HPRK - BACSU - GREMLIN Contacts

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HPRK - HPr kinase/phosphorylase

UniProt:	O34483	Sequences: MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYFTYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDASEKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKSETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAGAVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIEVAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	310 (301)
Sequences:	1096 (667)
Seq/√Len:	38.5

BACSU - HPRK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
16_E	111_R	6.303	1.00
76_D	104_K	5.415	1.00
112_S	119_L	5.387	1.00
71_K	97_E	4.228	1.00
252_K	257_E	4.085	1.00
96_Q	100_D	3.860	1.00
181_I	226_I	3.833	1.00
252_K	255_D	3.708	1.00
250_T	257_E	3.353	1.00
52_V	85_A	3.267	1.00
7_K	11_E	3.239	1.00
136_A	178_C	3.170	1.00
141_L	191_G	3.098	1.00
100_D	104_K	3.028	1.00
181_I	189_L	3.025	1.00
67_P	70_E	2.987	1.00
72_K	100_D	2.948	1.00
144_I	149_V	2.828	1.00
229_V	251_M	2.767	1.00
293_E	297_N	2.767	1.00
141_L	226_I	2.628	1.00
99_I	109_V	2.367	1.00
251_M	260_K	2.332	1.00
70_E	74_R	2.316	1.00
89_S	119_L	2.316	1.00
8_D	130_R	2.206	0.99
88_L	94_I	2.175	0.99
206_L	210_N	2.174	0.99
230_M	275_I	2.116	0.99
152_T	231_N	2.098	0.99
19_S	103_E	2.087	0.99
102_S	109_V	2.076	0.99
79_C	98_L	2.066	0.99
229_V	258_I	2.064	0.99
55_L	98_L	2.044	0.99
297_N	301_D	2.030	0.99
88_L	98_L	2.009	0.99
87_I	119_L	1.989	0.99
175_A	197_I	1.976	0.99
20_G	23_G	1.945	0.98
291_A	295_F	1.945	0.98
52_V	123_L	1.895	0.98
19_S	102_S	1.888	0.98
233_E	239_K	1.887	0.98
140_V	163_A	1.885	0.98
70_E	73_Q	1.792	0.97
143_D	221_R	1.755	0.97
10_M	17_L	1.752	0.97
39_E	44_F	1.726	0.97
19_S	23_G	1.698	0.96
129_S	223_N	1.684	0.96
9_V	123_L	1.678	0.96
154_K	231_N	1.646	0.96
85_A	110_L	1.645	0.96
86_I	107_V	1.642	0.96
39_E	58_T	1.585	0.95
60_L	95_P	1.572	0.94
152_T	253_I	1.560	0.94
62_F	66_L	1.545	0.94
10_M	24_I	1.518	0.93
129_S	184_E	1.517	0.93
147_V	286_R	1.507	0.93
134_T	182_R	1.506	0.93
54_L	120_S	1.497	0.93
35_R	84_P	1.497	0.93
231_N	260_K	1.479	0.92
269_R	278_A	1.462	0.92
137_I	150_L	1.448	0.91
7_K	25_N	1.387	0.90
68_E	97_E	1.386	0.90
195_E	198_E	1.385	0.90
143_D	224_K	1.367	0.89
47_Y	83_T	1.366	0.89
91_D	113_P	1.365	0.89
34_S	47_Y	1.363	0.89
66_L	74_R	1.355	0.88
136_A	196_L	1.354	0.88
235_W	241_Y	1.334	0.88
210_N	294_Q	1.329	0.87
151_I	230_M	1.304	0.86
75_M	263_I	1.286	0.86
165_E	168_K	1.282	0.85
169_R	271_L	1.279	0.85
73_Q	77_S	1.277	0.85
141_L	181_I	1.275	0.85
93_P	111_R	1.235	0.83
72_K	76_D	1.233	0.83
15_L	119_L	1.214	0.82
157_V	266_R	1.213	0.82
5_R	27_P	1.192	0.81
18_I	94_I	1.190	0.81
75_M	79_C	1.187	0.81
193_A	272_A	1.183	0.80
262_T	271_L	1.182	0.80
6_T	28_I	1.182	0.80
46_Y	90_R	1.173	0.80
233_E	241_Y	1.169	0.80
121_S	124_T	1.167	0.80
79_C	200_L	1.164	0.79
