GREMLIN Database
MAP12 - Methionine aminopeptidase 2
UniProt: O34484 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 249 (220)
Sequences: 16190 (9883)
Seq/√Len: 666.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_K153_E2.8561.00
45_A49_E2.7561.00
29_K42_I2.7061.00
21_L50_H2.5531.00
25_E46_V2.5091.00
111_V115_G2.4221.00
132_K135_Q2.2951.00
13_K227_S2.2871.00
120_H124_Q2.2111.00
44_K48_D2.1841.00
35_S84_I2.1761.00
11_G100_G2.1741.00
46_V50_H2.1151.00
119_L228_M2.0961.00
116_E119_L2.0911.00
124_Q128_N2.0401.00
42_I45_A2.0181.00
125_C157_Q2.0081.00
127_E131_Q1.9711.00
12_L198_V1.9481.00
14_K17_R1.9471.00
46_V49_E1.9371.00
154_A205_I1.9321.00
151_Y155_R1.9271.00
195_N223_T1.9021.00
117_E121_K1.8751.00
136_Q149_A1.8591.00
22_A46_V1.8401.00
70_V83_K1.8371.00
144_N190_N1.8251.00
128_N132_K1.8241.00
25_E28_R1.7741.00
41_L45_A1.7681.00
153_E157_Q1.7001.00
142_R145_Q1.6741.00
138_K141_K1.6711.00
27_K110_F1.6621.00
19_V106_T1.6501.00
148_R152_H1.6441.00
147_G151_Y1.6151.00
118_R210_E1.6111.00
215_A222_K1.6011.00
131_Q135_Q1.5931.00
152_H156_S1.5841.00
98_E103_Y1.5831.00
86_K89_D1.5711.00
118_R121_K1.5631.00
133_G150_V1.5581.00
9_L220_T1.5521.00
14_K99_F1.5311.00
42_I46_V1.5151.00
129_A153_E1.5101.00
139_A195_N1.4981.00
13_K17_R1.4971.00
121_K157_Q1.4731.00
117_E120_H1.4641.00
128_N153_E1.4521.00
111_V123_C1.4461.00
32_P87_A1.4421.00
25_E42_I1.4341.00
87_A114_E1.4271.00
129_A154_A1.4161.00
31_E34_M1.4041.00
136_Q141_K1.3871.00
37_K41_L1.3661.00
206_S229_V1.3581.00
35_S38_D1.3581.00
37_K82_S1.3501.00
83_K89_D1.3331.00
25_E29_K1.3221.00
142_R192_L1.3201.00
85_L112_L1.3051.00
19_V104_S1.2861.00
165_L221_F1.2681.00
3_V194_K1.2661.00
130_F134_L1.2521.00
102_F172_R1.2481.00
17_R21_L1.2471.00
18_I52_A1.2451.00
40_D44_K1.2321.00
141_K145_Q1.2221.00
90_L119_L1.2181.00
5_N8_E1.2151.00
121_K125_C1.2121.00
94_D105_D1.1971.00
25_E50_H1.1901.00
166_T179_N1.1831.00
26_M43_G1.1721.00
6_D10_E1.1711.00
7_Q10_E1.1691.00
61_D103_Y1.1691.00
170_I218_G1.1631.00
122_L211_T1.1521.00
10_E14_K1.1521.00
7_Q11_G1.1511.00
133_G149_A1.1341.00
11_G14_K1.1331.00
194_K197_T1.1321.00
132_K149_A1.1211.00
21_L46_V1.1181.00
193_F199_I1.1131.00
118_R207_T1.1111.00
145_Q148_R1.1051.00
14_K100_G1.1041.00
123_C232_V1.1031.00
133_G146_I1.0911.00
47_L97_A1.0841.00
23_R110_F1.0821.00
18_I99_F1.0741.00
132_K136_Q1.0421.00
124_Q127_E1.0361.00
