MAP12 - BACSU - GREMLIN Contacts

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MAP12 - Methionine aminopeptidase 2

UniProt:	O34484	Sequences: MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGKAVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGFYSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFTVIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDGWTFKTPDKSMVAQVEHTIVITKDEPIILTKL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	249 (220)
Sequences:	16190 (9883)
Seq/√Len:	666.3

ECOLI - MAP1 YPDF PEPQ AMPP
BACSU - MAP12 MAP11 YQHT YKVY
HALSA - Q9HRF6 Q9HQC0 Q9HMB3 Q9HP03
SULSO - Q981D7 Q980E9 MAP2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
132_K	153_E	2.856	1.00
45_A	49_E	2.756	1.00
29_K	42_I	2.706	1.00
21_L	50_H	2.553	1.00
25_E	46_V	2.509	1.00
111_V	115_G	2.422	1.00
132_K	135_Q	2.295	1.00
13_K	227_S	2.287	1.00
120_H	124_Q	2.211	1.00
44_K	48_D	2.184	1.00
35_S	84_I	2.176	1.00
11_G	100_G	2.174	1.00
46_V	50_H	2.115	1.00
119_L	228_M	2.096	1.00
116_E	119_L	2.091	1.00
124_Q	128_N	2.040	1.00
42_I	45_A	2.018	1.00
125_C	157_Q	2.008	1.00
127_E	131_Q	1.971	1.00
12_L	198_V	1.948	1.00
14_K	17_R	1.947	1.00
46_V	49_E	1.937	1.00
154_A	205_I	1.932	1.00
151_Y	155_R	1.927	1.00
195_N	223_T	1.902	1.00
117_E	121_K	1.875	1.00
136_Q	149_A	1.859	1.00
22_A	46_V	1.840	1.00
70_V	83_K	1.837	1.00
144_N	190_N	1.825	1.00
128_N	132_K	1.824	1.00
25_E	28_R	1.774	1.00
41_L	45_A	1.768	1.00
153_E	157_Q	1.700	1.00
142_R	145_Q	1.674	1.00
138_K	141_K	1.671	1.00
27_K	110_F	1.662	1.00
19_V	106_T	1.650	1.00
148_R	152_H	1.644	1.00
147_G	151_Y	1.615	1.00
118_R	210_E	1.611	1.00
215_A	222_K	1.601	1.00
131_Q	135_Q	1.593	1.00
152_H	156_S	1.584	1.00
98_E	103_Y	1.583	1.00
86_K	89_D	1.571	1.00
118_R	121_K	1.563	1.00
133_G	150_V	1.558	1.00
9_L	220_T	1.552	1.00
14_K	99_F	1.531	1.00
42_I	46_V	1.515	1.00
129_A	153_E	1.510	1.00
139_A	195_N	1.498	1.00
13_K	17_R	1.497	1.00
121_K	157_Q	1.473	1.00
117_E	120_H	1.464	1.00
128_N	153_E	1.452	1.00
111_V	123_C	1.446	1.00
32_P	87_A	1.442	1.00
25_E	42_I	1.434	1.00
87_A	114_E	1.427	1.00
129_A	154_A	1.416	1.00
31_E	34_M	1.404	1.00
136_Q	141_K	1.387	1.00
37_K	41_L	1.366	1.00
206_S	229_V	1.358	1.00
35_S	38_D	1.358	1.00
37_K	82_S	1.350	1.00
83_K	89_D	1.333	1.00
25_E	29_K	1.322	1.00
142_R	192_L	1.320	1.00
85_L	112_L	1.305	1.00
19_V	104_S	1.286	1.00
165_L	221_F	1.268	1.00
3_V	194_K	1.266	1.00
130_F	134_L	1.252	1.00
102_F	172_R	1.248	1.00
17_R	21_L	1.247	1.00
18_I	52_A	1.245	1.00
40_D	44_K	1.232	1.00
141_K	145_Q	1.222	1.00
90_L	119_L	1.218	1.00
5_N	8_E	1.215	1.00
121_K	125_C	1.212	1.00
94_D	105_D	1.197	1.00
25_E	50_H	1.190	1.00
166_T	179_N	1.183	1.00
26_M	43_G	1.172	1.00
6_D	10_E	1.171	1.00
7_Q	10_E	1.169	1.00
61_D	103_Y	1.169	1.00
170_I	218_G	1.163	1.00
122_L	211_T	1.152	1.00
10_E	14_K	1.152	1.00
7_Q	11_G	1.151	1.00
133_G	149_A	1.134	1.00
11_G	14_K	1.133	1.00
