ASPG2 - BACSU - GREMLIN Contacts

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ASPG2 - L-asparaginase 2

UniProt:	O34482	Sequences: MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASASEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQIVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKPVVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTTTTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGSYLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQDYAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	375 (313)
Sequences:	3397 (2439)
Seq/√Len:	137.9

ECOLI - ASPG2 ASPG1
BACSU - ASPG2 ASPG1
HALSA - GATD
SULSO - GATD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
151_L	163_I	4.383	1.00
52_N	97_N	4.122	1.00
280_D	310_S	4.035	1.00
269_Y	293_A	3.644	1.00
147_T	163_I	3.523	1.00
101_E	122_R	3.344	1.00
155_V	161_V	3.334	1.00
200_V	212_V	3.158	1.00
280_D	307_G	3.051	1.00
54_R	132_V	2.899	1.00
364_D	367_K	2.868	1.00
367_K	370_A	2.833	1.00
193_A	240_F	2.815	1.00
106_V	115_I	2.602	1.00
56_L	103_I	2.599	1.00
358_A	371_Y	2.476	1.00
207_A	225_S	2.441	1.00
52_N	99_S	2.393	1.00
99_S	132_V	2.366	1.00
289_G	355_L	2.294	1.00
123_I	137_V	2.234	1.00
266_D	287_A	2.178	1.00
136_V	188_A	2.171	1.00
293_A	348_P	2.140	1.00
57_A	63_A	2.129	1.00
113_N	273_N	2.106	1.00
309_D	313_K	2.097	1.00
127_L	135_I	2.088	1.00
321_S	343_S	2.086	1.00
127_L	159_K	2.076	1.00
127_L	157_S	2.076	1.00
201_V	206_I	2.075	1.00
283_V	311_A	2.074	1.00
215_T	224_K	2.058	1.00
207_A	212_V	2.056	1.00
54_R	126_L	1.936	1.00
320_R	340_L	1.904	1.00
206_I	232_G	1.904	1.00
120_A	154_T	1.856	1.00
56_L	101_E	1.813	1.00
82_V	100_G	1.807	1.00
187_V	206_I	1.798	1.00
183_N	204_D	1.768	1.00
112_D	115_I	1.768	1.00
56_L	122_R	1.763	1.00
276_S	280_D	1.752	1.00
319_V	343_S	1.748	1.00
116_L	272_Q	1.742	1.00
262_L	288_K	1.730	1.00
294_G	320_R	1.723	1.00
307_G	310_S	1.721	1.00
144_L	200_V	1.708	1.00
70_T	74_E	1.690	1.00
319_V	372_F	1.683	1.00
152_N	210_R	1.682	1.00
67_Q	73_T	1.679	1.00
104_V	115_I	1.664	1.00
164_V	202_L	1.659	1.00
365_P	369_Q	1.643	1.00
103_I	122_R	1.638	1.00
358_A	368_I	1.630	1.00
278_L	282_A	1.614	1.00
113_N	356_M	1.586	1.00
111_I	115_I	1.585	1.00
116_L	353_M	1.584	1.00
280_D	284_K	1.550	1.00
183_N	201_V	1.532	1.00
215_T	222_T	1.530	1.00
150_F	154_T	1.510	1.00
276_S	307_G	1.510	1.00
126_L	131_D	1.509	1.00
319_V	355_L	1.503	1.00
122_R	125_H	1.496	1.00
358_A	362_T	1.490	1.00