80_S83_K1.0301.00
34_M42_I1.0251.00
125_C153_E1.0221.00
34_M38_D1.0181.00
128_N157_Q1.0081.00
201_L219_W1.0021.00
66_T91_V1.0011.00
137_A201_L0.9971.00
144_N148_R0.9971.00
53_V98_E0.9861.00
68_I91_V0.9831.00
121_K124_Q0.9831.00
68_I85_L0.9801.00
137_A221_F0.9771.00
23_R106_T0.9751.00
74_V212_I0.9701.00
16_G20_A0.9631.00
10_E13_K0.9601.00
122_L207_T0.9531.00
18_I97_A0.9511.00
43_G47_L0.9451.00
39_L85_L0.9341.00
8_E172_R0.9321.00
24_E28_R0.9311.00
148_R187_P0.9281.00
115_G120_H0.9261.00
38_D41_L0.9231.00
19_V97_A0.9221.00
165_L214_E0.9171.00
146_I193_F0.9101.00
4_T176_E0.9071.00
42_I49_E0.9031.00
15_I104_S0.9011.00
87_A113_G0.8871.00
164_T210_E0.8871.00
200_A218_G0.8791.00
18_I101_G0.8791.00
169_G178_P0.8771.00
12_L16_G0.8741.00
143_Q193_F0.8741.00
222_K225_D0.8721.00
162_I206_S0.8701.00
30_A112_L0.8701.00
3_V197_T0.8671.00
44_K64_G0.8641.00
153_E156_S0.8611.00
30_A39_L0.8591.00
73_E83_K0.8591.00
43_G66_T0.8571.00
207_T227_S0.8511.00
137_A193_F0.8421.00
155_R160_T0.8401.00
83_K86_K0.8401.00
52_A97_A0.8371.00
141_K149_A0.8351.00
72_D222_K0.8321.00
143_Q191_A0.8311.00
134_L219_W0.8311.00
27_K108_I0.8311.00
63_P78_I0.8301.00
150_V166_T0.8291.00
134_L201_L0.8241.00
21_L25_E0.8171.00
137_A146_I0.8161.00
90_L111_V0.8111.00
18_I50_H0.8081.00
67_C77_G0.8071.00
149_A152_H0.8071.00
8_E102_F0.8071.00
149_A153_E0.8021.00
92_N107_G0.8021.00
128_N156_S0.8001.00
76_H175_H0.7921.00
115_G119_L0.7871.00
147_G166_T0.7851.00
47_L52_A0.7851.00
103_Y174_L0.7831.00
126_A230_A0.7811.00
182_M188_F0.7771.00
93_I110_F0.7751.00
144_N188_F0.7721.00
32_P112_L0.7721.00
71_N74_V0.7621.00
191_A197_T0.7591.00
17_R20_A0.7571.00
136_Q139_A0.7561.00
20_A24_E0.7551.00
48_D53_V0.7521.00
68_I83_K0.7481.00
71_N77_G0.7481.00
122_L159_F0.7481.00
29_K34_M0.7471.00
25_E49_E0.7461.00
132_K152_H0.7441.00
213_V222_K0.7411.00
69_S89_D0.7331.00
22_A43_G0.7331.00
37_K64_G0.7321.00
141_K146_I0.7301.00
125_C154_A0.7261.00
222_K227_S0.7241.00
125_C128_N0.7211.00
16_G104_S0.7181.00
22_A97_A0.7171.00
133_G136_Q0.7161.00
214_E221_F0.7151.00
45_A48_D0.7131.00
160_T206_S0.7131.00
23_R95_I0.7021.00
64_G78_I0.6961.00
30_A110_F0.6951.00
14_K18_I0.6891.00
38_D49_E0.6891.00
21_L24_E0.6841.00
142_R190_N0.6821.00
130_F217_D0.6801.00
170_I200_A0.6781.00
114_E120_H0.6731.00
128_N131_Q0.6691.00
43_G95_I0.6681.00
88_G112_L0.6681.00
74_V77_G0.6551.00
