232_V0.9200.96
136_E186_C0.9190.96
67_R75_L0.9140.96
66_L71_V0.9120.96
86_V278_C0.9120.96
97_E126_S0.9030.95
125_I130_M0.9030.95
164_E172_I0.9020.95
133_T156_D0.8980.95
183_H231_N0.8930.95
62_L263_I0.8900.95
23_K282_L0.8890.95
26_L75_L0.8850.95
100_F166_A0.8840.95
194_S215_Y0.8790.95
186_C228_L0.8760.95
90_D182_L0.8760.95
242_S262_E0.8730.95
191_I240_I0.8720.95
160_I164_E0.8720.95
93_F135_I0.8720.95
249_V256_R0.8690.94
59_H278_C0.8680.94
218_I252_Q0.8660.94
224_E249_V0.8550.94
43_K47_D0.8540.94
36_D39_N0.8520.94
135_I140_V0.8510.94
136_E183_H0.8490.94
162_Q166_A0.8480.94
117_K127_Y0.8440.94
150_G177_L0.8430.94
30_E77_P0.8430.94
190_I215_Y0.8430.94
91_I116_I0.8430.94
64_E255_K0.8380.93
105_T156_D0.8340.93
128_T131_L0.8330.93
20_T236_G0.8250.93
142_I147_V0.8250.93
133_T158_S0.8210.93
182_L186_C0.8200.93
244_P247_R0.8100.92
84_E182_L0.8080.92
87_F154_R0.8060.92
127_Y131_L0.8020.92
67_R73_V0.8000.92
91_I102_S0.7990.92
26_L73_V0.7970.91
135_I163_L0.7960.91
27_C33_T0.7940.91
198_I203_I0.7930.91
28_K56_N0.7890.91
195_E256_R0.7890.91
138_G154_R0.7870.91
239_T260_I0.7840.91
224_E248_H0.7820.91
39_N42_Q0.7810.91
186_C274_S0.7740.90
84_E87_F0.7700.90
116_I120_F0.7670.90
34_I39_N0.7670.90
154_R182_L0.7650.90
186_C276_R0.7620.90
92_G99_A0.7600.89
33_T36_D0.7580.89
74_V282_L0.7550.89
94_V282_L0.7550.89
265_L269_I0.7540.89
242_S250_N0.7500.89
28_K77_P0.7500.89
101_L117_K0.7500.89
94_V99_A0.7360.88
95_I98_K0.7340.88
143_D190_I0.7210.87
32_M84_E0.7210.87
247_R262_E0.7170.87
151_I155_T0.7050.86
147_V170_Y0.7040.86
223_D248_H0.7000.85
30_E56_N0.6990.85
185_D276_R0.6990.85
37_V40_E0.6970.85
89_R281_P0.6970.85
241_I275_F0.6950.85
164_E171_T0.6930.85
157_I165_E0.6930.85
147_V172_I0.6920.85
57_D60_S0.6910.84
60_S67_R0.6910.84
196_A217_L0.6890.84
93_F163_L0.6880.84
157_I174_P0.6860.84
138_G277_C0.6850.84
65_A240_I0.6820.84
218_I256_R0.6820.84
37_V44_H0.6790.83
92_G116_I0.6770.83
65_A68_S0.6770.83
150_G155_T0.6750.83
87_F138_G0.6730.83
210_M213_K0.6730.83
139_D184_L0.6710.83
229_G246_N0.6690.83
144_D193_E0.6680.82
28_K75_L0.6670.82
192_S234_S0.6600.82
91_I104_M0.6560.81
222_E226_F0.6560.81
144_D170_Y0.6540.81
102_S135_I0.6530.81
135_I138_G0.6520.81
59_H63_V0.6500.81
101_L131_L0.6470.80
186_C272_G0.6460.80
43_K80_D0.6430.80
228_L269_I0.6410.80
125_I129_R0.6410.80
154_R273_G0.6310.79
223_D226_F0.6300.79
54_T267_E0.6300.79
183_H186_C0.6290.78
120_F280_M0.6280.78
48_D270_K0.6270.78
145_D171_T0.6260.78
95_I142_I0.6260.78
112_E154_R0.6240.78
186_C278_C0.6220.78
198_I207_A0.6180.77
88_T91_I0.6180.77
220_V229_G0.6170.77