122_R	126_L	1.482	1.00
182_Y	186_K	1.480	1.00
267_I	348_P	1.478	1.00
187_V	201_V	1.468	1.00
123_I	161_V	1.459	1.00
81_G	84_S	1.454	1.00
264_Q	275_G	1.449	1.00
365_P	368_I	1.441	1.00
139_H	147_T	1.419	1.00
310_S	314_K	1.413	1.00
83_E	87_E	1.403	1.00
317_T	368_I	1.375	1.00
117_L	154_T	1.363	1.00
216_N	326_N	1.349	1.00
279_F	307_G	1.346	1.00
279_F	311_A	1.336	1.00
309_D	338_K	1.328	1.00
217_T	322_T	1.322	1.00
124_N	128_A	1.300	1.00
197_G	208_S	1.294	1.00
116_L	150_F	1.289	1.00
264_Q	288_K	1.278	1.00
321_S	348_P	1.278	1.00
234_I	238_I	1.266	1.00
57_A	82_V	1.264	1.00
369_Q	373_N	1.251	1.00
190_A	193_A	1.228	1.00
50_L	97_N	1.222	1.00
290_I	311_A	1.220	1.00
193_A	196_K	1.210	1.00
115_I	118_K	1.210	1.00
264_Q	277_Y	1.209	1.00
136_V	189_G	1.206	1.00
57_A	102_Q	1.205	1.00
175_A	178_P	1.203	1.00
120_A	124_N	1.197	1.00
106_V	111_I	1.194	1.00
101_E	126_L	1.191	1.00
196_K	240_F	1.182	1.00
269_Y	348_P	1.180	1.00
205_R	221_D	1.170	0.99
110_N	302_D	1.165	0.99
266_D	282_A	1.161	0.99
268_I	279_F	1.161	0.99
282_A	287_A	1.153	0.99
300_L	308_A	1.150	0.99
179_S	183_N	1.143	0.99
279_F	304_A	1.138	0.99
136_V	185_V	1.127	0.99
131_D	159_K	1.108	0.99
92_M	185_V	1.108	0.99
51_P	191_P	1.104	0.99
283_V	316_V	1.103	0.99
191_P	196_K	1.103	0.99
211_Y	242_N	1.093	0.99
312_V	318_V	1.092	0.99
52_N	133_D	1.089	0.99
80_V	170_S	1.078	0.99
308_A	340_L	1.078	0.99
121_K	125_H	1.077	0.99
233_T	241_N	1.062	0.99
82_V	85_L	1.061	0.99
199_L	231_V	1.058	0.99
265_V	359_L	1.056	0.99
123_I	135_I	1.055	0.99
119_L	137_V	1.055	0.99
113_N	116_L	1.050	0.99
263_P	360_T	1.050	0.99
281_A	285_A	1.048	0.99
144_L	165_G	1.045	0.99
362_T	371_Y	1.044	0.99
53_I	133_D	1.036	0.99
270_G	301_S	1.033	0.99
264_Q	287_A	1.024	0.99
162_V	199_L	1.022	0.99
276_S	310_S	1.017	0.99
317_T	341_L	1.014	0.98
292_F	308_A	1.003	0.98
99_S	126_L	0.992	0.98
135_I	159_K	0.991	0.98
137_V	163_I	0.988	0.98
114_K	118_K	0.982	0.98
268_I	282_A	0.978	0.98
146_E	323_R	0.972	0.98
141_T	165_G	0.970	0.98
121_K	258_N	0.970	0.98
165_G	202_L	0.960	0.98
277_Y	281_A	0.958	0.98
145_E	349_Q	0.957	0.98
56_L	137_V	0.956	0.98
53_I	189_G	0.951	0.98
109_T	299_S	0.948	0.98
207_A	230_F	0.947	0.98
196_K	243_E	0.946	0.98
124_N	256_V	0.933	0.97
201_V	234_I	0.933	0.97
187_V	193_A	0.933	0.97
352_R	356_M	0.930	0.97
54_R	101_E	0.928	0.97
142_D	296_G	0.928	0.97
124_N	258_N	0.927	0.97
149_Y	153_L	0.926	0.97
323_R	349_Q	0.925	0.97
363_N	367_K	0.923	0.97
