RECDL - BACSU - GREMLIN Contacts

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RECDL - ATP-dependent RecD-like DNA helicase

UniProt:	O34481	Sequences: MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSEAIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYLSSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQGLEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSRMGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMDAANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLALGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSLDPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIEGKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIPTVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVANALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDKILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHAYCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVKNNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	798 (694)
Sequences:	2276 (1811)
Seq/√Len:	68.8

BACSU - RECDL

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
364_L	501_L	6.778	1.00
700_L	718_A	4.852	1.00
27_N	30_N	4.839	1.00
531_M	719_I	4.251	1.00
136_V	139_D	4.178	1.00
459_A	462_L	3.843	1.00
308_N	468_N	3.774	1.00
250_E	748_Q	3.730	1.00
625_I	679_F	3.713	1.00
377_I	418_M	3.629	1.00
332_L	355_Q	3.598	1.00
309_V	464_I	3.166	1.00
662_V	679_F	3.152	1.00
661_V	664_F	3.136	1.00
451_G	454_L	3.100	1.00
663_S	666_G	3.097	1.00
502_L	509_T	3.023	1.00
385_G	424_L	2.946	1.00
339_E	351_K	2.930	1.00
128_N	132_A	2.870	1.00
365_L	376_V	2.811	1.00
257_D	260_S	2.797	1.00
67_T	88_K	2.746	1.00
346_Y	354_I	2.743	1.00
462_L	467_A	2.682	1.00
551_R	732_E	2.666	1.00
185_Y	203_D	2.652	1.00
145_K	149_D	2.651	1.00
313_V	507_I	2.636	1.00
408_A	432_L	2.633	1.00
312_R	315_H	2.592	1.00
125_S	128_N	2.581	1.00
564_V	568_A	2.576	1.00
347_A	514_D	2.574	1.00
406_V	451_G	2.573	1.00
363_L	510_V	2.559	1.00
430_H	466_L	2.558	1.00
534_G	712_R	2.494	1.00
580_V	598_L	2.476	1.00
241_C	249_I	2.468	1.00
645_T	668_E	2.455	1.00
181_I	185_Y	2.452	1.00
73_V	83_Q	2.410	1.00
475_P	478_I	2.378	1.00
429_I	462_L	2.377	1.00
456_I	470_L	2.363	1.00
621_T	646_S	2.360	1.00
335_L	339_E	2.349	1.00
251_T	295_G	2.349	1.00
660_A	664_F	2.346	1.00
313_V	362_M	2.342	1.00
118_I	126_A	2.331	1.00
454_L	474_I	2.266	1.00
565_V	568_A	2.247	1.00
111_G	115_A	2.220	1.00
305_A	468_N	2.217	1.00
138_Y	148_A	2.208	1.00
71_K	83_Q	2.176	1.00
582_A	591_I	2.167	1.00
696_P	724_K	2.161	1.00
188_E	191_E	2.157	1.00
69_Y	86_H	2.147	1.00
126_A	130_I	2.141	1.00
99_I	116_E	2.127	1.00
629_V	678_Q	2.106	1.00
347_A	516_Y	2.106	1.00
617_V	681_H	2.094	1.00
35_L	84_A	2.086	1.00
659_M	664_F	2.083	1.00
530_Q	535_L	2.066	1.00
341_R	382_E	2.057	1.00
309_V	467_A	2.041	1.00
248_Y	296_R	2.024	1.00
349_S	513_T	2.024	1.00
346_Y	379_G	1.997	1.00
463_D	493_G	1.977	1.00
351_K	355_Q	1.971	1.00
127_I	130_I	1.967	1.00
191_E	195_E	1.964	1.00
445_E	472_K	1.960	1.00
64_E	89_K	1.957	1.00
564_V	570_K	1.951	1.00
659_M	670_T	1.944	1.00
581_L	687_I	1.929	1.00
356_K	363_L	1.927	1.00
75_H	79_G	1.924	1.00
736_E	740_K	1.899	1.00
182_Y	185_Y	1.893	1.00
687_I	700_L	1.885	1.00
53_V	84_A	1.883	1.00
467_A	471_F	1.879	1.00
606_K	609_R	1.872	1.00