228_I	278_A	1.162	0.79
152_T	251_M	1.159	0.79
55_L	88_L	1.157	0.79
215_F	277_V	1.144	0.78
6_T	52_V	1.139	0.78
248_E	285_K	1.129	0.77
23_G	26_R	1.128	0.77
43_Y	61_S	1.127	0.77
183_Q	255_D	1.110	0.76
165_E	270_N	1.106	0.76
143_D	157_V	1.102	0.76
246_L	292_A	1.085	0.74
60_L	88_L	1.079	0.74
23_G	284_L	1.078	0.74
188_T	225_R	1.073	0.74
80_T	104_K	1.069	0.73
147_V	221_R	1.054	0.72
14_N	91_D	1.048	0.72
76_D	101_A	1.035	0.71
270_N	273_V	1.033	0.71
17_L	110_L	1.028	0.70
242_D	245_G	1.028	0.70
60_L	92_M	1.028	0.70
194_P	272_A	1.027	0.70
78_L	83_T	1.025	0.70
47_Y	53_Q	1.021	0.70
137_I	253_I	1.018	0.70
63_F	75_M	1.012	0.69
68_E	72_K	1.008	0.69
8_D	11_E	1.002	0.68
33_L	120_S	1.002	0.68
87_I	123_L	0.999	0.68
94_I	109_V	0.997	0.68
138_H	204_R	0.996	0.68
76_D	105_N	0.990	0.67
78_L	86_I	0.984	0.67
169_R	273_V	0.976	0.66
144_I	163_A	0.974	0.66
189_L	253_I	0.970	0.66
215_F	295_F	0.970	0.66
150_L	226_I	0.969	0.66
6_T	9_V	0.965	0.65
259_T	282_F	0.961	0.65
180_E	194_P	0.961	0.65
60_L	206_L	0.951	0.64
202_E	243_R	0.949	0.64
149_V	275_I	0.949	0.64
69_E	73_Q	0.948	0.64
290_N	293_E	0.943	0.64
196_L	284_L	0.937	0.63
147_V	227_T	0.936	0.63
116_T	291_A	0.930	0.62
36_P	51_R	0.927	0.62
161_E	177_D	0.923	0.62
95_P	98_L	0.919	0.61
163_A	173_L	0.919	0.61
51_R	116_T	0.915	0.61
155_S	160_S	0.913	0.61
165_E	272_A	0.912	0.61
196_L	210_N	0.909	0.61
267_P	291_A	0.905	0.60
285_K	288_G	0.905	0.60
55_L	305_D	0.905	0.60
20_G	108_P	0.899	0.60
201_L	273_V	0.885	0.59
236_E	239_K	0.883	0.58
221_R	224_K	0.883	0.58
75_M	95_P	0.875	0.58
80_T	105_N	0.874	0.58
175_A	179_V	0.873	0.57
199_H	212_M	0.865	0.57
79_C	86_I	0.860	0.56
20_G	200_L	0.855	0.56
163_A	267_P	0.850	0.55
135_T	254_I	0.848	0.55
65_Q	70_E	0.845	0.55
83_T	86_I	0.839	0.54
39_E	53_Q	0.833	0.54
261_L	265_V	0.829	0.54
243_R	264_P	0.829	0.54
165_E	273_V	0.828	0.53
172_R	283_R	0.828	0.53
71_K	75_M	0.827	0.53
210_N	284_L	0.824	0.53
200_L	289_L	0.823	0.53
267_P	289_L	0.822	0.53
77_S	80_T	0.821	0.53
145_Y	168_K	0.817	0.53
19_S	108_P	0.816	0.52
91_D	111_R	0.815	0.52
228_I	261_L	0.810	0.52
302_V	305_D	0.808	0.52
87_I	190_V	0.808	0.52
84_P	232_L	0.808	0.52
158_G	177_D	0.807	0.52
177_D	207_G	0.807	0.52
235_W	279_A	0.807	0.52
57_K	90_R	0.801	0.51
47_Y	279_A	0.798	0.51
241_Y	274_I	0.797	0.51
295_F	303_I	0.796	0.51
218_G	280_M	0.791	0.50
247_E	275_I	0.784	0.50
22_E	106_G	0.782	0.49
158_G	161_E	0.779	0.49
202_E	205_G	0.776	0.49
20_G	24_I	0.776	0.49
94_I	111_R	0.767	0.48
140_V	180_E	0.766	0.48
283_R	287_M	0.764	0.48
161_E	207_G	0.761	0.47
144_I	297_N	0.759	0.47
161_E	204_R	0.758	0.47
189_L	246_L	0.757	0.47
167_V	211_V	0.755	0.47
49_R	84_P	0.755	0.47
183_Q	200_L	0.754	0.47
280_M	295_F	0.753	0.47
32_D	35_R	0.752	0.47
144_I	164_L	0.750	0.46
290_N	295_F	0.747	0.46
175_A	253_I	0.746	0.46
211_V	289_L	0.744	0.46
177_D	204_R	0.743	0.46
131_L	140_V	0.742	0.46
164_L	224_K	0.736	0.45
