GREMLIN Database
YKOP - Uncharacterized protein YkoP
UniProt: O34495 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 183 (178)
Sequences: 183 (151)
Seq/√Len: 11.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_S157_V4.8841.00
145_S149_I3.1010.96
53_I112_G3.0210.95
36_R47_L2.8500.93
132_T166_S2.7730.92
117_T168_L2.7090.91
174_K178_T2.5390.88
25_I110_I2.4740.87
13_D16_Y2.4640.87
150_L160_R2.4640.87
138_Y142_K2.4120.85
13_D142_K2.1270.77
13_D65_H2.1260.77
120_D170_I2.0680.75
12_V155_K2.0600.75
77_E81_R2.0530.74
154_S160_R2.0340.74
32_V118_M1.9650.71
81_R119_L1.9620.71
64_L165_S1.9520.70
33_F97_L1.9400.70
61_K142_K1.9230.69
120_D147_V1.9040.68
94_M130_V1.8610.67
62_I149_I1.8480.66
68_K173_E1.7630.62
60_V101_I1.7510.62
2_K19_F1.7420.61
65_H142_K1.6910.59
133_P165_S1.6760.58
47_L70_I1.6750.58
61_K65_H1.6420.57
53_I171_S1.6360.56
47_L116_I1.6050.55
100_Y104_H1.5870.54
16_Y61_K1.5860.54
158_S164_N1.5840.54
16_Y119_L1.5590.53
104_H135_N1.5160.50
34_R114_I1.4940.49
49_D171_S1.4400.47
53_I72_E1.4140.45
47_L69_L1.4080.45
35_V100_Y1.3800.44
113_I121_K1.3790.44
13_D61_K1.3730.43
33_F90_V1.3460.42
16_Y142_K1.3350.42
64_L126_L1.2790.39
144_V168_L1.2770.39
16_Y83_G1.2680.39
17_F22_L1.2660.38
70_I116_I1.2650.38
39_K177_K1.2500.38
50_G101_I1.2430.37
97_L118_M1.2390.37
161_H166_S1.2350.37
31_S34_R1.2310.37
9_W175_L1.2230.36
21_R94_M1.2060.36
69_L78_S1.2060.36
135_N172_K1.2060.36
65_H107_S1.1940.35
16_Y110_I1.1850.35
146_H155_K1.1800.35
34_R65_H1.1800.35
35_V104_H1.1740.34
48_S121_K1.1640.34
5_F44_H1.1420.33
34_R142_K1.1390.33
145_S150_L1.1360.33
13_D167_Y1.1310.32
43_H116_I1.1100.32
133_P142_K1.1030.31
62_I111_K1.0990.31
67_I149_I1.0980.31
20_S36_R1.0810.30
28_D177_K1.0760.30
17_F61_K1.0750.30
137_F172_K1.0730.30
19_F64_L1.0720.30
83_G148_P1.0640.30
123_V130_V1.0540.29
35_V65_H1.0540.29
81_R117_T1.0290.28
70_I84_I1.0280.28
25_I55_K1.0250.28
86_I168_L1.0230.28
44_H103_N1.0230.28
169_F179_Y1.0230.28
32_V97_L1.0210.28
16_Y149_I1.0050.27
36_R112_G1.0040.27
36_R170_I1.0040.27
14_P117_T1.0040.27
63_H128_F1.0000.27
63_H127_G1.0000.27
35_V93_S0.9930.27
102_N180_Q0.9890.27
98_L176_Q0.9880.27
21_R166_S0.9850.27
36_R87_Y0.9750.26
90_V95_P0.9350.25
87_Y91_Y0.9290.24
150_L157_V0.9180.24
105_K121_K0.9050.24
46_V105_K0.9020.23
114_I119_L0.9010.23
126_L129_D0.8990.23
5_F179_Y0.8940.23
81_R150_L0.8890.23
121_K165_S0.8760.23
69_L94_M0.8740.23
86_I160_R0.8700.22
61_K149_I0.8690.22
20_S119_L0.8660.22
91_Y166_S0.8590.22
4_C177_K0.8590.22
44_H108_E0.8500.22
7_S71_R0.8480.22
100_Y110_I0.8460.22
138_Y152_L0.8380.21
157_V160_R0.8370.21
105_K125_R0.8320.21
8_I99_D0.8320.21
2_K152_L0.8230.21
77_E98_L0.8200.21
60_V98_L0.8120.20
20_S142_K0.8110.20
23_S31_S0.8110.20
2_K79_A0.8090.20
150_L155_K0.8070.20
10_R119_L0.8060.20
17_F35_V0.8040.20
34_R179_Y0.8030.20
45_V55_K0.8020.20
92_Q99_D0.8010.20
92_Q108_E0.7980.20
9_W16_Y0.7970.20
22_L169_F0.7920.20
13_D133_P0.7910.20
