GREMLIN Database
CYSM - Probable cysteine synthase
UniProt: O34476 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (282)
Sequences: 21337 (11196)
Seq/√Len: 666.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_A91_A3.9421.00
129_K132_E3.3731.00
30_Q290_V3.3481.00
19_R30_Q3.0541.00
163_I292_V2.5761.00
258_R262_E2.5701.00
176_A204_H2.5651.00
251_D280_E2.5621.00
101_K105_N2.5581.00
55_E59_N2.5211.00
14_D165_R2.4211.00
67_V92_I2.4131.00
209_A248_S2.3901.00
90_K113_E2.3291.00
55_E150_A2.2991.00
97_D118_P2.2841.00
57_E89_Y2.2761.00
202_T243_E2.2371.00
92_I113_E2.2321.00
132_E136_Q2.1881.00
94_V133_L2.1711.00
14_D166_A2.0551.00
191_G240_V2.0121.00
210_G249_D2.0041.00
54_I87_R2.0021.00
274_A293_C1.9851.00
32_Y290_V1.9791.00
248_S251_D1.9701.00
286_S289_K1.9691.00
92_I115_V1.9631.00
161_P193_A1.9621.00
198_F201_I1.9371.00
191_G203_V1.9251.00
147_D234_P1.9091.00
215_S219_P1.9031.00
17_L292_V1.8831.00
156_R196_E1.8621.00
57_E60_G1.8101.00
177_F194_L1.7951.00
181_S205_V1.7721.00
212_P216_G1.7571.00
206_V277_A1.7531.00
204_H243_E1.7271.00
156_R192_E1.7051.00
41_S82_M1.6931.00
144_M147_D1.6891.00
259_L267_V1.6871.00
131_K135_E1.6871.00
32_Y167_I1.6301.00
174_L292_V1.6171.00
255_T276_F1.6141.00
19_R32_Y1.5961.00
259_L275_C1.5841.00
258_R279_I1.5761.00
177_F190_T1.5561.00
175_G290_V1.5491.00
195_K242_D1.5461.00
175_G289_K1.5461.00
243_E284_R1.5391.00
104_I116_L1.5311.00
19_R24_Q1.4981.00
72_T77_G1.4811.00
57_E87_R1.4791.00
164_A197_L1.4731.00
33_L295_T1.4711.00
160_A190_T1.4661.00
227_T273_A1.4621.00
50_Y54_I1.4581.00
105_N108_K1.4411.00
176_A289_K1.3981.00
176_A286_S1.3971.00
160_A194_L1.3951.00
127_I131_K1.3921.00
187_I241_Y1.3781.00
104_I108_K1.3771.00
115_V129_K1.3691.00
255_T279_I1.3681.00
52_M148_N1.3581.00
67_V90_K1.3141.00
178_V281_T1.3101.00
216_G219_P1.3041.00
101_K104_I1.2901.00
178_V206_V1.2901.00
134_A142_I1.2871.00
176_A202_T1.2841.00
26_E258_R1.2791.00
276_F280_E1.2741.00
251_D276_F1.2681.00
172_K290_V1.2631.00
54_I58_Q1.2571.00
124_P128_K1.2561.00
95_M107_L1.2551.00
55_E58_Q1.2441.00
209_A246_K1.2321.00
192_E237_N1.2151.00
215_S246_K1.2141.00
107_L112_A1.2141.00
51_Q157_K1.2121.00
160_A193_A1.2121.00
26_E262_E1.2121.00
281_T284_R1.2091.00
104_I114_V1.2031.00
255_T275_C1.1981.00
20_L33_L1.1901.00
193_A197_L1.1871.00
22_R263_E1.1831.00
167_I174_L1.1771.00
267_V295_T1.1701.00
131_K134_A1.1691.00
187_I203_V1.1641.00
194_L201_I1.1541.00
254_T258_R1.1511.00
271_S295_T1.1461.00
161_P165_R1.1441.00
77_G107_L1.1431.00
94_V129_K1.1381.00
18_V35_L1.1331.00
53_I68_I1.1281.00
212_P246_K1.1251.00
164_A193_A1.1231.00
17_L167_I1.1081.00
16_P38_F1.1061.00
17_L163_I1.1021.00
247_I276_F1.0971.00
51_Q154_A1.0901.00
125_G128_K1.0901.00
128_K131_K1.0881.00
251_D254_T1.0851.00
98_T119_G1.0841.00
97_D119_G1.0821.00
173_P290_V1.0811.00
212_P217_G1.0781.00
216_G220_G1.0721.00
260_A266_L1.0681.00
224_L252_A1.0671.00
245_I277_A1.0661.00
205_V244_I1.0621.00
223_K253_Y1.0501.00
95_M116_L1.0471.00
128_K132_E1.0461.00
187_I205_V1.0451.00