213_T	348_P	0.920	0.97
97_N	133_D	0.920	0.97
152_N	209_A	0.919	0.97
65_A	84_S	0.917	0.97
143_T	295_S	0.916	0.97
96_A	189_G	0.915	0.97
104_V	119_L	0.914	0.97
270_G	292_F	0.914	0.97
168_R	220_T	0.907	0.97
96_A	185_V	0.904	0.97
274_D	304_A	0.900	0.97
95_I	182_Y	0.895	0.97
62_I	177_G	0.895	0.97
299_S	333_Q	0.879	0.96
362_T	367_K	0.878	0.96
355_L	368_I	0.870	0.96
312_V	339_D	0.867	0.96
270_G	295_S	0.863	0.96
367_K	371_Y	0.853	0.96
55_I	138_T	0.849	0.95
312_V	338_K	0.845	0.95
144_L	163_I	0.845	0.95
193_A	199_L	0.844	0.95
211_Y	350_K	0.839	0.95
187_V	234_I	0.834	0.95
187_V	238_I	0.831	0.95
142_D	299_S	0.826	0.95
149_Y	353_M	0.825	0.95
117_L	121_K	0.819	0.95
132_V	159_K	0.816	0.94
174_S	179_S	0.814	0.94
205_R	230_F	0.811	0.94
113_N	272_Q	0.811	0.94
283_V	290_I	0.805	0.94
197_G	231_V	0.802	0.94
63_A	138_T	0.802	0.94
238_I	241_N	0.800	0.94
90_P	182_Y	0.799	0.94
145_E	323_R	0.799	0.94
203_N	221_D	0.798	0.94
333_Q	336_A	0.797	0.94
58_T	139_H	0.795	0.94
291_V	319_V	0.793	0.94
218_T	297_N	0.792	0.93
149_Y	210_R	0.790	0.93
321_S	351_A	0.789	0.93
215_T	325_G	0.783	0.93
179_S	220_T	0.783	0.93
241_N	344_N	0.781	0.93
270_G	304_A	0.780	0.93
216_N	219_T	0.779	0.93
279_F	308_A	0.779	0.93
270_G	300_L	0.778	0.93
196_K	245_T	0.774	0.93
351_A	372_F	0.773	0.93
257_S	361_K	0.773	0.93
72_T	172_A	0.772	0.93
211_Y	345_S	0.767	0.92
277_Y	285_A	0.762	0.92
190_A	240_F	0.762	0.92
211_Y	354_L	0.758	0.92
51_P	133_D	0.757	0.92
55_I	181_L	0.756	0.92
312_V	315_G	0.752	0.92
274_D	301_S	0.752	0.92
283_V	307_G	0.752	0.92
284_K	310_S	0.748	0.91
213_T	347_N	0.744	0.91
102_Q	105_N	0.744	0.91
113_N	117_L	0.741	0.91
348_P	351_A	0.738	0.91
123_I	127_L	0.738	0.91
306_K	309_D	0.737	0.91
56_L	126_L	0.737	0.91
141_T	214_K	0.735	0.91
346_L	354_L	0.735	0.91
199_L	206_I	0.735	0.91
156_K	255_S	0.732	0.90
153_L	354_L	0.732	0.90
300_L	304_A	0.731	0.90
310_S	313_K	0.729	0.90
91_E	178_P	0.725	0.90
206_I	238_I	0.724	0.90
152_N	208_S	0.724	0.90
268_I	278_L	0.723	0.90
364_D	371_Y	0.721	0.90
217_T	328_V	0.721	0.90
265_V	291_V	0.721	0.90
162_V	187_V	0.719	0.90
132_V	135_I	0.718	0.90
214_K	296_G	0.717	0.90
308_A	312_V	0.716	0.90
170_S	175_A	0.715	0.89
162_V	188_A	0.711	0.89
306_K	310_S	0.706	0.89
90_P	96_A	0.705	0.89
217_T	324_T	0.705	0.89
331_P	334_D	0.703	0.89
137_V	151_L	0.703	0.89
156_K	257_S	0.701	0.89
125_H	128_A	0.701	0.89
295_S	301_S	0.700	0.88
169_P	172_A	0.696	0.88
65_A	79_V	0.693	0.88
216_N	327_G	0.692	0.88