125_R146_H0.7890.20
14_P110_I0.7830.20
12_V146_H0.7800.19
33_F95_P0.7770.19
151_Y158_S0.7760.19
32_V90_V0.7750.19
103_N131_I0.7730.19
120_D150_L0.7710.19
145_S160_R0.7700.19
44_H54_R0.7680.19
58_V109_K0.7570.19
130_V154_S0.7560.19
158_S180_Q0.7460.18
31_S91_Y0.7440.18
17_F142_K0.7410.18
91_Y112_G0.7400.18
15_I75_S0.7370.18
25_I130_V0.7360.18
83_G163_P0.7360.18
99_D177_K0.7350.18
116_I167_Y0.7300.18
162_L179_Y0.7280.18
88_Q118_M0.7280.18
91_Y105_K0.7270.18
97_L172_K0.7240.18
96_L143_K0.7210.18
40_Y115_G0.7180.18
32_V141_F0.7120.17
117_T129_D0.7020.17
42_G49_D0.7010.17
66_N122_G0.6960.17
123_V165_S0.6940.17
35_V60_V0.6860.17
108_E173_E0.6850.17
64_L129_D0.6840.17
45_V157_V0.6820.17
170_I180_Q0.6770.16
69_L130_V0.6760.16
13_D82_K0.6680.16
49_D66_N0.6670.16
21_R25_I0.6670.16
9_W138_Y0.6650.16
152_L179_Y0.6630.16
62_I88_Q0.6550.16
159_L162_L0.6540.16
38_T126_L0.6520.16
26_D130_V0.6500.16
72_E82_K0.6470.16
30_K120_D0.6430.16
8_I155_K0.6370.15
88_Q166_S0.6360.15
56_N105_K0.6340.15
12_V107_S0.6280.15
53_I98_L0.6230.15
48_S97_L0.6220.15
6_L123_V0.6210.15
94_M151_Y0.6190.15
49_D140_C0.6170.15
136_P146_H0.6170.15
170_I179_Y0.6160.15
73_L117_T0.6150.15
12_V68_K0.6120.15
4_C7_S0.6050.15
68_K146_H0.6050.15
114_I146_H0.6040.15
119_L175_L0.6040.15
8_I163_P0.5930.14
10_R13_D0.5930.14
52_H103_N0.5920.14
42_G128_F0.5920.14
42_G63_H0.5920.14
42_G127_G0.5920.14
66_N171_S0.5880.14
34_R86_I0.5840.14
24_L31_S0.5800.14
32_V79_A0.5780.14
83_G175_L0.5770.14
4_C111_K0.5760.14
138_Y148_P0.5750.14
8_I162_L0.5740.14
46_V78_S0.5740.14
41_K48_S0.5740.14
13_D138_Y0.5720.14
14_P169_F0.5720.14
49_D150_L0.5720.14
10_R17_F0.5720.14
30_K58_V0.5710.14
16_Y145_S0.5710.14
83_G138_Y0.5700.14
117_T174_K0.5700.14
113_I155_K0.5700.14
60_V85_I0.5670.14
45_V177_K0.5670.14
108_E177_K0.5640.14
149_I153_T0.5620.14
112_G167_Y0.5620.14
40_Y97_L0.5620.14
23_S137_F0.5580.14
44_H101_I0.5510.13
41_K62_I0.5490.13
59_L67_I0.5490.13
37_L46_V0.5480.13
45_V59_L0.5460.13
112_G169_F0.5430.13
31_S136_P0.5430.13
76_I84_I0.5410.13
32_V143_K0.5400.13
9_W83_G0.5390.13
26_D170_I0.5360.13
32_V131_I0.5330.13
34_R126_L0.5320.13
61_K112_G0.5320.13
47_L115_G0.5290.13
94_M132_T0.5270.13
95_P98_L0.5230.13
54_R103_N0.5190.13
77_E80_V0.5190.13
20_S114_I0.5190.13
51_T173_E0.5180.13
84_I120_D0.5090.12
147_V155_K0.5070.12
21_R129_D0.5070.12
79_A156_P0.5060.12
56_N62_I0.5040.12
111_K148_P0.5000.12
21_R59_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pwwA 1 0.5027 38.6 0.947 Contact Map
2r5xA 1 0.5082 38 0.947 Contact Map
4ftsA 6 0.4973 25.5 0.952 Contact Map
4ga6A 2 0.459 8.8 0.961 Contact Map
4h0aA 1 0.2295 6.1 0.964 Contact Map
2pqnB 1 0.1093 5.1 0.965 Contact Map
3na6A 4 0.5082 4.9 0.965 Contact Map
1vsy5 1 0.6393 3.7 0.967 Contact Map
1v0dA 2 0.4863 3.6 0.968 Contact Map
4ry2A 2 0.5301 3.3 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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