604_P	620_R	1.854	1.00
636_V	671_F	1.849	1.00
456_I	482_I	1.840	1.00
599_Q	620_R	1.825	1.00
625_I	662_V	1.825	1.00
503_A	752_K	1.824	1.00
285_G	292_I	1.822	1.00
752_K	756_S	1.821	1.00
527_L	530_Q	1.821	1.00
528_A	720_T	1.819	1.00
305_A	465_W	1.816	1.00
349_S	514_D	1.815	1.00
197_P	200_L	1.791	1.00
384_Y	453_L	1.771	1.00
28_D	114_T	1.766	1.00
37_V	68_F	1.748	1.00
468_N	472_K	1.740	1.00
199_Q	203_D	1.740	1.00
634_N	675_D	1.734	1.00
356_K	510_V	1.732	1.00
631_Q	678_Q	1.727	1.00
300_P	304_Y	1.718	1.00
694_E	723_K	1.716	1.00
599_Q	681_H	1.691	1.00
354_I	379_G	1.689	1.00
591_I	686_S	1.686	1.00
454_L	478_I	1.675	0.99
255_I	277_A	1.674	0.99
144_S	147_K	1.669	0.99
71_K	85_E	1.668	0.99
565_V	699_V	1.662	0.99
354_I	376_V	1.657	0.99
459_A	482_I	1.654	0.99
208_G	212_A	1.643	0.99
336_G	339_E	1.638	0.99
474_I	478_I	1.638	0.99
233_I	277_A	1.635	0.99
577_D	696_P	1.631	0.99
251_T	278_A	1.616	0.99
404_P	452_K	1.610	0.99
563_K	567_N	1.608	0.99
569_L	573_Y	1.604	0.99
593_E	596_V	1.600	0.99
122_L	126_A	1.595	0.99
463_D	466_L	1.579	0.99
564_V	569_L	1.577	0.99
349_S	352_E	1.575	0.99
232_A	262_L	1.572	0.99
453_L	481_I	1.570	0.99
474_I	480_I	1.569	0.99
597_M	600_D	1.568	0.99
482_I	501_L	1.562	0.99
378_R	382_E	1.557	0.99
35_L	53_V	1.552	0.99
621_T	647_I	1.550	0.99
338_L	383_L	1.545	0.99
53_V	68_F	1.539	0.99
451_G	478_I	1.539	0.99
352_E	356_K	1.536	0.99
461_M	688_H	1.525	0.99
715_L	735_L	1.517	0.99
750_S	753_N	1.515	0.99
624_K	641_I	1.514	0.99
362_M	482_I	1.511	0.99
108_E	111_G	1.509	0.99
357_A	365_L	1.507	0.99
47_E	102_L	1.507	0.99
327_P	330_E	1.506	0.99
635_N	667_N	1.499	0.99
26_H	33_T	1.493	0.99
68_F	82_F	1.489	0.99
67_T	90_E	1.488	0.99
281_I	290_I	1.470	0.99
24_I	122_L	1.466	0.99
619_Y	644_I	1.465	0.99
336_G	351_K	1.463	0.99
628_L	680_T	1.450	0.98
697_I	725_F	1.439	0.98
410_P	492_V	1.433	0.98
182_Y	186_E	1.431	0.98
491_S	497_V	1.422	0.98
341_R	386_E	1.422	0.98
585_Y	680_T	1.419	0.98
229_V	277_A	1.399	0.98
121_K	139_D	1.395	0.98
167_S	171_F	1.394	0.98
311_K	315_H	1.392	0.98
626_L	689_K	1.390	0.98
408_A	454_L	1.388	0.98
611_E	620_R	1.388	0.98
224_N	276_D	1.376	0.98
487_D	532_K	1.375	0.98
72_I	80_L	1.370	0.98
565_V	569_L	1.367	0.98
568_A	572_G	1.366	0.98
619_Y	679_F	1.366	0.98
408_A	456_I	1.365	0.98
368_G	371_T	1.361	0.98
285_G	290_I	1.359	0.98
598_L	602_L	1.351	0.98
313_V	501_L	1.350	0.98
603_N	620_R	1.348	0.98
309_V	471_F	1.347	0.98
412_G	428_T	1.339	0.97
659_M	662_V	1.333	0.97
524_I	527_L	1.321	0.97
20_V	35_L	1.320	0.97
28_D	84_A	1.319	0.97
298_Y	754_R	1.318	0.97
122_L	129_K	1.313	0.97
631_Q	634_N	1.311	0.97
702_V	728_L	1.310	0.97
699_V	727_I	1.307	0.97
374_T	421_S	1.304	0.97
114_T	117_E	1.289	0.97
582_A	594_L	1.289	0.97
66_Y	87_F	1.289	0.97
149_D	153_G	1.289	0.97
687_I	718_A	1.289	0.97
557_I	561_V	1.283	0.97
570_K	573_Y	1.280	0.97
250_E	253_Q	1.279	0.97
247_T	298_Y	1.278	0.97
317_A	508_P	1.277	0.97
362_M	480_I	1.273	0.97
645_T	663_S	1.272	0.97
696_P	723_K	1.268	0.96
417_R	421_S	1.266	0.96
110_I	151_L	1.264	0.96
630_N	638_N	1.259	0.96
364_L	507_I	1.258	0.96
560_V	563_K	1.258	0.96
279_N	282_I	1.255	0.96
247_T	464_I	1.246	0.96
688_H	714_L	1.242	0.96
412_G	639_G	1.240	0.96
407_L	418_M	1.238	0.96
655_E	659_M	1.237	0.96
133_D	136_V	1.233	0.96
