GREMLIN Database
YTPQ - UPF0354 protein YtpQ
UniProt: O34496 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (264)
Sequences: 193 (137)
Seq/√Len: 8.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_A217_A4.9821.00
201_E220_R4.3880.99
205_A228_L3.7660.97
204_L216_L3.6300.96
172_Y220_R3.5790.96
165_E172_Y3.2700.93
31_T44_T3.1010.91
150_E154_F2.8590.86
111_Y187_I2.8180.86
200_A204_L2.7690.85
192_I216_L2.7310.84
112_D149_R2.7010.83
11_I14_Q2.6730.82
83_M143_W2.6170.81
21_R36_D2.4710.77
101_D119_R2.4640.77
207_S232_S2.4250.75
187_I208_V2.4140.75
30_D48_P2.2890.71
167_T172_Y2.2820.71
8_L51_I2.2770.70
161_T176_F2.2400.69
103_S178_A2.2340.69
62_I66_V2.1410.65
10_D13_K2.0950.64
12_L219_I1.9940.60
25_F51_I1.9880.59
43_I104_S1.9700.59
33_R42_G1.9230.57
5_S30_D1.9130.56
234_S238_G1.8880.55
9_S13_K1.8120.52
102_K106_D1.7830.51
102_K232_S1.7700.50
50_I65_I1.7330.49
25_F201_E1.6630.46
167_T170_G1.6390.45
165_E203_E1.6360.45
143_W147_R1.6270.44
215_I231_M1.6220.44
156_L161_T1.6160.44
170_G254_K1.5990.43
219_I238_G1.5910.43
12_L66_V1.5620.42
163_V176_F1.5430.41
4_T9_S1.5360.41
28_E178_A1.5350.41
5_S48_P1.5340.41
165_E231_M1.5270.40
167_T199_H1.5130.40
88_T158_S1.4960.39
222_E267_K1.4840.38
78_G147_R1.4790.38
54_W58_K1.4580.37
109_L266_P1.4450.37
13_K32_L1.4380.37
76_M134_D1.4320.36
144_T165_E1.4280.36
110_I176_F1.4280.36
140_K148_I1.4060.35
134_D154_F1.4060.35
102_K108_P1.4030.35
227_I253_G1.3980.35
154_F157_R1.3970.35
207_S217_A1.3960.35
13_K163_V1.3830.35
28_E51_I1.3690.34
161_T220_R1.3580.34
153_A156_L1.3510.33
136_R241_V1.3480.33
193_L250_Y1.3290.33
176_F192_I1.3190.32
4_T7_K1.3080.32
113_D217_A1.2980.31
67_Y177_R1.2790.31
4_T39_T1.2580.30
48_P51_I1.2570.30
23_F32_L1.2520.30
67_Y264_S1.2310.29
103_S161_T1.2300.29
32_L68_Y1.2230.29
124_L160_P1.2230.29
8_L56_L1.2080.28
42_G64_E1.1930.28
72_A81_Q1.1900.28
88_T227_I1.1860.27
28_E71_E1.1820.27
118_T236_F1.1810.27
72_A227_I1.1800.27
187_I243_I1.1790.27
131_R233_M1.1710.27
146_E151_T1.1670.27
15_R63_D1.1590.27
102_K110_I1.1530.26
4_T262_A1.1470.26
226_D260_I1.1410.26
110_I138_L1.1410.26
203_E220_R1.1340.26
18_H69_V1.1320.26
13_K241_V1.1270.26
69_V77_E1.1250.25
19_E167_T1.1230.25
43_I128_K1.1090.25
60_E160_P1.1070.25
96_S129_T1.1030.25
32_L65_I1.1000.25
233_M247_S1.0970.25
69_V80_A1.0910.24
100_P119_R1.0800.24
133_I252_E1.0790.24
14_Q214_L1.0770.24
113_D139_E1.0730.24
129_T247_S1.0670.24
91_Y145_K1.0650.24
54_W73_M1.0620.24
67_Y131_R1.0600.23
45_L103_S1.0490.23
247_S262_A1.0450.23
123_A132_L1.0440.23
67_Y233_M1.0400.23
35_E73_M1.0400.23
196_Y265_R1.0390.23
207_S262_A1.0360.23
9_S52_A1.0340.23
140_K149_R1.0270.22
169_A245_A1.0220.22
7_K222_E1.0210.22
203_E245_A1.0200.22
177_R187_I1.0130.22
42_G53_K1.0060.22
169_A240_T1.0060.22
62_I69_V1.0010.22
165_E201_E1.0000.22
