GREMLIN Database
YCCF - Uncharacterized protein YccF
UniProt: O34478 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 358 (332)
Sequences: 162 (144)
Seq/√Len: 7.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_R19_K3.9150.97
6_R17_K3.5660.94
7_N17_K3.5460.94
10_C14_S3.1270.89
283_W306_Y3.0740.88
10_C13_G3.0390.88
12_C21_C2.9990.87
10_C21_C2.9990.87
7_N19_K2.9590.86
7_N15_G2.8320.84
14_S21_C2.7670.82
13_G21_C2.6280.79
17_K20_K2.6140.78
16_K19_K2.6050.78
8_A20_K2.5280.76
299_A333_T2.4420.73
174_I301_A2.4380.73
6_R15_G2.4350.73
12_C22_C2.3740.71
10_C22_C2.3740.71
7_N14_S2.3380.70
12_C15_G2.2960.68
10_C15_G2.2960.68
6_R16_K2.2800.68
6_R18_Y2.2580.67
7_N10_C2.2280.66
7_N12_C2.2280.66
18_Y21_C2.2140.65
14_S17_K2.1890.64
14_S19_K2.1780.64
7_N21_C2.1160.61
15_G19_K2.1140.61
7_N20_K2.1030.61
14_S22_C2.1010.61
7_N18_Y2.0980.61
250_W259_A2.0830.60
6_R20_K2.0310.58
6_R14_S2.0130.57
15_G21_C1.9980.57
10_C19_K1.9800.56
12_C19_K1.9800.56
305_E326_K1.9720.56
6_R10_C1.9300.54
6_R12_C1.9300.54
287_C303_A1.9020.53
10_C17_K1.8950.53
12_C17_K1.8950.53
13_G22_C1.8910.53
12_C16_K1.8770.52
10_C16_K1.8770.52
6_R21_C1.8520.51
305_E327_Y1.8390.50
12_C18_Y1.8020.49
10_C18_Y1.8020.49
7_N13_G1.7990.49
7_N16_K1.7570.47
17_K21_C1.7490.47
89_F172_Y1.7230.46
49_A85_W1.7050.45
44_D115_T1.6430.42
82_L89_F1.6340.42
16_K21_C1.6150.41
23_G183_F1.6040.41
283_W327_Y1.5760.40
15_G20_K1.5730.40
45_L296_K1.5720.40
14_S20_K1.5320.38
323_L331_A1.5290.38
280_I298_E1.5290.38
13_G18_Y1.5230.38
13_G19_K1.5140.37
14_S18_Y1.5130.37
41_I76_D1.4930.37
130_L308_V1.4890.37
6_R13_G1.4840.36
258_T283_W1.4440.35
13_G17_K1.4350.35
296_K332_S1.4230.34
99_F125_M1.4220.34
303_A341_I1.4210.34
13_G16_K1.4060.33
42_Q88_F1.3850.33
323_L334_I1.3700.32
127_P294_I1.3610.32
294_I337_R1.3500.31
97_T171_G1.3470.31
86_G285_T1.3410.31
283_W304_V1.3190.30
150_Q286_F1.3180.30
116_R303_A1.3120.30
112_R115_T1.3080.30
110_I115_T1.3080.30
16_K20_K1.3060.30
306_Y327_Y1.3010.30
134_D203_K1.2990.30
265_G327_Y1.2970.30
60_F82_L1.2930.29
8_A324_A1.2930.29
7_N22_C1.2920.29
85_W127_P1.2910.29
9_P20_K1.2860.29
175_H187_T1.2840.29
334_I338_Y1.2840.29
45_L295_R1.2790.29
283_W287_C1.2760.29
147_T201_V1.2720.29
18_Y22_C1.2710.29
8_A17_K1.2690.29
258_T301_A1.2670.29
119_V170_L1.2560.28
296_K329_V1.2510.28
173_P282_I1.2480.28
120_E297_P1.2340.28
9_P197_L1.2250.27
199_S327_Y1.2220.27
12_C20_K1.2090.27
10_C20_K1.2090.27
220_K341_I1.1980.26
324_A330_S1.1920.26
9_P14_S1.1910.26
303_A337_R1.1890.26
294_I303_A1.1880.26
187_T217_D1.1800.26
330_S346_Q1.1790.26
8_A11_P1.1790.26
330_S333_T1.1760.26
306_Y320_Q1.1650.25