560_V	568_A	1.230	0.96
707_Y	737_W	1.229	0.96
230_K	283_A	1.222	0.96
411_T	414_A	1.222	0.96
459_A	467_A	1.222	0.96
537_P	739_V	1.215	0.95
357_A	380_I	1.215	0.95
99_I	120_K	1.213	0.95
335_L	351_K	1.213	0.95
282_I	285_G	1.211	0.95
152_A	156_Q	1.208	0.95
722_A	726_L	1.205	0.95
334_A	338_L	1.204	0.95
381_V	385_G	1.192	0.95
552_C	560_V	1.189	0.95
557_I	703_V	1.186	0.95
427_V	431_R	1.185	0.95
548_S	552_C	1.178	0.95
354_I	380_I	1.174	0.95
549_F	730_G	1.169	0.94
377_I	455_I	1.169	0.94
30_N	121_K	1.166	0.94
645_T	661_V	1.166	0.94
57_F	84_A	1.166	0.94
299_F	302_L	1.163	0.94
181_I	204_V	1.162	0.94
726_L	729_C	1.161	0.94
363_L	509_T	1.152	0.94
454_L	480_I	1.152	0.94
410_P	428_T	1.151	0.94
610_R	621_T	1.147	0.94
174_G	177_L	1.146	0.94
627_Q	671_F	1.146	0.94
361_P	479_Q	1.124	0.93
253_Q	748_Q	1.121	0.93
585_Y	591_I	1.120	0.93
129_K	136_V	1.120	0.93
181_I	186_E	1.119	0.93
543_P	549_F	1.118	0.93
164_I	189_T	1.118	0.93
558_K	565_V	1.116	0.93
661_V	668_E	1.116	0.93
121_K	140_V	1.114	0.93
584_M	590_G	1.112	0.93
499_R	503_A	1.110	0.93
568_A	573_Y	1.107	0.93
334_A	386_E	1.107	0.93
583_P	590_G	1.106	0.93
487_D	511_R	1.106	0.93
134_A	152_A	1.105	0.93
34_V	54_T	1.103	0.93
94_T	97_G	1.101	0.92
644_I	660_A	1.101	0.92
193_I	197_P	1.100	0.92
204_V	208_G	1.099	0.92
184_A	203_D	1.092	0.92
412_G	630_N	1.091	0.92
338_L	342_M	1.082	0.92
153_G	200_L	1.080	0.92
84_A	87_F	1.078	0.92
353_A	365_L	1.078	0.92
155_L	159_Q	1.073	0.91
585_Y	592_N	1.069	0.91
209_F	213_D	1.067	0.91
98_I	127_I	1.067	0.91
732_E	736_E	1.064	0.91
702_V	715_L	1.064	0.91
363_L	481_I	1.063	0.91
580_V	644_I	1.063	0.91
417_R	420_E	1.058	0.91
307_Q	754_R	1.055	0.91
249_I	299_F	1.051	0.91
527_L	547_R	1.047	0.90
196_N	227_E	1.046	0.90
251_T	282_I	1.046	0.90
21_N	50_A	1.045	0.90
313_V	480_I	1.045	0.90
193_I	200_L	1.044	0.90
474_I	477_H	1.044	0.90
593_E	597_M	1.043	0.90
148_A	152_A	1.042	0.90
283_A	286_E	1.041	0.90
559_E	563_K	1.040	0.90
660_A	665_D	1.039	0.90
700_L	728_L	1.039	0.90
68_F	87_F	1.038	0.90
562_E	597_M	1.036	0.90
221_L	225_H	1.035	0.90
648_F	657_E	1.035	0.90
369_P	716_Y	1.034	0.90
233_I	281_I	1.033	0.90
552_C	556_Q	1.033	0.90
360_S	363_L	1.033	0.90
167_S	173_F	1.031	0.90
278_A	282_I	1.031	0.90
579_Q	695_F	1.031	0.90
486_E	511_R	1.030	0.90
627_Q	642_G	1.028	0.90
406_V	449_I	1.027	0.90
454_L	470_L	1.026	0.90
39_V	110_I	1.025	0.89
626_L	680_T	1.025	0.89
57_F	60_L	1.025	0.89
566_A	569_L	1.025	0.89
565_V	602_L	1.025	0.89
562_E	568_A	1.016	0.89
467_A	501_L	1.013	0.89
548_S	568_A	1.013	0.89
750_S	754_R	1.011	0.89
280_A	284_L	1.009	0.89
113_K	116_E	1.006	0.89
513_T	533_N	1.006	0.89
35_L	60_L	1.004	0.88
628_L	686_S	1.001	0.88
456_I	480_I	1.000	0.88
95_K	124_D	1.000	0.88
489_L	687_I	0.997	0.88
335_L	354_I	0.997	0.88
414_A	461_M	0.997	0.88
94_T	100_Q	0.997	0.88
57_F	87_F	0.996	0.88
256_I	260_S	0.996	0.88
543_P	547_R	0.995	0.88
403_F	453_L	0.994	0.88
361_P	477_H	0.989	0.88
185_Y	204_V	0.985	0.88
641_I	682_A	0.983	0.87
523_S	527_L	0.982	0.87
365_L	481_I	0.981	0.87
273_T	276_D	0.980	0.87
556_Q	559_E	0.979	0.87
461_M	489_L	0.979	0.87
308_N	312_R	0.977	0.87
346_Y	726_L	0.975	0.87
302_L	494_P	0.973	0.87
316_I	361_P	0.973	0.87
75_H	78_F	0.970	0.87
328_E	355_Q	0.970	0.87
496_Q	749_T	0.970	0.87
