GREMLIN Database
YFKO - Putative NAD(P)H nitroreductase YfkO
UniProt: O34475 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 221 (197)
Sequences: 7820 (6011)
Seq/√Len: 428.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_D25_K4.6361.00
34_F161_I4.0631.00
29_D57_Q3.1371.00
28_S31_D3.0471.00
29_D33_E2.9141.00
25_K201_Y2.8011.00
53_F150_A2.7321.00
164_D202_R2.4681.00
35_I158_A2.4081.00
59_P63_E2.3921.00
64_K179_I2.3651.00
177_H193_I2.2681.00
163_V201_Y2.2241.00
37_E40_R2.1481.00
38_T157_A2.0001.00
151_L195_V1.9931.00
61_F64_K1.9221.00
31_D163_V1.9171.00
31_D161_I1.8621.00
20_E203_V1.8511.00
22_D203_V1.8171.00
7_Q10_D1.7891.00
14_F159_A1.7631.00
68_Y179_I1.7421.00
13_N41_L1.7231.00
68_Y175_H1.7081.00
175_H178_R1.7071.00
155_M167_P1.7031.00
158_A199_F1.6941.00
39_G154_M1.6721.00
155_M165_S1.6601.00
8_I11_A1.6441.00
10_D14_F1.6361.00
8_I12_Y1.5661.00
65_L176_I1.5631.00
155_M197_V1.5621.00
33_E215_E1.5601.00
214_V218_V1.5591.00
6_T10_D1.5571.00
159_A164_D1.5391.00
66_R77_P1.5371.00
61_F179_I1.5261.00
112_Q116_E1.5261.00
59_P62_R1.5151.00
21_F198_A1.5131.00
212_S216_D1.4761.00
60_E63_E1.4621.00
63_E67_E1.4401.00
9_L13_N1.4351.00
35_I154_M1.4321.00
52_K191_F1.4291.00
95_Y99_Y1.4291.00
145_K148_Y1.4181.00
158_A165_S1.4111.00
151_L197_V1.3821.00
35_I199_F1.3801.00
35_I163_V1.3551.00
17_A166_C1.3501.00
147_T194_S1.3461.00
74_K78_T1.3201.00
38_T161_I1.3111.00
163_V199_F1.3071.00
58_N61_F1.3041.00
64_K67_E1.2991.00
123_E127_K1.2991.00
9_L38_T1.2961.00
149_I152_G1.2871.00
40_R217_V1.2721.00
172_Q175_H1.2551.00
9_L161_I1.2511.00
36_L218_V1.2461.00
53_F83_V1.2451.00
26_K57_Q1.2121.00
99_Y103_H1.2111.00
9_L34_F1.2081.00
97_A101_K1.2031.00
99_Y102_R1.2011.00
101_K105_K1.2001.00
145_K169_E1.1741.00
27_V163_V1.1731.00
12_Y153_N1.1711.00
31_D201_Y1.1361.00
174_D178_R1.1311.00
31_D34_F1.1171.00
33_E37_E1.0691.00
165_S199_F1.0671.00
165_S197_V1.0521.00
74_K77_P1.0511.00
13_N37_E1.0451.00
95_Y98_D1.0401.00
90_A93_I1.0361.00
154_M197_V1.0341.00
154_M199_F1.0311.00
42_S153_N1.0261.00
32_F199_F1.0201.00
21_F166_C0.9971.00
30_S33_E0.9971.00
144_S194_S0.9931.00
140_F192_D0.9891.00
96_N99_Y0.9861.00
27_V31_D0.9801.00
96_N100_I0.9801.00
27_V201_Y0.9711.00
10_D13_N0.9681.00
111_P114_V0.9631.00
107_V110_M0.9591.00
60_E64_K0.9571.00
36_L39_G0.9561.00
175_H179_I0.9481.00
83_V154_M0.9481.00
8_I156_T0.9461.00
33_E214_V0.9441.00
86_L191_F0.9411.00
120_S123_E0.9171.00
45_S142_W0.9141.00
153_N156_T0.9131.00
34_F38_T0.9041.00
7_Q160_Q0.9021.00
123_E126_Q0.8981.00
28_S201_Y0.8961.00
6_T160_Q0.8931.00
110_M114_V0.8911.00
79_A82_F0.8891.00
89_T92_D0.8891.00
63_E77_P0.8881.00
98_D101_K0.8881.00
166_C198_A0.8801.00
202_R205_D0.8691.00
55_V218_V0.8691.00
26_K59_P0.8681.00
36_L55_V0.8561.00
116_E119_L0.8541.00
37_E214_V0.8491.00
113_D116_E0.8411.00
11_A160_Q0.8391.00
34_F37_E0.8371.00
114_V117_G0.8371.00
120_S124_E0.8361.00
20_E204_R0.8331.00
35_I161_I0.8311.00
67_E71_G0.8291.00
45_S169_E0.8281.00
22_D201_Y0.8271.00
64_K68_Y0.8231.00
18_T206_P0.8211.00
63_E66_R0.8211.00
121_K124_E0.8161.00
75_Q78_T0.8141.00
39_G53_F0.8031.00
176_I193_I0.8011.00
116_E120_S0.8001.00
44_S51_W0.7991.00
141_D145_K0.7981.00
177_H192_D0.7971.00
78_T81_H0.7961.00
32_F81_H0.7941.00
