GREMLIN Database
YTMA - Uncharacterized peptidase YtmA
UniProt: O34493 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (224)
Sequences: 40360 (29293)
Seq/√Len: 1957.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_R97_D4.1921.00
117_H141_S4.0951.00
132_A142_F3.3631.00
48_L98_A2.8721.00
216_E226_V2.7801.00
213_Y230_Y2.5591.00
202_E232_S2.4981.00
229_W249_Q2.3781.00
21_C28_R2.3321.00
144_S147_G2.3081.00
102_F139_A2.2161.00
104_L108_H2.0461.00
42_Y72_V2.0271.00
69_Q251_T2.0211.00
45_F119_F1.9741.00
231_Y249_Q1.9541.00
44_G111_V1.9311.00
209_I230_Y1.8921.00
227_E249_Q1.8911.00
44_G72_V1.8881.00
202_E230_Y1.8511.00
65_Q69_Q1.8431.00
216_E228_T1.8371.00
112_K115_R1.8211.00
23_L28_R1.7941.00
209_I213_Y1.7811.00
196_V219_L1.7801.00
219_L224_K1.7601.00
143_V250_L1.7241.00
74_F105_L1.7101.00
129_M144_S1.6961.00
35_E72_V1.6921.00
31_G74_F1.6901.00
53_K126_I1.6771.00
142_F196_V1.6751.00
36_P72_V1.6681.00
128_G142_F1.6681.00
198_L216_E1.6371.00
200_H212_S1.6221.00
121_F146_G1.5971.00
213_Y228_T1.5591.00
118_I128_G1.5031.00
98_A131_T1.5001.00
99_F135_M1.4871.00
33_L72_V1.4781.00
33_L74_F1.4711.00
216_E220_K1.4701.00
45_F71_F1.4661.00
89_D93_E1.4541.00
47_Y119_F1.4391.00
72_V111_V1.4331.00
76_P101_A1.4191.00
44_G105_L1.4141.00
197_L229_W1.4101.00
106_Q138_Q1.4011.00
99_F134_E1.4001.00
188_Q191_K1.3971.00
36_P42_Y1.3881.00
46_L101_A1.3871.00
145_W250_L1.3671.00
248_R252_Q1.3651.00
119_F143_V1.3541.00
44_G74_F1.3421.00
202_E233_T1.3391.00
200_H209_I1.3341.00
20_I31_G1.3211.00
129_M215_L1.3041.00
217_E221_Q1.3031.00
99_F103_R1.2891.00
245_R249_Q1.2891.00
220_K226_V1.2801.00
50_G122_S1.2591.00
22_Y101_A1.2571.00
231_Y234_F1.2571.00
46_L102_F1.2501.00
249_Q252_Q1.2451.00
203_K233_T1.2431.00
63_I75_A1.2401.00
198_L212_S1.2371.00
96_E134_E1.2361.00
43_D115_R1.2351.00
48_L76_P1.2291.00
210_Q213_Y1.2161.00
58_V77_F1.2161.00
91_A94_D1.2031.00
218_K222_L1.2001.00
213_Y217_E1.1981.00
198_L215_L1.1921.00
144_S198_L1.1861.00
103_R135_M1.1831.00
103_R107_Q1.1811.00
95_R130_L1.1791.00
115_R140_A1.1781.00
176_V179_E1.1721.00
184_T187_D1.1681.00
121_F145_W1.1621.00
103_R138_Q1.1581.00
214_L217_E1.1461.00
135_M138_Q1.1441.00
59_R121_F1.1411.00
64_I68_S1.1331.00
104_L107_Q1.1301.00
100_S103_R1.1241.00
118_I131_T1.1171.00
202_E209_I1.1171.00
142_F215_L1.1141.00
200_H230_Y1.0921.00
99_F131_T1.0861.00
199_I229_W1.0861.00
34_A75_A1.0851.00
146_G237_Y1.0691.00
74_F101_A1.0681.00
48_L128_G1.0651.00