111_Y219_I1.0000.22
49_P217_A0.9950.22
20_N146_E0.9950.22
234_S245_A0.9880.21
161_T192_I0.9860.21
7_K128_K0.9850.21
67_Y204_L0.9800.21
6_R9_S0.9800.21
109_L160_P0.9770.21
87_E155_N0.9760.21
101_D109_L0.9760.21
34_V165_E0.9700.21
91_Y176_F0.9700.21
50_I109_L0.9680.21
71_E206_I0.9660.21
68_Y177_R0.9650.21
36_D69_V0.9630.21
49_P58_K0.9600.21
179_N183_D0.9580.21
42_G230_Q0.9500.20
45_L266_P0.9500.20
39_T73_M0.9500.20
148_I206_I0.9500.20
65_I120_I0.9500.20
62_I263_K0.9470.20
67_Y247_S0.9420.20
46_D54_W0.9420.20
69_V205_A0.9420.20
4_T55_E0.9400.20
23_F67_Y0.9390.20
236_F245_A0.9310.20
194_N217_A0.9250.20
72_A86_K0.9240.20
23_F68_Y0.9140.19
124_L190_E0.9130.19
197_K265_R0.9130.19
142_N222_E0.9120.19
10_D111_Y0.9100.19
144_T162_V0.9040.19
60_E137_M0.9000.19
91_Y211_Q0.8990.19
238_G253_G0.8970.19
96_S245_A0.8960.19
116_A207_S0.8910.19
20_N37_Q0.8870.19
108_P199_H0.8860.19
116_A166_D0.8810.18
205_A230_Q0.8800.18
192_I204_L0.8790.18
69_V230_Q0.8680.18
111_Y119_R0.8680.18
67_Y71_E0.8670.18
101_D258_V0.8620.18
67_Y179_N0.8500.18
7_K208_V0.8430.18
135_Q176_F0.8410.17
5_S15_R0.8380.17
46_D49_P0.8330.17
67_Y263_K0.8290.17
101_D111_Y0.8230.17
192_I247_S0.8170.17
35_E87_E0.8150.17
42_G154_F0.8120.17
21_R77_E0.8100.17
36_D77_E0.7960.16
85_G141_E0.7940.16
9_S43_I0.7940.16
192_I196_Y0.7870.16
47_L119_R0.7860.16
261_L265_R0.7810.16
75_A223_S0.7780.16
96_S258_V0.7780.16
97_T119_R0.7710.16
22_S26_D0.7680.16
29_K234_S0.7660.16
107_I136_R0.7660.16
46_D258_V0.7660.16
223_S264_S0.7660.16
204_L262_A0.7660.16
4_T72_A0.7600.16
135_Q199_H0.7580.16
110_I137_M0.7570.16
197_K245_A0.7550.15
90_I231_M0.7540.15
77_E178_A0.7540.15
28_E66_V0.7460.15
36_D39_T0.7420.15
97_T148_I0.7390.15
55_E137_M0.7390.15
84_T167_T0.7370.15
62_I65_I0.7360.15
110_I135_Q0.7330.15
42_G76_M0.7330.15
73_M158_S0.7330.15
4_T21_R0.7320.15
193_L229_G0.7310.15
138_L148_I0.7300.15
134_D247_S0.7220.15
49_P261_L0.7220.15
91_Y160_P0.7190.15
39_T77_E0.7120.15
33_R53_K0.7110.15
64_E251_N0.7110.15
89_R143_W0.7110.15
17_Q142_N0.7100.15
78_G151_T0.7100.15
43_I69_V0.7090.14
15_R258_V0.7050.14
12_L28_E0.7050.14
43_I86_K0.7040.14
189_N258_V0.7010.14
9_S20_N0.7010.14
43_I142_N0.6980.14
8_L11_I0.6960.14
129_T194_N0.6890.14
131_R263_K0.6850.14
234_S247_S0.6850.14
131_R264_S0.6820.14
52_A241_V0.6810.14
12_L116_A0.6790.14
8_L54_W0.6790.14
50_I133_I0.6760.14
199_H261_L0.6700.14
43_I62_I0.6660.14
33_R64_E0.6640.14
36_D163_V0.6630.14
147_R151_T0.6620.14
72_A141_E0.6620.14
58_K266_P0.6590.13
128_K222_E0.6580.13
123_A134_D0.6550.13
35_E64_E0.6530.13
72_A190_E0.6510.13
10_D156_L0.6490.13
141_E245_A0.6470.13
123_A154_F0.6460.13
50_I233_M0.6450.13
91_Y267_K0.6450.13
172_Y193_L0.6430.13
137_M227_I0.6430.13
13_K25_F0.6430.13
144_T170_G0.6410.13
16_L67_Y0.6400.13
23_F262_A0.6390.13
189_N233_M0.6390.13
