GREMLIN Database
YOEA - Probable multidrug resistance protein YoeA
UniProt: O34474 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 463 (424)
Sequences: 18332 (13794)
Seq/√Len: 669.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_N95_R4.7351.00
152_F214_I3.8881.00
60_S288_G3.3451.00
141_N203_Y3.3321.00
85_G313_A3.1971.00
354_L367_A3.0681.00
349_F352_Q3.0081.00
123_L140_A2.9951.00
249_V253_R2.9411.00
168_D171_T2.7991.00
320_E323_R2.7691.00
121_F124_D2.6951.00
123_L127_R2.6381.00
189_V194_M2.4961.00
80_S103_T2.4831.00
245_K249_V2.4801.00
46_A191_I2.4771.00
182_I215_A2.4641.00
145_I203_Y2.4501.00
140_A144_R2.4011.00
87_A95_R2.3471.00
396_T448_Y2.3471.00
46_A188_P2.2991.00
58_A138_V2.2891.00
54_D134_N2.2331.00
20_R24_L2.1971.00
308_V331_G2.1811.00
179_S216_T2.1451.00
175_T219_V2.0981.00
132_P281_S2.0971.00
98_A244_D2.0891.00
426_E429_G2.0771.00
138_V141_N2.0551.00
145_I206_A2.0531.00
329_R333_W2.0361.00
286_A366_I2.0241.00
155_L217_F1.9991.00
361_Q365_Y1.9931.00
315_S323_R1.9711.00
43_G209_T1.9631.00
350_S372_M1.9611.00
149_A210_V1.9471.00
191_I205_S1.9291.00
203_Y207_Y1.9201.00
369_R428_L1.9131.00
200_L207_Y1.9081.00
362_E365_Y1.8981.00
30_L303_S1.8821.00
137_H141_N1.8751.00
53_V360_E1.8721.00
52_G55_A1.8581.00
47_V205_S1.8571.00
87_A92_N1.8281.00
46_A187_L1.8281.00
351_H368_H1.8241.00
107_T158_A1.8111.00
27_V31_L1.7791.00
189_V193_G1.7621.00
194_M199_K1.7331.00
170_K174_Y1.7331.00
218_L222_V1.7281.00
87_A90_A1.6951.00
122_T140_A1.6951.00
148_Y151_P1.6931.00
193_G199_K1.6901.00
181_V185_A1.6831.00
350_S368_H1.6761.00
380_L439_A1.6711.00
175_T220_L1.6581.00
311_F327_V1.6511.00
26_L307_A1.6401.00
145_I207_Y1.6351.00
152_F217_F1.6291.00
316_I394_S1.6291.00
326_Q329_R1.6221.00
127_R136_I1.6151.00
282_N362_E1.6141.00
347_Y372_M1.6141.00
328_I387_I1.6141.00
244_D247_L1.5961.00
326_Q330_V1.5741.00
325_K329_R1.5731.00
316_I324_L1.5691.00
83_L99_V1.5691.00
335_N382_G1.5671.00
187_L205_S1.5551.00
188_P192_L1.5161.00
42_V184_I1.5111.00
351_H355_S1.5041.00
188_P194_M1.5001.00
315_S320_E1.4821.00
118_G147_F1.4811.00
124_D127_R1.4771.00
145_I210_V1.4701.00
115_A151_P1.4641.00
186_L208_A1.4621.00
136_I140_A1.4521.00
122_T144_R1.4501.00
190_L194_M1.4451.00
343_I347_Y1.4441.00
352_Q355_S1.4251.00
185_A189_V1.4171.00
126_L136_I1.4151.00
62_F143_A1.4141.00
159_Y220_L1.4111.00
322_D326_Q1.4091.00
425_L429_G1.4011.00
43_G183_N1.4001.00
123_L137_H1.4001.00
18_V311_F1.3981.00
328_I390_T1.3981.00
396_T399_W1.3971.00
95_R98_A1.3961.00
185_A188_P1.3951.00
19_W330_V1.3871.00
134_N137_H1.3871.00
133_E137_H1.3851.00
443_L447_G1.3831.00
182_I186_L1.3821.00
373_I432_V1.3791.00
127_R133_E1.3771.00
93_E97_K1.3751.00
190_L200_L1.3701.00
