GREMLIN Database
HPRK - HPr kinase/phosphorylase
UniProt: O34483 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 310 (301)
Sequences: 1096 (667)
Seq/√Len: 38.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_E111_R6.3031.00
76_D104_K5.4151.00
112_S119_L5.3871.00
71_K97_E4.2281.00
252_K257_E4.0851.00
96_Q100_D3.8601.00
181_I226_I3.8331.00
252_K255_D3.7081.00
250_T257_E3.3531.00
52_V85_A3.2671.00
7_K11_E3.2391.00
136_A178_C3.1701.00
141_L191_G3.0981.00
100_D104_K3.0281.00
181_I189_L3.0251.00
67_P70_E2.9871.00
72_K100_D2.9481.00
144_I149_V2.8281.00
229_V251_M2.7671.00
293_E297_N2.7671.00
141_L226_I2.6281.00
99_I109_V2.3671.00
251_M260_K2.3321.00
70_E74_R2.3161.00
89_S119_L2.3161.00
8_D130_R2.2060.99
88_L94_I2.1750.99
206_L210_N2.1740.99
230_M275_I2.1160.99
152_T231_N2.0980.99
19_S103_E2.0870.99
102_S109_V2.0760.99
79_C98_L2.0660.99
229_V258_I2.0640.99
55_L98_L2.0440.99
297_N301_D2.0300.99
88_L98_L2.0090.99
87_I119_L1.9890.99
175_A197_I1.9760.99
20_G23_G1.9450.98
291_A295_F1.9450.98
52_V123_L1.8950.98
19_S102_S1.8880.98
233_E239_K1.8870.98
140_V163_A1.8850.98
70_E73_Q1.7920.97
143_D221_R1.7550.97
10_M17_L1.7520.97
39_E44_F1.7260.97
19_S23_G1.6980.96
129_S223_N1.6840.96
9_V123_L1.6780.96
154_K231_N1.6460.96
85_A110_L1.6450.96
86_I107_V1.6420.96
39_E58_T1.5850.95
60_L95_P1.5720.94
152_T253_I1.5600.94
62_F66_L1.5450.94
10_M24_I1.5180.93
129_S184_E1.5170.93
147_V286_R1.5070.93
134_T182_R1.5060.93
54_L120_S1.4970.93
35_R84_P1.4970.93
231_N260_K1.4790.92
269_R278_A1.4620.92
137_I150_L1.4480.91
7_K25_N1.3870.90
68_E97_E1.3860.90
195_E198_E1.3850.90
143_D224_K1.3670.89
47_Y83_T1.3660.89
91_D113_P1.3650.89
34_S47_Y1.3630.89
66_L74_R1.3550.88
136_A196_L1.3540.88
235_W241_Y1.3340.88
210_N294_Q1.3290.87
151_I230_M1.3040.86
75_M263_I1.2860.86
165_E168_K1.2820.85
169_R271_L1.2790.85
73_Q77_S1.2770.85
141_L181_I1.2750.85
93_P111_R1.2350.83
72_K76_D1.2330.83
15_L119_L1.2140.82
157_V266_R1.2130.82
5_R27_P1.1920.81
18_I94_I1.1900.81
75_M79_C1.1870.81
193_A272_A1.1830.80
262_T271_L1.1820.80
6_T28_I1.1820.80
46_Y90_R1.1730.80
233_E241_Y1.1690.80
121_S124_T1.1670.80
79_C200_L1.1640.79
228_I278_A1.1620.79
152_T251_M1.1590.79
55_L88_L1.1570.79
215_F277_V1.1440.78
6_T52_V1.1390.78
248_E285_K1.1290.77
23_G26_R1.1280.77
43_Y61_S1.1270.77
183_Q255_D1.1100.76
165_E270_N1.1060.76
143_D157_V1.1020.76
246_L292_A1.0850.74
60_L88_L1.0790.74