160_I172_I0.6150.77
118_D121_H0.6130.77
239_T243_L0.6100.76
241_I265_L0.6090.76
121_H125_I0.6090.76
137_G150_G0.6070.76
248_H254_S0.6070.76
36_D40_E0.6050.76
50_I270_K0.6050.76
29_P154_R0.6030.76
125_I128_T0.6000.75
49_N57_D0.5960.75
185_D279_T0.5940.74
62_L265_L0.5920.74
146_I215_Y0.5910.74
53_K56_N0.5900.74
150_G184_L0.5890.74
89_R279_T0.5890.74
191_I194_S0.5880.74
154_R183_H0.5870.74
98_K128_T0.5870.74
142_I170_Y0.5850.73
85_Q115_V0.5850.73
59_H75_L0.5840.73
20_T126_S0.5840.73
62_L275_F0.5830.73
27_C58_Q0.5790.73
269_I274_S0.5780.72
106_E155_T0.5770.72
68_S264_D0.5750.72
138_G281_P0.5750.72
146_I214_R0.5740.72
78_V155_T0.5710.72
89_R272_G0.5710.72
24_V73_V0.5670.71
154_R277_C0.5670.71
148_Y175_V0.5650.71
137_G154_R0.5630.71
99_A158_S0.5630.71
200_S211_L0.5610.70
80_D111_G0.5600.70
60_S75_L0.5600.70
197_L211_L0.5600.70
53_K255_K0.5590.70
138_G182_L0.5560.70
143_D215_Y0.5540.69
25_I119_F0.5530.69
177_L276_R0.5520.69
158_S259_H0.5510.69
209_D255_K0.5500.69
154_R271_S0.5490.69
221_P224_E0.5490.69
243_L265_L0.5460.68
79_R115_V0.5430.68
100_F140_V0.5420.68
173_V210_M0.5410.67
67_R70_N0.5390.67
104_M113_E0.5370.67
129_R132_D0.5360.67
33_T52_V0.5350.67
24_V71_V0.5320.66
130_M162_Q0.5300.66
37_V42_Q0.5290.66
221_P247_R0.5290.66
198_I201_Q0.5280.66
231_N273_G0.5280.66
205_P209_D0.5280.66
188_F198_I0.5280.66
152_S177_L0.5270.65
90_D149_V0.5250.65
276_R281_P0.5240.65
247_R251_Q0.5240.65
50_I267_E0.5230.65
64_E69_H0.5230.65
138_G183_H0.5230.65
34_I38_I0.5220.65
83_P278_C0.5210.65
182_L228_L0.5180.64
24_V233_L0.5170.64
104_M276_R0.5170.64
140_V163_L0.5160.64
198_I202_A0.5140.64
57_D77_P0.5130.63
106_E153_Q0.5130.63
74_V77_P0.5110.63
102_S186_C0.5100.63
181_F187_V0.5100.63
240_I243_L0.5100.63
38_I42_Q0.5090.63
195_E209_D0.5090.63
232_V242_S0.5070.63
182_L272_G0.5060.62
102_S113_E0.5040.62
233_L281_P0.5040.62
39_N218_I0.5040.62
48_D53_K0.5030.62
35_K38_I0.5030.62
84_E89_R0.5030.62
58_Q274_S0.5020.62
154_R231_N0.5020.62
272_G276_R0.5020.62
229_G245_G0.5020.62
76_L116_I0.5020.62
157_I176_K0.5000.61
110_Q114_A0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a9gA 3 0.9685 100 0.21 Contact Map
4e4jA 4 0.965 100 0.216 Contact Map
1bwdA 1 0.965 100 0.219 Contact Map
1s9rA 2 0.993 100 0.223 Contact Map
4bofA 4 0.9825 100 0.226 Contact Map
1jdwA 2 0.965 100 0.258 Contact Map
3i4aA 1 0.9126 100 0.29 Contact Map
2ci1A 1 0.9056 100 0.298 Contact Map
1h70A 1 0.8741 100 0.298 Contact Map
2ewoA 4 0.9755 100 0.563 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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