174_Y178_V1.3631.00
203_Y206_A1.3581.00
134_N281_S1.3531.00
94_E98_A1.3481.00
57_A285_A1.3411.00
368_H372_M1.3381.00
31_L173_F1.3381.00
35_L177_I1.3331.00
89_G317_G1.3321.00
333_W337_I1.3281.00
47_V59_V1.3281.00
222_V226_K1.3261.00
355_S364_L1.3201.00
87_A99_V1.3081.00
418_V422_Y1.3051.00
406_F410_G1.3021.00
347_Y375_L1.3021.00
86_Q313_A1.3011.00
88_Y314_Q1.2961.00
352_Q356_L1.2751.00
335_N386_I1.2741.00
246_E249_V1.2701.00
55_A138_V1.2691.00
86_Q90_A1.2641.00
88_Y96_L1.2611.00
321_F325_K1.2571.00
175_T223_Y1.2421.00
123_L136_I1.2361.00
398_L402_V1.2341.00
186_L211_I1.2321.00
44_M292_Q1.2291.00
95_R247_L1.2291.00
365_Y369_R1.2211.00
399_W448_Y1.2201.00
344_I348_V1.2191.00
447_G450_Q1.2161.00
354_L364_L1.2121.00
411_V440_V1.2071.00
188_P191_I1.2071.00
183_N209_T1.2061.00
19_W334_L1.2021.00
124_D128_L1.2001.00
49_R359_T1.1961.00
102_T243_M1.1851.00
187_L208_A1.1851.00
51_L55_A1.1801.00
293_V353_I1.1731.00
119_S144_R1.1631.00
243_M248_L1.1611.00
417_F421_H1.1591.00
425_L432_V1.1541.00
102_T248_L1.1511.00
49_R192_L1.1421.00
178_V219_V1.1411.00
115_A119_S1.1351.00
429_G433_G1.1311.00
86_Q395_G1.1261.00
168_D172_P1.1241.00
305_G389_A1.1201.00
58_A135_V1.1201.00
44_M56_V1.1171.00
53_V282_N1.1161.00
283_A427_I1.1121.00
126_L139_S1.1071.00
17_S20_R1.0961.00
419_L425_L1.0951.00
256_V260_I1.0911.00
59_V202_I1.0881.00
190_L211_I1.0871.00
22_M331_G1.0841.00
312_A324_L1.0831.00
106_F248_L1.0741.00
190_L193_G1.0721.00
290_V370_L1.0661.00
54_D138_V1.0651.00
84_I165_G1.0591.00
43_G187_L1.0561.00
414_P418_V1.0561.00
182_I212_S1.0551.00
100_V162_F1.0551.00
364_L367_A1.0541.00
328_I449_Y1.0491.00
366_I369_R1.0471.00
54_D281_S1.0441.00
188_P193_G1.0441.00
337_I341_V1.0431.00
384_A438_F1.0351.00
171_T223_Y1.0341.00
358_L363_T1.0281.00
402_V406_F1.0241.00
89_G318_A1.0121.00
167_G314_Q1.0061.00
410_G414_P0.9941.00
107_T154_F0.9921.00
387_I449_Y0.9891.00
422_Y425_L0.9881.00
103_T251_L0.9871.00
144_R148_Y0.9851.00
23_S27_V0.9811.00
99_V247_L0.9751.00
274_S278_H0.9741.00
115_A148_Y0.9731.00
403_I445_I0.9721.00
415_V436_A0.9711.00
365_Y368_H0.9711.00
391_M448_Y0.9711.00
194_M200_L0.9681.00
108_F155_L0.9671.00
207_Y210_V0.9631.00
303_S307_A0.9621.00
315_S327_V0.9611.00
286_A363_T0.9581.00
330_V334_L0.9581.00
105_T243_M0.9571.00
120_I124_D0.9541.00
351_H365_Y0.9521.00
193_G200_L0.9501.00
122_T143_A0.9481.00
88_Y166_T0.9451.00
177_I181_V0.9451.00
373_I428_L0.9441.00
282_N366_I0.9401.00
340_G344_I0.9381.00
370_L427_I0.9361.00
98_A247_L0.9351.00
120_I144_R0.9341.00
159_Y217_F0.9341.00
250_L253_R0.9331.00
187_L209_T0.9241.00
45_M48_G0.9211.00
86_Q316_I0.9211.00
293_V346_I0.9181.00
324_L328_I0.9151.00
73_T154_F0.9141.00