194_K	197_T	1.132	1.00
132_K	149_A	1.121	1.00
21_L	46_V	1.118	1.00
193_F	199_I	1.113	1.00
118_R	207_T	1.111	1.00
145_Q	148_R	1.105	1.00
14_K	100_G	1.104	1.00
123_C	232_V	1.103	1.00
133_G	146_I	1.091	1.00
47_L	97_A	1.084	1.00
23_R	110_F	1.082	1.00
18_I	99_F	1.074	1.00
132_K	136_Q	1.042	1.00
124_Q	127_E	1.036	1.00
80_S	83_K	1.030	1.00
34_M	42_I	1.025	1.00
125_C	153_E	1.022	1.00
34_M	38_D	1.018	1.00
128_N	157_Q	1.008	1.00
201_L	219_W	1.002	1.00
66_T	91_V	1.001	1.00
137_A	201_L	0.997	1.00
144_N	148_R	0.997	1.00
53_V	98_E	0.986	1.00
68_I	91_V	0.983	1.00
121_K	124_Q	0.983	1.00
68_I	85_L	0.980	1.00
137_A	221_F	0.977	1.00
23_R	106_T	0.975	1.00
74_V	212_I	0.970	1.00
16_G	20_A	0.963	1.00
10_E	13_K	0.960	1.00
122_L	207_T	0.953	1.00
18_I	97_A	0.951	1.00
43_G	47_L	0.945	1.00
39_L	85_L	0.934	1.00
8_E	172_R	0.932	1.00
24_E	28_R	0.931	1.00
148_R	187_P	0.928	1.00
115_G	120_H	0.926	1.00
38_D	41_L	0.923	1.00
19_V	97_A	0.922	1.00
165_L	214_E	0.917	1.00
146_I	193_F	0.910	1.00
4_T	176_E	0.907	1.00
42_I	49_E	0.903	1.00
15_I	104_S	0.901	1.00
87_A	113_G	0.887	1.00
164_T	210_E	0.887	1.00
200_A	218_G	0.879	1.00
18_I	101_G	0.879	1.00
169_G	178_P	0.877	1.00
12_L	16_G	0.874	1.00
143_Q	193_F	0.874	1.00
222_K	225_D	0.872	1.00
162_I	206_S	0.870	1.00
30_A	112_L	0.870	1.00
3_V	197_T	0.867	1.00
44_K	64_G	0.864	1.00
153_E	156_S	0.861	1.00
30_A	39_L	0.859	1.00
73_E	83_K	0.859	1.00
43_G	66_T	0.857	1.00
207_T	227_S	0.851	1.00
137_A	193_F	0.842	1.00
155_R	160_T	0.840	1.00
83_K	86_K	0.840	1.00
52_A	97_A	0.837	1.00
141_K	149_A	0.835	1.00
72_D	222_K	0.832	1.00
143_Q	191_A	0.831	1.00
134_L	219_W	0.831	1.00
27_K	108_I	0.831	1.00
63_P	78_I	0.830	1.00
150_V	166_T	0.829	1.00
134_L	201_L	0.824	1.00
21_L	25_E	0.817	1.00
137_A	146_I	0.816	1.00
90_L	111_V	0.811	1.00
18_I	50_H	0.808	1.00
67_C	77_G	0.807	1.00
149_A	152_H	0.807	1.00
8_E	102_F	0.807	1.00
149_A	153_E	0.802	1.00
92_N	107_G	0.802	1.00
128_N	156_S	0.800	1.00
76_H	175_H	0.792	1.00
115_G	119_L	0.787	1.00
147_G	166_T	0.785	1.00
47_L	52_A	0.785	1.00
103_Y	174_L	0.783	1.00
126_A	230_A	0.781	1.00
182_M	188_F	0.777	1.00
93_I	110_F	0.775	1.00
144_N	188_F	0.772	1.00
32_P	112_L	0.772	1.00
71_N	74_V	0.762	1.00
191_A	197_T	0.759	1.00
17_R	20_A	0.757	1.00
136_Q	139_A	0.756	1.00
20_A	24_E	0.755	1.00
48_D	53_V	0.752	1.00
68_I	83_K	0.748	1.00
71_N	77_G	0.748	1.00
122_L	159_F	0.748	1.00
29_K	34_M	0.747	1.00
25_E	49_E	0.746	1.00
132_K	152_H	0.744	1.00
213_V	222_K	0.741	1.00
69_S	89_D	0.733	1.00
22_A	43_G	0.733	1.00
37_K	64_G	0.732	1.00
141_K	146_I	0.730	1.00
125_C	154_A	0.726	1.00
222_K	227_S	0.724	1.00
125_C	128_N	0.721	1.00
16_G	104_S	0.718	1.00
22_A	97_A	0.717	1.00
133_G	136_Q	0.716	1.00
214_E	221_F	0.715	1.00
45_A	48_D	0.713	1.00
160_T	206_S	0.713	1.00
23_R	95_I	0.702	1.00
64_G	78_I	0.696	1.00
30_A	110_F	0.695	1.00
14_K	18_I	0.689	1.00
38_D	49_E	0.689	1.00
21_L	24_E	0.684	1.00