605_P	611_E	0.969	0.87
32_Y	54_T	0.966	0.86
704_K	733_E	0.966	0.86
471_F	480_I	0.965	0.86
584_M	687_I	0.965	0.86
657_E	662_V	0.960	0.86
232_A	264_Q	0.960	0.86
536_L	739_V	0.956	0.86
117_E	140_V	0.955	0.86
167_S	194_Q	0.952	0.86
544_T	547_R	0.951	0.86
284_L	289_D	0.949	0.86
501_L	507_I	0.946	0.85
110_I	115_A	0.945	0.85
366_T	502_L	0.945	0.85
418_M	421_S	0.945	0.85
699_V	729_C	0.943	0.85
687_I	714_L	0.942	0.85
619_Y	660_A	0.942	0.85
413_R	641_I	0.941	0.85
563_K	568_A	0.939	0.85
302_L	464_I	0.939	0.85
315_H	476_D	0.939	0.85
564_V	567_N	0.939	0.85
360_S	508_P	0.939	0.85
376_V	512_L	0.934	0.85
339_E	345_Q	0.934	0.85
235_Y	239_T	0.934	0.85
337_E	386_E	0.933	0.85
174_G	181_I	0.933	0.85
566_A	570_K	0.930	0.84
364_L	498_L	0.929	0.84
659_M	663_S	0.927	0.84
700_L	726_L	0.927	0.84
496_Q	499_R	0.926	0.84
348_P	514_D	0.925	0.84
521_G	545_K	0.925	0.84
369_P	487_D	0.922	0.84
126_A	129_K	0.920	0.84
51_V	100_Q	0.920	0.84
429_I	470_L	0.920	0.84
543_P	548_S	0.920	0.84
584_M	709_M	0.918	0.84
595_N	684_C	0.918	0.84
407_L	426_A	0.917	0.83
112_K	116_E	0.915	0.83
558_K	597_M	0.915	0.83
660_A	663_S	0.913	0.83
122_L	136_V	0.911	0.83
568_A	571_K	0.911	0.83
410_P	640_D	0.910	0.83
576_K	643_E	0.906	0.83
214_E	218_R	0.901	0.82
624_K	643_E	0.900	0.82
181_I	207_I	0.900	0.82
175_P	181_I	0.898	0.82
246_H	748_Q	0.896	0.82
597_M	601_I	0.890	0.82
313_V	317_A	0.889	0.82
737_W	740_K	0.889	0.82
190_L	194_Q	0.888	0.81
74_T	80_L	0.887	0.81
564_V	729_C	0.884	0.81
431_R	435_W	0.882	0.81
178_S	182_Y	0.881	0.81
660_A	676_F	0.880	0.81
441_F	469_H	0.880	0.81
232_A	261_L	0.880	0.81
181_I	422_T	0.878	0.81
566_A	601_I	0.876	0.81
626_L	685_C	0.872	0.80
251_T	297_C	0.872	0.80
711_R	741_N	0.870	0.80
579_Q	693_S	0.869	0.80
254_L	290_I	0.869	0.80
626_L	682_A	0.864	0.80
259_Q	277_A	0.863	0.80
283_A	287_N	0.863	0.80
20_V	23_V	0.861	0.79
202_K	289_D	0.860	0.79
145_K	148_A	0.860	0.79
314_K	362_M	0.859	0.79
506_V	755_L	0.855	0.79
237_L	290_I	0.854	0.79
307_Q	311_K	0.851	0.79
717_T	720_T	0.847	0.78
248_Y	298_Y	0.846	0.78
151_L	154_A	0.845	0.78
568_A	725_F	0.844	0.78
567_N	729_C	0.842	0.78
312_R	471_F	0.840	0.78
369_P	694_E	0.840	0.78
612_L	673_K	0.839	0.78
726_L	730_G	0.839	0.78
567_N	571_K	0.834	0.77
641_I	685_C	0.834	0.77
656_K	661_V	0.834	0.77
547_R	550_I	0.831	0.77
657_E	660_A	0.830	0.77
734_A	738_G	0.828	0.77
252_E	256_I	0.828	0.77
441_F	444_T	0.826	0.77
331_F	358_L	0.825	0.76
558_K	593_E	0.824	0.76
207_I	212_A	0.820	0.76
605_P	609_R	0.820	0.76
656_K	662_V	0.820	0.76
642_G	718_A	0.817	0.76
611_E	618_V	0.817	0.76
274_E	278_A	0.815	0.76
558_K	568_A	0.814	0.76
407_L	424_L	0.813	0.75
656_K	663_S	0.810	0.75
569_L	572_G	0.810	0.75
335_L	383_L	0.810	0.75
154_A	157_R	0.808	0.75
290_I	313_V	0.807	0.75
84_A	114_T	0.807	0.75
561_V	565_V	0.807	0.75
335_L	355_Q	0.803	0.75
498_L	714_L	0.803	0.75
127_I	131_L	0.803	0.75
236_T	258_T	0.801	0.74
357_A	363_L	0.800	0.74
563_K	566_A	0.800	0.74
336_G	340_E	0.798	0.74
147_K	150_T	0.797	0.74
181_I	200_L	0.795	0.74
162_E	173_F	0.793	0.74
108_E	115_A	0.792	0.73
195_E	199_Q	0.791	0.73
281_I	297_C	0.791	0.73
573_Y	697_I	0.790	0.73
229_V	280_A	0.788	0.73
562_E	570_K	0.786	0.73
301_S	465_W	0.786	0.73
585_Y	628_L	0.785	0.73
471_F	482_I	0.784	0.73