77_P80_S0.7911.00
119_L122_T0.7901.00
8_I160_Q0.7901.00
27_V30_S0.7821.00
107_V111_P0.7811.00
135_S138_T0.7791.00
32_F36_L0.7781.00
173_Y193_I0.7771.00
185_L189_G0.7761.00
141_D144_S0.7751.00
167_P195_V0.7731.00
110_M113_D0.7691.00
142_W169_E0.7691.00
85_I88_R0.7681.00
115_Y118_Y0.7651.00
213_A216_D0.7591.00
54_V86_L0.7581.00
54_V180_L0.7571.00
85_I154_M0.7531.00
121_K126_Q0.7421.00
100_I104_L0.7371.00
113_D117_G0.7361.00
98_D102_R0.7331.00
112_Q115_Y0.7331.00
97_A100_I0.7221.00
18_T202_R0.7211.00
185_L191_F0.7211.00
108_K114_V0.7191.00
53_F85_I0.7171.00
157_A160_Q0.7171.00
150_A217_V0.7091.00
188_N191_F0.7081.00
120_S126_Q0.6941.00
73_Q77_P0.6931.00
69_T196_M0.6921.00
56_V180_L0.6911.00
32_F55_V0.6861.00
122_T126_Q0.6851.00
145_K194_S0.6851.00
124_E127_K0.6821.00
56_V61_F0.6821.00
87_A91_K0.6791.00
144_S148_Y0.6781.00
88_R91_K0.6781.00
54_V191_F0.6761.00
71_G175_H0.6681.00
80_S84_L0.6661.00
40_R53_F0.6621.00
176_I179_I0.6611.00
149_I153_N0.6600.99
117_G121_K0.6570.99
20_E206_P0.6560.99
108_K113_D0.6550.99
19_K75_Q0.6540.99
110_M115_Y0.6530.99
146_Q169_E0.6530.99
145_K195_V0.6510.99
68_Y176_I0.6500.99
151_L167_P0.6500.99
73_Q76_L0.6480.99
76_L79_A0.6470.99
118_Y121_K0.6450.99
102_R107_V0.6440.99
144_S192_D0.6400.99
12_Y160_Q0.6390.99
69_T76_L0.6390.99
84_L196_M0.6280.99
51_W147_T0.6270.99
171_F196_M0.6220.99
69_T176_I0.6220.99
85_I89_T0.6200.99
87_A143_A0.6200.99
27_V32_F0.6200.99
55_V81_H0.6200.99
110_M118_Y0.6180.99
100_I103_H0.6160.99
98_D216_D0.6110.99
177_H185_L0.6110.99
65_L180_L0.6100.99
35_I157_A0.6060.99
119_L123_E0.6050.99
30_S34_F0.6030.99
154_M165_S0.6020.99
6_T11_A0.5980.99
105_K109_Q0.5960.99
99_Y104_L0.5930.99
173_Y177_H0.5870.99
82_F198_A0.5830.99
66_R73_Q0.5790.99
75_Q79_A0.5780.99
204_R207_R0.5760.99
79_A83_V0.5760.99
31_D35_I0.5720.99
174_D177_H0.5720.99
44_S50_P0.5700.99
91_K95_Y0.5690.99
13_N38_T0.5670.98
44_S49_E0.5650.98
11_A156_T0.5610.98
185_L193_I0.5590.98
35_I39_G0.5590.98
89_T192_D0.5580.98
212_S217_V0.5570.98
97_A102_R0.5520.98
168_I198_A0.5510.98
148_Y152_G0.5480.98
20_E205_D0.5430.98
102_R105_K0.5430.98
151_L155_M0.5430.98
88_R92_D0.5350.98
22_D204_R0.5350.98
19_K166_C0.5340.98
12_Y38_T0.5340.98
32_F57_Q0.5340.98
107_V113_D0.5330.98
185_L188_N0.5320.98
111_P115_Y0.5320.98
154_M157_A0.5290.98
190_S193_I0.5280.98
108_K112_Q0.5280.98
142_W145_K0.5250.97
180_L185_L0.5250.97
28_S33_E0.5240.97
81_H84_L0.5230.97
61_F180_L0.5220.97
41_L208_P0.5220.97
152_G156_T0.5210.97
45_S146_Q0.5210.97
101_K104_L0.5190.97
117_G120_S0.5170.97
157_A161_I0.5160.97
87_A90_A0.5100.97
110_M116_E0.5100.97
148_Y167_P0.5100.97
16_H208_P0.5040.97
145_K149_I0.5030.97
138_T142_W0.5030.97
61_F68_Y0.5020.97
111_P117_G0.5010.97
177_H189_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hayA 2 0.9774 100 0.227 Contact Map
3ge6A 2 0.9502 100 0.232 Contact Map
3of4A 3 0.9186 100 0.237 Contact Map
4qlxA 2 0.9502 100 0.243 Contact Map
3gbhA 3 0.9457 100 0.244 Contact Map
3gagA 4 0.9276 100 0.247 Contact Map
2h0uA 2 0.8778 100 0.249 Contact Map
3bemA 2 0.9412 100 0.251 Contact Map
1noxA 2 0.905 100 0.252 Contact Map
1icrA 2 0.9367 100 0.255 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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