23_G284_L1.0780.74
188_T225_R1.0730.74
80_T104_K1.0690.73
147_V221_R1.0540.72
14_N91_D1.0480.72
76_D101_A1.0350.71
270_N273_V1.0330.71
17_L110_L1.0280.70
242_D245_G1.0280.70
60_L92_M1.0280.70
194_P272_A1.0270.70
78_L83_T1.0250.70
47_Y53_Q1.0210.70
137_I253_I1.0180.70
63_F75_M1.0120.69
68_E72_K1.0080.69
8_D11_E1.0020.68
33_L120_S1.0020.68
87_I123_L0.9990.68
94_I109_V0.9970.68
138_H204_R0.9960.68
76_D105_N0.9900.67
78_L86_I0.9840.67
169_R273_V0.9760.66
144_I163_A0.9740.66
189_L253_I0.9700.66
215_F295_F0.9700.66
150_L226_I0.9690.66
6_T9_V0.9650.65
259_T282_F0.9610.65
180_E194_P0.9610.65
60_L206_L0.9510.64
202_E243_R0.9490.64
149_V275_I0.9490.64
69_E73_Q0.9480.64
290_N293_E0.9430.64
196_L284_L0.9370.63
147_V227_T0.9360.63
116_T291_A0.9300.62
36_P51_R0.9270.62
161_E177_D0.9230.62
95_P98_L0.9190.61
163_A173_L0.9190.61
51_R116_T0.9150.61
155_S160_S0.9130.61
165_E272_A0.9120.61
196_L210_N0.9090.61
267_P291_A0.9050.60
285_K288_G0.9050.60
55_L305_D0.9050.60
20_G108_P0.8990.60
201_L273_V0.8850.59
236_E239_K0.8830.58
221_R224_K0.8830.58
75_M95_P0.8750.58
80_T105_N0.8740.58
175_A179_V0.8730.57
199_H212_M0.8650.57
79_C86_I0.8600.56
20_G200_L0.8550.56
163_A267_P0.8500.55
135_T254_I0.8480.55
65_Q70_E0.8450.55
83_T86_I0.8390.54
39_E53_Q0.8330.54
261_L265_V0.8290.54
243_R264_P0.8290.54
165_E273_V0.8280.53
172_R283_R0.8280.53
71_K75_M0.8270.53
210_N284_L0.8240.53
200_L289_L0.8230.53
267_P289_L0.8220.53
77_S80_T0.8210.53
145_Y168_K0.8170.53
19_S108_P0.8160.52
91_D111_R0.8150.52
228_I261_L0.8100.52
302_V305_D0.8080.52
87_I190_V0.8080.52
84_P232_L0.8080.52
158_G177_D0.8070.52
177_D207_G0.8070.52
235_W279_A0.8070.52
57_K90_R0.8010.51
47_Y279_A0.7980.51
241_Y274_I0.7970.51
295_F303_I0.7960.51
218_G280_M0.7910.50
247_E275_I0.7840.50
22_E106_G0.7820.49
158_G161_E0.7790.49
202_E205_G0.7760.49
20_G24_I0.7760.49
94_I111_R0.7670.48
140_V180_E0.7660.48
283_R287_M0.7640.48
161_E207_G0.7610.47
144_I297_N0.7590.47
161_E204_R0.7580.47
189_L246_L0.7570.47
167_V211_V0.7550.47
49_R84_P0.7550.47
183_Q200_L0.7540.47
280_M295_F0.7530.47
32_D35_R0.7520.47
144_I164_L0.7500.46
290_N295_F0.7470.46
175_A253_I0.7460.46
211_V289_L0.7440.46
177_D204_R0.7430.46
131_L140_V0.7420.46
164_L224_K0.7360.45
196_L244_L0.7340.45
210_N291_A0.7340.45
35_R47_Y0.7300.45
199_H210_N0.7280.45
138_H155_S0.7240.44
172_R274_I0.7220.44
68_E99_I0.7190.44
126_F229_V0.7160.43
55_L60_L0.7150.43