286_F329_V1.1610.25
37_E115_T1.1600.25
292_P295_R1.1510.25
127_P283_W1.1380.25
87_I130_L1.1310.24
206_D286_F1.1310.24
122_W292_P1.1230.24
305_E316_A1.1200.24
142_F226_V1.1140.24
42_Q84_I1.1140.24
15_G22_C1.1050.24
199_S260_A1.1020.23
262_I279_V1.1000.23
87_I308_V1.0990.23
131_L143_E1.0900.23
88_F168_L1.0870.23
250_W287_C1.0850.23
89_F300_F1.0790.23
45_L48_Y1.0760.23
334_I340_E1.0740.23
44_D102_Y1.0650.22
88_F184_M1.0640.22
195_E286_F1.0560.22
25_K134_D1.0540.22
119_V212_G1.0530.22
137_E248_V1.0450.22
330_S336_S1.0360.22
85_W335_S1.0330.21
345_L348_E1.0280.21
64_H82_L1.0270.21
22_C119_V1.0170.21
86_G227_L1.0170.21
287_C294_I1.0170.21
102_Y214_T1.0050.21
129_L168_L1.0030.21
98_I172_Y1.0000.21
60_F86_G0.9930.20
85_W300_F0.9920.20
102_Y145_V0.9910.20
122_W174_I0.9890.20
103_L142_F0.9850.20
116_R321_A0.9770.20
45_L324_A0.9770.20
224_N246_S0.9750.20
6_R22_C0.9700.20
11_P21_C0.9670.20
283_W301_A0.9670.20
23_G189_F0.9660.20
132_L305_E0.9610.20
84_I186_F0.9550.19
173_P329_V0.9530.19
162_L323_L0.9520.19
115_T334_I0.9470.19
70_M88_F0.9440.19
128_A153_V0.9370.19
300_F306_Y0.9340.19
120_E332_S0.9320.19
166_G343_S0.9300.19
284_K333_T0.9260.19
109_S259_A0.9240.19
103_L153_V0.9200.19
296_K330_S0.9190.19
308_V320_Q0.9130.18
57_I258_T0.9090.18
70_M135_L0.9070.18
48_Y97_T0.9060.18
116_R336_S0.8940.18
15_G18_Y0.8940.18
11_P14_S0.8920.18
9_P12_C0.8910.18
56_S86_G0.8910.18
19_K22_C0.8890.18
172_Y300_F0.8890.18
262_I338_Y0.8880.18
145_V162_L0.8820.18
296_K299_A0.8820.18
125_M197_L0.8780.18
165_V197_L0.8780.18
210_K301_A0.8770.18
96_K148_A0.8730.17
98_I130_L0.8720.17
317_S323_L0.8700.17
9_P17_K0.8700.17
304_V308_V0.8680.17
283_W330_S0.8660.17
11_P23_G0.8620.17
292_P296_K0.8610.17
115_T326_K0.8590.17
294_I306_Y0.8580.17
71_D217_D0.8530.17
27_V32_E0.8530.17
252_N329_V0.8500.17
23_G129_L0.8490.17
122_W324_A0.8480.17
66_F99_F0.8480.17
8_A57_I0.8470.17
78_S173_P0.8430.17
69_A143_E0.8380.17
204_Y328_G0.8360.17
122_W286_F0.8360.17
44_D300_F0.8350.17
80_F266_M0.8350.17
122_W182_F0.8340.17
217_D251_A0.8340.17
337_R340_E0.8320.16
119_V273_T0.8300.16
162_L298_E0.8280.16
85_W122_W0.8280.16
17_K22_C0.8280.16
320_Q335_S0.8280.16
91_P98_I0.8260.16
109_S215_P0.8260.16
343_S348_E0.8240.16
262_I304_V0.8230.16
9_P19_K0.8170.16
130_L172_Y0.8160.16
38_A42_Q0.8050.16
115_T173_P0.8050.16
140_I214_T0.8010.16
128_A144_D0.7970.16
100_E348_E0.7950.16
256_K323_L0.7930.16
171_G214_T0.7930.16
153_V172_Y0.7910.16
119_V174_I0.7900.16
333_T339_K0.7900.16
36_K153_V0.7880.16
86_G127_P0.7850.15
45_L320_Q0.7840.15
82_L115_T0.7800.15
78_S185_Q0.7770.15
200_K268_G0.7760.15