230_K	280_A	0.784	0.73
559_E	597_M	0.784	0.73
580_V	699_V	0.784	0.73
242_L	302_L	0.783	0.73
704_K	737_W	0.783	0.73
685_C	690_S	0.783	0.73
244_E	257_D	0.780	0.72
524_I	722_A	0.779	0.72
177_L	207_I	0.779	0.72
75_H	81_Q	0.776	0.72
67_T	86_H	0.774	0.72
216_G	220_G	0.774	0.72
76_P	83_Q	0.769	0.71
585_Y	686_S	0.768	0.71
180_K	184_A	0.767	0.71
131_L	159_Q	0.767	0.71
39_V	51_V	0.766	0.71
317_A	507_I	0.766	0.71
582_A	628_L	0.765	0.71
733_E	737_W	0.763	0.71
656_K	659_M	0.759	0.70
417_R	693_S	0.759	0.70
584_M	686_S	0.758	0.70
429_I	640_D	0.758	0.70
406_V	454_L	0.756	0.70
309_V	497_V	0.755	0.70
119_V	126_A	0.755	0.70
657_E	661_V	0.754	0.70
19_T	38_K	0.754	0.70
655_E	658_D	0.751	0.69
431_R	632_P	0.751	0.69
413_R	693_S	0.750	0.69
177_L	181_I	0.749	0.69
194_Q	567_N	0.748	0.69
133_D	139_D	0.748	0.69
518_Q	528_A	0.745	0.69
24_I	36_K	0.744	0.69
546_D	550_I	0.743	0.69
111_G	114_T	0.742	0.69
505_Q	511_R	0.741	0.68
255_I	278_A	0.740	0.68
70_G	82_F	0.739	0.68
658_D	673_K	0.739	0.68
331_F	355_Q	0.738	0.68
413_R	417_R	0.738	0.68
118_I	140_V	0.737	0.68
737_W	741_N	0.734	0.68
241_C	614_F	0.733	0.68
642_G	689_K	0.731	0.67
217_S	223_G	0.730	0.67
504_S	755_L	0.730	0.67
192_K	195_E	0.730	0.67
501_L	506_V	0.729	0.67
461_M	689_K	0.728	0.67
497_V	500_D	0.728	0.67
371_T	515_I	0.728	0.67
428_T	432_L	0.727	0.67
657_E	663_S	0.726	0.67
435_W	441_F	0.726	0.67
366_T	486_E	0.725	0.67
147_K	151_L	0.724	0.67
556_Q	560_V	0.723	0.67
562_E	566_A	0.721	0.66
407_L	411_T	0.721	0.66
411_T	461_M	0.721	0.66
547_R	552_C	0.721	0.66
461_M	630_N	0.721	0.66
455_I	483_V	0.720	0.66
598_L	696_P	0.720	0.66
692_G	721_R	0.720	0.66
357_A	481_I	0.718	0.66
326_F	330_E	0.718	0.66
254_L	483_V	0.718	0.66
192_K	199_Q	0.717	0.66
525_V	529_H	0.716	0.66
558_K	562_E	0.716	0.66
384_Y	403_F	0.716	0.66
452_K	478_I	0.714	0.66
182_Y	187_S	0.714	0.66
555_S	559_E	0.713	0.65
515_I	528_A	0.713	0.65
298_Y	750_S	0.713	0.65
98_I	166_I	0.712	0.65
415_A	419_S	0.711	0.65
582_A	585_Y	0.710	0.65
293_E	483_V	0.709	0.65
406_V	418_M	0.709	0.65
402_A	453_L	0.707	0.65
743_D	746_V	0.704	0.64
416_K	665_D	0.704	0.64
202_K	234_L	0.703	0.64
99_I	103_S	0.702	0.64
181_I	184_A	0.702	0.64
251_T	255_I	0.702	0.64
529_H	532_K	0.701	0.64
85_E	88_K	0.699	0.64
636_V	669_M	0.699	0.64
523_S	526_E	0.699	0.64
108_E	112_K	0.698	0.64
671_F	679_F	0.698	0.64
410_P	414_A	0.698	0.64
441_F	448_P	0.698	0.64
507_I	728_L	0.698	0.64
594_L	598_L	0.698	0.64
233_I	236_T	0.695	0.63
562_E	601_I	0.695	0.63
302_L	305_A	0.694	0.63
129_K	139_D	0.693	0.63
153_G	739_V	0.692	0.63
380_I	481_I	0.689	0.63
251_T	292_I	0.687	0.63
95_K	99_I	0.685	0.62
79_G	153_G	0.685	0.62
344_V	644_I	0.684	0.62
661_V	670_T	0.684	0.62
244_E	277_A	0.684	0.62
208_G	213_D	0.683	0.62
657_E	664_F	0.683	0.62
719_I	728_L	0.682	0.62
352_E	355_Q	0.681	0.62
174_G	180_K	0.680	0.62
694_E	717_T	0.680	0.62
417_R	694_E	0.679	0.62
225_H	229_V	0.677	0.61
285_G	297_C	0.677	0.61
430_H	452_K	0.677	0.61
704_K	731_E	0.677	0.61
646_S	668_E	0.676	0.61
621_T	645_T	0.675	0.61
625_I	678_Q	0.674	0.61
385_G	405_I	0.674	0.61
333_L	336_G	0.672	0.61
405_I	453_L	0.672	0.61
490_P	713_N	0.670	0.61
444_T	447_Q	0.669	0.61
369_P	411_T	0.668	0.60
558_K	561_V	0.668	0.60
412_G	415_A	0.668	0.60
464_I	494_P	0.668	0.60