200_H228_T1.0641.00
63_I67_A1.0621.00
231_Y245_R1.0491.00
78_Y123_R1.0391.00
199_I231_Y1.0251.00
31_G101_A1.0211.00
178_E182_W1.0201.00
47_Y63_I1.0121.00
24_S27_L1.0111.00
89_D92_G0.9981.00
218_K221_Q0.9971.00
163_R167_R0.9891.00
142_F194_A0.9871.00
178_E181_Q0.9871.00
177_P181_Q0.9861.00
60_P64_I0.9851.00
51_G123_R0.9731.00
41_Q112_K0.9711.00
199_I246_I0.9651.00
92_G96_E0.9641.00
43_D71_F0.9621.00
65_Q68_S0.9591.00
32_L58_V0.9541.00
22_Y31_G0.9511.00
189_V192_I0.9491.00
102_F106_Q0.9481.00
146_G238_F0.9441.00
118_I142_F0.9361.00
122_S236_H0.9301.00
39_P42_Y0.9291.00
146_G204_D0.9231.00
98_A127_M0.9201.00
195_P225_P0.9201.00
119_F145_W0.9161.00
246_I250_L0.9121.00
19_T30_K0.9081.00
129_M149_S0.9071.00
166_K170_G0.8911.00
214_L218_K0.8851.00
93_E96_E0.8811.00
102_F116_I0.8801.00
180_Y183_R0.8761.00
21_C30_K0.8751.00
151_M184_T0.8741.00
245_R248_R0.8721.00
219_L226_V0.8671.00
30_K77_F0.8561.00
179_E182_W0.8501.00
53_K148_V0.8501.00
67_A73_V0.8491.00
47_Y73_V0.8451.00
177_P180_Y0.8401.00
133_I215_L0.8361.00
181_Q187_D0.8341.00
44_G116_I0.8301.00
231_Y238_F0.8281.00
49_R78_Y0.8281.00
19_T32_L0.8271.00
126_I130_L0.8251.00
48_L118_I0.8191.00
45_F117_H0.8111.00
149_S215_L0.8091.00
133_I188_Q0.8061.00
130_L134_E0.8051.00
176_V180_Y0.7971.00
157_E210_Q0.7961.00
132_A194_A0.7931.00
125_G147_G0.7881.00
31_G104_L0.7881.00
47_Y75_A0.7871.00
46_L74_F0.7841.00
43_D112_K0.7701.00
240_P243_N0.7681.00
48_L78_Y0.7681.00
106_Q140_A0.7681.00
130_L133_I0.7661.00
128_G144_S0.7641.00
69_Q248_R0.7641.00
150_D214_L0.7611.00
165_M168_V0.7601.00
114_D140_A0.7601.00
146_G239_P0.7581.00
42_Y70_G0.7581.00
201_G238_F0.7571.00
129_M147_G0.7521.00
20_I33_L0.7501.00
34_A73_V0.7451.00
134_E182_W0.7441.00
89_D94_D0.7381.00
112_K140_A0.7361.00
129_M142_F0.7341.00
165_M169_I0.7291.00
38_E42_Y0.7281.00
190_N218_K0.7231.00
102_F131_T0.7221.00
32_L60_P0.7201.00
150_D153_L0.7201.00
118_I139_A0.7181.00
25_N79_R0.7181.00
217_E220_K0.7181.00
174_K178_E0.7171.00
41_Q110_N0.7161.00
150_D184_T0.7151.00
164_M168_V0.7111.00
145_W199_I0.7101.00
96_E100_S0.7021.00
24_S100_S0.7011.00
47_Y121_F0.6991.00
125_G144_S0.6971.00
45_F66_F0.6951.00
212_S216_E0.6911.00
167_R170_G0.6881.00
94_D127_M0.6871.00
144_S149_S0.6861.00
71_F117_H0.6831.00
129_M196_V0.6821.00
90_F94_D0.6811.00
143_V197_L0.6771.00
162_R165_M0.6771.00
210_Q214_L0.6761.00
163_R166_K0.6731.00
146_G201_G0.6661.00
175_K178_E0.6651.00
132_A196_V0.6641.00
34_A67_A0.6621.00