215_A219_V0.9131.00
40_Q63_F0.9071.00
289_V357_F0.9041.00
437_A441_S0.9041.00
380_L442_L0.9021.00
210_V214_I0.9011.00
168_D223_Y0.8931.00
42_V183_N0.8871.00
29_L306_I0.8861.00
141_N144_R0.8841.00
253_R398_L0.8821.00
163_L224_L0.8821.00
341_V344_I0.8791.00
347_Y351_H0.8791.00
411_V414_P0.8781.00
433_G437_A0.8761.00
186_L190_L0.8761.00
88_Y93_E0.8761.00
109_L113_V0.8751.00
46_A192_L0.8741.00
148_Y210_V0.8731.00
101_G241_L0.8731.00
138_V202_I0.8721.00
80_S84_I0.8711.00
21_S24_L0.8711.00
341_V345_L0.8691.00
362_E366_I0.8661.00
101_G240_Y0.8631.00
332_I383_N0.8631.00
214_I218_L0.8611.00
275_F416_A0.8601.00
277_N284_T0.8591.00
207_Y211_I0.8561.00
264_L405_I0.8511.00
324_L394_S0.8501.00
364_L368_H0.8461.00
226_K229_H0.8451.00
350_S371_L0.8441.00
183_N187_L0.8441.00
174_Y177_I0.8441.00
312_A393_A0.8431.00
116_V120_I0.8421.00
348_V352_Q0.8411.00
61_S131_T0.8371.00
119_S123_L0.8351.00
66_F146_L0.8301.00
287_Y431_W0.8291.00
168_D227_R0.8281.00
416_A420_S0.8271.00
25_F169_S0.8211.00
315_S318_A0.8181.00
428_L432_V0.8171.00
105_T241_L0.8161.00
22_M330_V0.8161.00
283_A366_I0.8141.00
276_V427_I0.8121.00
289_V367_A0.8111.00
260_I401_T0.8111.00
301_A339_G0.8101.00
42_V180_T0.8101.00
275_F278_H0.8091.00
219_V222_V0.8091.00
113_V117_I0.8091.00
35_L180_T0.8071.00
53_V363_T0.8071.00
86_Q250_L0.8051.00
133_E136_I0.8051.00
286_A367_A0.8051.00
135_V284_T0.8041.00
19_W333_W0.8041.00
156_Y216_T0.8031.00
407_A441_S0.8021.00
383_N442_L0.7971.00
292_Q357_F0.7961.00
54_D135_V0.7961.00
312_A390_T0.7951.00
354_L368_H0.7941.00
173_F177_I0.7901.00
159_Y224_L0.7871.00
145_I148_Y0.7871.00
337_I340_G0.7851.00
326_Q333_W0.7841.00
336_Y340_G0.7831.00
304_L331_G0.7821.00
47_V191_I0.7781.00
82_I86_Q0.7741.00
276_V430_V0.7731.00
187_L191_I0.7711.00
286_A370_L0.7701.00
72_F259_S0.7671.00
163_L220_L0.7661.00
347_Y350_S0.7661.00
419_L429_G0.7661.00
234_D239_R0.7661.00
122_T147_F0.7661.00
199_K203_Y0.7651.00
178_V182_I0.7641.00
97_K240_Y0.7621.00
141_N202_I0.7611.00
83_L254_L0.7611.00
323_R326_Q0.7611.00
278_H421_H0.7591.00
57_A135_V0.7581.00
117_I121_F0.7531.00
48_G56_V0.7521.00
255_G259_S0.7521.00
39_G209_T0.7521.00
85_G165_G0.7511.00
312_A328_I0.7511.00
420_S429_G0.7501.00
35_L38_V0.7491.00
84_I162_F0.7491.00
137_H140_A0.7481.00
21_S314_Q0.7481.00
183_N212_S0.7481.00
429_G432_V0.7471.00
263_I267_L0.7471.00
90_A317_G0.7471.00
439_A443_L0.7461.00
32_S176_L0.7451.00
21_S311_F0.7431.00
222_V225_R0.7431.00
279_Y420_S0.7431.00
315_S324_L0.7421.00
58_A202_I0.7421.00
103_T158_A0.7401.00
247_L250_L0.7391.00
373_I435_P0.7381.00
83_L87_A0.7381.00
164_R172_P0.7351.00
51_L199_K0.7311.00
105_T109_L0.7281.00
97_K234_D0.7281.00
331_G386_I0.7261.00
322_D329_R0.7221.00