39_E83_T0.7120.43
194_P271_L0.7110.43
175_A190_V0.7100.43
21_E103_E0.7100.43
54_L251_M0.7100.43
164_L203_I0.7060.43
16_E113_P0.7040.42
220_V301_D0.7020.42
57_K92_M0.7010.42
187_D190_V0.6980.42
26_R105_N0.6950.42
212_M220_V0.6910.41
152_T229_V0.6910.41
160_S202_E0.6900.41
69_E72_K0.6890.41
279_A287_M0.6880.41
65_Q87_I0.6880.41
76_D100_D0.6860.41
63_F71_K0.6860.41
71_K95_P0.6850.41
138_H205_G0.6830.41
285_K290_N0.6820.40
37_G245_G0.6790.40
162_T218_G0.6780.40
9_V106_G0.6770.40
131_L186_Q0.6770.40
78_L103_E0.6750.40
111_R305_D0.6740.40
7_K29_T0.6740.40
126_F215_F0.6700.39
210_N297_N0.6700.39
138_H161_E0.6690.39
212_M255_D0.6670.39
297_N300_A0.6670.39
68_E96_Q0.6670.39
165_E184_E0.6650.39
235_W274_I0.6640.39
23_G106_G0.6630.39
47_Y119_L0.6610.39
77_S81_D0.6600.39
114_L186_Q0.6580.38
300_A304_E0.6570.38
72_K97_E0.6570.38
138_H177_D0.6550.38
160_S177_D0.6540.38
109_V238_G0.6540.38
86_I98_L0.6510.38
284_L295_F0.6500.38
86_I167_V0.6490.38
164_L277_V0.6480.38
265_V278_A0.6480.38
158_G207_G0.6470.37
114_L118_R0.6470.37
16_E91_D0.6470.37
235_W246_L0.6470.37
68_E71_K0.6450.37
13_F88_L0.6430.37
142_V167_V0.6430.37
12_Q187_D0.6410.37
54_L130_R0.6410.37
178_C184_E0.6410.37
41_A209_I0.6370.37
196_L222_S0.6370.37
197_I290_N0.6360.37
24_I108_P0.6350.36
235_W267_P0.6350.36
18_I111_R0.6350.36
40_I254_I0.6340.36
17_L24_I0.6340.36
197_I219_A0.6320.36
114_L304_E0.6320.36
167_V296_T0.6310.36
271_L274_I0.6270.36
6_T144_I0.6240.36
5_R110_L0.6220.35
12_Q126_F0.6220.35
82_V236_E0.6200.35
147_V224_K0.6200.35
69_E76_D0.6190.35
277_V299_L0.6190.35
145_Y280_M0.6180.35
167_V184_E0.6180.35
118_R128_E0.6180.35
92_M258_I0.6180.35
62_F79_C0.6180.35
87_I135_T0.6150.35
145_Y275_I0.6130.35
40_I92_M0.6130.35
54_L248_E0.6090.34
247_E294_Q0.6050.34
28_I50_E0.6050.34
124_T183_Q0.6040.34
89_S157_V0.6030.34
199_H203_I0.6020.34
32_D90_R0.6020.34
154_K236_E0.6020.34
151_I233_E0.6010.34
99_I104_K0.5950.33
210_N240_Q0.5940.33
69_E301_D0.5930.33
269_R272_A0.5930.33
23_G103_E0.5920.33
137_I251_M0.5920.33
37_G264_P0.5910.33
51_R85_A0.5890.33
39_E181_I0.5890.33
181_I258_I0.5890.33
67_P97_E0.5880.33
241_Y245_G0.5880.33
202_E207_G0.5870.33
125_N128_E0.5870.33
5_R174_V0.5860.33
5_R230_M0.5860.33
158_G204_R0.5850.32
13_F66_L0.5850.32
168_K218_G0.5850.32
177_D202_E0.5820.32
66_L78_L0.5820.32
62_F221_R0.5820.32
256_T259_T0.5810.32
183_Q256_T0.5810.32
214_L242_D0.5760.32
184_E271_L0.5750.32