411_T	491_S	0.667	0.60
164_I	254_L	0.666	0.60
23_V	26_H	0.666	0.60
515_I	561_V	0.665	0.60
376_V	494_P	0.665	0.60
557_I	568_A	0.665	0.60
655_E	663_S	0.661	0.60
146_K	149_D	0.661	0.60
334_A	383_L	0.660	0.60
308_N	472_K	0.659	0.59
208_G	215_L	0.659	0.59
282_I	286_E	0.658	0.59
81_Q	460_S	0.658	0.59
150_T	154_A	0.657	0.59
32_Y	52_S	0.656	0.59
153_G	157_R	0.654	0.59
34_V	117_E	0.654	0.59
338_L	346_Y	0.654	0.59
109_G	115_A	0.654	0.59
353_A	376_V	0.653	0.59
699_V	718_A	0.653	0.59
580_V	686_S	0.652	0.59
254_L	297_C	0.652	0.59
553_G	731_E	0.652	0.59
302_L	465_W	0.652	0.59
248_Y	748_Q	0.651	0.58
366_T	420_E	0.651	0.58
116_E	120_K	0.649	0.58
114_T	144_S	0.649	0.58
505_Q	756_S	0.648	0.58
536_L	740_K	0.647	0.58
492_V	630_N	0.645	0.58
658_D	662_V	0.645	0.58
80_L	83_Q	0.645	0.58
122_L	130_I	0.645	0.58
574_T	602_L	0.644	0.58
634_N	706_Y	0.644	0.58
449_I	452_K	0.644	0.58
465_W	468_N	0.643	0.58
296_R	753_N	0.642	0.57
695_F	698_V	0.640	0.57
36_K	40_T	0.640	0.57
118_I	408_A	0.639	0.57
561_V	657_E	0.639	0.57
334_A	337_E	0.639	0.57
627_Q	636_V	0.638	0.57
366_T	369_P	0.637	0.57
88_K	163_Q	0.637	0.57
455_I	665_D	0.637	0.57
413_R	640_D	0.637	0.57
644_I	679_F	0.637	0.57
130_I	151_L	0.636	0.57
711_R	743_D	0.635	0.57
753_N	756_S	0.635	0.57
582_A	686_S	0.634	0.56
296_R	750_S	0.634	0.56
249_I	288_K	0.633	0.56
411_T	713_N	0.633	0.56
562_E	600_D	0.633	0.56
526_E	530_Q	0.631	0.56
581_L	698_V	0.631	0.56
110_I	114_T	0.630	0.56
208_G	211_K	0.630	0.56
167_S	170_Q	0.627	0.56
153_G	311_K	0.627	0.56
192_K	218_R	0.627	0.56
567_N	570_K	0.626	0.56
47_E	50_A	0.626	0.56
305_A	464_I	0.626	0.56
175_P	186_E	0.625	0.55
54_T	555_S	0.625	0.55
384_Y	405_I	0.624	0.55
209_F	212_A	0.624	0.55
83_Q	90_E	0.623	0.55
672_T	675_D	0.623	0.55
111_G	123_G	0.622	0.55
108_E	154_A	0.622	0.55
69_Y	88_K	0.621	0.55
411_T	471_F	0.620	0.55
61_Q	106_L	0.620	0.55
346_Y	365_L	0.620	0.55
358_L	384_Y	0.620	0.55
430_H	492_V	0.619	0.55
338_L	379_G	0.619	0.55
427_V	685_C	0.619	0.55
101_Y	104_S	0.619	0.55
528_A	532_K	0.619	0.55
625_I	642_G	0.618	0.55
547_R	551_R	0.618	0.55
54_T	57_F	0.618	0.55
364_L	369_P	0.617	0.54
41_E	48_D	0.615	0.54
348_P	352_E	0.615	0.54
215_L	219_M	0.615	0.54
21_N	38_K	0.614	0.54
539_N	746_V	0.614	0.54
686_S	738_G	0.613	0.54
701_P	730_G	0.612	0.54
488_Q	517_R	0.612	0.54
561_V	729_C	0.611	0.54
23_V	33_T	0.610	0.54
190_L	197_P	0.610	0.54
230_K	287_N	0.609	0.53
213_D	228_R	0.608	0.53
522_S	527_L	0.608	0.53
281_I	755_L	0.608	0.53
746_V	756_S	0.608	0.53
114_T	118_I	0.608	0.53
635_N	738_G	0.606	0.53
167_S	181_I	0.606	0.53
716_Y	721_R	0.606	0.53
596_V	600_D	0.606	0.53
444_T	448_P	0.604	0.53
369_P	410_P	0.604	0.53
226_P	283_A	0.603	0.53
173_F	215_L	0.603	0.53
173_F	185_Y	0.602	0.53
547_R	554_G	0.602	0.53
412_G	689_K	0.601	0.53
121_K	124_D	0.601	0.53
288_K	291_V	0.601	0.53
253_Q	257_D	0.600	0.52
637_F	640_D	0.600	0.52
591_I	595_N	0.600	0.52
176_Q	386_E	0.599	0.52
710_L	738_G	0.599	0.52
560_V	564_V	0.599	0.52
376_V	379_G	0.599	0.52
229_V	233_I	0.598	0.52
210_G	239_T	0.598	0.52
115_A	123_G	0.598	0.52
343_D	618_V	0.598	0.52
76_P	107_F	0.597	0.52
613_K	618_V	0.597	0.52
131_L	155_L	0.597	0.52
421_S	483_V	0.596	0.52
412_G	688_H	0.595	0.52
137_L	151_L	0.594	0.52
369_P	430_H	0.594	0.52