296_K335_S0.7750.15
9_P13_G0.7730.15
219_M286_F0.7720.15
45_L99_F0.7720.15
102_Y263_E0.7680.15
326_K340_E0.7680.15
49_A320_Q0.7670.15
102_Y106_K0.7660.15
175_H329_V0.7650.15
84_I153_V0.7650.15
57_I213_K0.7630.15
94_G273_T0.7620.15
85_W223_F0.7610.15
261_A297_P0.7580.15
329_V334_I0.7560.15
127_P219_M0.7490.15
174_I177_A0.7480.15
137_E206_D0.7480.15
76_D109_S0.7460.15
56_S142_F0.7440.15
53_H250_W0.7440.15
76_D323_L0.7430.15
23_G132_L0.7410.15
16_K132_L0.7390.15
49_A153_V0.7360.14
204_Y218_F0.7350.14
96_K145_V0.7350.14
122_W296_K0.7310.14
271_Y323_L0.7310.14
9_P18_Y0.7270.14
330_S339_K0.7270.14
90_H130_L0.7260.14
56_S95_E0.7250.14
305_E337_R0.7250.14
177_A246_S0.7250.14
52_V150_Q0.7230.14
45_L245_V0.7210.14
131_L218_F0.7210.14
71_D157_A0.7200.14
9_P21_C0.7200.14
84_I184_M0.7190.14
18_Y25_K0.7180.14
122_W258_T0.7180.14
42_Q183_F0.7170.14
120_E123_Q0.7140.14
22_C44_D0.7130.14
231_L323_L0.7100.14
69_A137_E0.7050.14
98_I147_T0.7030.14
343_S346_Q0.6980.14
57_I301_A0.6980.14
243_A249_E0.6950.14
13_G20_K0.6940.14
42_Q153_V0.6940.14
58_S121_S0.6910.14
306_Y319_S0.6910.14
123_Q306_Y0.6890.14
191_V310_A0.6890.14
48_Y85_W0.6880.14
103_L187_T0.6870.13
133_K141_H0.6870.13
42_Q49_A0.6850.13
306_Y310_A0.6840.13
194_T341_I0.6840.13
45_L283_W0.6830.13
304_V329_V0.6810.13
201_V256_K0.6790.13
307_Y345_L0.6780.13
118_I139_I0.6760.13
148_A231_L0.6750.13
204_Y207_A0.6750.13
48_Y185_Q0.6740.13
24_S34_A0.6710.13
128_A258_T0.6680.13
16_K22_C0.6640.13
283_W300_F0.6630.13
169_I187_T0.6620.13
102_Y198_I0.6600.13
192_K261_A0.6570.13
202_K299_A0.6560.13
84_I87_I0.6540.13
320_Q338_Y0.6480.13
97_T306_Y0.6470.13
41_I86_G0.6460.13
214_T248_V0.6460.13
99_F110_I0.6450.13
6_R9_P0.6440.13
202_K231_L0.6430.13
303_A336_S0.6420.13
156_D171_G0.6410.13
47_E52_V0.6400.13
60_F64_H0.6400.13
141_H282_I0.6390.13
277_P322_K0.6390.13
89_F130_L0.6390.13
177_A332_S0.6380.13
75_K88_F0.6370.13
201_V325_K0.6340.13
48_Y101_E0.6320.12
72_R94_G0.6300.12
103_L132_L0.6290.12
41_I44_D0.6280.12
321_A325_K0.6270.12
129_L331_A0.6240.12
81_N86_G0.6240.12
303_A323_L0.6230.12
100_E148_A0.6230.12
52_V146_I0.6230.12
8_A13_G0.6210.12
207_A322_K0.6200.12
171_G242_K0.6200.12
294_I300_F0.6190.12
88_F99_F0.6190.12
45_L308_V0.6190.12
287_C324_A0.6180.12
258_T287_C0.6170.12
110_I160_Q0.6160.12
84_I172_Y0.6150.12
332_S348_E0.6150.12
127_P306_Y0.6150.12
80_F118_I0.6140.12
107_G348_E0.6100.12
143_E192_K0.6070.12
149_K302_A0.6040.12
79_V86_G0.6040.12
88_F272_P0.6030.12
296_K336_S0.6030.12
296_K333_T0.6020.12
149_K205_A0.6010.12
231_L274_E0.5990.12
320_Q325_K0.5980.12
78_S266_M0.5970.12
83_G172_Y0.5970.12