176_D	214_K	0.692	0.88
205_R	224_K	0.692	0.88
289_G	351_A	0.688	0.88
110_N	335_Y	0.688	0.88
347_N	350_K	0.688	0.88
153_L	357_L	0.683	0.87
126_L	132_V	0.682	0.87
107_G	110_N	0.680	0.87
55_I	185_V	0.679	0.87
120_A	256_V	0.679	0.87
163_I	209_A	0.678	0.87
311_A	316_V	0.676	0.87
331_P	342_A	0.676	0.87
320_R	331_P	0.675	0.87
134_G	160_P	0.675	0.87
218_T	330_T	0.674	0.87
54_R	99_S	0.674	0.87
343_S	372_F	0.673	0.86
292_F	300_L	0.673	0.86
232_G	240_F	0.672	0.86
272_Q	349_Q	0.672	0.86
164_V	184_A	0.672	0.86
357_L	361_K	0.670	0.86
208_S	211_Y	0.660	0.85
104_V	118_K	0.660	0.85
66_D	70_T	0.659	0.85
66_D	171_T	0.657	0.85
127_L	155_V	0.657	0.85
276_S	303_A	0.655	0.85
90_P	95_I	0.655	0.85
317_T	365_P	0.655	0.85
109_T	336_A	0.654	0.85
288_K	316_V	0.654	0.85
266_D	275_G	0.653	0.85
294_G	300_L	0.653	0.85
307_G	311_A	0.650	0.84
270_G	274_D	0.650	0.84
305_E	338_K	0.649	0.84
312_V	340_L	0.649	0.84
120_A	150_F	0.648	0.84
283_V	286_G	0.648	0.84
64_G	109_T	0.647	0.84
208_S	231_V	0.647	0.84
62_I	166_S	0.646	0.84
63_A	82_V	0.645	0.84
109_T	295_S	0.644	0.84
114_K	314_K	0.641	0.84
283_V	314_K	0.638	0.83
58_T	119_L	0.638	0.83
288_K	363_N	0.638	0.83
148_A	212_V	0.638	0.83
53_I	185_V	0.637	0.83
56_L	123_I	0.633	0.83
226_E	326_N	0.632	0.83
299_S	334_D	0.631	0.83
123_I	155_V	0.629	0.83
205_R	233_T	0.629	0.83
148_A	200_V	0.628	0.82
289_G	321_S	0.628	0.82
124_N	156_K	0.627	0.82
299_S	336_A	0.626	0.82
116_L	147_T	0.626	0.82
118_K	122_R	0.626	0.82
146_E	352_R	0.625	0.82
296_G	299_S	0.625	0.82
221_D	224_K	0.625	0.82
145_E	212_V	0.624	0.82
62_I	138_T	0.623	0.82
51_P	96_A	0.622	0.82
311_A	317_T	0.621	0.82
54_R	123_I	0.621	0.82
366_Q	370_A	0.620	0.82
67_Q	74_E	0.619	0.82
297_N	320_R	0.619	0.82
302_D	306_K	0.618	0.81
95_I	189_G	0.617	0.81
107_G	209_A	0.615	0.81
83_E	99_S	0.614	0.81
167_M	296_G	0.613	0.81
341_L	369_Q	0.609	0.80
149_Y	354_L	0.605	0.80
124_N	157_S	0.605	0.80
289_G	317_T	0.602	0.80
153_L	350_K	0.601	0.80
167_M	202_L	0.600	0.79
126_L	135_I	0.598	0.79
359_L	362_T	0.597	0.79
213_T	325_G	0.596	0.79
166_S	279_F	0.596	0.79
106_V	112_D	0.595	0.79
284_K	314_K	0.595	0.79
167_M	222_T	0.594	0.79
289_G	359_L	0.592	0.79
68_S	73_T	0.589	0.78
153_L	210_R	0.588	0.78
213_T	349_Q	0.586	0.78
350_K	354_L	0.585	0.78
235_A	297_N	0.584	0.78
343_S	351_A	0.584	0.78
121_K	259_L	0.583	0.78
141_T	207_A	0.582	0.77
57_A	64_G	0.580	0.77
202_L	207_A	0.580	0.77
199_L	240_F	0.580	0.77
350_K	353_M	0.579	0.77