361_Q364_L0.7221.00
330_V333_W0.7171.00
340_G379_L0.7151.00
275_F420_S0.7151.00
126_L143_A0.7141.00
42_V46_A0.7091.00
221_M225_R0.7091.00
163_L171_T0.7091.00
427_I431_W0.7061.00
171_T219_V0.7061.00
58_A139_S0.7041.00
376_W379_L0.7031.00
41_L296_Y0.7031.00
38_V42_V0.7001.00
121_F125_I0.6981.00
389_A393_A0.6961.00
415_V419_L0.6941.00
19_W23_S0.6931.00
419_L422_Y0.6921.00
250_L395_G0.6921.00
275_F417_F0.6921.00
348_V351_H0.6921.00
304_L338_I0.6901.00
206_A210_V0.6881.00
399_W403_I0.6881.00
349_F353_I0.6871.00
22_M307_A0.6861.00
211_I214_I0.6861.00
336_Y382_G0.6851.00
142_Y187_L0.6851.00
45_M356_L0.6831.00
257_P401_T0.6831.00
322_D325_K0.6811.00
130_G133_E0.6791.00
294_A378_Y0.6791.00
333_W336_Y0.6781.00
123_L144_R0.6721.00
149_A213_T0.6711.00
271_A413_V0.6691.00
116_V119_S0.6691.00
90_A319_N0.6671.00
413_V417_F0.6661.00
254_L397_V0.6651.00
34_V38_V0.6641.00
432_V435_P0.6601.00
273_I277_N0.6601.00
178_V215_A0.6601.00
411_V415_V0.6571.00
316_I321_F0.6571.00
113_V116_V0.6561.00
309_S392_R0.6561.00
200_L203_Y0.6551.00
276_V287_Y0.6541.00
339_G382_G0.6531.00
143_A147_F0.6521.00
95_R99_V0.6511.00
358_L361_Q0.6511.00
190_L205_S0.6481.00
84_I96_L0.6481.00
308_V312_A0.6471.00
350_S354_L0.6471.00
212_S215_A0.6451.00
304_L335_N0.6441.00
98_A101_G0.6431.00
144_R203_Y0.6431.00
159_Y221_M0.6401.00
252_L256_V0.6391.00
47_V202_I0.6381.00
200_L204_G0.6381.00
149_A152_F0.6371.00
26_L303_S0.6351.00
54_D57_A0.6331.00
147_F150_M0.6331.00
148_Y152_F0.6331.00
82_I254_L0.6321.00
135_V138_V0.6321.00
21_S323_R0.6321.00
321_F324_L0.6311.00
298_Q381_F0.6291.00
286_A431_W0.6291.00
108_F112_V0.6291.00
360_E364_L0.6281.00
372_M376_W0.6281.00
338_I342_L0.6261.00
351_H364_L0.6251.00
45_M49_R0.6241.00
47_V55_A0.6241.00
418_V421_H0.6241.00
182_I211_I0.6201.00
51_L202_I0.6191.00
363_T367_A0.6181.00
131_T277_N0.6161.00
79_G255_G0.6151.00
94_E97_K0.6151.00
336_Y379_L0.6141.00
387_I445_I0.6131.00
75_G259_S0.6121.00
279_Y283_A0.6121.00
55_A201_G0.6111.00
142_Y205_S0.6101.00
111_G147_F0.6071.00
39_G179_S0.6051.00
390_T394_S0.6041.00
297_V342_L0.6021.00
39_G213_T0.5991.00
275_F421_H0.5991.00
156_Y217_F0.5981.00
177_I180_T0.5961.00
136_I139_S0.5961.00
119_S148_Y0.5951.00
81_S161_T0.5941.00
444_L447_G0.5941.00
178_V181_V0.5931.00
75_G309_S0.5931.00
358_L364_L0.5921.00
112_V116_V0.5921.00
397_V401_T0.5921.00
192_L200_L0.5901.00
17_S21_S0.5901.00
126_L140_A0.5891.00
334_L337_I0.5891.00
55_A58_A0.5881.00
82_I313_A0.5881.00
300_P338_I0.5871.00
98_A102_T0.5851.00
160_T164_R0.5851.00
147_F151_P0.5841.00
111_G151_P0.5841.00
219_V223_Y0.5831.00
115_A120_I0.5831.00
38_V180_T0.5821.00
126_L131_T0.5821.00
217_F221_M0.5811.00
332_I336_Y0.5801.00
101_G105_T0.5771.00