281_T285_L1.0341.00
51_Q55_E1.0271.00
59_N150_A1.0251.00
250_E254_T1.0241.00
280_E283_K1.0241.00
204_H245_I1.0221.00
51_Q54_I1.0201.00
68_I84_A1.0071.00
53_I87_R0.9981.00
167_I292_V0.9971.00
49_A79_G0.9931.00
21_N25_P0.9881.00
163_I174_L0.9871.00
80_L91_A0.9851.00
267_V271_S0.9821.00
218_K244_I0.9801.00
176_A291_V0.9751.00
66_S139_N0.9721.00
155_H159_T0.9691.00
257_R261_A0.9671.00
133_L138_P0.9621.00
28_A287_P0.9591.00
164_A198_F0.9591.00
168_E173_P0.9551.00
85_A91_A0.9541.00
53_I83_N0.9531.00
79_G83_N0.9531.00
129_K133_L0.9501.00
31_V278_A0.9461.00
52_M143_P0.9461.00
29_A289_K0.9461.00
22_R262_E0.9421.00
108_K113_E0.9421.00
245_I280_E0.9401.00
29_A288_D0.9401.00
212_P215_S0.9361.00
82_M110_Y0.9361.00
256_T272_G0.9221.00
81_A112_A0.9211.00
190_T294_M0.9111.00
202_T242_D0.9111.00
120_E125_G0.9061.00
278_A293_C0.9051.00
132_E135_E0.9001.00
232_I235_I0.8951.00
24_Q27_N0.8921.00
134_A140_S0.8911.00
282_A285_L0.8911.00
181_S187_I0.8831.00
222_H228_S0.8821.00
69_I130_A0.8771.00
69_I140_S0.8741.00
188_T235_I0.8731.00
69_I133_L0.8731.00
178_V278_A0.8721.00
156_R193_A0.8711.00
22_R25_P0.8651.00
70_E93_L0.8621.00
56_A141_Y0.8561.00
35_L295_T0.8541.00
157_K161_P0.8501.00
11_L50_Y0.8501.00
193_A196_E0.8491.00
271_S296_A0.8481.00
161_P197_L0.8461.00
227_T270_S0.8391.00
275_C295_T0.8371.00
179_A190_T0.8361.00
266_L299_G0.8301.00
274_A296_A0.8251.00
152_P235_I0.8201.00
255_T258_R0.8171.00
105_N109_A0.8161.00
15_T39_N0.8111.00
67_V140_S0.8061.00
223_K249_D0.8021.00
92_I140_S0.7991.00
92_I133_L0.7971.00
178_V204_H0.7881.00
108_K116_L0.7841.00
187_I237_N0.7831.00
167_I172_K0.7831.00
20_L275_C0.7831.00
154_A157_K0.7811.00
215_S244_I0.7761.00
159_T190_T0.7741.00
176_A285_L0.7731.00
214_L244_I0.7721.00
218_K221_A0.7721.00
65_G139_N0.7711.00
213_V230_G0.7691.00
176_A281_T0.7671.00
275_C293_C0.7671.00
178_V277_A0.7671.00
130_A134_A0.7591.00
78_I107_L0.7571.00
202_T289_K0.7561.00
159_T186_T0.7541.00
66_S90_K0.7541.00
164_A194_L0.7541.00
82_M86_A0.7511.00
85_A110_Y0.7491.00
51_Q150_A0.7491.00
211_S217_G0.7461.00
69_I134_A0.7431.00
217_G221_A0.7421.00
35_L38_F0.7411.00
57_E61_L0.7381.00
192_E196_E0.7371.00
130_A142_I0.7321.00
280_E284_R0.7261.00
23_L279_I0.7231.00
267_V272_G0.7221.00
253_Y269_P0.7211.00
174_L201_I0.7201.00
167_I290_V0.7201.00
20_L263_E0.7131.00
29_A291_V0.7121.00
27_N258_R0.7121.00
78_I106_L0.7111.00
237_N240_V0.7101.00
279_I283_K0.7091.00
123_M126_S0.7081.00
180_S296_A0.7051.00
238_E241_Y0.7051.00
159_T163_I0.7051.00
190_T194_L0.7031.00
61_L89_Y0.7011.00
21_N24_Q0.7011.00
56_A60_G0.7001.00
33_L293_C0.6941.00
181_S244_I0.6921.00
164_A168_E0.6921.00
285_L289_K0.6911.00
216_G221_A0.6891.00
159_T294_M0.6891.00
44_V186_T0.6871.00
33_L275_C0.6841.00
68_I89_Y0.6821.00
93_L107_L0.6821.00
133_L136_Q0.6801.00
25_P28_A0.6781.00
117_T129_K0.6781.00
245_I284_R0.6771.00
177_F294_M0.6751.00
243_E281_T0.6711.00
173_P198_F0.6701.00
152_P192_E0.6691.00
252_A273_A0.6681.00
214_L237_N0.6681.00
119_G125_G0.6671.00
91_A112_A0.6671.00
30_Q288_D0.6671.00