262_A267_K0.6390.13
4_T30_D0.6370.13
31_T101_D0.6360.13
128_K262_A0.6360.13
71_E233_M0.6360.13
123_A236_F0.6300.13
134_D150_E0.6300.13
8_L15_R0.6300.13
111_Y217_A0.6240.13
123_A230_Q0.6240.13
145_K148_I0.6210.13
36_D245_A0.6200.13
39_T234_S0.6150.13
52_A217_A0.6140.13
50_I147_R0.6110.13
69_V84_T0.6080.13
54_W72_A0.6080.13
20_N110_I0.6070.12
70_S170_G0.6050.12
176_F199_H0.6050.12
57_K266_P0.6040.12
160_P243_I0.6040.12
112_D145_K0.6040.12
122_Y230_Q0.6010.12
216_L223_S0.6000.12
229_G245_A0.6000.12
24_L27_R0.5980.12
196_Y229_G0.5970.12
41_K45_L0.5970.12
144_T164_K0.5960.12
187_I194_N0.5950.12
16_L32_L0.5950.12
9_S32_L0.5940.12
50_I264_S0.5940.12
73_M83_M0.5910.12
20_N89_R0.5900.12
48_P189_N0.5860.12
116_A127_G0.5840.12
165_E190_E0.5810.12
46_D58_K0.5810.12
80_A223_S0.5800.12
146_E220_R0.5790.12
81_Q196_Y0.5790.12
35_E230_Q0.5770.12
11_I15_R0.5770.12
223_S266_P0.5750.12
50_I70_S0.5740.12
102_K172_Y0.5740.12
103_S176_F0.5720.12
220_R236_F0.5720.12
7_K72_A0.5720.12
112_D245_A0.5700.12
204_L263_K0.5690.12
28_E238_G0.5680.12
68_Y262_A0.5670.12
109_L228_L0.5660.12
109_L264_S0.5660.12
177_R214_L0.5660.12
7_K241_V0.5650.12
50_I161_T0.5640.12
64_E232_S0.5630.12
244_T259_F0.5620.12
192_I253_G0.5610.12
6_R45_L0.5610.12
194_N207_S0.5600.12
262_A266_P0.5600.12
28_E96_S0.5580.12
51_I199_H0.5580.12
12_L36_D0.5580.12
76_M132_L0.5560.12
45_L267_K0.5550.12
45_L162_V0.5530.12
154_F158_S0.5520.12
116_A232_S0.5510.11
136_R139_E0.5500.11
76_M154_F0.5470.11
90_I196_Y0.5460.11
17_Q45_L0.5460.11
85_G109_L0.5460.11
86_K104_S0.5440.11
109_L262_A0.5440.11
56_L136_R0.5430.11
232_S254_K0.5420.11
59_D140_K0.5420.11
122_Y188_L0.5410.11
182_Y242_P0.5400.11
184_A211_Q0.5400.11
69_V112_D0.5390.11
21_R57_K0.5390.11
165_E227_I0.5390.11
80_A139_E0.5370.11
233_M264_S0.5360.11
190_E237_A0.5320.11
21_R55_E0.5320.11
7_K137_M0.5310.11
37_Q53_K0.5300.11
106_D133_I0.5280.11
9_S34_V0.5250.11
145_K176_F0.5240.11
75_A136_R0.5190.11
156_L243_I0.5190.11
111_Y147_R0.5160.11
110_I145_K0.5150.11
10_D63_D0.5140.11
9_S148_I0.5140.11
135_Q144_T0.5140.11
30_D189_N0.5120.11
48_P124_L0.5110.11
74_T220_R0.5110.11
97_T264_S0.5090.11
86_K91_Y0.5090.11
138_L240_T0.5080.11
13_K72_A0.5080.11
26_D96_S0.5060.11
145_K149_R0.5040.11
16_L44_T0.5040.11
150_E157_R0.5030.11
219_I244_T0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q4fC 2 0.3494 39.8 0.974 Contact Map
3tmaA 2 0.8587 16.2 0.979 Contact Map
3njrA 4 0.6134 10.9 0.98 Contact Map
3s8iA 2 0.4164 10.1 0.981 Contact Map
2ywqA 1 0.2677 8.6 0.981 Contact Map
3p91A 3 0.3978 8.1 0.981 Contact Map
1bvoA 1 0.2193 6.3 0.982 Contact Map
4bixA 2 0.342 5.7 0.983 Contact Map
2ogkA 4 0.2454 5.5 0.983 Contact Map
3q6bA 1 0.342 5.2 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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