255_I	260_S	0.593	0.52
68_F	84_A	0.593	0.52
549_F	641_I	0.592	0.51
619_Y	642_G	0.592	0.51
366_T	498_L	0.591	0.51
626_L	693_S	0.591	0.51
565_V	601_I	0.591	0.51
410_P	595_N	0.591	0.51
417_R	528_A	0.590	0.51
175_P	179_M	0.590	0.51
96_E	622_G	0.590	0.51
24_I	35_L	0.590	0.51
377_I	462_L	0.590	0.51
430_H	624_K	0.588	0.51
635_N	706_Y	0.587	0.51
465_W	469_H	0.587	0.51
583_P	714_L	0.586	0.51
358_L	383_L	0.586	0.51
564_V	580_V	0.586	0.51
20_V	60_L	0.585	0.51
707_Y	734_A	0.585	0.51
303_F	307_Q	0.583	0.50
433_L	466_L	0.582	0.50
153_G	156_Q	0.582	0.50
312_R	468_N	0.582	0.50
431_R	637_F	0.582	0.50
368_G	487_D	0.581	0.50
101_Y	694_E	0.580	0.50
564_V	573_Y	0.580	0.50
368_G	515_I	0.579	0.50
575_A	578_I	0.577	0.50
260_S	281_I	0.577	0.50
291_V	300_P	0.576	0.50
625_I	644_I	0.575	0.49
459_A	498_L	0.575	0.49
415_A	638_N	0.575	0.49
62_E	491_S	0.575	0.49
282_I	292_I	0.574	0.49
214_E	277_A	0.574	0.49
177_L	185_Y	0.573	0.49
216_G	231_A	0.573	0.49
382_E	385_G	0.573	0.49
215_L	509_T	0.572	0.49
719_I	726_L	0.572	0.49
349_S	511_R	0.572	0.49
428_T	583_P	0.571	0.49
369_P	532_K	0.571	0.49
741_N	744_A	0.570	0.49
222_S	521_G	0.570	0.49
481_I	498_L	0.569	0.49
614_F	676_F	0.569	0.49
505_Q	661_V	0.569	0.49
356_K	508_P	0.569	0.49
21_N	25_Y	0.569	0.49
183_Q	186_E	0.569	0.49
340_E	404_P	0.568	0.49
104_S	640_D	0.568	0.49
311_K	533_N	0.567	0.48
613_K	616_D	0.567	0.48
492_V	688_H	0.567	0.48
202_K	288_K	0.566	0.48
595_N	642_G	0.565	0.48
135_S	138_Y	0.564	0.48
265_S	275_M	0.564	0.48
317_A	362_M	0.563	0.48
644_I	647_I	0.563	0.48
525_V	528_A	0.563	0.48
561_V	594_L	0.563	0.48
314_K	755_L	0.562	0.48
411_T	583_P	0.562	0.48
204_V	207_I	0.560	0.48
346_Y	384_Y	0.560	0.48
146_K	287_N	0.559	0.47
157_R	505_Q	0.558	0.47
117_E	141_P	0.558	0.47
627_Q	637_F	0.558	0.47
214_E	330_E	0.558	0.47
364_L	509_T	0.558	0.47
275_M	545_K	0.557	0.47
461_M	490_P	0.557	0.47
489_L	714_L	0.557	0.47
328_E	334_A	0.556	0.47
435_W	686_S	0.556	0.47
727_I	730_G	0.556	0.47
51_V	72_I	0.556	0.47
560_V	729_C	0.555	0.47
691_Q	721_R	0.555	0.47
409_A	462_L	0.554	0.47
289_D	456_I	0.553	0.47
347_A	510_V	0.553	0.47
34_V	121_K	0.553	0.47
463_D	491_S	0.553	0.47
145_K	150_T	0.553	0.47
107_F	726_L	0.552	0.47
277_A	281_I	0.552	0.47
191_E	559_E	0.552	0.47
415_A	632_P	0.551	0.47
141_P	481_I	0.551	0.47
416_K	640_D	0.551	0.47
128_N	133_D	0.550	0.46
307_Q	526_E	0.550	0.46
185_Y	199_Q	0.549	0.46
198_Y	228_R	0.548	0.46
471_F	474_I	0.547	0.46
703_V	709_M	0.547	0.46
365_L	511_R	0.546	0.46
536_L	736_E	0.545	0.46
560_V	565_V	0.545	0.46
675_D	680_T	0.545	0.46
174_G	185_Y	0.544	0.46
110_I	123_G	0.544	0.46
590_G	709_M	0.543	0.46
530_Q	538_N	0.543	0.46
115_A	118_I	0.543	0.46
664_F	671_F	0.542	0.45
292_I	297_C	0.541	0.45
558_K	570_K	0.539	0.45
464_I	749_T	0.539	0.45
704_K	734_A	0.537	0.45
519_A	724_K	0.537	0.45
278_A	285_G	0.537	0.45
97_G	280_A	0.537	0.45
543_P	551_R	0.537	0.45
710_L	734_A	0.537	0.45
69_Y	84_A	0.537	0.45
98_I	126_A	0.537	0.45
380_I	557_I	0.536	0.45
113_K	117_E	0.535	0.45
173_F	177_L	0.535	0.45
146_K	150_T	0.534	0.44
172_G	185_Y	0.534	0.44
709_M	741_N	0.534	0.44
134_A	156_Q	0.533	0.44
461_M	512_L	0.533	0.44
425_P	431_R	0.533	0.44
477_H	644_I	0.533	0.44
734_A	737_W	0.533	0.44
119_V	138_Y	0.532	0.44
115_A	119_V	0.532	0.44