199_H233_E0.5740.32
64_E77_S0.5740.32
203_I211_V0.5740.32
282_F286_R0.5740.32
117_T122_R0.5730.31
270_N283_R0.5710.31
203_I280_M0.5690.31
50_E275_I0.5690.31
251_M258_I0.5680.31
160_S207_G0.5670.31
114_L297_N0.5650.31
203_I244_L0.5640.31
87_I294_Q0.5640.31
40_I55_L0.5630.31
120_S174_V0.5620.31
143_D259_T0.5610.31
76_D80_T0.5610.31
160_S276_E0.5560.30
210_N289_L0.5560.30
222_S244_L0.5550.30
138_H158_G0.5550.30
76_D248_E0.5550.30
234_L253_I0.5540.30
221_R284_L0.5530.30
169_R198_E0.5520.30
279_A283_R0.5520.30
82_V210_N0.5510.30
35_R38_I0.5480.30
114_L137_I0.5470.30
9_V12_Q0.5470.30
41_A50_E0.5460.29
118_R186_Q0.5450.29
188_T227_T0.5440.29
32_D172_R0.5430.29
249_E260_K0.5430.29
171_H271_L0.5420.29
267_P292_A0.5410.29
98_L109_V0.5400.29
6_T110_L0.5400.29
98_L101_A0.5400.29
119_L154_K0.5390.29
128_E263_I0.5390.29
78_L215_F0.5370.29
142_V279_A0.5370.29
52_V236_E0.5360.29
156_G161_E0.5350.29
157_V296_T0.5340.29
140_V280_M0.5340.29
16_E72_K0.5330.28
233_E281_N0.5320.28
198_E222_S0.5320.28
65_Q91_D0.5320.28
10_M110_L0.5310.28
228_I271_L0.5290.28
233_E292_A0.5280.28
130_R198_E0.5280.28
272_A278_A0.5280.28
157_V244_L0.5270.28
16_E74_R0.5270.28
155_S204_R0.5260.28
284_L292_A0.5250.28
18_I237_Q0.5240.28
54_L184_E0.5230.28
288_G295_F0.5220.28
149_V279_A0.5210.28
138_H207_G0.5200.28
14_N80_T0.5200.28
58_T201_L0.5200.28
218_G282_F0.5200.28
6_T126_F0.5200.28
197_I295_F0.5200.28
141_L243_R0.5180.27
37_G275_I0.5170.27
36_P116_T0.5160.27
89_S92_M0.5150.27
100_D103_E0.5100.27
69_E100_D0.5100.27
219_A261_L0.5090.27
93_P113_P0.5080.27
64_E80_T0.5080.27
15_L279_A0.5070.27
204_R207_G0.5060.27
35_R116_T0.5060.27
134_T180_E0.5060.27
161_E202_E0.5060.27
34_S44_F0.5050.26
143_D174_V0.5050.26
289_L294_Q0.5040.26
208_I264_P0.5030.26
86_I120_S0.5020.26
133_P182_R0.5010.26
152_T297_N0.5000.26
156_G215_F0.5000.26
75_M98_L0.5000.26
147_V201_L0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1knxA 5 0.9903 100 0.223 Contact Map
1ko7A 3 0.9194 100 0.245 Contact Map
3tqfA 3 0.5258 100 0.589 Contact Map
2qmhA 5 0.5839 100 0.594 Contact Map
2iojA 1 0.3774 99.9 0.813 Contact Map
3ephA 2 0.5097 95.5 0.947 Contact Map
4cr2L 1 0.8839 94.8 0.95 Contact Map
2ce7A 3 0.6065 93.7 0.952 Contact Map
3fozA 2 0.4871 93.3 0.953 Contact Map
4cr2I 1 0.8968 92.7 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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