20_I104_L0.6611.00
106_Q113_K0.6581.00
117_H143_V0.6581.00
141_S197_L0.6581.00
117_H140_A0.6551.00
145_W246_I0.6541.00
148_V151_M0.6531.00
152_I187_D0.6521.00
24_S29_V0.6521.00
35_E42_Y0.6501.00
46_L105_L0.6441.00
136_G139_A0.6401.00
125_G149_S0.6401.00
24_S28_R0.6391.00
66_F73_V0.6291.00
174_K177_P0.6281.00
186_F189_V0.6281.00
32_L55_V0.6271.00
101_A104_L0.6251.00
53_K123_R0.6231.00
193_Q196_V0.6171.00
76_P98_A0.6151.00
141_S195_P0.6141.00
241_K244_R0.6141.00
126_I148_V0.6131.00
65_Q251_T0.6121.00
106_Q116_I0.6111.00
47_Y59_R0.6081.00
198_L219_L0.6071.00
81_N94_D0.6031.00
31_G76_P0.6031.00
121_F237_Y0.6021.00
229_W245_R0.5981.00
51_G78_Y0.5981.00
102_F135_M0.5961.00
49_R80_G0.5961.00
196_V215_L0.5951.00
162_R166_K0.5921.00
63_I73_V0.5911.00
247_V250_L0.5891.00
190_N222_L0.5861.00
90_F93_E0.5851.00
153_L214_L0.5831.00
65_Q247_V0.5821.00
240_P244_R0.5811.00
51_G56_G0.5791.00
59_R62_R0.5781.00
189_V222_L0.5781.00
113_K116_I0.5771.00
143_V199_I0.5731.00
197_L227_E0.5731.00
150_D211_H0.5701.00
184_T188_Q0.5691.00
147_G207_V0.5691.00
66_F119_F0.5631.00
106_Q109_P0.5611.00
99_F102_F0.5611.00
187_D190_N0.5611.00
55_V83_G0.5611.00
164_M167_R0.5571.00
234_F243_N0.5561.00
78_Y81_N0.5561.00
133_I193_Q0.5541.00
93_E97_D0.5531.00
130_L188_Q0.5521.00
200_H207_V0.5521.00
99_F139_A0.5521.00
123_R127_M0.5511.00
204_D207_V0.5461.00
198_L226_V0.5461.00
34_A63_I0.5431.00
209_I228_T0.5421.00
133_I192_I0.5411.00
48_L131_T0.5371.00
29_V76_P0.5351.00
162_R170_G0.5331.00
22_Y100_S0.5321.00
92_G134_E0.5311.00
25_N96_E0.5301.00
165_M170_G0.5301.00
53_K57_M0.5301.00
212_S228_T0.5281.00
193_Q224_K0.5241.00
197_L249_Q0.5231.00
105_L111_V0.5221.00
133_I136_G0.5211.00
66_F250_L0.5171.00
152_I181_Q0.5171.00
166_K169_I0.5131.00
153_L211_H0.5121.00
162_R168_V0.5101.00
221_Q226_V0.5091.00
95_R127_M0.5091.00
103_R106_Q0.5041.00
151_M165_M0.5021.00
137_G193_Q0.5021.00
150_D186_F0.5011.00
116_I139_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z3zA 2 0.9455 100 0.319 Contact Map
4q1vA 2 0.9728 100 0.321 Contact Map
1xfdA 2 0.9728 100 0.325 Contact Map
4wjlA 2 0.9728 100 0.326 Contact Map
4hxfB 4 0.9922 100 0.326 Contact Map
4bp8A 1 0.9961 100 0.331 Contact Map
2ecfA 2 0.9728 100 0.333 Contact Map
1z68A 2 0.9767 100 0.336 Contact Map
2xdwA 2 0.9961 100 0.339 Contact Map
1yr2A 1 0.9611 100 0.34 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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