344_V	375_T	0.532	0.44
428_T	698_V	0.531	0.44
49_K	96_E	0.530	0.44
178_S	185_Y	0.529	0.44
173_F	211_K	0.529	0.44
460_S	583_P	0.529	0.44
543_P	550_I	0.529	0.44
28_D	59_A	0.528	0.44
244_E	719_I	0.528	0.44
333_L	337_E	0.528	0.44
122_L	155_L	0.528	0.44
229_V	281_I	0.528	0.44
492_V	640_D	0.527	0.44
178_S	186_E	0.527	0.44
114_T	147_K	0.527	0.44
194_Q	197_P	0.527	0.44
205_E	208_G	0.527	0.44
236_T	257_D	0.526	0.44
417_R	640_D	0.526	0.44
196_N	199_Q	0.526	0.44
166_I	169_N	0.525	0.43
715_L	738_G	0.525	0.43
493_G	689_K	0.525	0.43
382_E	447_Q	0.525	0.43
416_K	637_F	0.524	0.43
167_S	179_M	0.524	0.43
515_I	518_Q	0.524	0.43
746_V	752_K	0.524	0.43
414_A	417_R	0.524	0.43
88_K	218_R	0.524	0.43
29_T	71_K	0.523	0.43
153_G	343_D	0.523	0.43
473_A	500_D	0.523	0.43
574_T	577_D	0.523	0.43
47_E	65_T	0.522	0.43
112_K	115_A	0.522	0.43
123_G	126_A	0.522	0.43
170_Q	178_S	0.522	0.43
528_A	679_F	0.521	0.43
62_E	92_P	0.521	0.43
617_V	621_T	0.521	0.43
549_F	735_L	0.521	0.43
288_K	740_K	0.520	0.43
173_F	181_I	0.520	0.43
86_H	625_I	0.520	0.43
364_L	510_V	0.519	0.43
155_L	475_P	0.518	0.43
655_E	661_V	0.518	0.43
361_P	580_V	0.518	0.43
195_E	354_I	0.518	0.43
64_E	749_T	0.517	0.42
141_P	144_S	0.517	0.42
317_A	501_L	0.517	0.42
277_A	284_L	0.517	0.42
498_L	502_L	0.516	0.42
163_Q	166_I	0.516	0.42
706_Y	709_M	0.516	0.42
368_G	463_D	0.515	0.42
254_L	515_I	0.515	0.42
225_H	228_R	0.515	0.42
119_V	483_V	0.515	0.42
262_L	534_G	0.513	0.42
469_H	472_K	0.513	0.42
491_S	640_D	0.513	0.42
377_I	483_V	0.513	0.42
368_G	695_F	0.513	0.42
370_G	488_Q	0.512	0.42
114_T	123_G	0.512	0.42
377_I	624_K	0.512	0.42
24_I	294_D	0.512	0.42
342_M	382_E	0.512	0.42
553_G	672_T	0.511	0.42
644_I	673_K	0.511	0.42
429_I	461_M	0.510	0.42
535_L	538_N	0.510	0.42
621_T	644_I	0.510	0.42
371_T	512_L	0.510	0.42
332_L	335_L	0.510	0.42
412_G	466_L	0.510	0.42
749_T	752_K	0.510	0.42
435_W	626_L	0.509	0.42
147_K	159_Q	0.509	0.42
255_I	282_I	0.509	0.42
66_Y	293_E	0.508	0.41
313_V	364_L	0.508	0.41
592_N	680_T	0.508	0.41
738_G	741_N	0.508	0.41
539_N	672_T	0.508	0.41
598_L	601_I	0.508	0.41
482_I	710_L	0.507	0.41
500_D	590_G	0.507	0.41
743_D	753_N	0.506	0.41
162_E	167_S	0.506	0.41
139_D	156_Q	0.506	0.41
123_G	127_I	0.506	0.41
276_D	279_N	0.506	0.41
412_G	693_S	0.506	0.41
503_A	533_N	0.505	0.41
35_L	57_F	0.505	0.41
527_L	735_L	0.504	0.41
369_P	525_V	0.504	0.41
558_K	644_I	0.504	0.41
745_T	756_S	0.504	0.41
115_A	417_R	0.504	0.41
375_T	421_S	0.503	0.41
532_K	716_Y	0.503	0.41
711_R	744_A	0.503	0.41
559_E	562_E	0.503	0.41
349_S	512_L	0.502	0.41
364_L	531_M	0.502	0.41
302_L	481_I	0.502	0.41
209_F	412_G	0.501	0.41
290_I	667_N	0.501	0.41
117_E	482_I	0.501	0.41
194_Q	481_I	0.501	0.41
68_F	89_K	0.500	0.41

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3e1sA	1	0.6341	100	0.474	Contact Map
1w36D	1	0.5827	100	0.559	Contact Map
3upuA	1	0.4449	100	0.707	Contact Map
4l0jA	2	0.1667	100	0.772	Contact Map
2gk6A	1	0.6053	100	0.792	Contact Map
4n0nA	1	0.4737	100	0.8	Contact Map
1omhA	1	0.2544	100	0.807	Contact Map
3l6tA	2	0.1754	100	0.809	Contact Map
4pj3A	1	0.7719	100	0.81	Contact Map
2wjyA	1	0.7318	100	0.811	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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