170_S	177_G	0.576	0.77
274_D	279_F	0.575	0.77
276_S	279_F	0.575	0.77
227_E	345_S	0.575	0.77
117_L	150_F	0.574	0.76
103_I	273_N	0.574	0.76
89_V	95_I	0.572	0.76
167_M	214_K	0.570	0.76
127_L	132_V	0.570	0.76
58_T	61_T	0.569	0.76
157_S	252_T	0.569	0.76
186_K	237_D	0.569	0.76
89_V	185_V	0.568	0.76
287_A	316_V	0.568	0.76
118_K	125_H	0.568	0.76
269_Y	349_Q	0.568	0.76
328_V	344_N	0.567	0.76
127_L	131_D	0.565	0.75
364_D	370_A	0.563	0.75
89_V	96_A	0.563	0.75
66_D	172_A	0.562	0.75
120_A	155_V	0.561	0.75
241_N	244_I	0.560	0.75
210_R	345_S	0.558	0.74
117_L	259_L	0.558	0.74
162_V	206_I	0.557	0.74
184_A	201_V	0.556	0.74
263_P	288_K	0.556	0.74
186_K	190_A	0.555	0.74
121_K	263_P	0.554	0.74
192_E	196_K	0.554	0.74
149_Y	209_A	0.551	0.74
92_M	96_A	0.551	0.74
59_G	62_I	0.550	0.73
160_P	196_K	0.547	0.73
138_T	177_G	0.546	0.73
297_N	330_T	0.546	0.73
362_T	365_P	0.544	0.73
56_L	135_I	0.541	0.72
278_L	281_A	0.540	0.72
268_I	274_D	0.539	0.72
225_S	229_G	0.539	0.72
259_L	366_Q	0.537	0.72
279_F	290_I	0.537	0.72
187_V	240_F	0.537	0.72
165_G	214_K	0.534	0.71
329_V	342_A	0.533	0.71
278_L	287_A	0.532	0.71
332_N	336_A	0.530	0.71
183_N	237_D	0.529	0.70
152_N	197_G	0.529	0.70
267_I	352_R	0.528	0.70
305_E	309_D	0.525	0.70
84_S	87_E	0.525	0.70
109_T	202_L	0.524	0.70
138_T	197_G	0.524	0.70
292_F	320_R	0.523	0.70
259_L	360_T	0.522	0.69
99_S	133_D	0.521	0.69
168_R	174_S	0.519	0.69
301_S	304_A	0.518	0.69
317_T	359_L	0.517	0.69
52_N	131_D	0.517	0.69
116_L	139_H	0.516	0.69
271_Y	274_D	0.516	0.69
111_I	147_T	0.516	0.69
303_A	306_K	0.516	0.69
117_L	258_N	0.515	0.68
148_A	163_I	0.515	0.68
330_T	333_Q	0.513	0.68
57_A	100_G	0.513	0.68
98_V	136_V	0.512	0.68
89_V	182_Y	0.510	0.68
74_E	79_V	0.508	0.67
186_K	238_I	0.508	0.67
167_M	323_R	0.507	0.67
120_A	151_L	0.506	0.67
67_Q	70_T	0.506	0.67
199_L	232_G	0.506	0.67
123_I	151_L	0.506	0.67
107_G	144_L	0.503	0.67
108_S	139_H	0.500	0.66

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1zq1A	2	0.976	100	0.093	Contact Map
2d6fA	2	0.9573	100	0.096	Contact Map
3nxkA	4	0.8693	100	0.151	Contact Map
1wsaA	4	0.8453	100	0.153	Contact Map
1o7jA	4	0.864	100	0.154	Contact Map
2wltA	4	0.8613	100	0.154	Contact Map
1agxA	4	0.8667	100	0.156	Contact Map
1nnsA	4	0.8613	100	0.158	Contact Map
4pgaA	4	0.8693	100	0.169	Contact Map
2himA	4	0.8453	100	0.181	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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