144_M148_N0.6661.00
71_P142_I0.6631.00
12_I46_D0.6611.00
94_V115_V0.6611.00
49_A83_N0.6591.00
97_D116_L0.6591.00
213_V216_G0.6581.00
90_K140_S0.6551.00
24_Q30_Q0.6521.00
168_E172_K0.6461.00
55_E61_L0.6411.00
52_M150_A0.6401.00
165_R197_L0.6391.00
103_R225_V0.6371.00
42_G298_T0.6371.00
237_N241_Y0.6361.00
178_V291_V0.6331.00
101_K108_K0.6311.00
68_I143_P0.6301.00
94_V117_T0.6301.00
65_G90_K0.6301.00
27_N279_I0.6281.00
125_G129_K0.6261.00
177_F201_I0.6261.00
48_A52_M0.6261.00
174_L290_V0.6251.00
141_Y148_N0.6231.00
208_P227_T0.6221.00
99_M104_I0.6221.00
20_L23_L0.6211.00
61_L141_Y0.6191.00
71_P123_M0.6191.00
17_L32_Y0.6191.00
13_G40_P0.6181.00
69_I94_V0.6151.00
226_G270_S0.6141.00
126_S130_A0.6131.00
34_K162_E0.6111.00
221_A238_E0.6111.00
127_I130_A0.6091.00
95_M104_I0.6091.00
249_D253_Y0.6081.00
23_L275_C0.6071.00
149_T152_P0.6061.00
259_L295_T0.6061.00
259_L263_E0.6051.00
152_P236_L0.6041.00
74_G77_G0.6041.00
204_H281_T0.6021.00
154_A192_E0.5971.00
271_S274_A0.5961.00
46_D82_M0.5951.00
256_T269_P0.5941.00
180_S274_A0.5931.00
52_M151_N0.5921.00
99_M225_V0.5921.00
179_A187_I0.5911.00
164_A167_I0.5901.00
81_A107_L0.5881.00
259_L265_I0.5861.00
163_I190_T0.5861.00
206_V273_A0.5841.00
12_I50_Y0.5811.00
134_A138_P0.5801.00
133_L140_S0.5791.00
213_V217_G0.5771.00
29_A282_A0.5761.00
224_L227_T0.5741.00
95_M99_M0.5731.00
206_V245_I0.5721.00
35_L265_I0.5701.00
195_K240_V0.5681.00
277_A281_T0.5661.00
68_I91_A0.5651.00
37_F298_T0.5651.00
77_G93_L0.5641.00
24_Q31_V0.5631.00
195_K239_D0.5621.00
41_S110_Y0.5601.00
13_G39_N0.5591.00
131_K142_I0.5591.00
23_L258_R0.5581.00
188_T192_E0.5581.00
92_I138_P0.5571.00
124_P127_I0.5551.00
205_V241_Y0.5541.00
106_L109_A0.5531.00
81_A91_A0.5491.00
123_M145_Q0.5491.00
52_M141_Y0.5491.00
181_S214_L0.5471.00
23_L27_N0.5461.00
24_Q28_A0.5461.00
48_A76_T0.5461.00
177_F203_V0.5441.00
23_L255_T0.5431.00
40_P46_D0.5431.00
17_L166_A0.5421.00
72_T93_L0.5421.00
150_A154_A0.5401.00
11_L38_F0.5381.00
275_C279_I0.5381.00
152_P188_T0.5291.00
24_Q29_A0.5281.00
40_P82_M0.5250.99
23_L262_E0.5250.99
26_E279_I0.5250.99
129_K136_Q0.5230.99
254_T257_R0.5210.99
11_L54_I0.5200.99
67_V113_E0.5190.99
71_P143_P0.5170.99
167_I173_P0.5150.99
113_E138_P0.5140.99
80_L93_L0.5140.99
20_L24_Q0.5130.99
70_E80_L0.5130.99
209_A212_P0.5130.99
207_E213_V0.5120.99
270_S273_A0.5080.99
231_F234_P0.5070.99
123_M229_P0.5070.99
71_P127_I0.5070.99
204_H242_D0.5060.99
154_A158_T0.5040.99
29_A287_P0.5010.99
58_Q65_G0.5000.99
37_F265_I0.5000.99
76_T156_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q3bA 2 0.9614 100 0.137 Contact Map
2eguA 2 0.8682 100 0.137 Contact Map
2pqmA 2 0.9871 100 0.14 Contact Map
4r2vA 2 0.9775 100 0.141 Contact Map
1y7lA 2 0.9678 100 0.143 Contact Map
4ql4A 2 0.8778 100 0.143 Contact Map
3tbhA 2 0.9871 100 0.145 Contact Map
3vc3A 2 0.9904 100 0.151 Contact Map
4aecA 2 0.9904 100 0.151 Contact Map
1ve1A 2 0.9614 100 0.153 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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