175_H279_V0.5970.12
257_E297_P0.5960.12
26_V133_K0.5960.12
188_I333_T0.5950.12
189_F262_I0.5950.12
153_V343_S0.5940.12
336_S339_K0.5930.12
299_A304_V0.5920.12
57_I269_E0.5910.12
129_L151_F0.5900.12
92_L229_A0.5890.12
330_S337_R0.5880.12
341_I345_L0.5860.12
102_Y259_A0.5860.12
320_Q334_I0.5860.12
88_F91_P0.5840.12
90_H140_I0.5830.12
70_M251_A0.5800.12
127_P224_N0.5780.12
85_W98_I0.5770.12
49_A95_E0.5760.12
191_V289_K0.5740.11
300_F347_D0.5740.11
147_T334_I0.5740.11
125_M302_A0.5720.11
24_S327_Y0.5720.11
11_P328_G0.5710.11
153_V221_Q0.5710.11
165_V290_K0.5700.11
175_H286_F0.5670.11
13_G37_E0.5660.11
81_N175_H0.5650.11
103_L173_P0.5640.11
192_K323_L0.5640.11
48_Y137_E0.5640.11
94_G119_V0.5620.11
48_Y222_E0.5600.11
82_L122_W0.5590.11
45_L306_Y0.5590.11
225_N333_T0.5580.11
194_T279_V0.5570.11
217_D322_K0.5560.11
173_P183_F0.5540.11
48_Y74_T0.5500.11
35_A324_A0.5490.11
124_S203_K0.5480.11
73_Q286_F0.5470.11
97_T302_A0.5450.11
82_L300_F0.5450.11
130_L194_T0.5440.11
329_V336_S0.5440.11
92_L275_L0.5430.11
84_I88_F0.5420.11
201_V212_G0.5420.11
64_H340_E0.5410.11
104_Q325_K0.5400.11
57_I75_K0.5400.11
142_F187_T0.5390.11
254_L303_A0.5370.11
302_A330_S0.5370.11
258_T300_F0.5360.11
91_P121_S0.5360.11
116_R334_I0.5340.11
320_Q333_T0.5330.11
122_W190_P0.5300.11
132_L169_I0.5290.11
49_A297_P0.5290.11
70_M276_I0.5280.11
219_M248_V0.5270.11
147_T293_V0.5240.11
144_D219_M0.5220.11
253_D339_K0.5210.11
99_F287_C0.5200.11
164_P174_I0.5200.11
25_K278_A0.5200.11
49_A182_F0.5190.11
129_L180_A0.5190.11
121_S174_I0.5170.11
117_E333_T0.5170.11
49_A266_M0.5170.11
210_K245_V0.5160.11
148_A280_I0.5150.11
169_I172_Y0.5140.11
282_I307_Y0.5140.11
247_T266_M0.5140.11
198_I308_V0.5140.11
192_K219_M0.5130.11
295_R333_T0.5120.10
329_V340_E0.5120.10
164_P295_R0.5110.10
142_F149_K0.5100.10
141_H144_D0.5080.10
48_Y107_G0.5080.10
73_Q266_M0.5080.10
252_N289_K0.5070.10
178_E337_R0.5070.10
35_A38_A0.5070.10
80_F84_I0.5070.10
323_L327_Y0.5050.10
253_D341_I0.5040.10
63_Q150_Q0.5040.10
35_A181_E0.5040.10
168_L188_I0.5020.10
90_H170_L0.5020.10
295_R332_S0.5020.10
114_K266_M0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ozbI 1 0.067 99 0.878 Contact Map
2jq5A 1 0.3045 98.2 0.905 Contact Map
1aisB 1 0.5363 96.5 0.93 Contact Map
1c9bA 1 0.4944 96.1 0.933 Contact Map
3g33B 2 0.5223 93.6 0.942 Contact Map
4bbrM 1 0.3855 92.9 0.944 Contact Map
2i9wA 1 0.3408 92 0.945 Contact Map
2w96A 1 0.5866 91.4 0.946 Contact Map
4gfkA 2 0.176 91.3 0.946 Contact Map
4ac0A 2 0.1788 90.8 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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