196_L	244_L	0.734	0.45
210_N	291_A	0.734	0.45
35_R	47_Y	0.730	0.45
199_H	210_N	0.728	0.45
138_H	155_S	0.724	0.44
172_R	274_I	0.722	0.44
68_E	99_I	0.719	0.44
126_F	229_V	0.716	0.43
55_L	60_L	0.715	0.43
39_E	83_T	0.712	0.43
194_P	271_L	0.711	0.43
175_A	190_V	0.710	0.43
21_E	103_E	0.710	0.43
54_L	251_M	0.710	0.43
164_L	203_I	0.706	0.43
16_E	113_P	0.704	0.42
220_V	301_D	0.702	0.42
57_K	92_M	0.701	0.42
187_D	190_V	0.698	0.42
26_R	105_N	0.695	0.42
212_M	220_V	0.691	0.41
152_T	229_V	0.691	0.41
160_S	202_E	0.690	0.41
69_E	72_K	0.689	0.41
279_A	287_M	0.688	0.41
65_Q	87_I	0.688	0.41
76_D	100_D	0.686	0.41
63_F	71_K	0.686	0.41
71_K	95_P	0.685	0.41
138_H	205_G	0.683	0.41
285_K	290_N	0.682	0.40
37_G	245_G	0.679	0.40
162_T	218_G	0.678	0.40
9_V	106_G	0.677	0.40
131_L	186_Q	0.677	0.40
78_L	103_E	0.675	0.40
111_R	305_D	0.674	0.40
7_K	29_T	0.674	0.40
126_F	215_F	0.670	0.39
210_N	297_N	0.670	0.39
138_H	161_E	0.669	0.39
212_M	255_D	0.667	0.39
297_N	300_A	0.667	0.39
68_E	96_Q	0.667	0.39
165_E	184_E	0.665	0.39
235_W	274_I	0.664	0.39
23_G	106_G	0.663	0.39
47_Y	119_L	0.661	0.39
77_S	81_D	0.660	0.39
114_L	186_Q	0.658	0.38
300_A	304_E	0.657	0.38
72_K	97_E	0.657	0.38
138_H	177_D	0.655	0.38
160_S	177_D	0.654	0.38
109_V	238_G	0.654	0.38
86_I	98_L	0.651	0.38
284_L	295_F	0.650	0.38
86_I	167_V	0.649	0.38
164_L	277_V	0.648	0.38
265_V	278_A	0.648	0.38
158_G	207_G	0.647	0.37
114_L	118_R	0.647	0.37
16_E	91_D	0.647	0.37
235_W	246_L	0.647	0.37
68_E	71_K	0.645	0.37
13_F	88_L	0.643	0.37
142_V	167_V	0.643	0.37
12_Q	187_D	0.641	0.37
54_L	130_R	0.641	0.37
178_C	184_E	0.641	0.37
41_A	209_I	0.637	0.37
196_L	222_S	0.637	0.37
197_I	290_N	0.636	0.37
24_I	108_P	0.635	0.36
235_W	267_P	0.635	0.36
18_I	111_R	0.635	0.36
40_I	254_I	0.634	0.36
17_L	24_I	0.634	0.36
197_I	219_A	0.632	0.36
114_L	304_E	0.632	0.36
167_V	296_T	0.631	0.36
271_L	274_I	0.627	0.36
6_T	144_I	0.624	0.36
5_R	110_L	0.622	0.35
12_Q	126_F	0.622	0.35
82_V	236_E	0.620	0.35
147_V	224_K	0.620	0.35
69_E	76_D	0.619	0.35
277_V	299_L	0.619	0.35
145_Y	280_M	0.618	0.35
167_V	184_E	0.618	0.35
118_R	128_E	0.618	0.35
92_M	258_I	0.618	0.35
62_F	79_C	0.618	0.35
87_I	135_T	0.615	0.35
145_Y	275_I	0.613	0.35
40_I	92_M	0.613	0.35
54_L	248_E	0.609	0.34
247_E	294_Q	0.605	0.34
28_I	50_E	0.605	0.34
124_T	183_Q	0.604	0.34
89_S	157_V	0.603	0.34
199_H	203_I	0.602	0.34
32_D	90_R	0.602	0.34
154_K	236_E	0.602	0.34
151_I	233_E	0.601	0.34
99_I	104_K	0.595	0.33
210_N	240_Q	0.594	0.33
69_E	301_D	0.593	0.33
269_R	272_A	0.593	0.33
23_G	103_E	0.592	0.33
137_I	251_M	0.592	0.33
37_G	264_P	0.591	0.33
51_R	85_A	0.589	0.33
39_E	181_I	0.589	0.33
181_I	258_I	0.589	0.33
67_P	97_E	0.588	0.33
241_Y	245_G	0.588	0.33
202_E	207_G	0.587	0.33
125_N	128_E	0.587	0.33
5_R	174_V	0.586	0.33
5_R	230_M	0.586	0.33
158_G	204_R	0.585	0.32
13_F	66_L	0.585	0.32
168_K	218_G	0.585	0.32