37_K80_S0.6541.00
170_I198_V0.6531.00
35_S82_S0.6521.00
15_I99_F0.6521.00
60_Y64_G0.6491.00
29_K46_V0.6481.00
207_T210_E0.6451.00
19_V95_I0.6431.00
139_A194_K0.6401.00
213_V216_G0.6391.00
44_K60_Y0.6341.00
68_I112_L0.6311.00
144_N189_D0.6301.00
12_L172_R0.6291.00
150_V162_I0.6281.00
96_S104_S0.6251.00
126_A213_V0.6241.00
111_V119_L0.6231.00
26_M42_I0.6201.00
39_L91_V0.6191.00
129_A133_G0.6161.00
19_V22_A0.6101.00
125_C159_F0.6051.00
16_G106_T0.6041.00
94_D168_H0.6041.00
26_M29_K0.6031.00
145_Q149_A0.6031.00
71_N89_D0.5971.00
24_E108_I0.5961.00
90_L115_G0.5961.00
39_L66_T0.5921.00
173_S176_E0.5891.00
189_D192_L0.5881.00
123_C127_E0.5861.00
26_M39_L0.5861.00
133_G201_L0.5851.00
219_W226_K0.5851.00
37_K40_D0.5831.00
154_A159_F0.5831.00
118_R122_L0.5821.00
22_A47_L0.5791.00
4_T8_E0.5771.00
105_D216_G0.5761.00
94_D202_E0.5751.00
148_R190_N0.5701.00
213_V224_P0.5701.00
129_A150_V0.5691.00
23_R27_K0.5671.00
30_A91_V0.5651.00
191_A194_K0.5631.00
109_S232_V0.5631.00
44_K65_V0.5621.00
136_Q146_I0.5591.00
67_C72_D0.5581.00
105_D202_E0.5581.00
68_I89_D0.5561.00
143_Q181_I0.5551.00
146_I149_A0.5551.00
164_T212_I0.5531.00
22_A25_E0.5521.00
122_L230_A0.5501.00
140_G192_L0.5501.00
96_S174_L0.5491.00
61_D64_G0.5481.00
6_D195_N0.5481.00
222_K226_K0.5431.00
71_N83_K0.5431.00
130_F201_L0.5421.00
16_G19_V0.5411.00
52_A99_F0.5391.00
23_R26_M0.5381.00
22_A50_H0.5371.00
166_T182_M0.5371.00
105_D168_H0.5371.00
182_M187_P0.5361.00
130_F232_V0.5361.00
24_E27_K0.5311.00
122_L205_I0.5311.00
72_D92_N0.5250.99
8_E11_G0.5240.99
115_G123_C0.5240.99
168_H175_H0.5230.99
159_F207_T0.5220.99
44_K54_S0.5210.99
152_H155_R0.5210.99
60_Y63_P0.5190.99
47_L95_I0.5180.99
91_V112_L0.5140.99
9_L198_V0.5140.99
36_T68_I0.5110.99
136_Q145_Q0.5100.99
19_V96_S0.5080.99
94_D216_G0.5050.99
220_T229_V0.5050.99
47_L54_S0.5040.99
119_L207_T0.5010.99
6_D196_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s6bA 1 0.992 100 0.149 Contact Map
2b3hA 1 0.992 100 0.149 Contact Map
4iu6A 1 0.992 100 0.15 Contact Map
4fukA 2 0.992 100 0.152 Contact Map
1qxyA 1 0.992 100 0.153 Contact Map
3mx6A 1 0.988 100 0.153 Contact Map
2zsgA 2 0.9157 100 0.155 Contact Map
2gg2A 1 0.988 100 0.158 Contact Map
3tb5A 1 0.988 100 0.158 Contact Map
3tavA 2 0.996 100 0.159 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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