345_L349_F0.5771.00
56_V289_V0.5771.00
56_V358_L0.5761.00
272_V430_V0.5761.00
134_N138_V0.5751.00
412_E437_A0.5751.00
246_E250_L0.5741.00
283_A286_A0.5731.00
381_F438_F0.5711.00
336_Y383_N0.5711.00
183_N208_A0.5711.00
151_P214_I0.5701.00
76_I259_S0.5701.00
238_R241_L0.5701.00
432_V436_A0.5691.00
129_M270_I0.5691.00
375_L379_L0.5671.00
182_I185_A0.5661.00
314_Q318_A0.5661.00
92_N98_A0.5651.00
414_P417_F0.5641.00
272_V416_A0.5641.00
225_R228_K0.5641.00
387_I446_Y0.5611.00
256_V259_S0.5601.00
391_M396_T0.5601.00
308_V386_I0.5571.00
107_T111_G0.5571.00
223_Y227_R0.5541.00
22_M334_L0.5541.00
403_I444_L0.5541.00
275_F279_Y0.5521.00
141_N145_I0.5511.00
84_I99_V0.5501.00
417_F422_Y0.5501.00
204_G208_A0.5491.00
61_S139_S0.5491.00
18_V330_V0.5481.00
63_F67_F0.5481.00
289_V363_T0.5461.00
275_F430_V0.5451.00
57_A60_S0.5451.00
161_T164_R0.5451.00
115_A147_F0.5431.00
156_Y160_T0.5431.00
152_F210_V0.5431.00
18_V327_V0.5421.00
268_S408_I0.5411.00
47_V51_L0.5401.00
53_V285_A0.5391.00
184_I188_P0.5391.00
119_S122_T0.5391.00
343_I379_L0.5381.00
117_I120_I0.5341.00
49_R358_L0.5331.00
404_S407_A0.5331.00
346_I353_I0.5321.00
78_S306_I0.5301.00
294_A374_T0.5291.00
415_V418_V0.5281.00
112_V115_A0.5281.00
387_I442_L0.5240.99
135_V139_S0.5240.99
131_T136_I0.5240.99
280_G283_A0.5240.99
111_G115_A0.5230.99
94_E240_Y0.5230.99
119_S147_F0.5220.99
164_R169_S0.5210.99
415_V433_G0.5210.99
69_L150_M0.5210.99
282_N285_A0.5200.99
163_L223_Y0.5200.99
22_M26_L0.5200.99
42_V45_M0.5180.99
407_A444_L0.5180.99
248_L252_L0.5180.99
18_V326_Q0.5180.99
208_A212_S0.5160.99
351_H372_M0.5160.99
328_I332_I0.5160.99
76_I110_L0.5160.99
190_L207_Y0.5160.99
415_V440_V0.5160.99
384_A441_S0.5160.99
383_N446_Y0.5140.99
332_I387_I0.5140.99
45_M357_F0.5140.99
19_W326_Q0.5140.99
360_E363_T0.5130.99
38_V41_L0.5130.99
301_A382_G0.5120.99
311_F315_S0.5110.99
40_Q146_L0.5110.99
84_I100_V0.5110.99
295_S298_Q0.5100.99
135_V281_S0.5070.99
426_E433_G0.5050.99
227_R230_P0.5050.99
108_F111_G0.5050.99
271_A417_F0.5040.99
189_V199_K0.5040.99
91_K318_A0.5030.99
336_Y339_G0.5010.99
309_S389_A0.5010.99
234_D240_Y0.5000.99
329_R449_Y0.5000.99
51_L191_I0.5000.99
112_V151_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mktA 1 0.9762 100 0.278 Contact Map
4humA 1 0.9827 100 0.279 Contact Map
4lz6A 1 0.9611 100 0.296 Contact Map
3w4tA 1 0.9546 100 0.353 Contact Map
4ikvA 1 0.892 74.5 0.944 Contact Map
4xnjA 1 0.8575 71.4 0.945 Contact Map
3wdoA 1 0.8445 62.6 0.948 Contact Map
1pw4A 1 0.8834 60.2 0.949 Contact Map
2cfqA 1 0.8639 54.1 0.951 Contact Map
3o7qA 1 0.8359 51.5 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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