142_R	190_N	0.682	1.00
130_F	217_D	0.680	1.00
170_I	200_A	0.678	1.00
114_E	120_H	0.673	1.00
128_N	131_Q	0.669	1.00
43_G	95_I	0.668	1.00
88_G	112_L	0.668	1.00
74_V	77_G	0.655	1.00
37_K	80_S	0.654	1.00
170_I	198_V	0.653	1.00
35_S	82_S	0.652	1.00
15_I	99_F	0.652	1.00
60_Y	64_G	0.649	1.00
29_K	46_V	0.648	1.00
207_T	210_E	0.645	1.00
19_V	95_I	0.643	1.00
139_A	194_K	0.640	1.00
213_V	216_G	0.639	1.00
44_K	60_Y	0.634	1.00
68_I	112_L	0.631	1.00
144_N	189_D	0.630	1.00
12_L	172_R	0.629	1.00
150_V	162_I	0.628	1.00
96_S	104_S	0.625	1.00
126_A	213_V	0.624	1.00
111_V	119_L	0.623	1.00
26_M	42_I	0.620	1.00
39_L	91_V	0.619	1.00
129_A	133_G	0.616	1.00
19_V	22_A	0.610	1.00
125_C	159_F	0.605	1.00
16_G	106_T	0.604	1.00
94_D	168_H	0.604	1.00
26_M	29_K	0.603	1.00
145_Q	149_A	0.603	1.00
71_N	89_D	0.597	1.00
24_E	108_I	0.596	1.00
90_L	115_G	0.596	1.00
39_L	66_T	0.592	1.00
173_S	176_E	0.589	1.00
189_D	192_L	0.588	1.00
123_C	127_E	0.586	1.00
26_M	39_L	0.586	1.00
133_G	201_L	0.585	1.00
219_W	226_K	0.585	1.00
37_K	40_D	0.583	1.00
154_A	159_F	0.583	1.00
118_R	122_L	0.582	1.00
22_A	47_L	0.579	1.00
4_T	8_E	0.577	1.00
105_D	216_G	0.576	1.00
94_D	202_E	0.575	1.00
148_R	190_N	0.570	1.00
213_V	224_P	0.570	1.00
129_A	150_V	0.569	1.00
23_R	27_K	0.567	1.00
30_A	91_V	0.565	1.00
191_A	194_K	0.563	1.00
109_S	232_V	0.563	1.00
44_K	65_V	0.562	1.00
136_Q	146_I	0.559	1.00
67_C	72_D	0.558	1.00
105_D	202_E	0.558	1.00
68_I	89_D	0.556	1.00
143_Q	181_I	0.555	1.00
146_I	149_A	0.555	1.00
164_T	212_I	0.553	1.00
22_A	25_E	0.552	1.00
122_L	230_A	0.550	1.00
140_G	192_L	0.550	1.00
96_S	174_L	0.549	1.00
61_D	64_G	0.548	1.00
6_D	195_N	0.548	1.00
222_K	226_K	0.543	1.00
71_N	83_K	0.543	1.00
130_F	201_L	0.542	1.00
16_G	19_V	0.541	1.00
52_A	99_F	0.539	1.00
23_R	26_M	0.538	1.00
22_A	50_H	0.537	1.00
166_T	182_M	0.537	1.00
105_D	168_H	0.537	1.00
182_M	187_P	0.536	1.00
130_F	232_V	0.536	1.00
24_E	27_K	0.531	1.00
122_L	205_I	0.531	1.00
72_D	92_N	0.525	0.99
8_E	11_G	0.524	0.99
115_G	123_C	0.524	0.99
168_H	175_H	0.523	0.99
159_F	207_T	0.522	0.99
44_K	54_S	0.521	0.99
152_H	155_R	0.521	0.99
60_Y	63_P	0.519	0.99
47_L	95_I	0.518	0.99
91_V	112_L	0.514	0.99
9_L	198_V	0.514	0.99
36_T	68_I	0.511	0.99
136_Q	145_Q	0.510	0.99
19_V	96_S	0.508	0.99
94_D	216_G	0.505	0.99
220_T	229_V	0.505	0.99
47_L	54_S	0.504	0.99
119_L	207_T	0.501	0.99
6_D	196_G	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3s6bA	1	0.992	100	0.149	Contact Map
2b3hA	1	0.992	100	0.149	Contact Map
4iu6A	1	0.992	100	0.15	Contact Map
4fukA	2	0.992	100	0.152	Contact Map
1qxyA	1	0.992	100	0.153	Contact Map
3mx6A	1	0.988	100	0.153	Contact Map
2zsgA	2	0.9157	100	0.155	Contact Map
2gg2A	1	0.988	100	0.158	Contact Map
3tb5A	1	0.988	100	0.158	Contact Map
3tavA	2	0.996	100	0.159	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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