177_D	202_E	0.582	0.32
66_L	78_L	0.582	0.32
62_F	221_R	0.582	0.32
256_T	259_T	0.581	0.32
183_Q	256_T	0.581	0.32
214_L	242_D	0.576	0.32
184_E	271_L	0.575	0.32
199_H	233_E	0.574	0.32
64_E	77_S	0.574	0.32
203_I	211_V	0.574	0.32
282_F	286_R	0.574	0.32
117_T	122_R	0.573	0.31
270_N	283_R	0.571	0.31
203_I	280_M	0.569	0.31
50_E	275_I	0.569	0.31
251_M	258_I	0.568	0.31
160_S	207_G	0.567	0.31
114_L	297_N	0.565	0.31
203_I	244_L	0.564	0.31
87_I	294_Q	0.564	0.31
40_I	55_L	0.563	0.31
120_S	174_V	0.562	0.31
143_D	259_T	0.561	0.31
76_D	80_T	0.561	0.31
160_S	276_E	0.556	0.30
210_N	289_L	0.556	0.30
222_S	244_L	0.555	0.30
138_H	158_G	0.555	0.30
76_D	248_E	0.555	0.30
234_L	253_I	0.554	0.30
221_R	284_L	0.553	0.30
169_R	198_E	0.552	0.30
279_A	283_R	0.552	0.30
82_V	210_N	0.551	0.30
35_R	38_I	0.548	0.30
114_L	137_I	0.547	0.30
9_V	12_Q	0.547	0.30
41_A	50_E	0.546	0.29
118_R	186_Q	0.545	0.29
188_T	227_T	0.544	0.29
32_D	172_R	0.543	0.29
249_E	260_K	0.543	0.29
171_H	271_L	0.542	0.29
267_P	292_A	0.541	0.29
98_L	109_V	0.540	0.29
6_T	110_L	0.540	0.29
98_L	101_A	0.540	0.29
119_L	154_K	0.539	0.29
128_E	263_I	0.539	0.29
78_L	215_F	0.537	0.29
142_V	279_A	0.537	0.29
52_V	236_E	0.536	0.29
156_G	161_E	0.535	0.29
157_V	296_T	0.534	0.29
140_V	280_M	0.534	0.29
16_E	72_K	0.533	0.28
233_E	281_N	0.532	0.28
198_E	222_S	0.532	0.28
65_Q	91_D	0.532	0.28
10_M	110_L	0.531	0.28
228_I	271_L	0.529	0.28
233_E	292_A	0.528	0.28
130_R	198_E	0.528	0.28
272_A	278_A	0.528	0.28
157_V	244_L	0.527	0.28
16_E	74_R	0.527	0.28
155_S	204_R	0.526	0.28
284_L	292_A	0.525	0.28
18_I	237_Q	0.524	0.28
54_L	184_E	0.523	0.28
288_G	295_F	0.522	0.28
149_V	279_A	0.521	0.28
138_H	207_G	0.520	0.28
14_N	80_T	0.520	0.28
58_T	201_L	0.520	0.28
218_G	282_F	0.520	0.28
6_T	126_F	0.520	0.28
197_I	295_F	0.520	0.28
141_L	243_R	0.518	0.27
37_G	275_I	0.517	0.27
36_P	116_T	0.516	0.27
89_S	92_M	0.515	0.27
100_D	103_E	0.510	0.27
69_E	100_D	0.510	0.27
219_A	261_L	0.509	0.27
93_P	113_P	0.508	0.27
64_E	80_T	0.508	0.27
15_L	279_A	0.507	0.27
204_R	207_G	0.506	0.27
35_R	116_T	0.506	0.27
134_T	180_E	0.506	0.27
161_E	202_E	0.506	0.27
34_S	44_F	0.505	0.26
143_D	174_V	0.505	0.26
289_L	294_Q	0.504	0.26
208_I	264_P	0.503	0.26
86_I	120_S	0.502	0.26
133_P	182_R	0.501	0.26
152_T	297_N	0.500	0.26
156_G	215_F	0.500	0.26
75_M	98_L	0.500	0.26
147_V	201_L	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1knxA	5	0.9903	100	0.223	Contact Map
1ko7A	3	0.9194	100	0.245	Contact Map
3tqfA	3	0.5258	100	0.589	Contact Map
2qmhA	5	0.5839	100	0.594	Contact Map
2iojA	1	0.3774	99.9	0.813	Contact Map
3ephA	2	0.5097	95.5	0.947	Contact Map
4cr2L	1	0.8839	94.8	0.95	Contact Map
2ce7A	3	0.6065	93.7	0.952	Contact Map
3fozA	2	0.4871	93.3	0.953	Contact Map
4cr2I	1	0.8968	92.7	0.954	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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